ERK

Catalog No.Inhibitor Name ERK1ERK2ERK5ERKOther
A12824SCH772984
***
****
A12505VX-11e
***
GSK3,AURA,CDK2
A15802DEL-22379
*
*
A11794Ulixertinib
****
A13420GDC-0994
***
****
A14119FR 180204
*
**
A11609XMD8-92
**
A16232ERK5-IN-1
**
A11225Pluripotin (SC-1)
**
RasGAP

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

21 Item(s)

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  1. BAY885

    Catalog No. A13765
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    ERK5 inhibitor
    BAY885 is a novel ERK5 inhibitor. Learn More
  2. ERK5-IN-2

    Catalog No. A18871
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    ERK5 inhibitor
    ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. Learn More
  3. Tomatidine

    Catalog No. A16233
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    ERK/Akt/NF-kB inhibitor
    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties. Learn More
  4. CC-90003

    Catalog No. A16837
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    ERK1/2 inhibitor
    CC-90003 is an irreversible inhibitor of ERK1/2 with IC50s in the 10-20 nM range and shows good kinase selectivity in a 258-kinase biochemical assay. Learn More
  5. MK-8353 (SCH900353)

    Catalog No. A16838
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    ERK inhibitor
    MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay). Learn More
  6. AZD0364

    Catalog No. A16839
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    ERK inhibitor
    AZD0364 is a pre-clinical ERK1/2 inhibitor with an IC50 of 0.6 nM for ERK2. Learn More
  7. LY3214996

    Catalog No. A16843
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    ERK inhibitor
    LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines. Learn More
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    AG-126

    Catalog No. A17146
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    ERK2 inhibitor
    AG-126 is a ERK2 inhibitor that selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. Learn More
  8. ERK-IN-1

    Catalog No. A19080
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    RAF/ERK1/2 inhibitor
    ERK-IN-1 (compound B) is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. Learn More
  9. ERK5-IN-1

    Catalog No. A16232
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    ERK5 inhibitor
    ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 uM and enzymatic IC50 values of 0.087 uM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026uM. Learn More
  10. APS-2-79

    Catalog No. A16231
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    KSR/Ras inhibitor
    APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site. Learn More
  11. DEL-22379

    Catalog No. A15802
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    ERK inhibitor
    DEL-22379 is a potent and selective ERK Dimerization inhibitor that inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes. Learn More
  12. Ulixertinib (BVD-523, VRT752271)

    Catalog No. A11794
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    ERK1/ERK2 inhibitor
    VRT752271 is a pyrrole inhibitors of ERK protein kinase. Learn More
  13. SCH772984

    Catalog No. A12824
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    ERK Inhibitor
    SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. Learn More
  14. TCS ERK 11e (VX-11e)

    Catalog No. A12505
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    ERK2 inhibitor
    TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Learn More
  15. GDC0994 (Ravoxertinib)

    Catalog No. A13420
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    ERK1/2 inhibitor
    GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. Learn More
  16. XMD 17-109

    Catalog No. A14090
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    ERK5 inhibitor
    XMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 uM in HEK293 cells. Learn More
  17. FR 180204

    Catalog No. A14119
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    ERK inhibitor
    FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis. Learn More
  18. XMD8-92

    Catalog No. A11609
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    BMK1/ERK5 inhibitor
    XMD8-92 is a potent and selective BMK1/ERK5 inhibitor . Learn More
  19. TMCB

    Catalog No. A13977
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    CK2/ERK8 inhibitor
    MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8). Learn More
  20. Pluripotin (SC-1)

    Catalog No. A11225
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    ERK1/RasGAP Inhibitor
    The activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively. Learn More

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