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| Catalog No. | Inhibitor Name | ERK1 | ERK2 | ERK5 | ERK | Other |
|---|---|---|---|---|---|---|
| A12824 | SCH772984 | *** | **** | |||
| A12505 | VX-11e | *** | GSK3,AURA,CDK2 | |||
| A15802 | DEL-22379 | * | * | |||
| A11794 | Ulixertinib | **** | ||||
| A13420 | GDC-0994 | *** | **** | |||
| A14119 | FR 180204 | * | ** | |||
| A11609 | XMD8-92 | ** | ||||
| A16232 | ERK5-IN-1 | ** | ||||
| A11225 | Pluripotin (SC-1) | ** | RasGAP |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
21 Item(s)
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SCH772984
Catalog No. A12824 ERK InhibitorSCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. Learn More -
TCS ERK 11e (VX-11e)
Catalog No. A12505 ERK2 inhibitorTCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Learn More -
ERK5-IN-2
Catalog No. A18871 ERK5 inhibitorERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. Learn More -
FR 180204
Catalog No. A14119 ERK inhibitorFR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis. Learn More -
APS-2-79
Catalog No. A16231 KSR/Ras inhibitorAPS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site. Learn More -
ERK-IN-1
Catalog No. A19080 RAF/ERK1/2 inhibitorERK-IN-1 (compound B) is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. Learn More -
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AG-126
Catalog No. A17146 ERK2 inhibitorAG-126 is a ERK2 inhibitor that selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. Learn More -
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LY3214996
Catalog No. A16843 ERK inhibitorLY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines. Learn More -
AZD0364
Catalog No. A16839 ERK inhibitorAZD0364 is a pre-clinical ERK1/2 inhibitor with an IC50 of 0.6 nM for ERK2. Learn More -
MK-8353 (SCH900353)
Catalog No. A16838 ERK inhibitorMK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay). Learn More -
CC-90003
Catalog No. A16837 ERK1/2 inhibitorCC-90003 is an irreversible inhibitor of ERK1/2 with IC50s in the 10-20 nM range and shows good kinase selectivity in a 258-kinase biochemical assay. Learn More -
Tomatidine
Catalog No. A16233 ERK/Akt/NF-kB inhibitorTomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties. Learn More -
ERK5-IN-1
Catalog No. A16232 ERK5 inhibitorERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 uM and enzymatic IC50 values of 0.087 uM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026uM. Learn More -
Pluripotin (SC-1)
Catalog No. A11225 ERK1/RasGAP InhibitorThe activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively. Learn More -
DEL-22379
Catalog No. A15802 ERK inhibitorDEL-22379 is a potent and selective ERK Dimerization inhibitor that inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes. Learn More -
TMCB
Catalog No. A13977 CK2/ERK8 inhibitorMCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8). Learn More -
XMD8-92
Catalog No. A11609 BMK1/ERK5 inhibitorXMD8-92 is a potent and selective BMK1/ERK5 inhibitor . Learn More -
XMD 17-109
Catalog No. A14090 ERK5 inhibitorXMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 uM in HEK293 cells. Learn More -
GDC0994 (Ravoxertinib)
Catalog No. A13420 ERK1/2 inhibitorGDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. Learn More -
Ulixertinib (BVD-523, VRT752271)
Catalog No. A11794 ERK1/ERK2 inhibitorVRT752271 is a pyrrole inhibitors of ERK protein kinase. Learn More
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