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| Catalog No. | Inhibitor Name | MMP |
|---|---|---|
| A12985 | Batimastat (BB-94) | *** |
| A13320 | Ilomastat (GM6001, Galardin) | **** |
| A14253 | SB-3CT | * |
| A12826 | Marimastat (BB-2516) | *** |
| A13072 | NSC 405020 | |
| A10651 | Nobiletin |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
35 Item(s)
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UK 370106
Catalog No. A15316 MMP-3/MMP-12 InhiibitorUK 370106 is a highly selective MMP-3 and MMP-12 inhibitor . Learn More -
MMP3 inhibitor 1
Catalog No. A13185 MMP-3 inhibitorMMP3 inhibitor 1 is a potent and highly selective MMP-3 inhibitor with an IC50 of 1 nM. Learn More -
Apratastat
Catalog No. A13330 dual TACE/MMPs inhibitorApratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) . Learn More -
T-26c
Catalog No. A12853 matrix metalloproteinase-13 (MMP-13) inhibitorT-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes. Learn More -
DB04760
Catalog No. A18548 MMP-13 inhibitorDB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity. Learn More -
BR351
Catalog No. A18617 MMP inhibitorBR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively. Learn More -
Doxycycline monohydrate
Catalog No. A17813 MMP inhibitorDoxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor. Learn More -
Doxycycline
Catalog No. A17545 MMP inhibitorDoxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Learn More -
JNJ0966
Catalog No. A17025 MMP9 inhibitorJNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. Learn More -
20(R)-Ginsenoside Rh2
Catalog No. A15408 MMP Inhibitor20(R)-Ginsenoside Rh2 is a matrix metalloproteinase (MMP) inhibitor that acts as a cell antiproliferator. Learn More -
Batimastat sodium salt
Catalog No. A15326 MMP InhibitorBatimastat is an anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. Learn More -
UK 356618
Catalog No. A15323 MMP-3 inhibitorUK 356618 is a selective and potent inhibitor of MMP-3 that shows selectivity over a range of MMPs. Learn More -
WAY 170523
Catalog No. A15317 MMP-13 inhibitorWAY 170523 has been reported to be a selective and potent inhibitor of MMP-13. Learn More -
Ro 32-3555
Catalog No. A15311 -
PD 166793
Catalog No. A15307 Broad spectrum MMP inhibitorPD166793 is a cell-permeable compound that strongly inhibits MMP (matrix metalloproteinase) -2 , -3, and -13, and weakly inhibits AMP deaminase, MMP-1, -7, -9, and -14. Learn More -
CP 471474
Catalog No. A15297 MMP inhibitorCP 471474, broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Learn More -
4-epi-Chlortetracycline Hydrochloride
Catalog No. A12848 MMP inhibitor4-epi-Chlortetracycline Hydrochloride is a tetracycline derivative that acts as a metalloproteinase (MMP) inhibitor, used in treating tissue destructive diseases and cancer Learn More -
NSC 405020
Catalog No. A13072 MT1-MMP inhibitorNSC-405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Learn More -
Marimastat
Catalog No. A12826 MMP inhibitorMarimastat acted as a broad-spectrum matrix metalloproteinase inhibitor. Learn More -
GM 6001
Catalog No. A13320 MMP inhibitorGM 6001 is a potent, reversible broad spectrum inhibitor of zinc-containing proteases, including matrix metalloproteinases (MMPs). Learn More -
SB-3CT
Catalog No. A14253 MMP-2/MMP-9 inhibitorSB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9. Learn More -
CL-82198
Catalog No. A13597 MMP-13 inhibitorCL-82198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 mg/ml. Learn More -
ARP 100
Catalog No. A15292 MMP-2 inhibitorARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM. Learn More -
ARP 101
Catalog No. A15293 MMP-2 inhibitorARP 101, selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively). Learn More -
ONO 4817
Catalog No. A15305 Broad spectrum MMP inhibitorONO 4817 is used for testing effective treatment of MMP-related diseases. Learn More -
Abametapir
Catalog No. A15945 metalloproteinase inhibitorAbametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. Learn More -
Doxycycline HCl
Catalog No. A10745 Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity. Learn More -
DC_AC50
Catalog No. A16043 Atox1/CCS inhibitorDC_AC50 is an inhibitor of copper trafficking proteins Atox1 and CCS, resulting in a disruption of cellular copper transport. Learn More -
TAPI-0
Catalog No. A13724 TACE/MMP inhibitorTAPI-0 is an inhibitor of TACE (IC50 = 50-100 nM) as well as other matrix and membrane metalloproteases Learn More -
TMI-1
Catalog No. A17212 TACE/MMP inhibitorTMI-1 is a novel orally active dual inhibitor of ADAM17 (TACE) and MMP. Learn More -
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New
Incyclinide
Catalog No. A17240 MMP inhibitorIincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis. Learn More -
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TAPI-2
Catalog No. A14009 TACE/MMP inhibitorTAPI-2 is an inhibitor of TACE, ADAMs, ACE secretase, and other MMPs (metalloproteinases). TAPI-2 blocks release of DCC7, APP, TNFα, L-selectin, NOTCH, TGFα, IL-6R9, erbB2/HER2, and ACE. This inhibitor has been used in tissue culture. Learn More -
TAPI-1
Catalog No. A14070 TACE/MMP inhibitorTAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. Learn More -
Batimastat (BB-94)
Catalog No. A12985 MMP inhibitorBatimastat (BB-94) is a potent and synthetic inhibitor of a broad spectrum of matrix metalloproteinases (MMPs), including interstitial collagenase (IC50 = 3 nM), stromelysin (IC50 = 20 nM), Mr 72,000 type IV collagenase (IC50 = 4 nM), Mr 92,000 type IV collagenase (IC50 = 4 nM), and matrilysin (IC50 = 6 nM). It is a low-molecular-weight (MW = 478) and peptide-like collagen substrate analogue consisting of a peptide backbone and a hydroxamic acid group which bind to MMPs and the catalytically active zinc atom respectively. Learn More -
CTS-1027
Catalog No. A11345 Matrix Metalloproteinase InhibitorCTS-1027 is a potent MMP inhibitor that protects Against TNFα- and α-Fas-Induced liver Injury. Learn More
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