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- Dihydroartemisinin is the active metabolite of all artemisinin compounds (artemisinin, artesunate, artemether, etc.) and is also available as a drug in itself. It is a semi-synthetic derivative of artemisinin and is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs.
- Xinyu Zhou, .et al. , Cancers (Basel), 2020, Sep; 12(9): 2514 PMID: 32899699
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Protective agent
Dimesna is an uroprotective agent used to decrease urotoxicity. - Dioscin (Collettiside III) is extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively.
- Diphenhydramine is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic and sedative properties which is mainly used to treat allergies.
- Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. It is used in the United Kingdom, Canada, and United States for the treatment of the manic episodes of bipolar disorder.
- DL-Carnitine hydrochloride is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine. In living cells, it is required for the transport of fatty acids from the cytosol into the mitochondria during the breakdown of lipids (fats) for the generation of metabolic energy.
- Dofetilide is a class III antiarrhythmic agent. Dofetilide works by selectively blocking the rapid component of the delayed rectifier outward potassium current (Ikr).
- Doripenem (doripenem monohydrate) is an ultra-broad spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It is particularly active against Pseudomonas aeruginosa.
- Maria Yuliana, .et al. , Environ Res, 2021, Oct 2;112162 PMID: 34610325
- Doxercalciferol is a synthetic analog of ergocalciferol (vitamin D2). It suppresses parathyroid synthesis and secretion.
- Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands.
- Yanina G. Razuvaeva, .et al. , Appl Sci, 2023, 13(2), 860
- Miwako Toyofuku, .et al. , J Insect Physiol, 2021, Oct;134:104294 PMID: 34389412
- Ergosterol is a sterol and a biological precursor (a provitamin) to vitamin D2. Ergosterol is a component of fungal cell membranes, serving the same function that cholesterol serves in animal cells. Because ergosterol is present in fungal cell membranes yet absent in animal cell membranes, it is a useful target for antifungal drugs. .
- Flucytosine is an antifungal used in the treatment of severe candidal and cryptococcal infections. It converted to fluorouracil after entering fungi, which inhibits DNA and RNA synthesis
- Formononetin (Formononetol) is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone. It is used as a blood enhancer and to improve blood microcirculation in complementary and alternative medicine. It promotes endothelial repair and wound healing in a process involving the over-expression of Egr-1 transcription factor through the regulation of the ERK1/2 and p38 MAPK pathways.
- Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.
- Fumalic acid(Ferulic acid) is a hydroxycinnamic acid and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong. It has many pharmacology functions, such as anti-blood platelet collection , ease pain better the alive of prostate , relax the blood vessel convulsion.
- Gadodiamide is a gadolinium-based MRI contrast agent, used in MR imaging procedures to assist in the visualization of blood vessels.
- Gastrodin (Gastrodine) is a polyphenol. It is the glucoside of 4-hydroxybenzyl alcohol (gastrodigenin).
- Gentamycin(Gentacycol) is an aminoglycoside antibiotic and was isolated from Micromonospora species
- Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.
- Gramine is a naturally occurring indole alkaloid present in several plant species. Gramine may play a defensive role in these plants, since it is toxic to many organisms. It is used mostly in synthetic organic chemistry as a starting material for tryptophan syntheses.
- Elizabeth Read, .et al. , Crop and Pasture Science, 2020, 71(4), 389-400
- Gynostemma Extract is a saponins extract derived from the Gynostemma pentaphyllum. The increase of SGOT, SGPT activities in CCl4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio.
- Haematoxylin is extracted from the heartwood of the logwood tree.When oxidized it forms haematein, a compound that forms strongly coloured complexes with certain metal ions, the most notable ones being Fe(III) and Al(III) salts. Metal-haematein complexes are used to stain cell nuclei prior to examination under a microscope.
- Hydrochlorothiazide is a first line diuretic compound of the thiazide class.
- Hydroxyurea (Cytodrox) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
- Hyodeoxycholic (HDCA) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.
- Indapamide(Lozol) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
- Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables.
- L(+)-Rhamnose (Rham) is a naturally-occurring deoxy sugar. It can be classified as either a methyl-pentose or a 6-deoxy-hexose.
- Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.
- L-Ascorbyl 6-palmitate (Ascorbyl palmitate) is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C.
- Calcium Folinate, Pentahydrate supplies cells with tetrahydrofolate and diminishes methotrexate toxicity without abolishing antitumor effect.
- Loteprednol Etabonate is an ophthalmic corticosteroid. It is used as an anti-inflammatory.
- Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1. It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, and increase gastrointestinal transit.
- Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively.
- Meropenem is a β-lactam antibiotic of the carbapenem subclass that has been shown to inhibit penicillinase-negative, -positive and methicillin-susceptible staphylococci.
- Viktoria Lazar, .et al. , Nature, 2022, 610: 540-546 PMID: 36198788
- Heidi Kaech, .et al. , Ecol Evol, 2022, Jan 24;12(1):e8551 PMID: 35127049
- Sreevalli Sharma, .et al. , ACS Infect Dis, 2021, Nov 12;7(11):3009-3024 PMID: 34699190