Cysteine protease

Catalog No.Inhibitor Name Cysteine ProteaseOther
A11265Odanacatib (MK-0822)
****
A13257E-64
***
A14245PD 151746
*
A15295Calpeptin
**
A11466Cathepsin Inhibitor 1
***
A11901PMSF
chymotrypsin
A13259Aloxistatin
A13258Loxistatin Acid (E-64C)
A14145Leupeptin Hemisulfate
serine protease
A14284Z-FA-FMK
A14220MG-101 (ALLN)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Z-FA-FMK

    Catalog No. A16381
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    Cysteine protease inhibitor
    Z-FA-FMK is an irreversible inhibitor of cysteine protease Learn More
  2. Acetyl-Calpastatin (184-210) (human)

    Catalog No. A15290
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    Selective calpain inhibitor
    Acetyl-Calpastatin (184-210) (human), selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 uM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio. Learn More
  3. Calpeptin

    Catalog No. A15295
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    Calpain inhibitor
    Calpeptin is a cell permeable calpain inhibitor. Learn More
  4. SJA6017

    Catalog No. A13640
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    reversible Calpain inhibitor
    SJA6017 is a cell permeable peptide aldehyde which functions as a reversible calpain inhibitor. Learn More
  5. MDL 28170

    Catalog No. A15303
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    Calpain Inhibitor III
    MDL 28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent cysteine protease which has been implicated in apoptosis of immune cells as well as neuronal cells. Learn More
  6. PD 150606

    Catalog No. A15306
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    Non-peptide calpain inhibitor
    PD 150606 is a cell-permeable, non-competitive, selective, non-peptide Ca2+ dependent calpain inhibitor for calpain-1 and for calpain-2 directed towards the Ca2+ binding sites of calpain. Learn More
  7. Z-FA-FMK

    Catalog No. A14284
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    Irreversible Cysteine Protease inhibitor
    Z-FA-FMK is an irreversible cysteine protease inhibitor. Learn More
  8. PD 151746

    Catalog No. A14245
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    Calpain inhibitor
    PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 uM for μ-Calpain, about 20-fold selectivity over m-calpain. Learn More
  9. MG-101

    Catalog No. A14220
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    Cysteine Protease inhibitor
    MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins. Learn More
  10. Cathepsin Inhibitor 1

    Catalog No. A11466
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    Cathepsin Inhibitor
    Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. Learn More
  11. Balicatib

    Catalog No. A12020
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    Cathepsin K inhibitor
    Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Learn More
  12. Calpain Inhibitor II, ALLM

    Catalog No. A14911
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    Calpain Inhibitor
    Calpain Inhibitor II, ALLM is a cell-permeable inhibitor of calpain I, calpain II, cathepsin L and cathepsin B with Ki values of 120 nM, 230 nM, 0.6 nM and 100 nM, respectively. Learn More
  13. SID 26681509

    Catalog No. A15313
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    Human cathepsin L inhibitor
    SID 26681509 is a reversible and potent human cathepsin L inhibitor. SID 26681509 displays no inhibitory activity of cathepsin G. Learn More
  14. L 006235

    Catalog No. A15302
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    Cathepsin K Inhibitor
    L006235 is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Learn More
  15. PMSF

    Catalog No. A11901
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    Serine/cysteine protease inhibitor
    PMSF is an irreversible serine/cysteine protease inhibitor. Learn More
  16. Z-FL-COCHO

    Catalog No. A13502
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    Cathepsin S inhibitor
    Z-FL-COCHO is a novel Cathepsin S inhibitor. Learn More
  17. CA-074 Methyl Ester

    Catalog No. A13593
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    Cathepsin B inhibitor
    CA-074 methyl ester is a cell-permeable analog of CA-074 that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro. Learn More
  18. Gly-Phe-beta-naphthylamide

    Catalog No. A13611
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    cathepsin C substrate
    Gly-Phe-beta-naphthylamide is a cathepsin C substrate. The compound is described to accumulate inside lysosomes leading to their destruction. Learn More
  19. E-64

    Catalog No. A13257
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    Cysteine Protease inhibitor
    E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. Learn More
  20. Loxistatin Acid (E64-C)

    Catalog No. A13258
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    Cysteine Protease inhibitor
    Loxistatin Acid, a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. Learn More
  21. Leupeptin hemisulfate

    Catalog No. A14145
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    Cysteine Protease inhibitor
    Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Learn More
  22. E 64d (Aloxistatin)

    Catalog No. A13259
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    Cysteine Protease inhibitor
    E-64d is an inhibitor of cathepsins B and L and it is lysosome and cell permeable. Learn More
  23. CA-074

    Catalog No. A13256
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    Cathepsin B inhibitor
  24. Odanacatib (MK-0822)

    Catalog No. A11265
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    Cathepsin K Inhibitor
    Odanacatib is an inhibitor of cathepsin K,an enzyme involved in bone resorption. Learn More

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