Catalog No.
Product Name
Application
Product Information
Product Citation
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PKA, PKG, Casein Kinase I and II inhibitor
A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM). -
myosin II inhibitor
Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light. -
microtubule dynamics inhibitor
Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. -
PAK inhibitor
FRAX486 is a small-molecule PAK inhibitor.- Natalia Barraza-Núñez, .et al. , Neurotox Res, 2023, Mar 3 PMID: 36867391
- Yukie Yamahashi, .et al. , Mol Psychiatry, 2022, 03 June
- Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.
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Integrin agonist
Leukadherin 1 is an allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM). -
CaMKII inhibitor
KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.- Kazuki Yuasa, .et al. , Sci Rep, 2018, 8: 9037 PMID: 29899565
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Mps1 inhibitor
MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 - Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
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DRP1 inhibitor
Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 uM.- Umut Kerem Kolac, .et al. , Mol Biol Rep, 2023, Jan;50(1):493-506 PMID: 36352179
- KOLAC UK, .et al. , Research Square, 2022, 03 Jun
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microtubule stabilizer
Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity.- Payal Ranaa, .et al. , Toxicol In Vitro, 2017, Dec;45(Pt 1):111-118 PMID: 28843493
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Microtubule polymerization inhibitor
Cucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. Also it is an potent Microtubule polymerization inhibitor -
Dynamin inhibitor
Dynamin Inhibitory Peptide is a peptide inhibitor of the GTPase dynamin. -
Panx-1 mimetic inhibitor
Scrambled 10Panx, Panx-1 mimetic inhibitory peptide, is a blocker of pannexin-1 gap junctions. -
αvβ3 integrin inhibitor
Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin.- Julian Tu, .et al. , Synlett, 2020, 31, A-F
- 7-Epi 10-Desacetyl Paclitaxel is a derivative of Paclitaxel, which is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
- 7-xylosyltaxol is a taxol derivative, Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.
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KSP inhibitor
ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM. - Docetaxel trihydrate, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
- Ogawa C, .et al. , Yakugaku Zasshi, 2018, 138(7):973-984 PMID: 29962477
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Gap Junction Modifier
GAP-134 , a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.- Yi Zhu, .et al. , Acta Pharmaceutica Sinica B, 2022, Feb,12(7)
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Gap-junction modifier
GAP-134 Hydrochloride, a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability. -
PAK4/NAMPT Inhibitor
KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay. -
Inhibits integrin binding to RGD motifs
RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.- Kan Zhang, .et al. , Exp Neurol, 2021, Feb 26;340:113659 PMID: 33640375
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Kinesin Eg5 inhibitor
Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 with IC50 value of 200 nM. -
Integrin inhibitor
Cyclo(RGDyK) trifluoroacetate is a potent and selective alphaVbeta3 integrin inhibitor with IC50 of 20 nM. -
αV integrins inhibitor
CWHM 12 can suppress all 5 alpha V integrins. CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method, it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs. -
tau protein aggregation inhibitor
TRx 0237 (LMT) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
