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| Catalog No. | Inhibitor Name | DUB | USP/UBP | UCH | Other |
|---|---|---|---|---|---|
| A13190 | PR-619 | ** | *** | JOSD2,SENP6 core,DEN1 | |
| A13277 | P5091 | ** | |||
| A12715 | LDN-57444 | **** | |||
| A13209 | IU1 | * | |||
| A12933 | P22077 | * | |||
| A14030 | ML323 | **** | |||
| A15391 | b-AP15 | *** | |||
| A10988 | Degrasyn | Bcr-Abl |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
18 Item(s)
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Vialinin A
Catalog No. A15321 USP4 InhibitorVialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis. Learn More -
GNE-6640
Catalog No. A16883 USP7 inhibitorGNE-6640 is a novel selective USP7 inhibitor, inducing tumor cell death. GNE-6640 enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors. Learn More -
VLX1570
Catalog No. A16853 DUB inhibitorVLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10?μM in vitro. Learn More -
DUBs-IN-2
Catalog No. A12842 USP7/USP8 inhibitorDUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 7.2 uM/0.93 uM for USP7/USP8 respectively. Learn More -
DUBs-IN-3
Catalog No. A12830 USP7/USP8 inhibitorDUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 3.1 uM for USP8; >30 fold selectivity over USP7 (IC50 > 100 uM). Learn More -
DUBs-IN-1
Catalog No. A12827 USP7/USP8 inhibitorDUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 uM/0.71 uM for USP7/USP8 respectively. Learn More -
SJB3-019A
Catalog No. A12822 USP1 inhibitorSJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. Learn More -
USP7-IN-1
Catalog No. A12813 USP7 inhibitorUSP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase(IC50>200 uM); HCT116 cell viability GI50 is 67 uM. Learn More -
b-AP15 (NSC 687852)
Catalog No. A15391 DUB inhibitorNSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs. Learn More -
WP1130 (Degrasyn)
Catalog No. A10988 DUB/Bcr/ABL InhibitorWP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells. Learn More -
SJB2-043
Catalog No. A15238 USP1 InhibitorSJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. Learn More -
ML-323
Catalog No. A14030 USP1-UAF1 inhibitorML323 is a selective and highly potent USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Learn More -
HBX 41108
Catalog No. A13352 USP 7 inhibitorHBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Learn More -
IU1
Catalog No. A13209 Usp14 inhibitorIU1 is a selective inhibitor of Usp14. It inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 uM). Learn More -
P005091
Catalog No. A13277 DUB/USP7 InhibitorP005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 uM). Learn More -
LDN-57444
Catalog No. A12715 UCH-L1 InhibitorLDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1. Learn More -
P 22077
Catalog No. A12933 USP7 inhibitorP 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 μM) and the closely related deubiquitinase (DUB) USP47. Learn More -
PR-619
Catalog No. A13190 DUB inhibitorPR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs). Learn More
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