DUB

Catalog No.Inhibitor Name DUBUSP/UBPUCHOther
A13190PR-619
**
***
JOSD2,SENP6 core,DEN1
A13277P5091
**
A12715LDN-57444
****
A13209IU1
*
A12933P22077
*
A14030ML323
****
A15391b-AP15
***
A10988Degrasyn
Bcr-Abl

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

18 Item(s)

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  1. WP1130 (Degrasyn)

    Catalog No. A10988
    DUB/Bcr/ABL Inhibitor
    WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells. Learn More
  2. VLX1570

    Catalog No. A16853
    DUB inhibitor
    VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10?μM in vitro. Learn More
  3. DUBs-IN-2

    Catalog No. A12842
    USP7/USP8 inhibitor
    DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 7.2 uM/0.93 uM for USP7/USP8 respectively. Learn More
  4. DUBs-IN-3

    Catalog No. A12830
    USP7/USP8 inhibitor
    DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 3.1 uM for USP8; >30 fold selectivity over USP7 (IC50 > 100 uM). Learn More
  5. DUBs-IN-1

    Catalog No. A12827
    USP7/USP8 inhibitor
    DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 uM/0.71 uM for USP7/USP8 respectively. Learn More
  6. SJB3-019A

    Catalog No. A12822
    USP1 inhibitor
    SJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. Learn More
  7. USP7-IN-1

    Catalog No. A12813
    USP7 inhibitor
    USP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase(IC50>200 uM); HCT116 cell viability GI50 is 67 uM. Learn More
  8. b-AP15 (NSC 687852)

    Catalog No. A15391
    DUB inhibitor
    NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs. Learn More
  9. Vialinin A

    Catalog No. A15321
    USP4 Inhibitor
    Vialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis. Learn More
  10. SJB2-043

    Catalog No. A15238
    USP1 Inhibitor
    SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. Learn More
  11. ML-323

    Catalog No. A14030
    USP1-UAF1 inhibitor
    ML323 is a selective and highly potent USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Learn More
  12. HBX 41108

    Catalog No. A13352
    USP 7 inhibitor
    HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Learn More
  13. IU1

    Catalog No. A13209
    Usp14 inhibitor
    IU1 is a selective inhibitor of Usp14. It inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 uM). Learn More
  14. P005091

    Catalog No. A13277
    DUB/USP7 Inhibitor
    P005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 uM). Learn More
  15. LDN-57444

    Catalog No. A12715
    UCH-L1 Inhibitor
    LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1. Learn More
  16. P 22077

    Catalog No. A12933
    USP7 inhibitor
    P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 μM) and the closely related deubiquitinase (DUB) USP47. Learn More
  17. PR-619

    Catalog No. A13190
    DUB inhibitor
    PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs). Learn More
  18. GNE-6640

    Catalog No. A16883
    USP7 inhibitor
    GNE-6640 is a novel selective USP7 inhibitor, inducing tumor cell death. GNE-6640 enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors. Learn More

18 Item(s)

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