GSK-3

Catalog No.Inhibitor Name GSK-3 GSK-3α GSK-3β Other Targets
A10825SB216763
**
**
A11085CHIR-98014
****
****
Cdc2
A11223TWS119
**
A11592Tideglusib
*
A11061SB415286
*
*
A10199CHIR-99021
***
****
A13060AZD2858
*
A12819AZD1080
***
**
A13728AR-A014418
**
A11941TDZD-8
*
A12741LY2090314
****
****
A15555BIO-acetoxime
***
***
A14196IM-12
**
A10471Indirubin
*
CDK2/CyclinA,CDK5/p35,CDK1/CyclinB
A15526Bikinin
A143031-Azakenpaullone
A16280Indirubin-3-monoxime
***
CDK1/5
A16230CP21R7

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. GSK-3b

    Catalog No. A15471
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    GSK-3 beta Inhibitor
  2. 9-ING-41

    Catalog No. A22066
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    glycogen synthase kinase-3β (GSK-3β) inhibitor
    9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. Learn More
  3. GSK3 Inhibitor XIII

    Catalog No. A22128
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    ATP-binding site inhibitor of GSK-3
    GSK3 Inhibitor XIII (GSK3i XIII) is an ATP-binding site inhibitor of GSK-3. Learn More
  4. BRD0705

    Catalog No. A22561
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    GSK3α inhibitor
    BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor. Learn More
  5. A 1070722

    Catalog No. A19973
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    GSK-3 inhibitor
    A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. Learn More
  6. 5-Iodo-indirubin-3'-monoxime

    Catalog No. A19479
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    GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor
    5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. Learn More
  7. Indirubin-3'-monoxime-5-sulphonic acid

    Catalog No. A19470
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    CDK1, CDK5, and GSK-3βinhibitor
    Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively. Learn More
  8. GSK-3β inhibitor 1

    Catalog No. A19186
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    GSK-3β inhibitor
    GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM. Learn More
  9. Indirubin-3-monoxime

    Catalog No. A16280
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    GSK-3β inhibitor
    Indirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM). Learn More
  10. CP21R7

    Catalog No. A16230
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    GSK-3β inhibitor
    CP21R7 is a potent and selective GSK-3β inhibitor. Learn More
  11. CHIR-99021

    Catalog No. A10199
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    GSK-3 Inhibitor
    CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. Learn More
  12. BIO-acetoxime

    Catalog No. A15555
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    GSK-3 inhibitor
    BIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity. Learn More
  13. AR-A 014418

    Catalog No. A13728
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    GSK-3 inhibitor
    AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Learn More
  14. AZD1080

    Catalog No. A12819
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    GSK3 inhibitor
    AZD1080 is a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. Learn More
  15. CHIR-99021 trihydrochloride

    Catalog No. A21436
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    GSK-3α/β inhibitor
    CHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM. Learn More
  16. Indirubin

    Catalog No. A10471
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    CDK & GSK-3β inhibitor
    Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM. Learn More
  17. SB 216763

    Catalog No. A10825
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    GSK-3 inhibitor
    SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β). Learn More
  18. SB 415286

    Catalog No. A11061
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    GSK-3 inhibitor
    SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. Learn More
  19. CHIR-98014

    Catalog No. A11085
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    GSK-3 inhibitor
    CHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3. Learn More
  20. TWS119

    Catalog No. A11223
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    GSK-3 Inhibitor
    TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM. Learn More
  21. TDZD-8

    Catalog No. A11941
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    GSK-3 Inhibitor
    TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity Learn More
  22. Tideglusib

    Catalog No. A11592
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    GSK-3 Inhibitor
    Tideglusib is a GSK-3 inhibitor currently in phase II clinical trials for the treatment of Alzheimer disease and progressive supranuclear palsy Learn More
  23. GSK-3 inhibitor 1

    Catalog No. A21803
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    GSK-3 inhibitor
    GSK-3 inhibitor 1 is an inhibitor of GSK-3. Learn More
  24. VP3.15 dihydrobromide

    Catalog No. A21789
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    PDE7/GSK3 inhibitor
    VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. Learn More
  25. 1-Azakenpaullone

    Catalog No. A14303
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    GSK-3β inhibitor
    1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. Learn More
  26. CHIR-99021 monohydrochloride

    Catalog No. A21430
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    GSK-3α/β inhibitor
    CHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Learn More
  27. VP3.15

    Catalog No. A18538
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    dual PDE7/GSK-3 inhibitor
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). Learn More
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    BIO

    Catalog No. A17129
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    GSK3 inhibitor
    BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β with IC50 value of 5 nM. Learn More
  28. LY2090314

    Catalog No. A12741
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    GSK-3 inhibitor
    LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis. Learn More
  29. AZD2858

    Catalog No. A13060
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    GSK-3β inhibitor
    AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats. Learn More
  30. Bikinin

    Catalog No. A15526
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    GSK-3 inhibitor
    Bikinin is a potent inhibitor of plant GSK-3/Shaggy-like kinase; activates BR signaling downstream of the BR receptor. Learn More
  31. IM-12

    Catalog No. A14196
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    GSK-3β inhibitor
    IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. Learn More

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