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| Catalog No. | Inhibitor Name | GSK-3 | GSK-3α | GSK-3β | Other Targets |
|---|---|---|---|---|---|
| A10825 | SB216763 | ** | ** | ||
| A11085 | CHIR-98014 | **** | **** | Cdc2 | |
| A11223 | TWS119 | ** | |||
| A11592 | Tideglusib | * | |||
| A11061 | SB415286 | * | * | ||
| A10199 | CHIR-99021 | *** | **** | ||
| A13060 | AZD2858 | * | |||
| A12819 | AZD1080 | *** | ** | ||
| A13728 | AR-A014418 | ** | |||
| A11941 | TDZD-8 | * | |||
| A12741 | LY2090314 | **** | **** | ||
| A15555 | BIO-acetoxime | *** | *** | ||
| A14196 | IM-12 | ** | |||
| A10471 | Indirubin | * | CDK2/CyclinA,CDK5/p35,CDK1/CyclinB | ||
| A15526 | Bikinin | ||||
| A14303 | 1-Azakenpaullone | ||||
| A16280 | Indirubin-3-monoxime | *** | CDK1/5 | ||
| A16230 | CP21R7 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
32 Item(s)
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9-ING-41
Catalog No. A22066 glycogen synthase kinase-3β (GSK-3β) inhibitor9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. Learn More -
GSK3 Inhibitor XIII
Catalog No. A22128 ATP-binding site inhibitor of GSK-3GSK3 Inhibitor XIII (GSK3i XIII) is an ATP-binding site inhibitor of GSK-3. Learn More -
BRD0705
Catalog No. A22561 GSK3α inhibitorBRD0705 is a potent, paralog selective and orally active GSK3α inhibitor. Learn More -
A 1070722
Catalog No. A19973 GSK-3 inhibitorA 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. Learn More -
5-Iodo-indirubin-3'-monoxime
Catalog No. A19479 GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. Learn More -
Indirubin-3'-monoxime-5-sulphonic acid
Catalog No. A19470 CDK1, CDK5, and GSK-3βinhibitorIndirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively. Learn More -
GSK-3β inhibitor 1
Catalog No. A19186 GSK-3β inhibitorGSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM. Learn More -
Indirubin-3-monoxime
Catalog No. A16280 GSK-3β inhibitorIndirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM). Learn More -
CP21R7
Catalog No. A16230 -
CHIR-99021
Catalog No. A10199 GSK-3 InhibitorCHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. Learn More -
BIO-acetoxime
Catalog No. A15555 GSK-3 inhibitorBIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity. Learn More -
AR-A 014418
Catalog No. A13728 GSK-3 inhibitorAR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Learn More -
AZD1080
Catalog No. A12819 GSK3 inhibitorAZD1080 is a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. Learn More -
CHIR-99021 trihydrochloride
Catalog No. A21436 GSK-3α/β inhibitorCHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM. Learn More -
Indirubin
Catalog No. A10471 CDK & GSK-3β inhibitorIndirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM. Learn More -
SB 216763
Catalog No. A10825 GSK-3 inhibitorSB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β). Learn More -
SB 415286
Catalog No. A11061 GSK-3 inhibitorSB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. Learn More -
CHIR-98014
Catalog No. A11085 GSK-3 inhibitorCHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3. Learn More -
TWS119
Catalog No. A11223 GSK-3 InhibitorTWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM. Learn More -
TDZD-8
Catalog No. A11941 GSK-3 InhibitorTDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity Learn More -
Tideglusib
Catalog No. A11592 GSK-3 InhibitorTideglusib is a GSK-3 inhibitor currently in phase II clinical trials for the treatment of Alzheimer disease and progressive supranuclear palsy Learn More -
GSK-3 inhibitor 1
Catalog No. A21803 -
VP3.15 dihydrobromide
Catalog No. A21789 PDE7/GSK3 inhibitorVP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. Learn More -
1-Azakenpaullone
Catalog No. A14303 GSK-3β inhibitor1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. Learn More -
CHIR-99021 monohydrochloride
Catalog No. A21430 GSK-3α/β inhibitorCHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Learn More -
VP3.15
Catalog No. A18538 dual PDE7/GSK-3 inhibitorVP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). Learn More -
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New
BIO
Catalog No. A17129 GSK3 inhibitorBIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β with IC50 value of 5 nM. Learn More -
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LY2090314
Catalog No. A12741 GSK-3 inhibitorLY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis. Learn More -
AZD2858
Catalog No. A13060 GSK-3β inhibitorAZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats. Learn More -
Bikinin
Catalog No. A15526 GSK-3 inhibitorBikinin is a potent inhibitor of plant GSK-3/Shaggy-like kinase; activates BR signaling downstream of the BR receptor. Learn More -
IM-12
Catalog No. A14196 GSK-3β inhibitorIM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. Learn More
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