Histone Demethylases

29 Item(s)

per page

Set Descending Direction
  1. T-448

    Catalog No. A21959
    Quick View
    LSD1 inhibitor
    T-448 is a specific and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. Learn More
  2. GSK-LSD1 dihydrochloride

    Catalog No. A21815
    Quick View
    LSD1 inhibitor
    GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM. Learn More
  3. ORY-1001(trans)

    Catalog No. A21622
    Quick View
    KDM1A/LSD1 inhibitor
    ORY-1001 trans is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. Learn More
  4. Toxoflavin

    Catalog No. A12174
    Quick View
    KDM4A inhibitor
    Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity. Learn More
  5. NCGC00244536

    Catalog No. A13025
    Quick View
    KDM4B inhibitor
    NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM. Learn More
  6. QC6352

    Catalog No. A19477
    Quick View
    KDM4C inhibitor
    QC6352 is a potent KDM4C inhibitor with an IC50 of 35 nM. Learn More
  7. T-3775440 hydrochloride

    Catalog No. A18340
    Quick View
    LSD1 inhibitor
    T-3775440 (hydrochloride) is an irreversible lysine-specific histone demethylase (LSD1) inhibitor with an IC50 value of 2.1 nM. Learn More
  8. CPI 455

    Catalog No. A16178
    Quick View
    KDM5 inhibitor
    CPI 455 possesses the target specificity required for an in vitro tool compound for exploring KDM5-dependent disease biology, including drug tolerance. Learn More
  9. YUKA1

    Catalog No. A12101
    Quick View
    KDM5A inhibitor
    YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM. Learn More
  10. KDM4-IN-2

    Catalog No. A18856
    Quick View
    KDM4/KDM5 dual inhibitor
    KDM4-IN-2 (Compound 19a) is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7?nM for KDM4A and KDM5B, respectively. Learn More
  11. GSK467

    Catalog No. A18807
    Quick View
    KDM5B (JARID1B or PLU1) inhibitor
    GSK467 is a potent and selective inhibitor of KDM5 (also known as JARID1) with a Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members. GSK467 exploits unique binding modes. Learn More
  12. CBB1007

    Catalog No. A16374
    Quick View
    LSD1 inhibitor
    CBB1007 is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1). Learn More
  13. TC-E 5002

    Catalog No. A16373
    Quick View
    KDM2/7 inhibitor
    TC-E 5002, selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 uM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro. Learn More
  14. 2,4-Pyridinedicarboxylic Acid

    Catalog No. A16372
    Quick View
    KDM inhibitor
    2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of histone lysine-specific demethylases that targets on JMJD2A (KDM4A), KDM4C, KDM4E (IC50, 1.4 μM), KDM5B (IC50, 3 μM), KDM6A and other 2-oxogynases. Learn More
  15. AS8351

    Catalog No. A16371
    Quick View
    KDM5 inhibitor.
    AS8351 is a histone demethylase inhibitor. Learn More
  16. OG-L002

    Catalog No. A13246
    Quick View
    LSD1 inhibitor
    OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively. Learn More
  17. CPI 4203

    Catalog No. A16177
    Quick View
    KDM5 demethylases inhibitor
    CPI 4203 is a selective inhibitor of KDM5 demethylases, structurally related to CPI 455 but ~25-fold less potent (IC50 value 250 nM for inhibition of full length KDM5A). Learn More
  18. CBB1003

    Catalog No. A12734
    Quick View
    LSD1 inhibitor
    CBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM. Learn More
  19. ORY-1001 (RG-6016)

    Catalog No. A15893
    Quick View
    LSD1 Inhibitor
    ORY-1001 is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1. Learn More
  20. ML-324

    Catalog No. A15829
    Quick View
    JMJD2 inhibitor‎
    ML-324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity. Learn More
  21. SP2509 (HCI-2509)

    Catalog No. A14443
    Quick View
    LSD1 inhibitor
    SP2509 is a novel histone demethylase LSD1 (KDM1A) antagonist with IC50 of 13 nM; no inhibition on MAO-A and MAO-B. Learn More
  22. GSK-J4

    Catalog No. A12732
    Quick View
    Demethylase Inhibitor
    GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF?? release). Learn More
  23. GSK2879552

    Catalog No. A15547
    Quick View
    LSD1 inhibitor
    GSK2879552 is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Learn More
  24. PBIT

    Catalog No. A14366
    Quick View
    JARID1 inhibitor
    PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 uM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively). Learn More
  25. IOX1

    Catalog No. A14277
    Quick View
    2OG oxygenases Inhibitor
    IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. Learn More
  26. JIB-04

    Catalog No. A13806
    Quick View
    Histone Demethylase inhibitor
    JIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. Learn More
  27. LSD1-C76

    Catalog No. A12927
    Quick View
    LSD1 Inhibitor
    LSD1-C76 is a potent and selective Lysine Specific Demethylase-1 (LSD1) inhibitor. Learn More
  28. GSK J1

    Catalog No. A12918
    Quick View
    Histone demethylase inhibitor
    GSK J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX Learn More
  29. Tranylcypromine hydrochloride

    Catalog No. A13358
    Quick View
    LSD1/BHC110 & MAO inhibitor
    Tranylcypromine hydrochloride is a non-selective MAO-A/B inhibitor. Learn More

29 Item(s)

per page

Set Descending Direction