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$0.00 Histone Demethylases
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T-448
Catalog No. A21959 LSD1 inhibitorT-448 is a specific and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. Learn More -
GSK-LSD1 dihydrochloride
Catalog No. A21815 LSD1 inhibitorGSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM. Learn More -
ORY-1001(trans)
Catalog No. A21622 KDM1A/LSD1 inhibitorORY-1001 trans is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. Learn More -
Toxoflavin
Catalog No. A12174 KDM4A inhibitorToxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity. Learn More -
NCGC00244536
Catalog No. A13025 KDM4B inhibitorNCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM. Learn More -
QC6352
Catalog No. A19477 -
T-3775440 hydrochloride
Catalog No. A18340 LSD1 inhibitorT-3775440 (hydrochloride) is an irreversible lysine-specific histone demethylase (LSD1) inhibitor with an IC50 value of 2.1 nM. Learn More -
CPI 455
Catalog No. A16178 KDM5 inhibitorCPI 455 possesses the target specificity required for an in vitro tool compound for exploring KDM5-dependent disease biology, including drug tolerance. Learn More -
YUKA1
Catalog No. A12101 KDM5A inhibitorYUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM. Learn More -
KDM4-IN-2
Catalog No. A18856 KDM4/KDM5 dual inhibitorKDM4-IN-2 (Compound 19a) is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7?nM for KDM4A and KDM5B, respectively. Learn More -
GSK467
Catalog No. A18807 KDM5B (JARID1B or PLU1) inhibitorGSK467 is a potent and selective inhibitor of KDM5 (also known as JARID1) with a Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members. GSK467 exploits unique binding modes. Learn More -
CBB1007
Catalog No. A16374 LSD1 inhibitorCBB1007 is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1). Learn More -
TC-E 5002
Catalog No. A16373 KDM2/7 inhibitorTC-E 5002, selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 uM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro. Learn More -
2,4-Pyridinedicarboxylic Acid
Catalog No. A16372 KDM inhibitor2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of histone lysine-specific demethylases that targets on JMJD2A (KDM4A), KDM4C, KDM4E (IC50, 1.4 μM), KDM5B (IC50, 3 μM), KDM6A and other 2-oxogynases. Learn More -
AS8351
Catalog No. A16371 -
OG-L002
Catalog No. A13246 LSD1 inhibitorOG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively. Learn More -
CPI 4203
Catalog No. A16177 KDM5 demethylases inhibitorCPI 4203 is a selective inhibitor of KDM5 demethylases, structurally related to CPI 455 but ~25-fold less potent (IC50 value 250 nM for inhibition of full length KDM5A). Learn More -
CBB1003
Catalog No. A12734 LSD1 inhibitorCBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM. Learn More -
ORY-1001 (RG-6016)
Catalog No. A15893 LSD1 InhibitorORY-1001 is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1. Learn More -
ML-324
Catalog No. A15829 JMJD2 inhibitorML-324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity. Learn More -
SP2509 (HCI-2509)
Catalog No. A14443 LSD1 inhibitorSP2509 is a novel histone demethylase LSD1 (KDM1A) antagonist with IC50 of 13 nM; no inhibition on MAO-A and MAO-B. Learn More -
GSK-J4
Catalog No. A12732 Demethylase InhibitorGSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF?? release). Learn More -
GSK2879552
Catalog No. A15547 LSD1 inhibitorGSK2879552 is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Learn More -
PBIT
Catalog No. A14366 JARID1 inhibitorPBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 uM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively). Learn More -
IOX1
Catalog No. A14277 2OG oxygenases InhibitorIOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. Learn More -
JIB-04
Catalog No. A13806 Histone Demethylase inhibitorJIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. Learn More -
LSD1-C76
Catalog No. A12927 LSD1 InhibitorLSD1-C76 is a potent and selective Lysine Specific Demethylase-1 (LSD1) inhibitor. Learn More -
GSK J1
Catalog No. A12918 Histone demethylase inhibitorGSK J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX Learn More -
Tranylcypromine hydrochloride
Catalog No. A13358 LSD1/BHC110 & MAO inhibitorTranylcypromine hydrochloride is a non-selective MAO-A/B inhibitor. Learn More
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- 2OG oxygenases (2)
- Jumonji histone demethylase (1)
- KDM1A (LSD1) (8)
- KDM2 (1)
- KDM4 (JMJD2) (1)
- KDM5 (JARID1) (4)
- KDM6A (UTX) (2)
- KDM6B (JMJD3) (2)
- KDM7 (1)
- MAO-A (1)
- MAO-B (1)
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