Histone Demethylases

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  1. OG-L002

    Catalog No. A13246
    LSD1 inhibitor
    OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively. Learn More
  2. TC-E 5002

    Catalog No. A16373
    KDM2/7 inhibitor
    TC-E 5002, selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 uM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro. Learn More
  3. KDM inhibitor
    2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of histone lysine-specific demethylases that targets on JMJD2A (KDM4A), KDM4C, KDM4E (IC50, 1.4 μM), KDM5B (IC50, 3 μM), KDM6A and other 2-oxogynases. Learn More
  4. AS8351

    Catalog No. A16371
    KDM5 inhibitor.
    AS8351 is a histone demethylase inhibitor. Learn More
  5. CPI 455

    Catalog No. A16178
    KDM5 inhibitor
    CPI 455 possesses the target specificity required for an in vitro tool compound for exploring KDM5-dependent disease biology, including drug tolerance. Learn More
  6. CPI 4203

    Catalog No. A16177
    KDM5 demethylases inhibitor
    CPI 4203 is a selective inhibitor of KDM5 demethylases, structurally related to CPI 455 but ~25-fold less potent (IC50 value 250 nM for inhibition of full length KDM5A). Learn More
  7. CBB1003

    Catalog No. A12734
    LSD1 inhibitor
    CBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM. Learn More
  8. ORY-1001 (RG-6016)

    Catalog No. A15893
    LSD1 Inhibitor
    ORY-1001 is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1. Learn More
  9. ML-324

    Catalog No. A15829
    JMJD2 inhibitor‎
    ML-324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity. Learn More
  10. SP2509 (HCI-2509)

    Catalog No. A14443
    LSD1 inhibitor
    SP2509 is a novel histone demethylase LSD1 (KDM1A) antagonist with IC50 of 13 nM; no inhibition on MAO-A and MAO-B. Learn More
  11. GSK-J4

    Catalog No. A12732
    Demethylase Inhibitor
    GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF?? release). Learn More
  12. GSK2879552

    Catalog No. A15547
    LSD1 inhibitor
    GSK2879552 is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Learn More
  13. PBIT

    Catalog No. A14366
    JARID1 inhibitor
    PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 uM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively). Learn More
  14. IOX1

    Catalog No. A14277
    2OG oxygenases Inhibitor
    IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. Learn More
  15. JIB-04

    Catalog No. A13806
    Histone Demethylase inhibitor
    JIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. Learn More
  16. LSD1-C76

    Catalog No. A12927
    LSD1 Inhibitor
    LSD1-C76 is a potent and selective Lysine Specific Demethylase-1 (LSD1) inhibitor. Learn More
  17. GSK J1

    Catalog No. A12918
    Histone demethylase inhibitor
    GSK J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX Learn More
  18. LSD1/BHC110 & MAO inhibitor
    Tranylcypromine hydrochloride is a non-selective MAO-A/B inhibitor. Learn More
  19. CBB1007

    Catalog No. A16374
    LSD1 inhibitor
    CBB1007 is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1). Learn More

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