Caspase

Catalog No.Inhibitor Name Pan-CaspaseCaspase-1Caspase-2Caspase-3Caspase-4Caspase-5Caspase-6Caspase-7Caspase-8Caspase-9Caspase-10
A10984VX-765 (Belnacasan)
**
***
A12373Z-VAD-FMK
*
A13503Z-DEVD-FMK
A14915Q-VD-OPh hydrate
****
****
***
***
A14919Caspase-3/7 Inhibitor I
****
***
A12611Z-VEID-FMK
A12637Z-VDVAD-FMK
A12697Z-DQMD-FMK
A12800Z-IETD-FMK
A14358Z-LEHD-FMK
A14284Z-FA-FMK
A15300Ivachtin
****
A15392Boc-D-FMK
A14916Z-WEHD-FMK
A15816Ac-DEVD-CHO
***
*
****
**
**
**
***
****
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

32 Item(s)

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  1. VX-765 (Belnacasan)

    Catalog No. A10984
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    Caspase-1/4 inhibitor
    VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18. Learn More
  2. AZ 10417808

    Catalog No. A15294
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    Caspase-3 inhibitor
    AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM). Learn More
  3. Ivachtin

    Catalog No. A15300
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    Caspase-3 inhibitor
    Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM). Learn More
  4. PETCM

    Catalog No. A15308
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    Caspase-3 activator
    PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols. Learn More
  5. Ac-IEPD-AFC

    Catalog No. A15319
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    Fluorogenic caspase substrate
    Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9. Learn More
  6. Ac-DEVD-CHO

    Catalog No. A15816
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    Caspase Inhibitor
    Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor. Learn More
  7. Z-VEID-FMK

    Catalog No. A12611
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    Caspase-6 inhibitor
    Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2. Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability. Learn More
  8. Z-VDVAD-FMK

    Catalog No. A12637
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    Caspase-2 inhibitor
    Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. Learn More
  9. Z-DQMD-FMK

    Catalog No. A12697
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    Caspase-3 inhibitor
    Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3. Learn More
  10. Z-IETD-FMK

    Catalog No. A12800
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    caspase 8 inhibitor
    Z-IETD-FMK is a specific inhibitor of caspase 8. Learn More
  11. EP1013

    Catalog No. A11212
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    caspase inhibitor
    EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes. Learn More
  12. BOC-D-FMK

    Catalog No. A11356
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    caspase inhibitor
    Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 ?M. Learn More
  13. Ac-LEHD-AFC

    Catalog No. A15291
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    Fluorogenic caspase substrate
    Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC. Learn More
  14. Caspase-3/7 Inhibitor I

    Catalog No. A14919
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    Caspase-3/7 Inhibitor
    Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM). Learn More
  15. Z-VAD-FMK

    Catalog No. A12373
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    Pan Caspase Inhibitor
    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo. Learn More
  16. ML132

    Catalog No. A21557
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    caspase 1 inhibitor
    ML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM. Learn More
  17. Nivocasan (GS-9450)

    Catalog No. A14100
    Caspase inhibitor
    Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models. Learn More
  18. Z-DEVD-FMK

    Catalog No. A13503
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    Caspase-3 Inhibitor
    Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor. Learn More
  19. Z-LEHD-FMK

    Catalog No. A14358
    Caspase-9 Inhibitor
    Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. Learn More
  20. Q-VD-OPh hydrate

    Catalog No. A14915
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    Caspase inhibitor
    Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Learn More
  21. Z-WEHD-FMK

    Catalog No. A14916
    Caspase inhibitor
    Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity. Learn More
  22. Boc-D-FMK

    Catalog No. A15392
    Caspase inhibitor
    BOC-D-FMK is a Novel inhibitor of Caspase-3. Learn More
  23. PAC-1

    Catalog No. A11090
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    Caspase activator
    PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM. Learn More
  24. Apoptosis Activator 2

    Catalog No. A11944
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    Apoptosis Activator
    Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells Learn More
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    MX1013

    Catalog No. A17218
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    pan-caspase inhibitor
    MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1, caspase-3, and caspase-6, 7, 8, and 9. Learn More
  25. Z-FA-FMK

    Catalog No. A16381
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    Cysteine protease inhibitor
    Z-FA-FMK is an irreversible inhibitor of cysteine protease Learn More
  26. Z-VAD(OH)-FMK

    Catalog No. A16340
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    Caspase inhibitor
    Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. Learn More
  27. Z-YVAD-FMK

    Catalog No. A16317
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    Caspase-1 inhibitor
    Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1. Learn More
  28. Emricasan

    Catalog No. A11394
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    Caspase inhibitor
    Emricasan is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. Learn More
  29. 25-hydroxy Cholesterol

    Catalog No. A13704
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    25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types Learn More
  30. Z-FA-FMK

    Catalog No. A14284
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    Irreversible Cysteine Protease inhibitor
    Z-FA-FMK is an irreversible cysteine protease inhibitor. Learn More
  31. LY573636 (Tasisulam)

    Catalog No. A13070
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    Apoptosis inducer
    LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism. Learn More

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