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| Catalog No. | Inhibitor Name | Pan-Caspase | Caspase-1 | Caspase-2 | Caspase-3 | Caspase-4 | Caspase-5 | Caspase-6 | Caspase-7 | Caspase-8 | Caspase-9 | Caspase-10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A10984 | VX-765 (Belnacasan) | ** | *** | |||||||||
| A12373 | Z-VAD-FMK | * | ||||||||||
| A13503 | Z-DEVD-FMK | |||||||||||
| A14915 | Q-VD-OPh hydrate | **** | **** | *** | *** | |||||||
| A14919 | Caspase-3/7 Inhibitor I | **** | *** | |||||||||
| A12611 | Z-VEID-FMK | |||||||||||
| A12637 | Z-VDVAD-FMK | |||||||||||
| A12697 | Z-DQMD-FMK | |||||||||||
| A12800 | Z-IETD-FMK | |||||||||||
| A14358 | Z-LEHD-FMK | |||||||||||
| A14284 | Z-FA-FMK | |||||||||||
| A15300 | Ivachtin | **** | ||||||||||
| A15392 | Boc-D-FMK | |||||||||||
| A14916 | Z-WEHD-FMK | |||||||||||
| A15816 | Ac-DEVD-CHO | *** | * | **** | ** | ** | ** | *** | **** | ** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
32 Item(s)
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PETCM
Catalog No. A15308 Caspase-3 activatorPETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols. Learn More -
ML132
Catalog No. A21557 caspase 1 inhibitorML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM. Learn More -
BOC-D-FMK
Catalog No. A11356 caspase inhibitorBoc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 ?M. Learn More -
EP1013
Catalog No. A11212 caspase inhibitorEP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes. Learn More -
Z-IETD-FMK
Catalog No. A12800 caspase 8 inhibitorZ-IETD-FMK is a specific inhibitor of caspase 8. Learn More -
Z-DQMD-FMK
Catalog No. A12697 Caspase-3 inhibitorZ-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3. Learn More -
Z-VDVAD-FMK
Catalog No. A12637 Caspase-2 inhibitorZ-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. Learn More -
Z-VEID-FMK
Catalog No. A12611 Caspase-6 inhibitorZ-VEID-FMK is the specific recognition sequence for caspase-6/Mch2. Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability. Learn More -
Ac-DEVD-CHO
Catalog No. A15816 Caspase InhibitorAc-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor. Learn More -
Ac-IEPD-AFC
Catalog No. A15319 Fluorogenic caspase substrateAc-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9. Learn More -
VX-765 (Belnacasan)
Catalog No. A10984 Caspase-1/4 inhibitorVX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18. Learn More -
Ivachtin
Catalog No. A15300 Caspase-3 inhibitorIvachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM). Learn More -
AZ 10417808
Catalog No. A15294 Caspase-3 inhibitorAZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM). Learn More -
Caspase-3/7 Inhibitor I
Catalog No. A14919 Caspase-3/7 InhibitorCaspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM). Learn More -
Z-VAD-FMK
Catalog No. A12373 Pan Caspase InhibitorZ-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo. Learn More -
Nivocasan (GS-9450)
Catalog No. A14100 Caspase inhibitorNivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models. Learn More -
Z-DEVD-FMK
Catalog No. A13503 Caspase-3 InhibitorZ-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor. Learn More -
Z-LEHD-FMK
Catalog No. A14358 Caspase-9 InhibitorZ-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. Learn More -
Q-VD-OPh hydrate
Catalog No. A14915 Caspase inhibitorQ-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Learn More -
Z-WEHD-FMK
Catalog No. A14916 Caspase inhibitorZ-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity. Learn More -
Ac-LEHD-AFC
Catalog No. A15291 Fluorogenic caspase substrateAc-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC. Learn More -
Boc-D-FMK
Catalog No. A15392 -
25-hydroxy Cholesterol
Catalog No. A13704 25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types Learn More -
Z-FA-FMK
Catalog No. A14284 Irreversible Cysteine Protease inhibitorZ-FA-FMK is an irreversible cysteine protease inhibitor. Learn More -
LY573636 (Tasisulam)
Catalog No. A13070 Apoptosis inducerLY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism. Learn More -
Emricasan
Catalog No. A11394 Caspase inhibitorEmricasan is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. Learn More -
Z-YVAD-FMK
Catalog No. A16317 Caspase-1 inhibitorZ-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1. Learn More -
Z-VAD(OH)-FMK
Catalog No. A16340 Caspase inhibitorZ-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. Learn More -
Z-FA-FMK
Catalog No. A16381 Cysteine protease inhibitorZ-FA-FMK is an irreversible inhibitor of cysteine protease Learn More -
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MX1013
Catalog No. A17218 pan-caspase inhibitorMX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1, caspase-3, and caspase-6, 7, 8, and 9. Learn More -
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Apoptosis Activator 2
Catalog No. A11944 Apoptosis ActivatorApoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells Learn More -
PAC-1
Catalog No. A11090 Caspase activatorPAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM. Learn More
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