Sodium Channels

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  1. Raxatrigine hydrochloride

    Catalog No. A21645
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    Nav1.7 sodium channel inhibitor
    Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. Learn More
  2. Funapide

    Catalog No. A21298
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    Sodium Channel Nav1.7 inhibitor
    Funapide (TV 45070; XEN402) is a potent Sodium Channel Nav1.7 inhibitor. Learn More
  3. Nav1.7-IN-3

    Catalog No. A13626
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    voltage-gated sodium channel Nav1.7 inhibitor
    Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration. Learn More
  4. Metaflumizone

    Catalog No. A18830
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    Sodium channel blocker
    Metaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker. Learn More
  5. Ralfinamide mesylate

    Catalog No. A22002
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    Na+ channel blocker
    Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain. Learn More
  6. beta-Pompilidotoxin

    Catalog No. A15422
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    Slows neuronal Na+ channel inactivation
    beta-Pompilidotoxin is a peptide with the sequence H2N-Arg. Learn More
  7. Vernakalant HCl

    Catalog No. A15275
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    Ion channel blocker
    Vernakalant Hcl is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic. Learn More
  8. Sodium Channel inhibitor 1

    Catalog No. A15243
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    Sodium Channel inhibitor
    Sodium Channel inhibitor 1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment. Learn More
  9. S0859

    Catalog No. A15228
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    NBC inhibitor
    S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). Learn More
  10. Flecainide acetate

    Catalog No. A15088
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    Cardiac Na+ channel blocker
    Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. Learn More
  11. ICA-121431

    Catalog No. A13773
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    NaV1.3 and NaV1.1 channels inhibitor
    ICA-121431 is a potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Learn More
  12. Disopyramide

    Catalog No. A13900
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    Sodium channel blocker
    Disopyramide is an antiarrhythmic (class IA) and a sodium channel blocker. Learn More
  13. GS967

    Catalog No. A14361
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    late INa Inhibitor
    GS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa); inhibits ATX-II-induced late I(Na) in ventricular myocytes and isolated hearts with IC(50) values of 0.13 and 0.21 uM, respectively. Learn More
  14. Levobupivacaine

    Catalog No. A15979
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    sodium channel inhibitor
    Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. Learn More
  15. Benzocaine hydrochloride

    Catalog No. A16130
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    Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. Learn More
  16. Procaine

    Catalog No. A16131
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    voltage-gated sodium channel inhibitor
    Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Learn More
  17. Pilsicainide HCl

    Catalog No. A16362
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    Sodium Channel Blocker
    Pilsicainide is a water soluble selective Na+ channel blocker. Learn More
  18. PF-05089771

    Catalog No. A16365
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    Nav1.7 Inhibitor
    PF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV. Learn More
  19. Benzocaine

    Catalog No. A14560
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    Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops. Learn More
  20. Ambroxol HCl

    Catalog No. A16398
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    Sodium Channel inhibitor
    AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 uM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3. Learn More
  21. Raxatrigine (GSK1014802)

    Catalog No. A13020
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    Sodium channel blocker
    Raxatrigine (GSK1014802) is a novel sodium channel blocker and is an effective anticonvulsant agent. In rats, GSK1014802 (20 - 80 mg/kg p.o.) attenuated the deficit in reversal learning induced by phencyclidine (PCP) in a dose-dependent way, which suggested the potential of GSK1014802 in the treatment of cognitive symptoms of schizophrenia. GSK2 was also a potent inhibitor of human MAO-B with pIC50 value of 7.96 but did not inhibit human MAO-A. Learn More
  22. Encainide HCl

    Catalog No. A13898
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    Sodium channel blocker
    Encainide HCl is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative. Learn More
  23. Oxcarbazepine

    Catalog No. A13943
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    sodium channel protein inhibitor
    Oxcarbazepine is a sodium channel protein inhibitor. Learn More
  24. Ibutilide fumarate

    Catalog No. A11750
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    Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells. Learn More
  25. Amiloride hydrochloride dihydrate

    Catalog No. A11728
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    Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker and selective low threshold (T-type) calcium channel protein inhibitor (KD=30μM). Learn More
  26. Proparacaine HCl

    Catalog No. A11715
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    Voltage-gated sodium channels antagonist
    Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM. Learn More
  27. Orphenadrine citrate

    Catalog No. A11712
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    NMDA receptor antagonist
    Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker. Learn More
  28. PF-04971729

    Catalog No. A11102
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    SGLT2 inhibitor
    PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2. Learn More
  29. Bupivacaine HCl

    Catalog No. A10168
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    Bupivacaine is a more potent inhibitor of cAMP production than are chemically related local anesthetics that are less prone to produce cardiovascular toxicity. Learn More
  30. Amiloride HCl

    Catalog No. A10064
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    Na+ channel blocker
    Amiloride hydrochloride is a Na+ channel blocker, also inhibits TRPP3 channels and Na+/H+ exchanger (NHE). Learn More
  31. Lacosamide

    Catalog No. A10510
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    Lacosamide is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Learn More
  32. A 803467

    Catalog No. A11234
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    Sodium channel Blocker
    A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively). Learn More
  33. Carbamazepine

    Catalog No. A10179
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    Carbamazepine is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. Learn More
  34. Lidocaine (Alphacaine)

    Catalog No. A10530
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    Lidocaine (Alphacaine) is an anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state. Learn More
  35. Chloroprocaine HCl

    Catalog No. A14260
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    Chloroprocaine HCl is a local anesthetic during surgical procedures. Learn More
  36. Procainamide HCl

    Catalog No. A14240
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    Sodium channel blocker/DNMT inhibitor
    Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor. Learn More
  37. Digoxin

    Catalog No. A14242
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    sodium-potassium pump inhibitor
    Digoxin is a sodium-potassium pump inhibitor. Learn More
  38. ENIPORIDE

    Catalog No. A14139
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    Na(+)/H(+) exchange inhibitor
    ENIPORIDE is a potent Na+/H+ exchange inhibitor. Learn More
  39. Vinpocetine

    Catalog No. A11602
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    PDE1 inhibitor
    Vinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. Learn More
  40. QX 314 chloride

    Catalog No. A13760
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    Sodium channel Blocker
    QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a voltage-activated Na+ channel blocker Learn More
  41. Lamotrigine

    Catalog No. A11873
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    Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker. Learn More
  42. Phenytoin sodium (Dilantin)

    Catalog No. A10722
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    Phenytoin sodium (Dilantin) is a sodium channel protein inhibitor. Learn More
  43. Phenytoin (Lepitoin)

    Catalog No. A10721
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    Phenytoin is a sodium channel protein inhibitor. Learn More
  44. Riluzole (Rilutek)

    Catalog No. A10795
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    Riluzole preferentially blocks TTX-sensitive sodium channels, which are associated with damaged neurons.This reduces influx of calcium ions and indirectly prevents stimulation of glutamate receptors. Learn More

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