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Sodium Channels
40 Item(s)
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| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A10795 SALE |
Riluzole (Rilutek) |
- |
Riluzole preferentially blocks TTX-sensitive sodium channels, which are associated with damaged neurons.This reduces influx of calcium ions and indirectly prevents stimulation of glutamate receptors.
|
A15243 |
Sodium Channel inhibitor 1 |
Sodium Channel inhibitor |
Sodium Channel inhibitor 1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.
|
A15228 SALE |
S0859 |
NBC inhibitor |
S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM).
|
A15088 |
Flecainide acetate |
Cardiac Na+ channel blocker |
Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
|
A14011 |
Tenapanor |
NHE3 inhibitor |
Tenapanor acts as an inhibitor of the sodium-proton exchanger NHE3. This antiporter protein is found in the kidney and intestines, and normally acts to regulate the levels of sodium absorbed and secreted by the body.
|
A13773 SALE |
ICA-121431 |
NaV1.3 and NaV1.1 channels inhibitor |
ICA-121431 is a potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively).
|
A13900 |
Disopyramide |
Sodium channel blocker |
Disopyramide is an antiarrhythmic (class IA) and a sodium channel blocker.
|
A13898 |
Encainide HCl |
Sodium channel blocker |
Encainide HCl is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.
|
A13943 |
Oxcarbazepine |
sodium channel protein inhibitor |
Oxcarbazepine is a sodium channel protein inhibitor.
|
A15275 SALE |
Vernakalant HCl |
Ion channel blocker |
Vernakalant Hcl is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.
|
A15422 |
beta-Pompilidotoxin
|
Slows neuronal Na+ channel inactivation |
beta-Pompilidotoxin is a peptide with the sequence H2N-Arg.
|
A16398 |
Ambroxol HCl |
Sodium Channel inhibitor |
AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 uM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
|
A14560 |
Benzocaine |
- |
Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops.
|
A16365 |
PF-05089771 |
Nav1.7 Inhibitor |
PF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV.
|
A16362 |
Pilsicainide HCl |
Sodium Channel Blocker |
Pilsicainide is a water soluble selective Na+ channel blocker.
|
A16131 |
Procaine |
voltage-gated sodium channel inhibitor |
Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties.
|
A16130 |
Benzocaine hydrochloride |
- |
Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
|
A15979 |
Levobupivacaine |
sodium channel inhibitor |
Levobupivacaine is a local anaesthetic drug belonging to the amino amide group.
|
A14361 |
GS967 |
late INa Inhibitor |
GS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa); inhibits ATX-II-induced late I(Na) in ventricular myocytes and isolated hearts with IC(50) values of 0.13 and 0.21 uM, respectively.
|
A14260 |
Chloroprocaine HCl |
- |
Chloroprocaine HCl is a local anesthetic during surgical procedures.
|
A14240 |
Procainamide HCl |
Sodium channel blocker/DNMT inhibitor |
Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor.
|
A11728 SALE |
Amiloride hydrochloride dihydrate |
- |
Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker and selective low threshold (T-type) calcium channel protein inhibitor (KD=30μM).
|
A11715 SALE |
Proparacaine HCl |
Voltage-gated sodium channels antagonist |
Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
|
A11712 SALE |
Orphenadrine citrate |
- |
Orphenadrine is known to have the following pharmacology: mACh receptor antagonist (anticholinergic); H1 receptor antagonist (antihistamine); NMDA receptor antagonist; NET blocker (norepinephrine reuptake inhibitor); Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker; HERG potassium channel blocker.
|
A11102 |
PF-04971729 |
SGLT2 inhibitor |
PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2.
|
A10168 SALE |
Bupivacaine HCl |
- |
Bupivacaine is a more potent inhibitor of cAMP production than are chemically related local anesthetics that are less prone to produce cardiovascular toxicity.
|
A10064 SALE |
Amiloride HCl |
Na+ channel blocker |
Amiloride hydrochloride is a Na+ channel blocker, also inhibits TRPP3 channels and Na+/H+ exchanger (NHE).
|
A10510 SALE |
Lacosamide |
- |
Lacosamide is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain.
|
A11234 SALE |
A 803467 |
Sodium channel Blocker |
A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively).
|
A11750 SALE |
Ibutilide fumarate |
- |
Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells.
|
A10179 SALE |
Carbamazepine |
- |
Carbamazepine is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia.
|
A14242 SALE |
Digoxin |
sodium-potassium pump inhibitor |
Digoxin is a sodium-potassium pump inhibitor.
|
A14139 |
ENIPORIDE |
Na(+)/H(+) exchange inhibitor |
ENIPORIDE is a potent Na+/H+ exchange inhibitor.
|
A11602 |
Vinpocetine |
PDE1 inhibitor |
Vinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
|
A13760 SALE |
QX 314 chloride |
Sodium channel Blocker |
QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a voltage-activated Na+ channel blocker
|
A11873 SALE |
Lamotrigine |
- |
Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
|
A10722 SALE |
Phenytoin sodium (Dilantin) |
- |
Phenytoin sodium (Dilantin) is a sodium channel protein inhibitor.
|
A10721 SALE |
Phenytoin (Lepitoin) |
- |
Phenytoin is a sodium channel protein inhibitor.
|
A10530 SALE |
Lidocaine (Alphacaine) |
- |
Lidocaine (Alphacaine) is an anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state.
|
A13020 |
Raxatrigine (GSK1014802) |
Sodium channel blocker |
Raxatrigine (GSK1014802) is a novel sodium channel blocker and is an effective anticonvulsant agent. In rats, GSK1014802 (20 - 80 mg/kg p.o.) attenuated the deficit in reversal learning induced by phencyclidine (PCP) in a dose-dependent way, which suggested the potential of GSK1014802 in the treatment of cognitive symptoms of schizophrenia. GSK2 was also a potent inhibitor of human MAO-B with pIC50 value of 7.96 but did not inhibit human MAO-A.
|
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