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Raxatrigine hydrochloride
Catalog No. A21645 Nav1.7 sodium channel inhibitorRaxatrigine hydrochloride (GSK-1014802 hydrochloride) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. Learn More -
Funapide
Catalog No. A21298 Sodium Channel Nav1.7 inhibitorFunapide (TV 45070; XEN402) is a potent Sodium Channel Nav1.7 inhibitor. Learn More -
Nav1.7-IN-3
Catalog No. A13626 voltage-gated sodium channel Nav1.7 inhibitorNav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration. Learn More -
Metaflumizone
Catalog No. A18830 Sodium channel blockerMetaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker. Learn More -
Ralfinamide mesylate
Catalog No. A22002 Na+ channel blockerRalfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain. Learn More -
beta-Pompilidotoxin
Catalog No. A15422 Slows neuronal Na+ channel inactivationbeta-Pompilidotoxin is a peptide with the sequence H2N-Arg. Learn More -
Vernakalant HCl
Catalog No. A15275 Ion channel blockerVernakalant Hcl is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic. Learn More -
Sodium Channel inhibitor 1
Catalog No. A15243 Sodium Channel inhibitorSodium Channel inhibitor 1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment. Learn More -
S0859
Catalog No. A15228 NBC inhibitorS0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). Learn More -
Flecainide acetate
Catalog No. A15088 Cardiac Na+ channel blockerFlecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. Learn More -
ICA-121431
Catalog No. A13773 NaV1.3 and NaV1.1 channels inhibitorICA-121431 is a potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Learn More -
Disopyramide
Catalog No. A13900 Sodium channel blockerDisopyramide is an antiarrhythmic (class IA) and a sodium channel blocker. Learn More -
GS967
Catalog No. A14361 late INa InhibitorGS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa); inhibits ATX-II-induced late I(Na) in ventricular myocytes and isolated hearts with IC(50) values of 0.13 and 0.21 uM, respectively. Learn More -
Levobupivacaine
Catalog No. A15979 sodium channel inhibitorLevobupivacaine is a local anaesthetic drug belonging to the amino amide group. Learn More -
Benzocaine hydrochloride
Catalog No. A16130 Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. Learn More -
Procaine
Catalog No. A16131 voltage-gated sodium channel inhibitorProcaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Learn More -
Pilsicainide HCl
Catalog No. A16362 Sodium Channel BlockerPilsicainide is a water soluble selective Na+ channel blocker. Learn More -
PF-05089771
Catalog No. A16365 Nav1.7 InhibitorPF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV. Learn More -
Benzocaine
Catalog No. A14560 Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops. Learn More -
Ambroxol HCl
Catalog No. A16398 Sodium Channel inhibitorAmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 uM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3. Learn More -
Raxatrigine (GSK1014802)
Catalog No. A13020 Sodium channel blockerRaxatrigine (GSK1014802) is a novel sodium channel blocker and is an effective anticonvulsant agent. In rats, GSK1014802 (20 - 80 mg/kg p.o.) attenuated the deficit in reversal learning induced by phencyclidine (PCP) in a dose-dependent way, which suggested the potential of GSK1014802 in the treatment of cognitive symptoms of schizophrenia. GSK2 was also a potent inhibitor of human MAO-B with pIC50 value of 7.96 but did not inhibit human MAO-A. Learn More -
Encainide HCl
Catalog No. A13898 Sodium channel blockerEncainide HCl is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative. Learn More -
Oxcarbazepine
Catalog No. A13943 sodium channel protein inhibitorOxcarbazepine is a sodium channel protein inhibitor. Learn More -
Ibutilide fumarate
Catalog No. A11750 Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells. Learn More -
Amiloride hydrochloride dihydrate
Catalog No. A11728 Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker and selective low threshold (T-type) calcium channel protein inhibitor (KD=30μM). Learn More -
Proparacaine HCl
Catalog No. A11715 Voltage-gated sodium channels antagonistProparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM. Learn More -
Orphenadrine citrate
Catalog No. A11712 NMDA receptor antagonistOrphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker. Learn More -
PF-04971729
Catalog No. A11102 SGLT2 inhibitorPF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2. Learn More -
Bupivacaine HCl
Catalog No. A10168 Bupivacaine is a more potent inhibitor of cAMP production than are chemically related local anesthetics that are less prone to produce cardiovascular toxicity. Learn More -
Amiloride HCl
Catalog No. A10064 Na+ channel blockerAmiloride hydrochloride is a Na+ channel blocker, also inhibits TRPP3 channels and Na+/H+ exchanger (NHE). Learn More -
Lacosamide
Catalog No. A10510 Lacosamide is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Learn More -
A 803467
Catalog No. A11234 Sodium channel BlockerA 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively). Learn More -
Carbamazepine
Catalog No. A10179 Carbamazepine is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. Learn More -
Lidocaine (Alphacaine)
Catalog No. A10530 Lidocaine (Alphacaine) is an anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state. Learn More -
Chloroprocaine HCl
Catalog No. A14260 Chloroprocaine HCl is a local anesthetic during surgical procedures. Learn More -
Procainamide HCl
Catalog No. A14240 Sodium channel blocker/DNMT inhibitorProcainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor. Learn More -
Digoxin
Catalog No. A14242 sodium-potassium pump inhibitorDigoxin is a sodium-potassium pump inhibitor. Learn More -
ENIPORIDE
Catalog No. A14139 Na(+)/H(+) exchange inhibitorENIPORIDE is a potent Na+/H+ exchange inhibitor. Learn More -
Vinpocetine
Catalog No. A11602 PDE1 inhibitorVinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. Learn More -
QX 314 chloride
Catalog No. A13760 Sodium channel BlockerQX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a voltage-activated Na+ channel blocker Learn More -
Lamotrigine
Catalog No. A11873 Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker. Learn More -
Phenytoin sodium (Dilantin)
Catalog No. A10722 Phenytoin sodium (Dilantin) is a sodium channel protein inhibitor. Learn More -
Riluzole (Rilutek)
Catalog No. A10795 Riluzole preferentially blocks TTX-sensitive sodium channels, which are associated with damaged neurons.This reduces influx of calcium ions and indirectly prevents stimulation of glutamate receptors. Learn More
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