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Sodium Channels

Catalog No.	Product Name	Application	Product Information
A10795 SALE	Riluzole (Rilutek)	-	Riluzole preferentially blocks TTX-sensitive sodium channels, which are associated with damaged neurons.This reduces influx of calcium ions and indirectly prevents stimulation of glutamate receptors.
A15243	Sodium Channel inhibitor 1	Sodium Channel inhibitor	Sodium Channel inhibitor 1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.
A15228 SALE	S0859	NBC inhibitor	S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM).
A15088	Flecainide acetate	Cardiac Na+ channel blocker	Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
A14011	Tenapanor	NHE3 inhibitor	Tenapanor acts as an inhibitor of the sodium-proton exchanger NHE3. This antiporter protein is found in the kidney and intestines, and normally acts to regulate the levels of sodium absorbed and secreted by the body. Product Citations (4) Yu Y, .et al. Expression, Localization and Functional Activity of the Major Na+/H+ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe, Cell Physiol Biochem, 2019, 52(5):1017-1038 PMID: 30977986 Thammayon N, .et al. Na+/H+ exchanger 3 inhibitor diminishes the amino-acid-enhanced transepithelial calcium transport across the rat duodenum, Amino Acids, 2017, Apr;49(4):725-734 PMID: 27981415 Charoenphandhu N, .et al. Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous β-globin knockout thalassemic mice, Mol Cell Biochem, 2017, Mar;427(1-2):201-208 PMID: 27995414 Jantarajit W, .et al. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels, Am J Physiol Cell Physiol, 2017, Jul 1;313(1):C118-C129 PMID: 28490422
A13773 SALE	ICA-121431	NaV1.3 and NaV1.1 channels inhibitor	ICA-121431 is a potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively).
A13900	Disopyramide	Sodium channel blocker	Disopyramide is an antiarrhythmic (class IA) and a sodium channel blocker.
A13898	Encainide HCl	Sodium channel blocker	Encainide HCl is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.
A13943	Oxcarbazepine	sodium channel protein inhibitor	Oxcarbazepine is a sodium channel protein inhibitor.
A15275 SALE	Vernakalant HCl	Ion channel blocker	Vernakalant Hcl is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic. Product Citations (1) Joe Z.Zhang, .et al. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles, Cell Stem Cell, 2019, 24, 1-10
A15422	beta-Pompilidotoxin	Slows neuronal Na+ channel inactivation	beta-Pompilidotoxin is a peptide with the sequence H2N-Arg.
A16398	Ambroxol HCl	Sodium Channel inhibitor	AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 uM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
A14560	Benzocaine	-	Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops.
A16365	PF-05089771	Nav1.7 Inhibitor	PF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV.
A16362	Pilsicainide HCl	Sodium Channel Blocker	Pilsicainide is a water soluble selective Na+ channel blocker.
A16131	Procaine	voltage-gated sodium channel inhibitor	Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties.
A16130	Benzocaine hydrochloride	-	Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
A15979	Levobupivacaine	sodium channel inhibitor	Levobupivacaine is a local anaesthetic drug belonging to the amino amide group.
A14361	GS967	late INa Inhibitor	GS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa); inhibits ATX-II-induced late I(Na) in ventricular myocytes and isolated hearts with IC(50) values of 0.13 and 0.21 uM, respectively.
A14260	Chloroprocaine HCl	-	Chloroprocaine HCl is a local anesthetic during surgical procedures.
A14240	Procainamide HCl	Sodium channel blocker/DNMT inhibitor	Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor.
A11728 SALE	Amiloride hydrochloride dihydrate	-	Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker and selective low threshold (T-type) calcium channel protein inhibitor (KD=30μM).
A11715 SALE	Proparacaine HCl	Voltage-gated sodium channels antagonist	Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
A11712 SALE	Orphenadrine citrate	-	Orphenadrine is known to have the following pharmacology: mACh receptor antagonist (anticholinergic); H1 receptor antagonist (antihistamine); NMDA receptor antagonist; NET blocker (norepinephrine reuptake inhibitor); Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker; HERG potassium channel blocker.
A11102	PF-04971729	SGLT2 inhibitor	PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2.
A10168 SALE	Bupivacaine HCl	-	Bupivacaine is a more potent inhibitor of cAMP production than are chemically related local anesthetics that are less prone to produce cardiovascular toxicity.
A10064 SALE	Amiloride HCl	Na+ channel blocker	Amiloride hydrochloride is a Na+ channel blocker, also inhibits TRPP3 channels and Na+/H+ exchanger (NHE). Product Citations (2) Yu Y, .et al. Expression, Localization and Functional Activity of the Major Na+/H+ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe, Cell Physiol Biochem, 2019, 52(5):1017-1038 PMID: 30977986 Thomas D. Williams, .et al. The physiological regulation of macropinocytosis during Dictyostelium growth and development, J Cell Sci, 2018, Mar 15; 131(6): jcs213736 PMID: 29440238
A10510 SALE	Lacosamide	-	Lacosamide is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Product Citations (1) Namer B, .et al. Pain relief in a neuropathy patient by lacosamide: Proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors, EBioMedicine, 2018, Nov 28. pii: S2352-3964(18)30546-2 PMID: 30503201
A11234 SALE	A 803467	Sodium channel Blocker	A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively).
A11750 SALE	Ibutilide fumarate	-	Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells.
A10179 SALE	Carbamazepine	-	Carbamazepine is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. Product Citations (3) Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489 Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504 Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
A14242 SALE	Digoxin	sodium-potassium pump inhibitor	Digoxin is a sodium-potassium pump inhibitor.
A14139	ENIPORIDE	Na(+)/H(+) exchange inhibitor	ENIPORIDE is a potent Na+/H+ exchange inhibitor.
A11602	Vinpocetine	PDE1 inhibitor	Vinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
A13760 SALE	QX 314 chloride	Sodium channel Blocker	QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a voltage-activated Na+ channel blocker
A11873 SALE	Lamotrigine	-	Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
A10722 SALE	Phenytoin sodium (Dilantin)	-	Phenytoin sodium (Dilantin) is a sodium channel protein inhibitor.
A10721 SALE	Phenytoin (Lepitoin)	-	Phenytoin is a sodium channel protein inhibitor.
A10530 SALE	Lidocaine (Alphacaine)	-	Lidocaine (Alphacaine) is an anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state.
A13020	Raxatrigine (GSK1014802)	Sodium channel blocker	Raxatrigine (GSK1014802) is a novel sodium channel blocker and is an effective anticonvulsant agent. In rats, GSK1014802 (20 - 80 mg/kg p.o.) attenuated the deficit in reversal learning induced by phencyclidine (PCP) in a dose-dependent way, which suggested the potential of GSK1014802 in the treatment of cognitive symptoms of schizophrenia. GSK2 was also a potent inhibitor of human MAO-B with pIC50 value of 7.96 but did not inhibit human MAO-A.

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Sodium Channels

A10795 SALE

A15243

A15228 SALE

A15088

A14011

A13773 SALE

A13900

A13898

A13943

A15275 SALE

A15422

A16398

A14560

A16365

A16362

A16131

A16130

A15979

A14361

A14260

A14240

A11728 SALE

A11715 SALE

A11712 SALE

A11102

A10168 SALE

A10064 SALE

A10510 SALE

A11234 SALE

A11750 SALE

A10179 SALE

A14242 SALE

A14139

A11602

A13760 SALE

A11873 SALE

A10722 SALE

A10721 SALE

A10530 SALE

A13020

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