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Indirubin
Catalog No. A10471 CDK & GSK-3β inhibitorIndirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM. Learn More -
Indirubin-3-monoxime
Catalog No. A16280 GSK-3β inhibitorIndirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM). Learn More -
CP21R7
Catalog No. A16230 -
BIO-acetoxime
Catalog No. A15555 GSK-3 inhibitorBIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity. Learn More -
Bikinin
Catalog No. A15526 GSK-3 inhibitorBikinin is a potent inhibitor of plant GSK-3/Shaggy-like kinase; activates BR signaling downstream of the BR receptor. Learn More -
IM-12
Catalog No. A14196 GSK-3β inhibitorIM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. Learn More -
1-Azakenpaullone
Catalog No. A14303 GSK-3β inhibitor1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. Learn More -
AR-A 014418
Catalog No. A13728 GSK-3 inhibitorAR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Learn More -
AZD2858
Catalog No. A13060 GSK-3β inhibitorAZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats. Learn More -
AZD1080
Catalog No. A12819 GSK3 inhibitorAZD1080 is a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. Learn More -
LY2090314
Catalog No. A12741 GSK-3 inhibitorLY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis. Learn More -
Tideglusib
Catalog No. A11592 GSK-3 InhibitorTideglusib is a GSK-3 inhibitor currently in phase II clinical trials for the treatment of Alzheimer disease and progressive supranuclear palsy Learn More -
TDZD-8
Catalog No. A11941 GSK-3 InhibitorTDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity Learn More -
TWS119
Catalog No. A11223 GSK-3 InhibitorTWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM. Learn More -
CHIR-98014
Catalog No. A11085 GSK-3 inhibitorCHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3. Learn More -
SB 415286
Catalog No. A11061 GSK-3 inhibitorSB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. Learn More -
SB 216763
Catalog No. A10825 GSK-3 inhibitorSB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β). Learn More -
CHIR-99021
Catalog No. A10199 GSK-3 InhibitorCHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. Learn More -
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New
BIO
Catalog No. A17129 GSK3 inhibitorBIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β with IC50 value of 5 nM. Learn More -
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VP3.15
Catalog No. A18538 dual PDE7/GSK-3 inhibitorVP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). Learn More -
CHIR-99021 monohydrochloride
Catalog No. A21430 GSK-3α/β inhibitorCHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Learn More -
CHIR-99021 trihydrochloride
Catalog No. A21436 GSK-3α/β inhibitorCHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM. Learn More -
VP3.15 dihydrobromide
Catalog No. A21789 PDE7/GSK3 inhibitorVP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. Learn More -
GSK-3 inhibitor 1
Catalog No. A21803
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