GSK-3

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  1. CHIR-99021

    Catalog No. A10199
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    GSK-3 Inhibitor
    CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. Learn More
  2. AR-A 014418

    Catalog No. A13728
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    GSK-3 inhibitor
    AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Learn More
  3. 1-Azakenpaullone

    Catalog No. A14303
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    GSK-3β inhibitor
    1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. Learn More
  4. IM-12

    Catalog No. A14196
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    GSK-3β inhibitor
    IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. Learn More
  5. Bikinin

    Catalog No. A15526
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    GSK-3 inhibitor
    Bikinin is a potent inhibitor of plant GSK-3/Shaggy-like kinase; activates BR signaling downstream of the BR receptor. Learn More
  6. BIO-acetoxime

    Catalog No. A15555
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    GSK-3 inhibitor
  7. GSK-3b

    Catalog No. A15471
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    GSK-3 beta Inhibitor
  8. CP21R7

    Catalog No. A16230
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    GSK-3β inhibitor
    CP21R7 is a potent and selective GSK-3β inhibitor. Learn More
  9. Indirubin-3-monoxime

    Catalog No. A16280
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    GSK-3β inhibitor
    Indirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM). Learn More
  10. AZD2858

    Catalog No. A13060
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    GSK-3β inhibitor
    AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats. Learn More
  11. AZD1080

    Catalog No. A12819
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    GSK3 inhibitor
    AZD1080 is a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. Learn More
  12. Indirubin

    Catalog No. A10471
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    CDK & GSK-3β inhibitor
    Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM. Learn More
  13. SB 216763

    Catalog No. A10825
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    GSK-3 inhibitor
    SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β). Learn More
  14. SB 415286

    Catalog No. A11061
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    GSK-3 inhibitor
    SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. Learn More
  15. CHIR-98014

    Catalog No. A11085
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    GSK-3 inhibitor
    CHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3. Learn More
  16. TWS119

    Catalog No. A11223
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    GSK-3 Inhibitor
    TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM. Learn More
  17. TDZD-8

    Catalog No. A11941
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    GSK-3 Inhibitor
    TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity Learn More
  18. Tideglusib

    Catalog No. A11592
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    GSK-3 Inhibitor
    Tideglusib is a GSK-3 inhibitor currently in phase II clinical trials for the treatment of Alzheimer disease and progressive supranuclear palsy Learn More
  19. LY2090314

    Catalog No. A12741
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    GSK-3 inhibitor
    LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis. Learn More
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    BIO

    Catalog No. A17129
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    GSK3 inhibitor
    BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β with IC50 value of 5 nM. Learn More

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