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$0.00 Trk Receptors
| Catalog No. | Inhibitor Name | TrkA | TrkB | TrkC | Trk receptor | Other |
|---|---|---|---|---|---|---|
| A11059 | BMS-754807 | ** | *** | Insulin Receptor,IGF-1R,Met | ||
| A16238 | GW441756 | **** | ||||
| A16259 | Sitravatinib (MGCD516) | *** | * | DDR2,EPHA3,Axl | ||
| A13877 | ANA-12 | * | ||||
| A13730 | GNF-5837 | ** | * | ** | ||
| A15801 | Entrectinib (RXDX-101) | ALK,ROS1 | ||||
| A10053 | Tyrphostin AG 879 | * | Her2 | |||
| A10715 | Danusertib (PHA-739358) | * | Aurora A, Abl, RET, FGFR1, Aurora C, Aurora B | |||
| A15494 | LM22A-4 | * | ||||
| A15974 | Larotrectinib (LOXO-101) sulfate | |||||
| A16123 | 7,8-Dihydroxyflavone |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Danusertib (PHA-739358)
Catalog No. A10715 Aurora inhibitorDanusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2 Learn More -
LOXO-101 sulfate
Catalog No. A16239 TRK inhibitorLOXO-101 is a small molecule that was designed to block the ATP binding site of the TRK family of receptors, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases. Learn More -
GW 441756
Catalog No. A16238 TrkA inhibitorGW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2. Learn More -
7,8-Dihydroxyflavone
Catalog No. A16123 TrkB agonist7,8-Dihydroxyflavone, a selective tyrosine kinase receptor B (neurotrophic factor/tropomyosin-receptor-kinase B; TrkB) agonist, may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving neuroprotection, memory, vasorelaxation and hypertension. Learn More -
LOXO-101 (ARRY-470, Larotrectinib)
Catalog No. A15974 TRK inhibitorLOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. Learn More -
Entrectinib
Catalog No. A15801 TRK, ROS1, ALK inhibitorEntrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. Learn More -
LM22A-4
Catalog No. A15494 TrkB agonistLM22A-4 is a potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM). Learn More -
ANA-12
Catalog No. A13877 TrkB inhibitorANA-12 is a TrkB receptor antagonist that demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively. Learn More -
GNF 5837
Catalog No. A13730 TRK inhibitorGNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. Learn More -
BMS-754807
Catalog No. A11059 IGF-1R inhibitorBMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents. Learn More -
TLQP 21
Catalog No. A15345 VGF-derived peptideTLQP 21, VGF-derived peptide; spans residues 556-576 of the precursor sequence. Learn More -
AZ 23
Catalog No. A12666 TrkA inhibitorAZ 23 is a potent and selective tyrosine kinase Trk inhibitor with IC50 to 2 and 8 nM for TrkA and TrkB respectively Learn More -
Tyrphostin AG 879
Catalog No. A10053 HER2 inhibitorTyrphostin AG 879 is an inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. Learn More -
Sitravatinib (MGCD516)
Catalog No. A16259 RTK inhibitorSitravatinib is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth. Learn More
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