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Trk Receptors
Inhibitory Selectivity
| Catalog No. | Inhibitor Name | TrkA | TrkB | TrkC | Trk receptor | Other |
|---|---|---|---|---|---|---|
| A11059 | BMS-754807 | ** | *** | Insulin Receptor,IGF-1R,Met | ||
| A16238 | GW441756 | **** | ||||
| A16259 | Sitravatinib (MGCD516) | *** | * | DDR2,EPHA3,Axl | ||
| A13877 | ANA-12 | * | ||||
| A13730 | GNF-5837 | ** | * | ** | ||
| A15801 | Entrectinib (RXDX-101) | ALK,ROS1 | ||||
| A10053 | Tyrphostin AG 879 | * | Her2 | |||
| A10715 | Danusertib (PHA-739358) | * | Aurora A, Abl, RET, FGFR1, Aurora C, Aurora B | |||
| A15494 | LM22A-4 | * | ||||
| A15974 | Larotrectinib (LOXO-101) sulfate | |||||
| A16123 | 7,8-Dihydroxyflavone |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
14 Item(s)
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| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A15494 SALE |
LM22A-4 |
TrkB agonist |
LM22A-4 is a potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM).
|
A16239 |
LOXO-101 sulfate |
TRK inhibitor |
LOXO-101 is a small molecule that was designed to block the ATP binding site of the TRK family of receptors, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.
|
A16238 |
GW 441756 |
TrkA inhibitor |
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2.
|
A16123 |
7,8-Dihydroxyflavone |
TrkB agonist |
7,8-Dihydroxyflavone, a selective tyrosine kinase receptor B (neurotrophic factor/tropomyosin-receptor-kinase B; TrkB) agonist, may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving neuroprotection, memory, vasorelaxation and hypertension.
|
A15974 |
LOXO-101 (ARRY-470, Larotrectinib) |
TRK inhibitor |
LOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC.
|
A13877 SALE |
ANA-12 |
TrkB inhibitor |
ANA-12 is a TrkB receptor antagonist that demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively.
|
A15801 |
Entrectinib |
TRK, ROS1, ALK inhibitor |
Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.
|
A10715 SALE |
Danusertib (PHA-739358) |
Aurora inhibitor |
Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2
|
A15345 |
TLQP 21
|
VGF-derived peptide |
TLQP 21, VGF-derived peptide; spans residues 556-576 of the precursor sequence.
|
A13730 SALE |
GNF 5837 |
TRK inhibitor |
GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.
|
A12666 |
AZ 23 |
TrkA inhibitor |
AZ 23 is a potent and selective tyrosine kinase Trk inhibitor with IC50 to 2 and 8 nM for TrkA and TrkB respectively
|
A10053 SALE |
Tyrphostin AG 879 |
HER2 inhibitor |
Tyrphostin AG 879 is an inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA.
|
A11059 SALE |
BMS-754807 |
IGF-1R inhibitor |
BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.
|
A16259 |
Sitravatinib |
RTK inhibitor |
Sitravatinib is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth.
|
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