Trk Receptors

Catalog No.Inhibitor Name TrkATrkBTrkCTrk receptorOther
A11059BMS-754807
**
***
Insulin Receptor,IGF-1R,Met
A16238GW441756
****
A16259Sitravatinib (MGCD516)
***
*
DDR2,EPHA3,Axl
A13877ANA-12
*
A13730GNF-5837
**
*
**
A15801Entrectinib (RXDX-101)
ALK,ROS1
A10053Tyrphostin AG 879
*
Her2
A10715Danusertib (PHA-739358)
*
Aurora A, Abl, RET, FGFR1, Aurora C, Aurora B
A15494LM22A-4
*
A15974Larotrectinib (LOXO-101) sulfate
A161237,8-Dihydroxyflavone

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. LM22A-4

    Catalog No. A15494
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    TrkB agonist
    LM22A-4 is a potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM). Learn More
  2. LOXO-101 sulfate

    Catalog No. A16239
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    TRK inhibitor
    LOXO-101 is a small molecule that was designed to block the ATP binding site of the TRK family of receptors, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases. Learn More
  3. GW 441756

    Catalog No. A16238
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    TrkA inhibitor
    GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2. Learn More
  4. 7,8-Dihydroxyflavone

    Catalog No. A16123
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    TrkB agonist
    7,8-Dihydroxyflavone, a selective tyrosine kinase receptor B (neurotrophic factor/tropomyosin-receptor-kinase B; TrkB) agonist, may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving neuroprotection, memory, vasorelaxation and hypertension. Learn More
  5. LOXO-101 (ARRY-470, Larotrectinib)

    Catalog No. A15974
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    TRK inhibitor
    LOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. Learn More
  6. ANA-12

    Catalog No. A13877
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    TrkB inhibitor
    ANA-12 is a TrkB receptor antagonist that demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively. Learn More
  7. Entrectinib

    Catalog No. A15801
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    TRK, ROS1, ALK inhibitor
    Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. Learn More
  8. Danusertib (PHA-739358)

    Catalog No. A10715
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    Aurora inhibitor
    Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2 Learn More
  9. TLQP 21

    Catalog No. A15345
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    VGF-derived peptide
    TLQP 21, VGF-derived peptide; spans residues 556-576 of the precursor sequence. Learn More
  10. GNF 5837

    Catalog No. A13730
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    TRK inhibitor
    GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. Learn More
  11. AZ 23

    Catalog No. A12666
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    TrkA inhibitor
    AZ 23 is a potent and selective tyrosine kinase Trk inhibitor with IC50 to 2 and 8 nM for TrkA and TrkB respectively Learn More
  12. Tyrphostin AG 879

    Catalog No. A10053
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    HER2 inhibitor
    Tyrphostin AG 879 is an inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. Learn More
  13. BMS-754807

    Catalog No. A11059
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    IGF-1R inhibitor
    BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents. Learn More
  14. Sitravatinib

    Catalog No. A16259
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    RTK inhibitor
    Sitravatinib is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth. Learn More

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