BTK

Catalog No.Inhibitor Name BTKOther
A11020Ibrutinib
****
BLK,Bmx,FGR
A13202AVL-292
****
YES,c-Src,BRK
A13233CNX-774
***
A15558ONO-4059 analogue
**
A16261LFM-A13
*
A12535RN486
**
A11348CGI1746
***
A12706GDC-0834
**
A15008AVL-292 benzenesulfonate
****
YES,c-Src,BRK
A15824ACP-196 (Acalabrutinib)
**
A15976Olmutinib (HM71224)
***
A16262PCI 29732
**
A16263QL47
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Olmutinib (HM71224)

    Catalog No. A15976
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    BTK inhibitor
    Olmutinib is a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK). Learn More
  2. LFM-A13

    Catalog No. A16261
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    BTK inhibitor
    LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 uM; also inhibits PLK3 with IC50 of 7.2 uM. Learn More
  3. ONO-4059

    Catalog No. A15558
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    BTK inhibitor
    ONO-4059 is a highly potent and selective oral BTK inhibitor Learn More
  4. PCI 29732

    Catalog No. A16262
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    BTK inhibitor
    PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. Learn More
  5. QL47

    Catalog No. A16263
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    BTK inhibitor
    QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM. Learn More
  6. Btk inhibitor 1

    Catalog No. A16260
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    BTK inhibitor
    Btk inhibitor 1 is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Learn More
  7. GDC0853

    Catalog No. A16339
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    BTK inhibitor
    GDC0853 is a potent and orally BTK inhibitor. Learn More
  8. Evobrutinib

    Catalog No. A16824
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    BTK inhibitor
    Evobrutinib is a highly selective BTK inhibitor with an IC50 of 37.9 nM. It has potential anti-neoplastic activity. Learn More
  9. BMS-935177

    Catalog No. A16905
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    BTK inhibitor
    BMS-935177 a potent BTK inhibitor with improved kinase selectivity and superior oral exposure in multiple species. should provide useful clinical efficacy in autoimmune diseases. Learn More
  10. Btk inhibitor 2

    Catalog No. A17057
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    Btk inhibitor
    Btk inhibitor 2 is a Bruton's tyrosine kinase (BTK) inhibitor. Learn More
  11. PCI-32765 (Ibrutinib)

    Catalog No. A11020
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    Bruton tyrosine kinase inhibitor
    PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Learn More
  12. ACP-196 (Acalabrutinib)

    Catalog No. A15824
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    Btk Inhibitor
    ACP-196 is an orally available inhibitor of Bruton‘s tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Learn More
  13. AVL-292 benzenesulfonate

    Catalog No. A15008
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    BTK inhibitor
    AVL-292 benzenesulfonate is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM, >1400-fold selectivity over the other kinases assayed. Learn More
  14. RN486

    Catalog No. A12535
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    BTK inhibitor
    RN486 is a Bruton's tyrosine kinase (Btk) inhibitor. Learn More
  15. CNX-774

    Catalog No. A13233
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    BTK Inhibitor
    CNX-774 is a potent Btk inhibitor (IC50 < 1 nM) Learn More
  16. AVL-292

    Catalog No. A13202
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    Btk inhibitor
    AVL-292 is a highly selective, covalent Btk inhibitor. Learn More
  17. GDC-0834

    Catalog No. A12706
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    BTK inhibitor
    GDC-0834 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK), investigated as a potential treatment for rheumatoid arthritis. Learn More
  18. CGI1746

    Catalog No. A11348
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    BTK inhibitor
    CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation. Learn More
  19. Vecabrutinib

    Catalog No. A17189
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    BTK inhibitor
    Vecabrutinib is a potent, noncovalent, reversible BTK inhibitor that inhibits signaling through the BCR pathway. Learn More

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