BTK

Catalog No.Inhibitor Name BTKOther
A11020Ibrutinib
****
BLK,Bmx,FGR
A13202AVL-292
****
YES,c-Src,BRK
A13233CNX-774
***
A15558ONO-4059 analogue
**
A16261LFM-A13
*
A12535RN486
**
A11348CGI1746
***
A12706GDC-0834
**
A15008AVL-292 benzenesulfonate
****
YES,c-Src,BRK
A15824ACP-196 (Acalabrutinib)
**
A15976Olmutinib (HM71224)
***
A16262PCI 29732
**
A16263QL47
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Tirabrutinib

    Catalog No. A21019
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    BTK inhibitor
    Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM. Learn More
  2. Poseltinib (HM71224, LY3337641)

    Catalog No. A19450
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    BTK inhibitor
    Poseltinib, an orally active, selective and irreversible Bruton??s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Learn More
  3. QL47

    Catalog No. A16263
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    BTK inhibitor
    QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM. Learn More
  4. PCI 29732

    Catalog No. A16262
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    BTK inhibitor
    PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. Learn More
  5. LFM-A13

    Catalog No. A16261
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    BTK inhibitor
    LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 uM; also inhibits PLK3 with IC50 of 7.2 uM. Learn More
  6. Btk inhibitor 1

    Catalog No. A16260
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    BTK inhibitor
    Btk inhibitor 1 is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Learn More
  7. Olmutinib (HM71224)

    Catalog No. A15976
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    BTK inhibitor
    Olmutinib is a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK). Learn More
  8. CHMFL-BTK-01

    Catalog No. A12538
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    BTK inhibitor
    CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation. Learn More
  9. ONO-4059

    Catalog No. A15558
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    BTK inhibitor
    ONO-4059 is a highly potent and selective oral BTK inhibitor Learn More
  10. GDC-0834

    Catalog No. A21243
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    BTK inhibitor
    GDC-0834 is a potent and selective BTK inhibitor. Learn More
  11. Btk inhibitor 1 R enantiomer hydrochloride

    Catalog No. A21865
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    BTK inhibitor
    Btk inhibitor 1 R enantiomer hydrochloride (Ibrutinib analog hydrochloride) (Compound 14) is a covalent and irreversible Bruton??s tyrosine kinase (BTK) inhibitor and can be used in synthesis of Ibrutinib and ibrutinib-based activity-based probes (ABPs). Learn More
  12. Btk inhibitor 1 (R enantiomer)

    Catalog No. A21861
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    BTK inhibitor
    Btk inhibitor 1 R enantiomer (Ibrutinib analog) (Compound 14) is a covalent and irreversible Bruton??s tyrosine kinase (BTK) inhibitor and can be used in synthesis of Ibrutinib and ibrutinib-based activity-based probes (ABPs). Learn More
  13. (R)-Zanubrutinib

    Catalog No. A21342
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    BTK inhibitor
    (R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor. Learn More
  14. Ibrutinib Racemate

    Catalog No. A18022
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    Btk inhibitor
    Ibrutinib Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC50 value of 0.5 nM. Learn More
  15. PCI-33380

    Catalog No. A12270
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    BTK inhibitor
    PCI-33380 is an irreversible Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe). Learn More
  16. MT-802

    Catalog No. A18589
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    BTK degrader
    MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL). Learn More
  17. PF-06250112

    Catalog No. A18612
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    BTK inhibitor
    PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively. Learn More
  18. Vecabrutinib

    Catalog No. A17189
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    BTK inhibitor
    Vecabrutinib is a potent, noncovalent, reversible BTK inhibitor that inhibits signaling through the BCR pathway. Learn More
  19. Btk inhibitor 2

    Catalog No. A17057
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    Btk inhibitor
    Btk inhibitor 2 is a Bruton's tyrosine kinase (BTK) inhibitor. Learn More
  20. CGI1746

    Catalog No. A11348
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    BTK inhibitor
    CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation. Learn More
  21. GDC-0834 Racemate

    Catalog No. A12706
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    BTK inhibitor
    GDC-0834 Racemate is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK), investigated as a potential treatment for rheumatoid arthritis. Learn More
  22. AVL-292

    Catalog No. A13202
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    Btk inhibitor
    AVL-292 is a highly selective, covalent Btk inhibitor. Learn More
  23. CNX-774

    Catalog No. A13233
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    BTK Inhibitor
    CNX-774 is a potent Btk inhibitor (IC50 < 1 nM) Learn More
  24. RN486

    Catalog No. A12535
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    BTK inhibitor
    RN486 is a Bruton's tyrosine kinase (Btk) inhibitor. Learn More
  25. AVL-292 benzenesulfonate

    Catalog No. A15008
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    BTK inhibitor
    AVL-292 benzenesulfonate is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM, >1400-fold selectivity over the other kinases assayed. Learn More
  26. ACP-196 (Acalabrutinib)

    Catalog No. A15824
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    Btk Inhibitor
    ACP-196 is an orally available inhibitor of Bruton‘s tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Learn More
  27. GDC0853

    Catalog No. A16339
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    BTK inhibitor
    GDC0853 is a potent and orally BTK inhibitor. Learn More
  28. Evobrutinib

    Catalog No. A16824
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    BTK inhibitor
    Evobrutinib is a highly selective BTK inhibitor with an IC50 of 37.9 nM. It has potential anti-neoplastic activity. Learn More
  29. BMS-935177

    Catalog No. A16905
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    BTK inhibitor
    BMS-935177 a potent BTK inhibitor with improved kinase selectivity and superior oral exposure in multiple species. should provide useful clinical efficacy in autoimmune diseases. Learn More
  30. PCI-32765 (Ibrutinib)

    Catalog No. A11020
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    Bruton tyrosine kinase inhibitor
    PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Learn More

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