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| Catalog No. | Inhibitor Name | BTK | Other |
|---|---|---|---|
| A11020 | Ibrutinib | **** | BLK,Bmx,FGR |
| A13202 | AVL-292 | **** | YES,c-Src,BRK |
| A13233 | CNX-774 | *** | |
| A15558 | ONO-4059 analogue | ** | |
| A16261 | LFM-A13 | * | |
| A12535 | RN486 | ** | |
| A11348 | CGI1746 | *** | |
| A12706 | GDC-0834 | ** | |
| A15008 | AVL-292 benzenesulfonate | **** | YES,c-Src,BRK |
| A15824 | ACP-196 (Acalabrutinib) | ** | |
| A15976 | Olmutinib (HM71224) | *** | |
| A16262 | PCI 29732 | ** | |
| A16263 | QL47 | ** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
42 Item(s)
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BMS-986142
Catalog No. A19993 BTK inhibitorBMS-986142 is a potent and highly selective reversible inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 0.5 nM. Learn More -
PCI-33380
Catalog No. A12270 BTK inhibitorPCI-33380 is an irreversible Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe). Learn More -
Ibrutinib Racemate
Catalog No. A18022 BTK inhibitorIbrutinib Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC50 value of 0.5 nM. Learn More -
(R)-Zanubrutinib
Catalog No. A21342 BTK inhibitor(R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor. Learn More -
Btk inhibitor 1 (R enantiomer)
Catalog No. A21861 BTK inhibitorBtk inhibitor 1 R enantiomer (Ibrutinib analog) (Compound 14) is a covalent and irreversible Bruton??s tyrosine kinase (BTK) inhibitor and can be used in synthesis of Ibrutinib and ibrutinib-based activity-based probes (ABPs). Learn More -
Btk inhibitor 1 R enantiomer hydrochloride
Catalog No. A21865 BTK inhibitorBtk inhibitor 1 R enantiomer hydrochloride (Ibrutinib analog hydrochloride) (Compound 14) is a covalent and irreversible Bruton??s tyrosine kinase (BTK) inhibitor and can be used in synthesis of Ibrutinib and ibrutinib-based activity-based probes (ABPs). Learn More -
GDC-0834
Catalog No. A21243 -
Tirabrutinib
Catalog No. A21019 BTK inhibitorTirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM. Learn More -
BTK IN-1
Catalog No. A19463 BTK inhibitorBTK IN-1 (SNS062 analog) is a potent BTK inhibitor, with an IC50 of <100 nM. Learn More -
CG-806
Catalog No. A19814 FLT3/BTK inhibitorCG-806 is an orally active, potent and non-covalent pan-FLT3/pan-BTK inhibitor with an IC50 of 0.08 μM for FLT3. CG-806 has an IC50 of 11 nM against FLT3 wild type (WT)-transfected Ba/F3 cells. Learn More -
ARQ 531
Catalog No. A19823 BTK inhibitorARQ 531 is a reversible non-covalent inhibitor of Bruton??s Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively. Learn More -
CHMFL-BTK-01
Catalog No. A12538 BTK inhibitorCHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation. Learn More -
PRN1008
Catalog No. A19999 BTK inhibitorPRN1008 is a reversible covalent, selective and oral active inhibitor of Bruton??s Tyrosine Kinase (BTK), with an IC50 of 1.3 nM. Learn More -
Branebrutinib
Catalog No. A20043 BTK inhibitorBranebrutinib (BMS-986195) is a highly potent, selective covalent, irreversible inhibitor of Bruton??s tyrosine kinase (BTK), with an IC50 of 0.1 nM. Learn More -
G-744
Catalog No. A20227 BTK inhibitorG-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis. Learn More -
(±)-Zanubrutinib
Catalog No. A20381 BTK inhibitor(±)-Zanubrutinib is a potent, selective and orally available Bruton's tyrosine kinase (Btk) inhibitor. Learn More -
Zanubrutinib (BGB-3111)
Catalog No. A22044 BTK inhibitorZanubrutinib (BGB-3111) is a selective Bruton tyrosine kinase (BTK) inhibitor. Learn More -
BTK inhibitor 1 (Compound 27)
Catalog No. A22445 BTK inhibitorBTK inhibitor 1 (compound 27) is an inhibitor of BTK with an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM. Learn More -
Tirabrutinib hydrochloride
Catalog No. A22375 BTK inhibitorTirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development. Learn More -
Remibrutinib
Catalog No. A22322 BTK inhibitorRemibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Learn More -
Orelabrutinib
Catalog No. A22225 BTK inhibitorOrelabrutinib (ICP-022) is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Learn More -
Poseltinib (HM71224, LY3337641)
Catalog No. A19450 BTK inhibitorPoseltinib, an orally active, selective and irreversible Bruton??s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Learn More -
ONO-4059
Catalog No. A15558 BTK inhibitorONO-4059 is a highly potent and selective oral BTK inhibitor Learn More -
Olmutinib (HM61713)
Catalog No. A15976 BTK inhibitorOlmutinib is a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK). Learn More -
Btk inhibitor 1
Catalog No. A16260 BTK inhibitorBtk inhibitor 1 is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Learn More -
LFM-A13
Catalog No. A16261 BTK inhibitorLFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 uM; also inhibits PLK3 with IC50 of 7.2 uM. Learn More -
PCI 29732
Catalog No. A16262 BTK inhibitorPCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. Learn More -
QL47
Catalog No. A16263 BTK inhibitorQL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM. Learn More -
GDC0853
Catalog No. A16339 -
BMS-935177
Catalog No. A16905 BTK inhibitorBMS-935177 a potent BTK inhibitor with improved kinase selectivity and superior oral exposure in multiple species. should provide useful clinical efficacy in autoimmune diseases. Learn More -
Btk inhibitor 2
Catalog No. A17057 Btk inhibitorBtk inhibitor 2 is a Bruton's tyrosine kinase (BTK) inhibitor. Learn More -
Vecabrutinib
Catalog No. A17189 BTK inhibitorVecabrutinib is a potent, noncovalent, reversible BTK inhibitor that inhibits signaling through the BCR pathway. Learn More -
PF-06250112
Catalog No. A18612 BTK inhibitorPF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively. Learn More -
MT-802
Catalog No. A18589 BTK degraderMT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL). Learn More -
ACP-196 (Acalabrutinib)
Catalog No. A15824 Btk InhibitorACP-196 is an orally available inhibitor of Bruton‘s tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Learn More -
PCI-32765 (Ibrutinib)
Catalog No. A11020 Bruton tyrosine kinase inhibitorPCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Learn More -
AVL-292 benzenesulfonate
Catalog No. A15008 BTK inhibitorAVL-292 benzenesulfonate is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM, >1400-fold selectivity over the other kinases assayed. Learn More -
RN486
Catalog No. A12535 BTK inhibitorRN486 is a Bruton's tyrosine kinase (Btk) inhibitor. Learn More -
CNX-774
Catalog No. A13233 -
AVL-292
Catalog No. A13202 Btk inhibitorAVL-292 is a highly selective, covalent Btk inhibitor. Learn More -
GDC-0834 Racemate
Catalog No. A12706 BTK inhibitorGDC-0834 Racemate is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK), investigated as a potential treatment for rheumatoid arthritis. Learn More -
CGI1746
Catalog No. A11348 BTK inhibitorCGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation. Learn More
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