Estrogen Receptors

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  1. TAK-875 (Fasiglifam)

    Catalog No. A11018
    GPR agonist
    TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist. Learn More
  2. Arzoxifene HCl

    Catalog No. A13292
    Arzoxifene HCl is the hydrochloride salt of arzoxifene, a synthetic aromatic derivative with anti-estrogenic properties. Arzoxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist. Learn More
  3. XCT 790

    Catalog No. A13299
    ERRα antagonist/inverse agonist
    XCT 790 is a potent and specific inverse agonist of ERRα. Learn More
  4. Ospemifene

    Catalog No. A14261
    estrogen receptor modulator
    Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM). Learn More
  5. IRL-2500

    Catalog No. A13638
    ETBR antagonist
    IRL-2500 is a potent, selective ETBR antagonist. It shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Learn More
  6. Bazedoxifene

    Catalog No. A15019
    Estrogen modulator
    Bazedoxifene is a third generation selective modulator of estrogen receptor. Learn More
  7. DY131

    Catalog No. A15071
    ERRβ and ERRγ agonist
    DY131(GSK 9089) is a novel selective agonist of ERRα and ERRβ. Learn More
  8. Toremifene

    Catalog No. A15265
    Estrogen receptor modulator
    Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Learn More
  9. Endoxifen

    Catalog No. A12639
    Estrogen receptor antagonist
    Endoxifen is a secondary metabolite of tamoxifen. It is a primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer. Learn More
  10. AZD9496

    Catalog No. A15822
    estrogen receptor downregulator and antagonist
    AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. Learn More
  11. 4-Hydroxytamoxifen

    Catalog No. A12532
    Estrogen receptor antagonist
    4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Learn More
  12. RAD1901 HCl salt

    Catalog No. A15990
    RAD1901 is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities. Learn More
  13. GDC-0810 (Brilanestrant)

    Catalog No. A15958
    Estrogen receptor degrader
    GDC-0810 an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts. Learn More
  14. Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). Learn More
  15. GSK4716

    Catalog No. A16956
    ERRβ & ERRγ Agonist
    GSK4716 is an Estrogen-related receptors ERRβ and ERRγ agonist with minimal activity for ERRα, ERα and ERβ Learn More
  16. Zearalenone

    Catalog No. A13740
    Zearalenone is a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. Learn More
  17. estrogen receptor modulator
    acolbifene is a substance being studied in the prevention of breast cancer in women at high risk of breast cancer. Acolbifene hydrochloride binds to estrogen receptors in the body and blocks the effects of estrogen in the breast. It is a type of selective estrogen receptor modulator (SERM). Learn More
  18. Fulvestrant (Faslodex)

    Catalog No. A10410
    Aromatase inhibitor
    Fulvestrant is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. Learn More
  19. Dienogest

    Catalog No. A10308
    Dienogest is an oral progestin that has antiandrogenic activity and as a result can improve androgenic symptoms. Learn More
  20. Kaempferol

    Catalog No. A10495
    ERRα and ERRγ inverse agonist
    Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway. Learn More
  21. Hexestrol

    Catalog No. A10451
    Estrogen/progestogen Receptor agonist
    Hexestrol is a carcinogenic synthetic estrogen that inhibits microtubule polymerization and the formation of ribbon structures. It is an inhibitor of lipid peroxidation. Learn More
  22. Evista (Raloxifene HCl)

    Catalog No. A10375
    Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women. Learn More
  23. GSK1292263

    Catalog No. A10439
    GPR119 agonist
    GSK-1292263 is a novel GPR119 agonist. Learn More
  24. LY500307

    Catalog No. A10550
    ERβ agonist
    LY500307 is a potent, selective estrogen receptor beta agonist with an EC50 of 0.66 nM. Learn More
  25. Bazedoxifene acetate

    Catalog No. A11665
    Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). Bazedoxifene acetate significantly prevents bone mass loss at 20 mg/day in healthy postmenopausal women with normal or low bone mineral density. Learn More
  26. Ethisterone

    Catalog No. A11667
    Ethisterone is a progestogen hormone. Learn More
  27. Clomifene citrate

    Catalog No. A10230
    Clomifene inhibits estrogen receptors in hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic-Cpituitary-Cadrenal axis. Learn More
  28. Drospirenone

    Catalog No. A10336
    Drospirenone is a synthetic hormone used in birth control pills. Learn More
  29. GW9508

    Catalog No. A11965
    GPR40 Inhibitor
    GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ?50 nM) with reduced activity towards family members GRP120 (EC50 ?3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors. Learn More
  30. Mifepristone (Mifeprex)

    Catalog No. A10591
    Mifepristone, an antioxidant and glucocorticoid receptor antagonist, demonstrates the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes. Learn More
  31. Liquiritigenin

    Catalog No. A12083
    Liquiritigenin is a plant-derived highly selective estrogen receptor ?? agonist Learn More
  32. (R)-Equol

    Catalog No. A16986
    Estrogen receptor agonist
    (R)-Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively. Learn More

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