PPAR

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  1. Peliglitazar racemate

    Catalog No. A21411
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    dual α/γ PPAR activator
    Peliglitazar racemate is the racemate of Peliglitazar. Peliglitazar is a novel dual α/γ PPAR activator. Learn More
  2. DG172 dihydrochloride

    Catalog No. A16309
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    PPARβ/δ inverse agonist
    DG-172 is an orally active potent PPARβ/δ inverse agonist (IC50 = 26.9 nM). DG-172 inhibits Angptl4 gene expression in mouse myoblasts (IC50 = 9.5 nM) in vitro. Learn More
  3. Balaglitazone

    Catalog No. A15013
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    PPAR-γ partial agonist
    Balaglitazone is a novel partial agonist of PPAR-gamma (γ). Learn More
  4. BMS-687453

    Catalog No. A15836
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    PPAR agonist
    BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays. Learn More
  5. T0070907

    Catalog No. A11588
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    PPAR-γ antagonist
    T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2. Learn More
  6. Aleglitazar

    Catalog No. A12492
    PPAR-α/γ agonist
    Aleglitazar is a new dual PPAR-α/γ agonist with IC50 of 2.8 nM/4.6 nM. Learn More
  7. Elafibranor

    Catalog No. A15454
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    PPAR agonist
    Elafibranor is an agonist of the peroxisome proliferator-activated Receptor-α and -δ, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. Learn More
  8. CDDO-Im

    Catalog No. A16308
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    PPARγ Agonist
    CDDO-Im is a novel synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo; PPARγ Agonist. Learn More
  9. GW 6471

    Catalog No. A21934
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    PPARα antagonist
    GW 6471 is a potent PPARα antagonist. Learn More
  10. 5-Aminosalicylic Acid

    Catalog No. A10570
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    PPARγ agonist
    5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. Learn More
  11. Pioglitazone hydrochloride

    Catalog No. A16670
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    PPARγ agonist
    Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Learn More
  12. Fonadelpar

    Catalog No. A20848
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    PPARδ agonist
    Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy. Learn More
  13. Arhalofenate

    Catalog No. A21135
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    PPARγ agonist
    Arhalofenate (MBX 102) is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ, used for the treatment of type 2 diabetes. Learn More
  14. Indeglitazar

    Catalog No. A21148
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    PPAR agonist
    Indeglitazar is an orally available peroxisome proliferator-activated receptor (PPAR) pan-agonist for all three PPAR subtypes alpha (α), delta (δ) and gamma (γ). Learn More
  15. Inolitazone

    Catalog No. A21180
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    PPARγ agonist
    Inolitazone a novel high-affinity PPARγ agonist that is dependent upon PPARγ for its biological activity with IC50 of 0.8 nM for growth inhibition. Learn More
  16. GW1929

    Catalog No. A15099
    PPAR agonist
    GW1929 is a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist with IC50 of 6.2 nM and 13 nM for human and mouse, respectively. Learn More
  17. Tesaglitazar

    Catalog No. A20891
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    PPAR alpha/gamma agonist
    Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively. Learn More
  18. GW0742

    Catalog No. A14958
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    PPAR agonist
    GW0742 is a selective agonist of PPARδ with EC50 value of 1.1 nM. Learn More
  19. VCE-004.8

    Catalog No. A18549
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    PPARγ and CB2 receptor dual agonist
    VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity. Learn More
  20. LJ570

    Catalog No. A20081
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    PPARα/PPARγ dual agonist
    LJ570 is a PPARα/PPARγ dual agonist with EC50s of 1.05 and 0.12 μM, respectively. Learn More
  21. MA-0204

    Catalog No. A19031
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    PPARδ modulator
    MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD). Learn More
  22. L-165,041

    Catalog No. A11983
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    PPARδ agonist
    L-165,041 is a potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. Learn More
  23. Chiglitazar

    Catalog No. A12701
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    PPARα/γ dual agonist
    Chiglitazar is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively. Learn More
  24. GW 7647

    Catalog No. A11982
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    PPARα agonist
    GW 7647 is a potent and highly selective PPARα agonist (EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors respectively). Learn More
  25. Choline Fenofibrate

    Catalog No. A15044
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    CYP2C19/CYP2B6 inhibitor
    Choline Fenofibrate (ABT-335) is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia. Learn More
  26. Ciprofibrate

    Catalog No. A11727
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    Ciprofibrate is a peroxisome proliferator-activated receptor agonist. Learn More
  27. Troglitazone

    Catalog No. A11981
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    PPARγ agonist
    Troglitazone is a selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively). Learn More
  28. Rosiglitazone (BRL-49653)

    Catalog No. A10807
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    PPAR agonist
    Rosiglitazone works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Learn More
  29. Pioglitazone (Actos)

    Catalog No. A11680
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    PPARγ agonist
    Pioglitazone selectively stimulates the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) and to a lesser extent PPAR-α. Learn More
  30. Cetaben

    Catalog No. A11137
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    Peroxisome Proliferator
    Cetaben is a unique, PPARα-independent peroxisome proliferator with hypolipidemic activity that inhibits cholesterol synthesis in the human hepatoma Hep-G2 cells resulting in reversible changes in Golgi morphology. Learn More
  31. Rosiglitazone maleate

    Catalog No. A10809
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    PPAR agonist
    Rosiglitazone maleate, an antidiabetic drug, works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Learn More
  32. NXT629

    Catalog No. A18771
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    PPAR-α antagonist
    NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively. Learn More
  33. BR102375

    Catalog No. A18849
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    PPAR γ agonist
    BR102375 is a non-TZD peroxisome proliferator-activated receptor γ (PPAR γ) full agonist for the treatment of type 2 diabetes, reveals EC50 value of 0.28?μM and Amax ratio?of 98%. Learn More
  34. GW6471

    Catalog No. A12413
    PPARα antagonist
    GW6471 is a PPARα antagonist, shown to completely inhibit GW409544-induced activation of PPARα. Learn More
  35. GSK 0660

    Catalog No. A12392
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    PPARδ antagonist
    GSK 0660 is a selective PPARβ antagonist (IC50 values are 0.155, > 10 and ≥ 10 µM at PPARβ, PPARα and PPARγ respectively). Learn More
  36. GSK-3787

    Catalog No. A12391
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    PPAR antagonist
    GSK-3787 is a potent and selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6). Learn More
  37. Fenofibric acid

    Catalog No. A16001
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    Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides. Learn More
  38. Fenofibrate

    Catalog No. A10385
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    Fenofibrate is a drug of the fibrate class. It is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. Learn More
  39. GW 501516

    Catalog No. A11437
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    PPARδ receptor agonist
    GW501516 (GW1516 or GSK-516) is a drug that acts as a PPARδ modulator. Learn More
  40. pirinixic acid (WY 14643)

    Catalog No. A12360
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    PPARα agonist
    WY 14643 is a highly potent PPARα agonist. Learn More
  41. Gemfibrozil (Lopid)

    Catalog No. A10424
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    Gemfibrozil (Lopid) is a compound used to lower lipid levels. Learn More
  42. Bezafibrate

    Catalog No. A16307
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    PPAR agonist
    Bezafibrate is the first clinically tested dual and pan-PPAR co-agonist. Learn More
  43. GW 9662

    Catalog No. A11984
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    PPARγ antagonist
    GW 9662 is a selective PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Learn More
  44. Inolitazone dihydrochloride

    Catalog No. A15129
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    PPARγ agonist
    Inolitazone dihydrochloride is a novel high-affinity PPARγ agonist, which activates PPARγ with an EC50 about 1/50 that of rosiglitazone and has no effect on RIE cells. Learn More
  45. Clofibric Acid

    Catalog No. A16463
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    PPARα agonist
    Clofibric acid is a PPARα agonist and hypolipidemic agent. Learn More
  46. Etofylline

    Catalog No. A17491
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    PPAR agonist
    Etofylline, also known as BRN-0251760, is a peroxisome proliferator-activated receptor (PPAR) agonist used to treat respiratory and cardiovascular disorders. Etofylline is often used as a bronchodilator. Learn More
  47. Leriglitazone

    Catalog No. A18636
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    PPAR gamma agonist
    Leriglitazone is a peroxisome proliferator activated receptor (PPAR) gamma agonist. Learn More

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