ROCK

Catalog No.Inhibitor Name ROCKROCK1ROCK2Other
A11001Y-27632 2HCl
*
*
A10928Thiazovivin
*
A10381Fasudil HCl
*
PKA,PKG,PKC
A10441GSK429286A
***
**
A13067RKI-1447
***
***
A12348GSK269962
****
****
MSK1,RSK1
A15888Ripasudil
**
**
A15239KD025
**
A12464AT13148
***
****
PKA,p70S6K,Akt1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

24 Item(s)

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  1. Y-27632 2HCl

    Catalog No. A11001
    ROCK Inhibitor
    Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs). Learn More
  2. Thiazovivin

    Catalog No. A10928
    ROCK inhibitor
    Thiazovivin is a selective inhibitor of Rho-associated kinase (ROCK). Learn More
  3. RKI-1313

    Catalog No. A10899
    ROCK inhibitor
    RKI-1313 is a negative control for RKI-1447 which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Learn More
  4. BMS-5

    Catalog No. A12839
    LIMK inhibitor
    BMS-5 is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively. Learn More
  5. GSK429286A

    Catalog No. A10441
    ROCK Inhibitor
    GSK429286A is a cell-permeable, selective small molecule inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Learn More
  6. GSK 269962

    Catalog No. A12348
    ROCK inhibitor
    GSK 269962 is a potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Learn More
  7. Fasudil HCl (HA-1077)

    Catalog No. A10381
    ROCK inhibitor
    Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Learn More
  8. HA-1077 dihydrochloride

    Catalog No. A13785
    ROCK Inhibitor
    HA-1077 inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist. Learn More
  9. RKI-1447

    Catalog No. A13067
    ROCK1/ROCK2 inhibitor
    RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Learn More
  10. Y-33075

    Catalog No. A11610
    ROCK inhibitor
    Y-33075 is ROCK (Rho-associated coiled coil-forming protein kinase) inhibitor. Learn More
  11. AT13148

    Catalog No. A12464
    multi-AGC kinase inhibitor
    AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. Learn More
  12. chroman 1

    Catalog No. A15045
    ROCK Inhibitor
    Chroman 1 is a highly potent and selective ROCK II inhibitor. Learn More
  13. H-1152

    Catalog No. A15101
    ROCK inhibitor
    H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. Learn More
  14. H-1152 dihydrochloride

    Catalog No. A15102
    ROCK inhibitor
    H-1152 dihydrochloride, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. Learn More
  15. Glycyl-H 1152 2HCl

    Catalog No. A13659
    ROCK inhibitor
    Glycyl-H 1152 2HCl is a selective and potent ROCK inhibitor (IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 uM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.) Learn More
  16. SLx-2119 (KD025)

    Catalog No. A15239
    ROCK2 Inhibitor
    SLx-2119 is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM). Learn More
  17. SAR407899 HCl

    Catalog No. A15921
    ROCK inhibitor
    SAR407899 is a potent and selective Rho kinase inhibitor with promising antihypertensive activity. Learn More
  18. LX7101

    Catalog No. A16211
    LIMK2 inhibitor
    LX7101 is a pyrrolopyrimidine-based, topically-delivered inhibitor of LIM domain kinase 2 (LIMK2), a kinase associated with the regulation of intraocular pressure. Learn More
  19. ROCK inhibitor-1

    Catalog No. A15226
    ROCK inhibitor
  20. ROCK inhibitor

    Catalog No. A15225
    ROCK inhibitor
    ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively. Learn More
  21. Narciclasine

    Catalog No. A15178
    ROCK activator
    Narciclasine is a Rho/Rho kinase/LIM kinase/cofilin signaling pathway activator. Learn More
  22. Hydroxyfasudil

    Catalog No. A15118
    ROCK inhibitor
    Hydroxyfasudil, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator. Learn More
  23. ROCK inhibitor
    Hydroxyfasudil hydrochloride, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator. Learn More
  24. SR 3677 dihydrochloride

    Catalog No. A12674
    ROCK inhibitor
    SR 3677 dihydrochloride is a potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively). Learn More

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