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| Catalog No. | Inhibitor Name | ROCK | ROCK1 | ROCK2 | Other |
|---|---|---|---|---|---|
| A11001 | Y-27632 2HCl | * | * | ||
| A10928 | Thiazovivin | * | |||
| A10381 | Fasudil HCl | * | PKA,PKG,PKC | ||
| A10441 | GSK429286A | *** | ** | ||
| A13067 | RKI-1447 | *** | *** | ||
| A12348 | GSK269962 | **** | **** | MSK1,RSK1 | |
| A15888 | Ripasudil | ** | ** | ||
| A15239 | KD025 | ** | |||
| A12464 | AT13148 | *** | **** | PKA,p70S6K,Akt1 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
37 Item(s)
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Y-27632 2HCl
Catalog No. A11001 ROCK InhibitorY-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs). Learn More -
ZINC00881524
Catalog No. A20477 -
Rho-Kinase-IN-1
Catalog No. A20403 ROCK inhibitorRho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008. Learn More -
SB-772077B dihydrochloride
Catalog No. A20090 ROCK inhibitorSB-772077B dihydrochloride is an aminofurazan-based Rho kinase (ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively. Learn More -
ROCK2-IN-2
Catalog No. A20062 ROCK2 inhibitorROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM. Learn More -
Fasudil HCl (HA-1077)
Catalog No. A10381 ROCK inhibitorFasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Learn More -
GSK 269962
Catalog No. A12348 ROCK inhibitorGSK 269962 is a potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Learn More -
Thiazovivin
Catalog No. A10928 ROCK inhibitorThiazovivin is a selective inhibitor of Rho-associated kinase (ROCK). Learn More -
BMS-3
Catalog No. A20999 LIMK inhibitorBMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively. Learn More -
Fasudil
Catalog No. A21628 ROCK inhibitorFasudil (HA-1077; AT877), is a nonspecific ROCK inhibitor and also has inhibitory effect on protein kinases. Learn More -
Y-27632
Catalog No. A21448 ROCK-I/ROCK-II inhibitorY-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively. Learn More -
Y-33075 dihydrochloride
Catalog No. A11611 ROCK inhibitorY-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM. Learn More -
T56-LIMKi
Catalog No. A12266 LIMK2 inhibitorT56-LIMKi is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM. Learn More -
ROCK inhibitor-2
Catalog No. A18912 ROCK1/ROCK2 inhibitorROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively. Learn More -
R-10015
Catalog No. A18806 LIMK inhibitorR-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1. Learn More -
BDP5290
Catalog No. A16966 ROCK and MRCK inhibitorBDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively. Learn More -
BMS-5
Catalog No. A12839 LIMK inhibitorBMS-5 is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively. Learn More -
RKI-1313
Catalog No. A10899 ROCK inhibitorRKI-1313 is a negative control for RKI-1447 which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Learn More -
GSK429286A
Catalog No. A10441 ROCK InhibitorGSK429286A is a cell-permeable, selective small molecule inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Learn More -
HA-1077 dihydrochloride
Catalog No. A13785 ROCK InhibitorHA-1077 inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist. Learn More -
RKI-1447
Catalog No. A13067 ROCK1/ROCK2 inhibitorRKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Learn More -
AT13148
Catalog No. A12464 multi-AGC kinase inhibitorAT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. Learn More -
Y-33075
Catalog No. A11610 ROCK inhibitorY-33075 is ROCK (Rho-associated coiled coil-forming protein kinase) inhibitor. Learn More -
chroman 1
Catalog No. A15045 ROCK InhibitorChroman 1 is a highly potent and selective ROCK II inhibitor. Learn More -
H-1152
Catalog No. A15101 ROCK inhibitorH-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. Learn More -
H-1152 dihydrochloride
Catalog No. A15102 ROCK inhibitorH-1152 dihydrochloride, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. Learn More -
Glycyl-H 1152 2HCl
Catalog No. A13659 ROCK inhibitorGlycyl-H 1152 2HCl is a selective and potent ROCK inhibitor (IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 uM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.) Learn More -
SLx-2119 (KD025)
Catalog No. A15239 ROCK2 InhibitorSLx-2119 is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM). Learn More -
SAR407899 HCl
Catalog No. A15921 ROCK inhibitorSAR407899 is a potent and selective Rho kinase inhibitor with promising antihypertensive activity. Learn More -
Ripasudil
Catalog No. A15888 ROCK inhibitorRipasudil (K-115) is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension. Learn More -
LX7101
Catalog No. A16211 LIMK2 inhibitorLX7101 is a pyrrolopyrimidine-based, topically-delivered inhibitor of LIM domain kinase 2 (LIMK2), a kinase associated with the regulation of intraocular pressure. Learn More -
ROCK inhibitor
Catalog No. A15225 ROCK inhibitorROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively. Learn More -
Narciclasine
Catalog No. A15178 ROCK activatorNarciclasine is a Rho/Rho kinase/LIM kinase/cofilin signaling pathway activator. Learn More -
Hydroxyfasudil
Catalog No. A15118 ROCK inhibitorHydroxyfasudil, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator. Learn More -
Hydroxyfasudil hydrochloride
Catalog No. A15119 ROCK inhibitorHydroxyfasudil hydrochloride, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator. Learn More -
SR 3677 dihydrochloride
Catalog No. A12674 ROCK inhibitorSR 3677 dihydrochloride is a potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively). Learn More
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