HIF

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  1. Activator (1)
  2. Inhibitor (7)


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Catalog No. Product Name Product Information
A10012

2-Methoxyestradiol

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.
A12978

BAY 87-2243

BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.
A15358

Chetomin

Chetomin is reported to be an antibiotic metabolite of Chaetomium spp. which contains bacteriostatic effects on Gram-positive bacteria.
A11237

FG-4592 (Roxadustat)

FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.
A12883

FM19G11

FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), which are transcription factors that respond to changes in available oxygen in the cellular environment.
A12921

HIF-C2

HIF-C2 is a potent and selective allosteric inhibitor of hypoxia inducible factor-2 (HIF-2)
A11924

IOX 2

IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF).
A15359

KC7F2

KC7F2 is an inhibitor of HIF-1?? protein translation, but not transcription, that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K).
A15360

ML 228

ML-228 is an activator of the HIF signaling pathway, as demonstrated by HIF response element (HRE) reporter assay, HIF-1?? nuclear translocation assay, and increased VEGF expression.

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