NF-κB

Catalog No.Inhibitor Name NF-κBOther
A12748QNZ (EVP4593)
****
TNF-α
A14142JSH-23
**
A14278SC75741
***
A13698Caffeic Acid Phenethyl Ester
A10077Andrographolide
A15046CID-2858522
***
A16301(+)-DHMEQ
A16302(-)-DHMEQ
A16306Pyrrolidinedithiocarbamate ammonium
A10698Parthenolide
p53,MDM2 ubiquitination,HDAC1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. CID-2858522

    Catalog No. A15046
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    NF-κB inhibitor
    CID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 uM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways. Learn More
  2. Pyrrolidinedithiocarbamate ammonium

    Catalog No. A16306
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    NF-kB inhibitor
    Pyrrolidinedithiocarbamate ammonium is a selective NF-kB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction. Learn More
  3. JSH 23

    Catalog No. A14142
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    NF-κB inhibitor
    JSH 23 is an inhibitor of NF-kB, blocking its translocation into the nucleus (IC50 = 7.1 uM) Learn More
  4. SC75741

    Catalog No. A14278
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    NF-κB inhibitor
    SC75741 is a potent NF-kB inhibitor with EC50 of 200 nM. Learn More
  5. (-)-DHMEQ

    Catalog No. A16302
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    NF-kB inhibitor
    (-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ (HY-14645A). Learn More
  6. (+)-DHMEQ

    Catalog No. A16301
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    NF-kB inhibitor
    The (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-kB. Learn More
  7. CBL-0137

    Catalog No. A16836
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    p53 activator / NF-κB inhibitor
    CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex). Learn More
  8. Adjudin

    Catalog No. A16303
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    Adjudin is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production. Learn More
  9. Tomatidine

    Catalog No. A16233
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    ERK/Akt/NF-kB inhibitor
    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties. Learn More
  10. Andrographolide

    Catalog No. A10077
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    Apoptosis Inducer
    Andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent. Learn More
  11. Dehydrocostus Lactone

    Catalog No. A14809
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    Dehydrocostus Lactone inhibits NF kappa B activation by preventing TNF-α induced degradation and phosphorylation. Learn More
  12. Caffeic Acid Phenethyl Ester

    Catalog No. A13698
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    NF-κB activation inhibitor
    Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation Learn More
  13. QNZ (EVP4593)

    Catalog No. A12748
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    NF-κB inhibitor
    QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling. Learn More
  14. Parthenolide ((-)-Parthenolide)

    Catalog No. A10698
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    Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium). Learn More
  15. Ac2-26

    Catalog No. A17205
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    NF-κB Inhibitor
    Ac2-26 is an active N-terminal peptide of annexin A1 (AnxA1). Learn More

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