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$0.00 NF-κB
| Catalog No. | Inhibitor Name | NF-κB | Other |
|---|---|---|---|
| A12748 | QNZ (EVP4593) | **** | TNF-α |
| A14142 | JSH-23 | ** | |
| A14278 | SC75741 | *** | |
| A13698 | Caffeic Acid Phenethyl Ester | ||
| A10077 | Andrographolide | ||
| A15046 | CID-2858522 | *** | |
| A16301 | (+)-DHMEQ | ||
| A16302 | (-)-DHMEQ | ||
| A16306 | Pyrrolidinedithiocarbamate ammonium | ||
| A10698 | Parthenolide | p53,MDM2 ubiquitination,HDAC1 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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JSH 23
Catalog No. A14142 NF-κB inhibitorJSH 23 is an inhibitor of NF-kB, blocking its translocation into the nucleus (IC50 = 7.1 uM) Learn More -
SC75741
Catalog No. A14278 NF-κB inhibitorSC75741 is a potent NF-kB inhibitor with EC50 of 200 nM. Learn More -
CID-2858522
Catalog No. A15046 NF-κB inhibitorCID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 uM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways. Learn More -
(+)-DHMEQ
Catalog No. A16301 NF-kB inhibitorThe (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-kB. Learn More -
(-)-DHMEQ
Catalog No. A16302 NF-kB inhibitor(-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ (HY-14645A). Learn More -
Pyrrolidinedithiocarbamate ammonium
Catalog No. A16306 NF-kB inhibitorPyrrolidinedithiocarbamate ammonium is a selective NF-kB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction. Learn More -
Andrographolide
Catalog No. A10077 Apoptosis InducerAndrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent. Learn More -
Parthenolide ((-)-Parthenolide)
Catalog No. A10698 Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium). Learn More -
QNZ (EVP4593)
Catalog No. A12748 NF-κB inhibitorQNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling. Learn More -
Caffeic Acid Phenethyl Ester
Catalog No. A13698 NF-κB activation inhibitorCaffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation Learn More -
Dehydrocostus Lactone
Catalog No. A14809 Dehydrocostus Lactone inhibits NF kappa B activation by preventing TNF-α induced degradation and phosphorylation. Learn More -
Tomatidine
Catalog No. A16233 ERK/Akt/NF-kB inhibitorTomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties. Learn More -
Adjudin
Catalog No. A16303 Adjudin is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production. Learn More -
CBL-0137
Catalog No. A16836 p53 activator / NF-κB inhibitorCBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex). Learn More -
Ac2-26
Catalog No. A17205 NF-κB InhibitorAc2-26 is an active N-terminal peptide of annexin A1 (AnxA1). Learn More
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