PDE

Catalog No.Inhibitor Name PDEPDE1PDE2PDE3PDE4PDE5PDE6PDE9APDE10AOther
A10804Roflumilast
****
A10216Cilomilast
***
A10883Tadalafil
***
A10733Pimobendan
**
A11073GSK256066
****
A11191PF-2545920
****
A10805Rolipram
**
A10217Cilostazol
**
A10592Milrinone
**
**
ATPase
A12619Avanafil
****
A10066Aminophylline
*
adenosine receptor
A15799TAK-063
****
A13722Deltarasin
***
A10541Luteolin
*
*
*
*
*
A10464Icariin
**
mAChR,AChR
A10480Irsogladine
A10319Dipyridamole
A10339Dyphylline
A11527PF-8380
***
A10965Vardenafil
***
****
A11019Ibudilast (KC-404)
A11289Apremilast (CC 10004)
***
A11326Bay 60-7550
****
A11602Vinpocetine
Sodium channel
A12550Zardaverine
**
**
A12631Sildenafil
***
***
A12776AN2728
***
A13121PF-04447943
***
A13467MK-0359
A13596Cilostamide
***
A15191Nortadalafil
A15197Oglemilast
****
A15198Olprinone Hydrochloride

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Olprinone Hydrochloride

    Catalog No. A15198
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    PDE3 inhibitor
    Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor. Learn More
  2. Oglemilast

    Catalog No. A15197
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    PDE4 inhibitor
    Oglemilast is a potent inhibitor of PDE4. Learn More
  3. TAK-063

    Catalog No. A15799
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    PDE10A inhibitor‎
    TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. Learn More
  4. Nortadalafil

    Catalog No. A15191
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    PDE5 inhibitor
    Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension. Learn More
  5. Sildenafil

    Catalog No. A12631
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    PDE5 inhibitor
    Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. Learn More
  6. GSK256066 2,2,2-trifluoroacetic acid

    Catalog No. A15097
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    PDE Inhibitor
    GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. Learn More
  7. MK-0359

    Catalog No. A13467
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    PDE4 inhibitor
    MK-0359 is a selective and potent oral PDE4 inhibitor, in chronic asthma. Learn More
  8. Cilostamide

    Catalog No. A13596
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    PDE3 inhibitor
    Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively. Learn More
  9. Vinpocetine

    Catalog No. A11602
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    PDE1 inhibitor
    Vinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. Learn More
  10. Dyphylline

    Catalog No. A10339
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    Adenosine receptor antagonist
    Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor. Learn More
  11. Deltarasin HCl

    Catalog No. A13722
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    PDE-KRAS inhibitor
    Deltarasin is a novel small molecule inhibiting the KRAS PDEδ interaction and thus impairing oncogenic KRAS signalling. Learn More
  12. Roflumilast N-oxide

    Catalog No. A16984
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    PDE4 inhibitor
    Roflumilast N-oxide is the active metabolite of roflumilast. Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. Learn More
  13. HA130

    Catalog No. A15546
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    Autotaxin Inhibitor
  14. BRL-50481

    Catalog No. A17008
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    PDE7 inhibitor
    BRL-50481 acts as a phosphodiesterase inhibitor selective for the PDE7 subtype. Learn More
  15. BAY 73-6691

    Catalog No. A17024
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    PDE9 inhibitor
    BAY 73-6691 is a potent, selective brain penetrant PDE9A inhibitor. Learn More
  16. BW-A78U

    Catalog No. A17098
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    PDE4 inhibitor
    BW-A78U is a PDE4 inhibitor with an IC50 of 3 μM. Learn More
  17. Vesnarinone

    Catalog No. A13313
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    PDE3 inhibitor
    Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux. Learn More
  18. Udenafil

    Catalog No. A13291
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    PDE5 inhibitor
    Udenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction. Learn More
  19. Sildenafil Mesylate

    Catalog No. A16142
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    PDE5 inhibitor
    Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5. Learn More
  20. Tadalafil

    Catalog No. A10883
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    PDE5 inhibitor
    Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM. Learn More
  21. PF-8380

    Catalog No. A11527
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    Autotaxin inhibitor
    PF-8380 is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM. Learn More
  22. PF-04447943

    Catalog No. A13121
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    PDE9 inhibitor
    PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. Learn More
  23. AN2728

    Catalog No. A12776
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    PDE4 inhibitor‎
    AN2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines Learn More
  24. Hesperetin

    Catalog No. A10449
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    PDE4 inhibitor
    Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer. Learn More
  25. Cilomilast (SB-207499)

    Catalog No. A10216
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    PDE-4 inhibitor
    Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD. Learn More
  26. Ibudilast (KC-404)

    Catalog No. A11019
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    PDE Inhibitor
    Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency Virus-1 Tat-Mediated activation of microglial cells. Learn More
  27. PF-2545920

    Catalog No. A11191
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    PDE10A inhibitor

    PF-2545920 is a phosphodiesterase inhibitor selective for the PDE10A subtype.

    Learn More
  28. GSK256066

    Catalog No. A11073
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    PDE Inhibitor
    GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17). Learn More
  29. Pimobendan (Vetmedin)

    Catalog No. A10733
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    PDE inhibitor
    Pimobendan (Vetmedin) is a calcium sensitizer with positive inotropic and vasodilator effects. It is also a selective inhibitor of phosphodiesterase III (PDE3). Learn More
  30. Icariin

    Catalog No. A10464
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    PDE5 inhibitor
    Icariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively. Learn More
  31. Rolipram

    Catalog No. A10805
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    PDE4 inhibitor
    Rolipram is a PDE4-inhibitor with IC50 = 2.0 μM. Learn More
  32. Luteolin

    Catalog No. A10541
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    PDE4 inhibitor
    Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin acts as a monoamine transporter activator, and is one of the few chemicals demonstrated to possess this property. Learn More
  33. Apremilast (CC 10004)

    Catalog No. A11289
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    PDE4 Inhibitor
    Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Learn More
  34. Vardenafil

    Catalog No. A10965
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    PDE-5 Inhibitor
    Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction. Learn More
  35. Avanafil

    Catalog No. A12619
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    PDE5 inhibitor
    Avanafil is a PDE5 Inhibitor for the Treatment of Erectile Dysfunction Learn More
  36. Zardaverine

    Catalog No. A12550
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    PDE 3/4 inhibitor
    Zardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 uM respectively). Learn More
  37. Milrinone (Primacor)

    Catalog No. A10592
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    PDE3 inhibitor
    Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE Learn More
  38. Irsogladine

    Catalog No. A10480
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    Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. Learn More
  39. Dipyridamole

    Catalog No. A10319
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    PDE inhibitor
    Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Learn More
  40. Aminophylline

    Catalog No. A10066
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    Adenosine receptor antagonist
    Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor capable of reversing ischemia-induced bradyasystole. Learn More
  41. Bay 60-7550

    Catalog No. A11326
    PDE-2 Inhibitor
    BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). Learn More
  42. Roflumilast

    Catalog No. A10804
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    PDE inhibitor
    Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4. Learn More
  43. Cilostazol

    Catalog No. A10217
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    PDE3 inhibitor
    Cilostazol is a selective inhibitor of 3-type phosphodiesterase (PDE3) with therapeutic focus on cAMP. Learn More

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