PDE

Catalog No.Inhibitor Name PDEPDE1PDE2PDE3PDE4PDE5PDE6PDE9APDE10AOther
A10804Roflumilast
****
A10216Cilomilast
***
A10883Tadalafil
***
A10733Pimobendan
**
A11073GSK256066
****
A11191PF-2545920
****
A10805Rolipram
**
A10217Cilostazol
**
A10592Milrinone
**
**
ATPase
A12619Avanafil
****
A10066Aminophylline
*
adenosine receptor
A15799TAK-063
****
A13722Deltarasin
***
A10541Luteolin
*
*
*
*
*
A10464Icariin
**
mAChR,AChR
A10480Irsogladine
A10319Dipyridamole
A10339Dyphylline
A11527PF-8380
***
A10965Vardenafil
***
****
A11019Ibudilast (KC-404)
A11289Apremilast (CC 10004)
***
A11326Bay 60-7550
****
A11602Vinpocetine
Sodium channel
A12550Zardaverine
**
**
A12631Sildenafil
***
***
A12776AN2728
***
A13121PF-04447943
***
A13467MK-0359
A13596Cilostamide
***
A15191Nortadalafil
A15197Oglemilast
****
A15198Olprinone Hydrochloride

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Deltasonamide 2 (TFA)

    Catalog No. A21979
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    PDEδ inhibitor
    Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. Learn More
  2. PF-04957325

    Catalog No. A21246
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    PDE8 inhibitor
    PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. Learn More
  3. Mirodenafil

    Catalog No. A21260
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    PDE-5 inhibitor
    Mirodenafil(SK3530) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. Learn More
  4. Saterinone hydrochloride

    Catalog No. A21402
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    PDE3 inhibitor
    Saterinone hydrochloride is a phosphodiesterase III (PDE III) inhibitor. Learn More
  5. ITI214

    Catalog No. A21422
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    PDE1 inhibitor
    ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). Learn More
  6. AMG 579

    Catalog No. A21478
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    PDE10A inhibitor
    AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. Learn More
  7. BAY 73-6691 racemate

    Catalog No. A21745
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    PDE9 inhibitor
    BAY 73-6691 racemate is a phosphodiesterase 9 inhibitor extracted from patent WO 2017070293 A1. Learn More
  8. VP3.15 dihydrobromide

    Catalog No. A21789
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    PDE7/GSK3 inhibitor
    VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. Learn More
  9. IBMX

    Catalog No. A21847
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    PDE inhibitor
    IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively. Learn More
  10. Olprinone

    Catalog No. A21869
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    PDE3 inhibitor
    Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. Learn More
  11. TP-10

    Catalog No. A21935
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    PDE10A inhibitor
    TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM. Learn More
  12. ITI214 free base

    Catalog No. A21947
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    picomolar PDE1 inhibitor
    ITI-214 (free base) is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). Learn More
  13. Deltasonamide 2

    Catalog No. A21970
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    PDEδ inhibitor
    Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. Learn More
  14. D159687

    Catalog No. A21228
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    PDE4D inhibitor
    D159687 is a selective PDE4D inhibitor. Learn More
  15. Mirodenafil dihydrochloride

    Catalog No. A18047
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    PDE-5 inhibitor
    Mirodenafil dihydrochloride (SK3530 dihydrochloride) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. Learn More
  16. Sildenafil citrate

    Catalog No. A10841
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    PDE5 inhibitor
    Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM. Learn More
  17. Vinpocetine

    Catalog No. A11602
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    PDE1 inhibitor
    Vinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. Learn More
  18. Cilostamide

    Catalog No. A13596
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    PDE3 inhibitor
    Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively. Learn More
  19. MK-0359

    Catalog No. A13467
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    PDE4 inhibitor
    MK-0359 is a selective and potent oral PDE4 inhibitor, in chronic asthma. Learn More
  20. GSK256066 2,2,2-trifluoroacetic acid

    Catalog No. A15097
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    PDE Inhibitor
    GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. Learn More
  21. Nortadalafil

    Catalog No. A15191
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    PDE5 inhibitor
    Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension. Learn More
  22. Oglemilast

    Catalog No. A15197
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    PDE4 inhibitor
    Oglemilast is a potent inhibitor of PDE4. Learn More
  23. Olprinone Hydrochloride

    Catalog No. A15198
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    PDE3 inhibitor
    Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor. Learn More
  24. TAK-063

    Catalog No. A15799
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    PDE10A inhibitor‎
    TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. Learn More
  25. BI-409306

    Catalog No. A12970
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    PDE9A inhibitor
    BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM. Learn More
  26. PF-05180999

    Catalog No. A13006
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    PDE2A inhibitor
    PF-05180999 is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC50 of 1.6 nM. Learn More
  27. AN3199

    Catalog No. A12228
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    PDE4 inhibitor
    AN3199 is a PDE4 inhibitor with IC50 of 94.5 nM. Learn More
  28. PDE-9 inhibitor

    Catalog No. A11532
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    PDE-9 inhibitor
    PDE-9 inhibitor is useful for neurodegenerative diseases. Learn More
  29. Sildenafil

    Catalog No. A12631
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    PDE5 inhibitor
    Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. Learn More
  30. BRL-50481

    Catalog No. A17008
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    PDE7 inhibitor
    BRL-50481 acts as a phosphodiesterase inhibitor selective for the PDE7 subtype. Learn More
  31. BAY 73-6691

    Catalog No. A17024
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    PDE9 inhibitor
    BAY 73-6691 is a potent, selective brain penetrant PDE9A inhibitor. Learn More
  32. BW-A78U

    Catalog No. A17098
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    PDE4 inhibitor
    BW-A78U is a PDE4 inhibitor with an IC50 of 3 μM. Learn More
  33. Vesnarinone

    Catalog No. A13313
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    PDE3 inhibitor
    Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux. Learn More
  34. Udenafil

    Catalog No. A13291
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    PDE5 inhibitor
    Udenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction. Learn More
  35. Sildenafil Mesylate

    Catalog No. A16142
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    PDE5 inhibitor
    Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5. Learn More
  36. Tadalafil

    Catalog No. A10883
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    PDE5 inhibitor
    Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM. Learn More
  37. PF-8380

    Catalog No. A11527
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    Autotaxin inhibitor
    PF-8380 is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM. Learn More
  38. HA130

    Catalog No. A15546
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    Autotaxin Inhibitor
    HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM. Learn More
  39. Roflumilast N-oxide

    Catalog No. A16984
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    PDE4 inhibitor
    Roflumilast N-oxide is the active metabolite of roflumilast. Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. Learn More
  40. Ademetionine

    Catalog No. A17531
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    PDE4B inhibitor
    Ademetionine, also known as AdoMet; MSI-195; SAMe, S-adenosylmethionine, is a PDE4B inhibitor potentially for treatment of primary biliary cirrhosis and major depressive disorder. Learn More
  41. Lodenafil

    Catalog No. A18029
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    PDE5 inhibitor
    Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED). Learn More
  42. R 80123

    Catalog No. A21836
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    PDE inhibitor
    R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. Learn More
  43. PF-05085727

    Catalog No. A20098
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    PDE2A inhibitor
    PF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM. Learn More
  44. TPN171

    Catalog No. A18464
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    PDE5 inhibitor
    TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. Learn More
  45. VP3.15

    Catalog No. A18538
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    dual PDE7/GSK-3 inhibitor
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). Learn More
  46. PDE12-IN-3

    Catalog No. A18579
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    PDE12 inhibitor
    PDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. Antiviral activity. Learn More
  47. MT-3014

    Catalog No. A18580
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    PDE 10A inhibitor
    MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively. Learn More
  48. BPN14770

    Catalog No. A18663
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    PDE4D inhibitor
    BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. Learn More
  49. CM-675

    Catalog No. A18741
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    PDE5/HDAC-1 inhibitor
    CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. Learn More
  50. Fosphenytoin disodium

    Catalog No. A18184
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    PDE3 inhibitor
    Fosphenytoin Sodium is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin. It is an PDE3 (phosphodiesterase 3) inhibitor. Learn More

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