PDE

Catalog No.Inhibitor Name PDEPDE1PDE2PDE3PDE4PDE5PDE6PDE9APDE10AOther
A10804Roflumilast
****
A10216Cilomilast
***
A10883Tadalafil
***
A10733Pimobendan
**
A11073GSK256066
****
A11191PF-2545920
****
A10805Rolipram
**
A10217Cilostazol
**
A10592Milrinone
**
**
ATPase
A12619Avanafil
****
A10066Aminophylline
*
adenosine receptor
A15799TAK-063
****
A13722Deltarasin
***
A10541Luteolin
*
*
*
*
*
A10464Icariin
**
mAChR,AChR
A10480Irsogladine
A10319Dipyridamole
A10339Dyphylline
A11527PF-8380
***
A10965Vardenafil
***
****
A11019Ibudilast (KC-404)
A11289Apremilast (CC 10004)
***
A11326Bay 60-7550
****
A11602Vinpocetine
Sodium channel
A12550Zardaverine
**
**
A12631Sildenafil
***
***
A12776AN2728
***
A13121PF-04447943
***
A13467MK-0359
A13596Cilostamide
***
A15191Nortadalafil
A15197Oglemilast
****
A15198Olprinone Hydrochloride

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Deltasonamide 2 (TFA)

    Catalog No. A21979
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    PDEδ inhibitor
    Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. Learn More
  2. Sildenafil

    Catalog No. A12631
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    PDE5 inhibitor
    Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. Learn More
  3. TAK-063

    Catalog No. A15799
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    PDE10A inhibitor‎
    TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. Learn More
  4. Olprinone Hydrochloride

    Catalog No. A15198
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    PDE3 inhibitor
    Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor. Learn More
  5. Oglemilast

    Catalog No. A15197
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    PDE4 inhibitor
    Oglemilast is a potent inhibitor of PDE4. Learn More
  6. Nortadalafil

    Catalog No. A15191
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    PDE5 inhibitor
    Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension. Learn More
  7. GSK256066 2,2,2-trifluoroacetic acid

    Catalog No. A15097
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    PDE Inhibitor
    GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. Learn More
  8. MK-0359

    Catalog No. A13467
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    PDE4 inhibitor
    MK-0359 is a selective and potent oral PDE4 inhibitor, in chronic asthma. Learn More
  9. Cilostamide

    Catalog No. A13596
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    PDE3 inhibitor
    Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively. Learn More
  10. Vinpocetine

    Catalog No. A11602
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    PDE1 inhibitor
    Vinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. Learn More
  11. PDE-9 inhibitor

    Catalog No. A11532
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    PDE-9 inhibitor
    PDE-9 inhibitor is useful for neurodegenerative diseases. Learn More
  12. AN3199

    Catalog No. A12228
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    PDE4 inhibitor
    AN3199 is a PDE4 inhibitor with IC50 of 94.5 nM. Learn More
  13. PF-05180999

    Catalog No. A13006
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    PDE2A inhibitor
    PF-05180999 is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC50 of 1.6 nM. Learn More
  14. BI-409306

    Catalog No. A12970
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    PDE9A inhibitor
    BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM. Learn More
  15. Sildenafil citrate

    Catalog No. A10841
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    PDE5 inhibitor
    Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM. Learn More
  16. Mirodenafil dihydrochloride

    Catalog No. A18047
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    PDE-5 inhibitor
    Mirodenafil dihydrochloride (SK3530 dihydrochloride) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. Learn More
  17. PF-04957325

    Catalog No. A21246
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    PDE8 inhibitor
    PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. Learn More
  18. Deltasonamide 2

    Catalog No. A21970
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    PDEδ inhibitor
    Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. Learn More
  19. ITI214 free base

    Catalog No. A21947
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    picomolar PDE1 inhibitor
    ITI-214 (free base) is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). Learn More
  20. TP-10

    Catalog No. A21935
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    PDE10A inhibitor
    TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM. Learn More
  21. Olprinone

    Catalog No. A21869
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    PDE3 inhibitor
    Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. Learn More
  22. IBMX

    Catalog No. A21847
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    PDE inhibitor
    IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively. Learn More
  23. VP3.15 dihydrobromide

    Catalog No. A21789
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    PDE7/GSK3 inhibitor
    VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. Learn More
  24. AMG 579

    Catalog No. A21478
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    PDE10A inhibitor
    AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. Learn More
  25. ITI214

    Catalog No. A21422
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    PDE1 inhibitor
    ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). Learn More
  26. Saterinone hydrochloride

    Catalog No. A21402
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    PDE3 inhibitor
    Saterinone hydrochloride is a phosphodiesterase III (PDE III) inhibitor. Learn More
  27. Mirodenafil

    Catalog No. A21260
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    PDE-5 inhibitor
    Mirodenafil(SK3530) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. Learn More
  28. BAY 73-6691 racemate

    Catalog No. A21745
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    PDE9 inhibitor
    BAY 73-6691 racemate is a phosphodiesterase 9 inhibitor extracted from patent WO 2017070293 A1. Learn More
  29. D159687

    Catalog No. A21228
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    PDE4D inhibitor
    D159687 is a selective PDE4D inhibitor. Learn More
  30. PDE12-IN-3

    Catalog No. A18579
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    PDE12 inhibitor
    PDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. Antiviral activity. Learn More
  31. Roflumilast N-oxide

    Catalog No. A16984
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    PDE4 inhibitor
    Roflumilast N-oxide is the active metabolite of roflumilast. Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. Learn More
  32. Ademetionine

    Catalog No. A17531
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    PDE4B inhibitor
    Ademetionine, also known as AdoMet; MSI-195; SAMe, S-adenosylmethionine, is a PDE4B inhibitor potentially for treatment of primary biliary cirrhosis and major depressive disorder. Learn More
  33. Lodenafil

    Catalog No. A18029
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    PDE5 inhibitor
    Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED). Learn More
  34. Fosphenytoin disodium

    Catalog No. A18184
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    PDE3 inhibitor
    Fosphenytoin Sodium is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin. It is an PDE3 (phosphodiesterase 3) inhibitor. Learn More
  35. CM-675

    Catalog No. A18741
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    PDE5/HDAC-1 inhibitor
    CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. Learn More
  36. BPN14770

    Catalog No. A18663
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    PDE4D inhibitor
    BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. Learn More
  37. Udenafil

    Catalog No. A13291
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    PDE5 inhibitor
    Udenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction. Learn More
  38. MT-3014

    Catalog No. A18580
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    PDE 10A inhibitor
    MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively. Learn More
  39. VP3.15

    Catalog No. A18538
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    dual PDE7/GSK-3 inhibitor
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). Learn More
  40. R 80123

    Catalog No. A21836
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    PDE inhibitor
    R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. Learn More
  41. PF-05085727

    Catalog No. A20098
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    PDE2A inhibitor
    PF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM. Learn More
  42. TPN171

    Catalog No. A18464
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    PDE5 inhibitor
    TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. Learn More
  43. Dyphylline

    Catalog No. A10339
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    Adenosine receptor antagonist
    Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor. Learn More
  44. Rolipram

    Catalog No. A10805
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    PDE4 inhibitor
    Rolipram is a PDE4-inhibitor with IC50 = 2.0 μM. Learn More
  45. Icariin

    Catalog No. A10464
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    PDE5 inhibitor
    Icariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively. Learn More
  46. Pimobendan (Vetmedin)

    Catalog No. A10733
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    PDE inhibitor
    Pimobendan (Vetmedin) is a calcium sensitizer with positive inotropic and vasodilator effects. It is also a selective inhibitor of phosphodiesterase III (PDE3). Learn More
  47. GSK256066

    Catalog No. A11073
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    PDE Inhibitor
    GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17). Learn More
  48. PF-2545920

    Catalog No. A11191
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    PDE10A inhibitor

    PF-2545920 is a phosphodiesterase inhibitor selective for the PDE10A subtype.

    Learn More
  49. Ibudilast (KC-404)

    Catalog No. A11019
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    PDE Inhibitor
    Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency Virus-1 Tat-Mediated activation of microglial cells. Learn More
  50. Cilomilast (SB-207499)

    Catalog No. A10216
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    PDE-4 inhibitor
    Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD. Learn More

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