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PDE
Inhibitory Selectivity
| Catalog No. | Inhibitor Name | PDE | PDE1 | PDE2 | PDE3 | PDE4 | PDE5 | PDE6 | PDE9A | PDE10A | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A10804 | Roflumilast | **** | |||||||||
| A10216 | Cilomilast | *** | |||||||||
| A10883 | Tadalafil | *** | |||||||||
| A10733 | Pimobendan | ** | |||||||||
| A11073 | GSK256066 | **** | |||||||||
| A11191 | PF-2545920 | **** | |||||||||
| A10805 | Rolipram | ** | |||||||||
| A10217 | Cilostazol | ** | |||||||||
| A10592 | Milrinone | ** | ** | ATPase | |||||||
| A12619 | Avanafil | **** | |||||||||
| A10066 | Aminophylline | * | adenosine receptor | ||||||||
| A15799 | TAK-063 | **** | |||||||||
| A13722 | Deltarasin | *** | |||||||||
| A10541 | Luteolin | * | * | * | * | * | |||||
| A10464 | Icariin | ** | mAChR,AChR | ||||||||
| A10480 | Irsogladine | ||||||||||
| A10319 | Dipyridamole | ||||||||||
| A10339 | Dyphylline | ||||||||||
| A11527 | PF-8380 | *** | |||||||||
| A10965 | Vardenafil | *** | **** | ||||||||
| A11019 | Ibudilast (KC-404) | ||||||||||
| A11289 | Apremilast (CC 10004) | *** | |||||||||
| A11326 | Bay 60-7550 | **** | |||||||||
| A11602 | Vinpocetine | Sodium channel | |||||||||
| A12550 | Zardaverine | ** | ** | ||||||||
| A12631 | Sildenafil | *** | *** | ||||||||
| A12776 | AN2728 | *** | |||||||||
| A13121 | PF-04447943 | *** | |||||||||
| A13467 | MK-0359 | ||||||||||
| A13596 | Cilostamide | *** | |||||||||
| A15191 | Nortadalafil | ||||||||||
| A15197 | Oglemilast | **** | |||||||||
| A15198 | Olprinone Hydrochloride |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
39 Item(s)
per page
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A15197 |
Oglemilast |
PDE4 inhibitor |
Oglemilast is a potent inhibitor of PDE4.
|
A15191 |
Nortadalafil |
PDE5 inhibitor |
Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
|
A13467 |
MK-0359 |
PDE4 inhibitor |
MK-0359 is a selective and potent oral PDE4 inhibitor, in chronic asthma.
|
A15198 |
Olprinone Hydrochloride |
PDE3 inhibitor |
Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor.
|
A13596 |
Cilostamide |
PDE3 inhibitor |
Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively.
|
A15097 |
GSK256066 2,2,2-trifluoroacetic acid |
PDE Inhibitor |
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.
|
A15799 |
TAK-063 |
PDE10A inhibitor |
TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
|
A11602 |
Vinpocetine |
PDE1 inhibitor |
Vinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
|
A12631 |
Sildenafil |
PDE5 inhibitor |
Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
|
A13121 |
PF-04447943 |
PDE9 inhibitor |
PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice.
|
A12776 SALE |
AN2728 |
PDE4 inhibitor |
AN2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines
|
A13722 SALE |
Deltarasin HCl |
PDE-KRAS inhibitor |
Deltarasin is a novel small molecule inhibiting the KRAS PDEδ interaction and thus impairing oncogenic KRAS signalling.
|
A10217 |
Cilostazol |
PDE3 inhibitor |
Cilostazol is a selective inhibitor of 3-type phosphodiesterase (PDE3) with therapeutic focus on cAMP.
|
A15546 |
HA130 |
Autotaxin Inhibitor |
N/A
|
A11527 |
PF-8380 |
Autotaxin inhibitor |
PF-8380 is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM.
|
A10883 |
Tadalafil |
PDE5 inhibitor |
Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM.
|
A16142 |
Sildenafil Mesylate |
PDE5 inhibitor |
Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
|
A13291 |
Udenafil |
PDE5 inhibitor |
Udenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction.
|
A12619 |
Avanafil |
PDE5 inhibitor |
Avanafil is a PDE5 Inhibitor for the Treatment of Erectile Dysfunction
|
A12550 |
Zardaverine |
PDE 3/4 inhibitor |
Zardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 uM respectively).
|
A10592 SALE |
Milrinone (Primacor) |
PDE3 inhibitor |
Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE
|
A10805 SALE |
Rolipram |
PDE4 inhibitor |
Rolipram is a PDE4-inhibitor with IC50 = 2.0 μM.
|
A10464 SALE |
Icariin |
PDE5 inhibitor |
Icariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively.
|
A10733 |
Pimobendan (Vetmedin) |
PDE inhibitor |
Pimobendan (Vetmedin) is a calcium sensitizer with positive inotropic and vasodilator effects. It is also a selective inhibitor of phosphodiesterase III (PDE3).
|
A11073 |
GSK256066 |
PDE Inhibitor |
GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17).
|
A11191 SALE |
PF-2545920 |
PDE10A inhibitor |
PF-2545920 is a phosphodiesterase inhibitor selective for the PDE10A subtype. |
A11019 SALE |
Ibudilast (KC-404) |
PDE Inhibitor |
Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency Virus-1 Tat-Mediated activation of microglial cells.
|
A10216 |
Cilomilast (SB-207499) |
PDE-4 inhibitor |
Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD.
|
A10449 SALE |
Hesperetin |
PDE4 inhibitor |
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer.
|
A10541 SALE |
Luteolin |
PDE4 inhibitor |
Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin acts as a monoamine transporter activator, and is one of the few chemicals demonstrated to possess this property.
|
A11289 SALE |
Apremilast (CC 10004) |
PDE4 Inhibitor |
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
|
A10965 SALE |
Vardenafil |
PDE-5 Inhibitor |
Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction.
|
A10804 SALE |
Roflumilast |
PDE inhibitor |
Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4.
|
A11326 |
Bay 60-7550 |
PDE-2 Inhibitor |
BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human).
|
A10066 SALE |
Aminophylline |
Adenosine receptor antagonist |
Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor capable of reversing ischemia-induced bradyasystole.
|
A10319 |
Dipyridamole |
PDE inhibitor |
Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
|
A10339 SALE |
Dyphylline |
Adenosine receptor antagonist |
Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor.
|
A10480 SALE |
Irsogladine |
- |
Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
|
A13313 |
Vesnarinone |
PDE3 inhibitor |
Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux.
|
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