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| Catalog No. | Inhibitor Name | PDE | PDE1 | PDE2 | PDE3 | PDE4 | PDE5 | PDE6 | PDE9A | PDE10A | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A10804 | Roflumilast | **** | |||||||||
| A10216 | Cilomilast | *** | |||||||||
| A10883 | Tadalafil | *** | |||||||||
| A10733 | Pimobendan | ** | |||||||||
| A11073 | GSK256066 | **** | |||||||||
| A11191 | PF-2545920 | **** | |||||||||
| A10805 | Rolipram | ** | |||||||||
| A10217 | Cilostazol | ** | |||||||||
| A10592 | Milrinone | ** | ** | ATPase | |||||||
| A12619 | Avanafil | **** | |||||||||
| A10066 | Aminophylline | * | adenosine receptor | ||||||||
| A15799 | TAK-063 | **** | |||||||||
| A13722 | Deltarasin | *** | |||||||||
| A10541 | Luteolin | * | * | * | * | * | |||||
| A10464 | Icariin | ** | mAChR,AChR | ||||||||
| A10480 | Irsogladine | ||||||||||
| A10319 | Dipyridamole | ||||||||||
| A10339 | Dyphylline | ||||||||||
| A11527 | PF-8380 | *** | |||||||||
| A10965 | Vardenafil | *** | **** | ||||||||
| A11019 | Ibudilast (KC-404) | ||||||||||
| A11289 | Apremilast (CC 10004) | *** | |||||||||
| A11326 | Bay 60-7550 | **** | |||||||||
| A11602 | Vinpocetine | Sodium channel | |||||||||
| A12550 | Zardaverine | ** | ** | ||||||||
| A12631 | Sildenafil | *** | *** | ||||||||
| A12776 | AN2728 | *** | |||||||||
| A13121 | PF-04447943 | *** | |||||||||
| A13467 | MK-0359 | ||||||||||
| A13596 | Cilostamide | *** | |||||||||
| A15191 | Nortadalafil | ||||||||||
| A15197 | Oglemilast | **** | |||||||||
| A15198 | Olprinone Hydrochloride |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Deltasonamide 2 (TFA)
Catalog No. A21979 PDEδ inhibitorDeltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. Learn More -
Sildenafil
Catalog No. A12631 PDE5 inhibitorSildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. Learn More -
TAK-063
Catalog No. A15799 PDE10A inhibitorTAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. Learn More -
Olprinone Hydrochloride
Catalog No. A15198 PDE3 inhibitorOlprinone is a selective phosphodiesterase 3 (PDE3) inhibitor. Learn More -
Oglemilast
Catalog No. A15197 -
Nortadalafil
Catalog No. A15191 PDE5 inhibitorNortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension. Learn More -
GSK256066 2,2,2-trifluoroacetic acid
Catalog No. A15097 PDE InhibitorGSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. Learn More -
MK-0359
Catalog No. A13467 PDE4 inhibitorMK-0359 is a selective and potent oral PDE4 inhibitor, in chronic asthma. Learn More -
Cilostamide
Catalog No. A13596 PDE3 inhibitorCilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively. Learn More -
Vinpocetine
Catalog No. A11602 PDE1 inhibitorVinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. Learn More -
PDE-9 inhibitor
Catalog No. A11532 -
AN3199
Catalog No. A12228 -
PF-05180999
Catalog No. A13006 PDE2A inhibitorPF-05180999 is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC50 of 1.6 nM. Learn More -
BI-409306
Catalog No. A12970 PDE9A inhibitorBI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM. Learn More -
Sildenafil citrate
Catalog No. A10841 PDE5 inhibitorSildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM. Learn More -
Mirodenafil dihydrochloride
Catalog No. A18047 PDE-5 inhibitorMirodenafil dihydrochloride (SK3530 dihydrochloride) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. Learn More -
PF-04957325
Catalog No. A21246 PDE8 inhibitorPF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. Learn More -
Deltasonamide 2
Catalog No. A21970 PDEδ inhibitorDeltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. Learn More -
ITI214 free base
Catalog No. A21947 picomolar PDE1 inhibitorITI-214 (free base) is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). Learn More -
TP-10
Catalog No. A21935 -
Olprinone
Catalog No. A21869 PDE3 inhibitorOlprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. Learn More -
IBMX
Catalog No. A21847 PDE inhibitorIBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively. Learn More -
VP3.15 dihydrobromide
Catalog No. A21789 PDE7/GSK3 inhibitorVP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. Learn More -
AMG 579
Catalog No. A21478 PDE10A inhibitorAMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. Learn More -
ITI214
Catalog No. A21422 PDE1 inhibitorITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). Learn More -
Saterinone hydrochloride
Catalog No. A21402 PDE3 inhibitorSaterinone hydrochloride is a phosphodiesterase III (PDE III) inhibitor. Learn More -
Mirodenafil
Catalog No. A21260 PDE-5 inhibitorMirodenafil(SK3530) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. Learn More -
BAY 73-6691 racemate
Catalog No. A21745 PDE9 inhibitorBAY 73-6691 racemate is a phosphodiesterase 9 inhibitor extracted from patent WO 2017070293 A1. Learn More -
D159687
Catalog No. A21228 -
PDE12-IN-3
Catalog No. A18579 PDE12 inhibitorPDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. Antiviral activity. Learn More -
Roflumilast N-oxide
Catalog No. A16984 PDE4 inhibitorRoflumilast N-oxide is the active metabolite of roflumilast. Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. Learn More -
Ademetionine
Catalog No. A17531 PDE4B inhibitorAdemetionine, also known as AdoMet; MSI-195; SAMe, S-adenosylmethionine, is a PDE4B inhibitor potentially for treatment of primary biliary cirrhosis and major depressive disorder. Learn More -
Lodenafil
Catalog No. A18029 PDE5 inhibitorLodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED). Learn More -
Fosphenytoin disodium
Catalog No. A18184 PDE3 inhibitorFosphenytoin Sodium is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin. It is an PDE3 (phosphodiesterase 3) inhibitor. Learn More -
CM-675
Catalog No. A18741 PDE5/HDAC-1 inhibitorCM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. Learn More -
BPN14770
Catalog No. A18663 PDE4D inhibitorBPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. Learn More -
Udenafil
Catalog No. A13291 PDE5 inhibitorUdenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction. Learn More -
MT-3014
Catalog No. A18580 PDE 10A inhibitorMT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively. Learn More -
VP3.15
Catalog No. A18538 dual PDE7/GSK-3 inhibitorVP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). Learn More -
R 80123
Catalog No. A21836 PDE inhibitorR 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. Learn More -
PF-05085727
Catalog No. A20098 PDE2A inhibitorPF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM. Learn More -
TPN171
Catalog No. A18464 PDE5 inhibitorTPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. Learn More -
Dyphylline
Catalog No. A10339 Adenosine receptor antagonistDyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor. Learn More -
Rolipram
Catalog No. A10805 -
Icariin
Catalog No. A10464 PDE5 inhibitorIcariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively. Learn More -
Pimobendan (Vetmedin)
Catalog No. A10733 PDE inhibitorPimobendan (Vetmedin) is a calcium sensitizer with positive inotropic and vasodilator effects. It is also a selective inhibitor of phosphodiesterase III (PDE3). Learn More -
GSK256066
Catalog No. A11073 PDE InhibitorGSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17). Learn More -
PF-2545920
Catalog No. A11191 PDE10A inhibitorPF-2545920 is a phosphodiesterase inhibitor selective for the PDE10A subtype.
Learn More -
Ibudilast (KC-404)
Catalog No. A11019 PDE InhibitorIbudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency Virus-1 Tat-Mediated activation of microglial cells. Learn More -
Cilomilast (SB-207499)
Catalog No. A10216 PDE-4 inhibitorCilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD. Learn More
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