PDE

Catalog No.Inhibitor Name PDEPDE1PDE2PDE3PDE4PDE5PDE6PDE9APDE10AOther
A10804Roflumilast
****
A10216Cilomilast
***
A10883Tadalafil
***
A10733Pimobendan
**
A11073GSK256066
****
A11191PF-2545920
****
A10805Rolipram
**
A10217Cilostazol
**
A10592Milrinone
**
**
ATPase
A12619Avanafil
****
A10066Aminophylline
*
adenosine receptor
A15799TAK-063
****
A13722Deltarasin
***
A10541Luteolin
*
*
*
*
*
A10464Icariin
**
mAChR,AChR
A10480Irsogladine
A10319Dipyridamole
A10339Dyphylline
A11527PF-8380
***
A10965Vardenafil
***
****
A11019Ibudilast (KC-404)
A11289Apremilast (CC 10004)
***
A11326Bay 60-7550
****
A11602Vinpocetine
Sodium channel
A12550Zardaverine
**
**
A12631Sildenafil
***
***
A12776AN2728
***
A13121PF-04447943
***
A13467MK-0359
A13596Cilostamide
***
A15191Nortadalafil
A15197Oglemilast
****
A15198Olprinone Hydrochloride

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Vinpocetine

    Catalog No. A11602
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    PDE1 inhibitor
    Vinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. Learn More
  2. Sildenafil

    Catalog No. A12631
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    PDE5 inhibitor
    Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. Learn More
  3. TAK-063

    Catalog No. A15799
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    PDE10A inhibitor‎
    TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. Learn More
  4. Olprinone Hydrochloride

    Catalog No. A15198
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    PDE3 inhibitor
    Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor. Learn More
  5. Oglemilast

    Catalog No. A15197
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    PDE4 inhibitor
    Oglemilast is a potent inhibitor of PDE4. Learn More
  6. Nortadalafil

    Catalog No. A15191
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    PDE5 inhibitor
    Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension. Learn More
  7. GSK256066 2,2,2-trifluoroacetic acid

    Catalog No. A15097
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    PDE Inhibitor
    GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. Learn More
  8. MK-0359

    Catalog No. A13467
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    PDE4 inhibitor
    MK-0359 is a selective and potent oral PDE4 inhibitor, in chronic asthma. Learn More
  9. Cilostamide

    Catalog No. A13596
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    PDE3 inhibitor
    Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively. Learn More
  10. BAY 73-6691

    Catalog No. A17024
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    PDE9 inhibitor
    BAY 73-6691 is a potent, selective brain penetrant PDE9A inhibitor. Learn More
  11. BW-A78U

    Catalog No. A17098
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    PDE4 inhibitor
    BW-A78U is a PDE4 inhibitor with an IC50 of 3 μM. Learn More
  12. Vesnarinone

    Catalog No. A13313
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    PDE3 inhibitor
    Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux. Learn More
  13. Udenafil

    Catalog No. A13291
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    PDE5 inhibitor
    Udenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction. Learn More
  14. Sildenafil Mesylate

    Catalog No. A16142
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    PDE5 inhibitor
    Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5. Learn More
  15. Tadalafil

    Catalog No. A10883
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    PDE5 inhibitor
    Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM. Learn More
  16. PF-8380

    Catalog No. A11527
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    Autotaxin inhibitor
    PF-8380 is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM. Learn More
  17. HA130

    Catalog No. A15546
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    Autotaxin Inhibitor
  18. Deltarasin HCl

    Catalog No. A13722
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    PDE-KRAS inhibitor
    Deltarasin is a novel small molecule inhibiting the KRAS PDEδ interaction and thus impairing oncogenic KRAS signalling. Learn More
  19. BRL-50481

    Catalog No. A17008
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    PDE7 inhibitor
    BRL-50481 acts as a phosphodiesterase inhibitor selective for the PDE7 subtype. Learn More
  20. Roflumilast N-oxide

    Catalog No. A16984
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    PDE4 inhibitor
    Roflumilast N-oxide is the active metabolite of roflumilast. Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. Learn More
  21. TPN171

    Catalog No. A18464
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    PDE5 inhibitor
    TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. Learn More
  22. VP3.15

    Catalog No. A18538
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    dual PDE7/GSK-3 inhibitor
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). Learn More
  23. PDE12-IN-3

    Catalog No. A18579
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    PDE12 inhibitor
    PDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. Antiviral activity. Learn More
  24. MT-3014

    Catalog No. A18580
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    PDE 10A inhibitor
    MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively. Learn More
  25. BPN14770

    Catalog No. A18663
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    PDE4D inhibitor
    BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. Learn More
  26. CM-675

    Catalog No. A18741
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    PDE5/HDAC-1 inhibitor
    CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. Learn More
  27. Fosphenytoin disodium

    Catalog No. A18184
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    PDE3 inhibitor
    Fosphenytoin Sodium is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin. It is an PDE3 (phosphodiesterase 3) inhibitor. Learn More
  28. Lodenafil

    Catalog No. A18029
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    PDE5 inhibitor
    Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED). Learn More
  29. Ademetionine

    Catalog No. A17531
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    PDE4B inhibitor
    Ademetionine, also known as AdoMet; MSI-195; SAMe, S-adenosylmethionine, is a PDE4B inhibitor potentially for treatment of primary biliary cirrhosis and major depressive disorder. Learn More
  30. PF-04447943

    Catalog No. A13121
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    PDE9 inhibitor
    PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. Learn More
  31. AN2728

    Catalog No. A12776
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    PDE4 inhibitor‎
    AN2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines Learn More
  32. Avanafil

    Catalog No. A12619
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    PDE5 inhibitor
    Avanafil is a PDE5 Inhibitor for the Treatment of Erectile Dysfunction Learn More
  33. Hesperetin

    Catalog No. A10449
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    PDE4 inhibitor
    Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer. Learn More
  34. Cilomilast (SB-207499)

    Catalog No. A10216
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    PDE-4 inhibitor
    Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD. Learn More
  35. Ibudilast (KC-404)

    Catalog No. A11019
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    PDE Inhibitor
    Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency Virus-1 Tat-Mediated activation of microglial cells. Learn More
  36. PF-2545920

    Catalog No. A11191
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    PDE10A inhibitor

    PF-2545920 is a phosphodiesterase inhibitor selective for the PDE10A subtype.

    Learn More
  37. GSK256066

    Catalog No. A11073
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    PDE Inhibitor
    GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17). Learn More
  38. Pimobendan (Vetmedin)

    Catalog No. A10733
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    PDE inhibitor
    Pimobendan (Vetmedin) is a calcium sensitizer with positive inotropic and vasodilator effects. It is also a selective inhibitor of phosphodiesterase III (PDE3). Learn More
  39. Icariin

    Catalog No. A10464
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    PDE5 inhibitor
    Icariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively. Learn More
  40. Rolipram

    Catalog No. A10805
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    PDE4 inhibitor
    Rolipram is a PDE4-inhibitor with IC50 = 2.0 μM. Learn More
  41. Luteolin

    Catalog No. A10541
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    PDE4 inhibitor
    Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin acts as a monoamine transporter activator, and is one of the few chemicals demonstrated to possess this property. Learn More
  42. Apremilast (CC 10004)

    Catalog No. A11289
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    PDE4 Inhibitor
    Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Learn More
  43. Vardenafil

    Catalog No. A10965
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    PDE-5 Inhibitor
    Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction. Learn More
  44. Zardaverine

    Catalog No. A12550
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    PDE 3/4 inhibitor
    Zardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 uM respectively). Learn More
  45. Milrinone (Primacor)

    Catalog No. A10592
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    PDE3 inhibitor
    Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE Learn More
  46. Irsogladine

    Catalog No. A10480
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    Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. Learn More
  47. Dyphylline

    Catalog No. A10339
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    Adenosine receptor antagonist
    Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor. Learn More
  48. Dipyridamole

    Catalog No. A10319
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    PDE inhibitor
    Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Learn More
  49. Aminophylline

    Catalog No. A10066
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    Adenosine receptor antagonist
    Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor capable of reversing ischemia-induced bradyasystole. Learn More
  50. Bay 60-7550

    Catalog No. A11326
    PDE-2 Inhibitor
    BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). Learn More

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