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| Catalog No. | Inhibitor Name | PDE | PDE1 | PDE2 | PDE3 | PDE4 | PDE5 | PDE6 | PDE9A | PDE10A | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A10804 | Roflumilast | **** | |||||||||
| A10216 | Cilomilast | *** | |||||||||
| A10883 | Tadalafil | *** | |||||||||
| A10733 | Pimobendan | ** | |||||||||
| A11073 | GSK256066 | **** | |||||||||
| A11191 | PF-2545920 | **** | |||||||||
| A10805 | Rolipram | ** | |||||||||
| A10217 | Cilostazol | ** | |||||||||
| A10592 | Milrinone | ** | ** | ATPase | |||||||
| A12619 | Avanafil | **** | |||||||||
| A10066 | Aminophylline | * | adenosine receptor | ||||||||
| A15799 | TAK-063 | **** | |||||||||
| A13722 | Deltarasin | *** | |||||||||
| A10541 | Luteolin | * | * | * | * | * | |||||
| A10464 | Icariin | ** | mAChR,AChR | ||||||||
| A10480 | Irsogladine | ||||||||||
| A10319 | Dipyridamole | ||||||||||
| A10339 | Dyphylline | ||||||||||
| A11527 | PF-8380 | *** | |||||||||
| A10965 | Vardenafil | *** | **** | ||||||||
| A11019 | Ibudilast (KC-404) | ||||||||||
| A11289 | Apremilast (CC 10004) | *** | |||||||||
| A11326 | Bay 60-7550 | **** | |||||||||
| A11602 | Vinpocetine | Sodium channel | |||||||||
| A12550 | Zardaverine | ** | ** | ||||||||
| A12631 | Sildenafil | *** | *** | ||||||||
| A12776 | AN2728 | *** | |||||||||
| A13121 | PF-04447943 | *** | |||||||||
| A13467 | MK-0359 | ||||||||||
| A13596 | Cilostamide | *** | |||||||||
| A15191 | Nortadalafil | ||||||||||
| A15197 | Oglemilast | **** | |||||||||
| A15198 | Olprinone Hydrochloride |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Vinpocetine
Catalog No. A11602 PDE1 inhibitorVinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. Learn More -
Sildenafil
Catalog No. A12631 PDE5 inhibitorSildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. Learn More -
TAK-063
Catalog No. A15799 PDE10A inhibitorTAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. Learn More -
Olprinone Hydrochloride
Catalog No. A15198 PDE3 inhibitorOlprinone is a selective phosphodiesterase 3 (PDE3) inhibitor. Learn More -
Oglemilast
Catalog No. A15197 -
Nortadalafil
Catalog No. A15191 PDE5 inhibitorNortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension. Learn More -
GSK256066 2,2,2-trifluoroacetic acid
Catalog No. A15097 PDE InhibitorGSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. Learn More -
MK-0359
Catalog No. A13467 PDE4 inhibitorMK-0359 is a selective and potent oral PDE4 inhibitor, in chronic asthma. Learn More -
Cilostamide
Catalog No. A13596 PDE3 inhibitorCilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively. Learn More -
BAY 73-6691
Catalog No. A17024 PDE9 inhibitorBAY 73-6691 is a potent, selective brain penetrant PDE9A inhibitor. Learn More -
BW-A78U
Catalog No. A17098 -
Vesnarinone
Catalog No. A13313 PDE3 inhibitorVesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux. Learn More -
Udenafil
Catalog No. A13291 PDE5 inhibitorUdenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction. Learn More -
Sildenafil Mesylate
Catalog No. A16142 PDE5 inhibitorSildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5. Learn More -
Tadalafil
Catalog No. A10883 -
PF-8380
Catalog No. A11527 Autotaxin inhibitorPF-8380 is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM. Learn More -
Deltarasin HCl
Catalog No. A13722 PDE-KRAS inhibitorDeltarasin is a novel small molecule inhibiting the KRAS PDEδ interaction and thus impairing oncogenic KRAS signalling. Learn More -
BRL-50481
Catalog No. A17008 PDE7 inhibitorBRL-50481 acts as a phosphodiesterase inhibitor selective for the PDE7 subtype. Learn More -
Roflumilast N-oxide
Catalog No. A16984 PDE4 inhibitorRoflumilast N-oxide is the active metabolite of roflumilast. Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. Learn More -
TPN171
Catalog No. A18464 PDE5 inhibitorTPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. Learn More -
VP3.15
Catalog No. A18538 dual PDE7/GSK-3 inhibitorVP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). Learn More -
PDE12-IN-3
Catalog No. A18579 PDE12 inhibitorPDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. Antiviral activity. Learn More -
MT-3014
Catalog No. A18580 PDE 10A inhibitorMT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively. Learn More -
BPN14770
Catalog No. A18663 PDE4D inhibitorBPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. Learn More -
CM-675
Catalog No. A18741 PDE5/HDAC-1 inhibitorCM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. Learn More -
Fosphenytoin disodium
Catalog No. A18184 PDE3 inhibitorFosphenytoin Sodium is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin. It is an PDE3 (phosphodiesterase 3) inhibitor. Learn More -
Lodenafil
Catalog No. A18029 PDE5 inhibitorLodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED). Learn More -
Ademetionine
Catalog No. A17531 PDE4B inhibitorAdemetionine, also known as AdoMet; MSI-195; SAMe, S-adenosylmethionine, is a PDE4B inhibitor potentially for treatment of primary biliary cirrhosis and major depressive disorder. Learn More -
PF-04447943
Catalog No. A13121 PDE9 inhibitorPF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. Learn More -
AN2728
Catalog No. A12776 PDE4 inhibitorAN2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines Learn More -
Avanafil
Catalog No. A12619 PDE5 inhibitorAvanafil is a PDE5 Inhibitor for the Treatment of Erectile Dysfunction Learn More -
Hesperetin
Catalog No. A10449 PDE4 inhibitorHesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer. Learn More -
Cilomilast (SB-207499)
Catalog No. A10216 PDE-4 inhibitorCilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD. Learn More -
Ibudilast (KC-404)
Catalog No. A11019 PDE InhibitorIbudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency Virus-1 Tat-Mediated activation of microglial cells. Learn More -
PF-2545920
Catalog No. A11191 PDE10A inhibitorPF-2545920 is a phosphodiesterase inhibitor selective for the PDE10A subtype.
Learn More -
GSK256066
Catalog No. A11073 PDE InhibitorGSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17). Learn More -
Pimobendan (Vetmedin)
Catalog No. A10733 PDE inhibitorPimobendan (Vetmedin) is a calcium sensitizer with positive inotropic and vasodilator effects. It is also a selective inhibitor of phosphodiesterase III (PDE3). Learn More -
Icariin
Catalog No. A10464 PDE5 inhibitorIcariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively. Learn More -
Rolipram
Catalog No. A10805 -
Luteolin
Catalog No. A10541 PDE4 inhibitorLuteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin acts as a monoamine transporter activator, and is one of the few chemicals demonstrated to possess this property. Learn More -
Apremilast (CC 10004)
Catalog No. A11289 PDE4 InhibitorApremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Learn More -
Vardenafil
Catalog No. A10965 PDE-5 InhibitorVardenafil is a PDE5 inhibitor used for treating erectile dysfunction. Learn More -
Zardaverine
Catalog No. A12550 PDE 3/4 inhibitorZardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 uM respectively). Learn More -
Milrinone (Primacor)
Catalog No. A10592 PDE3 inhibitorMilrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE Learn More -
Irsogladine
Catalog No. A10480 Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. Learn More -
Dyphylline
Catalog No. A10339 Adenosine receptor antagonistDyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor. Learn More -
Dipyridamole
Catalog No. A10319 PDE inhibitorDipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Learn More -
Aminophylline
Catalog No. A10066 Adenosine receptor antagonistAminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor capable of reversing ischemia-induced bradyasystole. Learn More -
Bay 60-7550
Catalog No. A11326 PDE-2 InhibitorBAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). Learn More
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