SRC

Inhibitory Selectivity
Catalog No.Inhibitor Name SrcLckFynLynYesOther
A10290Dasatinib
****
Abl,c-Kit (D816V),c-Kit (wt)
A10108Saracatinib
***
***
**
***
EGFR (L861Q),c-YES,EGFR (L858R)
A10161Bosutinib
****
Abl
A11177KX2-391
**
A10661NVP-BHG712
*
EphB4,C-Raf,c-Abl
A12723PP2
***
***
***
EGFR
A12724PP1
***
***
**
Kit,EGFR,Bcr-Abl
A15518SU6656
*
*
*
*
A16320Dasatinib Monohydrate
****
Abl ,c-Kit (D816V),c-Kit (wt)
A14117WH-4-023
****
****
A10766Quercetin
Sirtuin,PKC,PI3Kγ
A11288A-770041
*
A12417MLR 1023
**
A132321-NA-PP1
c-Abl, CDK2, CAMK II
A13415MCB-613
A13819TG 100801
VEGFR1, VEGFR2, FGFR1
A13820TG 100572
VEGFR1, VEGFR2, FGFR1
A13868PD 166285
FGFR1, PDGFRβ, Wee1
A16241AZM475271
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A13232 SALE

1-NA-PP1

Src Kinase inhibitor
1-NA-PP1 is a selective inhibitor of v-Src and c-Fyn as well as c-Abl
A13290

A-419259

SFK inhibitor
A-419259 is an inhibitor of Src family kinases (SFK) (IC50 = 0.1 - 0.3 uM).
A11288

A-770041

Lck inhibitor
A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.
A14323

A419259

Src inhibitor
A419259 trihydrochloride is an apoptosis inducing agent that inhibits Src family kinases (c-Src).
A16241

AZM475271

Src inhibitor
AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM; no inhibitory activity on Flt3, KDR, Tie-2.
A10161 SALE

Bosutinib (SKI-606)

Src inhibitor
Bosutinib (SKI-606) is a tyrosine kinase inhibitor undergoing research for use in the treatment of cancer.
A13821

CGP77675

Src inhibitor
CGP77675 is a potent Src kinase inhibitor. CGP77675 inhibited phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50: 5-20 and 40 nM, respectively).
A10290 SALE

Dasatinib (BMS-354825)

Abl-Src inhibitor
Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2.
A15060

Dasatinib hydrochloride

Src inhibitor
Dasatinib hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of ??1 nM/0.8 nM respectively; also inhibit c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM.
A12214 SALE

KX1-004

Src-PTK inhibitor
KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL.
A11177 SALE

KX2-391

Src inhibitor

KX2-391 is a novel non-ATP competitive substrate-pocket directed SRC inhibitor.

A11471

KX2-391 2HCl

Src inhibitor
KX2-391 2Hcl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
A16265

Lyn-IN-1

dual Bcr-Abl/Lyn inhibitor
Lyn-IN-1 is a potent and selective dual Bcr-Abl/Lyn inhibitor, extracted from patent WO2014169128A1.
A13415

MCB-613

steroid receptor coactivator stimulator
MCB-613 is a potent, pan steroid receptor coactivator (SRC) stimulator.
A12417 SALE

MLR 1023

-
MLR 1023 is a selective allosteric activator of Lyn kinase (EC50 = 63 nM)
A16240

MNS

Src/Syk inhibitor
MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases.
A10661 SALE

NVP-BHG712

EphB4 inhibitor
NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
A13868

PD-166285

Src inhibitor
PD 166285 is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1).
A12724 SALE

PP1

Src Inhibitor
PP1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl
A13573 SALE

PP1 Analog II, 1NM-PP1

-
PP1 Analog II, 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.
A11207 SALE

PP121

PI3K Inhibitor
PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).
A12723 SALE

PP2

Src Inhibitor
PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).
A10766 SALE

Quercetin (Sophoretin)

MAO-B inhibitor
Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C.
A10108 SALE

Saracatinib (AZD0530)

Src/Abl inhibitor
Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.
A15518 SALE

SU6656

SRC inhibitor
SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively).

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