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| Catalog No. | Inhibitor Name | Mdm2 | Other |
|---|---|---|---|
| A10657 | Nutlin-3 | ** | |
| A11501 | Nutlin-3a | *** | |
| A11502 | Nutlin-3b | * | |
| A16348 | MX69 | ** | |
| A15440 | MI-773 (SAR405838) | **** | p53 |
| A14211 | Idasanutlin (RG-7388) | **** | |
| A11523 | RG-7112 | *** | |
| A14118 | YH239-EE |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
32 Item(s)
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Nutlin-3
Catalog No. A10657 Mdm2 antagonistMDM2 antagonist nutlin-3 is a potent inducer of apoptosis. Learn More -
RO8994
Catalog No. A20865 MDM2 inhibitorRO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). Learn More -
APG-115
Catalog No. A12575 MDM2 inhibitorAPG-115 (AA-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively. Learn More -
MA242
Catalog No. A13480 dual MDM2/NFAT1 inhibitorMA242 is a dual inhibitor of murine double minute 2 (MDM2) and nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy. Learn More -
PROTAC MDM2 Degrader-4
Catalog No. A18877 MDM2 inhibitorPROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. Learn More -
PROTAC MDM2 Degrader-3
Catalog No. A18883 MDM2 degraderPROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. Learn More -
PROTAC MDM2 Degrader-2
Catalog No. A18890 MDM2 inhibitorPROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. Learn More -
PROTAC MDM2 Degrader-1
Catalog No. A18897 MDM2 degraderPROTAC MDM2 Degrader-1 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-1 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. Learn More -
Nutlin carboxylic acid
Catalog No. A18917 Nutlin 3-based MDM2 ligandNutlin carboxylic acid (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid (MDM2 ligand 1) can be connected to the ligand for protein by a linker to form PROTACs. Learn More -
(4R,5S)-nutlin carboxylic acid
Catalog No. A18924 Nutlin 3-based MDM2 ligand(4R,5S)-nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R,5S)-nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs. Learn More -
MI-773
Catalog No. A15440 MDM2 inhibitorMI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM. Learn More -
WR 1065
Catalog No. A15353 P53/p21waf-1/MDM2 activatorWR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure. Learn More -
p53 and MDM2 proteins-interaction-inhibitor racemic
Catalog No. A15202 p53-MDM2 interaction inhibitorp53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins. Learn More -
NSC-207895 (XI-006)
Catalog No. A11179 MDMX InhibitorNSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.
Learn More -
Nutlin 3a
Catalog No. A11501 MDM2 inhibitorNutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53. Learn More -
Nutlin 3b
Catalog No. A11502 MDM2 inhibitorNutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. Learn More -
Idasanutlin (RG7388)
Catalog No. A14211 MDM2/p53 InhibitorIdasanutlin is a potent and selective p53-MDM2 inhibitor. Learn More -
YH239-EE
Catalog No. A14118 Mdm2 inhibitorYH239-EE is a potent p53-MDM2 antagonist and an apoptosis inducer. Learn More -
AMG232
Catalog No. A14394 MDM2 inhibitorAMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM). Learn More -
p53 and MDM2 proteins-interaction-inhibitor chiral
Catalog No. A15201 p53-MDM2 interaction inhibitorp53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins. Learn More -
SJ 172550
Catalog No. A15352 MDMX inhibitorSJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. Learn More -
HDM201
Catalog No. A16834 MDM2 inhibitorHDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4. Learn More -
RO-5963
Catalog No. A18813 MDM2/MDMX inhibitorRO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53 with IC50s of ~17 nM and ~24 nM, respectively. Learn More -
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New
MD-224
Catalog No. A18712 MDM2 degraderMD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent. Learn More -
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MI-1061
Catalog No. A18450 MDM2 inhibitorMI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity. Learn More -
Kevetrin HCl
Catalog No. A13797 Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Learn More -
MX-69
Catalog No. A16348 MDM2/XIAP inhibitorMX-69 is the MDM2/XIAP inhibitor, used for cancer treatment. Learn More -
NVP-CGM097
Catalog No. A16326 MDM2 inhibitorNVP-CGM097 is a potent and selective MDM2 inhibitor; an orally bioavailable HDM2 antagonist with potential antineoplastic activity. Learn More -
MI-773 (SAR405838)
Catalog No. A14423 Mdm2 inhibitorMI-773 is a new small molecule inhibitor of the MDM2-p53 interaction, binds to MDM2 with high affinity (Ki=0.88 nM) and blocks the p53-MDM2 interaction. Learn More -
WK23
Catalog No. A14051 MDM2/MDMX inhibitorWK23 is an inhibitor based on four aromatic groups and able to efficiently fill the binding pockets of MDM2/MDMX, its median inhibitory concentration (IC50) values to MDM2/MDMX are 1.17 and 36 uM, respectively Learn More -
RG7112
Catalog No. A11523 selective p53-MDM2 inhibitorRG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. Learn More -
MDM2 Inhibitor
Catalog No. A13582 MDM2 inhibitorMDM2 Inhibitor is a cell-permeable boranyl-chalcone exhibiting strong binding to MDM2 and irreversibly disrupts the MDM2/p53 protein complex. Learn More
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