MDM2

Catalog No.Inhibitor Name Mdm2Other
A10657Nutlin-3
**
A11501Nutlin-3a
***
A11502Nutlin-3b
*
A16348MX69
**
A15440MI-773 (SAR405838)
****
p53
A14211Idasanutlin (RG-7388)
****
A11523RG-7112
***
A14118YH239-EE

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. NSC-207895 (XI-006)

    Catalog No. A11179
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    MDMX Inhibitor

    NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

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  2. MI-773

    Catalog No. A15440
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    MDM2 inhibitor
    MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM. Learn More
  3. RO8994

    Catalog No. A20865
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    MDM2 inhibitor
    RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). Learn More
  4. (4R,5S)-nutlin carboxylic acid

    Catalog No. A18924
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    Nutlin 3-based MDM2 ligand
    (4R,5S)-nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R,5S)-nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs. Learn More
  5. Nutlin carboxylic acid

    Catalog No. A18917
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    Nutlin 3-based MDM2 ligand
    Nutlin carboxylic acid (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid (MDM2 ligand 1) can be connected to the ligand for protein by a linker to form PROTACs. Learn More
  6. PROTAC MDM2 Degrader-1

    Catalog No. A18897
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    MDM2 degrader
    PROTAC MDM2 Degrader-1 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-1 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. Learn More
  7. PROTAC MDM2 Degrader-2

    Catalog No. A18890
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    MDM2 inhibitor
    PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. Learn More
  8. PROTAC MDM2 Degrader-3

    Catalog No. A18883
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    MDM2 degrader
    PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. Learn More
  9. PROTAC MDM2 Degrader-4

    Catalog No. A18877
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    MDM2 inhibitor
    PROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. Learn More
  10. MA242

    Catalog No. A13480
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    dual MDM2/NFAT1 inhibitor
    MA242 is a dual inhibitor of murine double minute 2 (MDM2) and nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy. Learn More
  11. APG-115

    Catalog No. A12575
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    MDM2 inhibitor
    APG-115 (AA-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively. Learn More
  12. WR 1065

    Catalog No. A15353
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    P53/p21waf-1/MDM2 activator
    WR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure. Learn More
  13. SJ 172550

    Catalog No. A15352
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    MDMX inhibitor
    SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. Learn More
  14. p53 and MDM2 proteins-interaction-inhibitor racemic

    Catalog No. A15202
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    p53-MDM2 interaction inhibitor
    p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins. Learn More
  15. YH239-EE

    Catalog No. A14118
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    Mdm2 inhibitor
    YH239-EE is a potent p53-MDM2 antagonist and an apoptosis inducer. Learn More
  16. Idasanutlin (RG7388)

    Catalog No. A14211
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    MDM2/p53 Inhibitor
    Idasanutlin is a potent and selective p53-MDM2 inhibitor. Learn More
  17. Nutlin 3b

    Catalog No. A11502
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    MDM2 inhibitor
    Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. Learn More
  18. Nutlin 3a

    Catalog No. A11501
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    MDM2 inhibitor
    Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53. Learn More
  19. p53 and MDM2 proteins-interaction-inhibitor chiral

    Catalog No. A15201
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    p53-MDM2 interaction inhibitor
    p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins. Learn More
  20. AMG232

    Catalog No. A14394
    MDM2 inhibitor
    AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM). Learn More
  21. MDM2 Inhibitor

    Catalog No. A13582
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    MDM2 inhibitor
    MDM2 Inhibitor is a cell-permeable boranyl-chalcone exhibiting strong binding to MDM2 and irreversibly disrupts the MDM2/p53 protein complex. Learn More
  22. WK23

    Catalog No. A14051
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    MDM2/MDMX inhibitor
    WK23 is an inhibitor based on four aromatic groups and able to efficiently fill the binding pockets of MDM2/MDMX, its median inhibitory concentration (IC50) values to MDM2/MDMX are 1.17 and 36 uM, respectively Learn More
  23. Nutlin-3

    Catalog No. A10657
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    Mdm2 antagonist
    MDM2 antagonist nutlin-3 is a potent inducer of apoptosis. Learn More
  24. MI-1061

    Catalog No. A18450
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    MDM2 inhibitor
    MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity. Learn More
  25. MD-224

    Catalog No. A18712
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    MDM2 degrader
    MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent. Learn More
  26. RO-5963

    Catalog No. A18813
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    MDM2/MDMX inhibitor
    RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53 with IC50s of ~17 nM and ~24 nM, respectively. Learn More
  27. HDM201

    Catalog No. A16834
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    MDM2 inhibitor
    HDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4. Learn More
  28. MX-69

    Catalog No. A16348
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    MDM2/XIAP inhibitor
    MX-69 is the MDM2/XIAP inhibitor, used for cancer treatment. Learn More
  29. NVP-CGM097

    Catalog No. A16326
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    MDM2 inhibitor
    NVP-CGM097 is a potent and selective MDM2 inhibitor; an orally bioavailable HDM2 antagonist with potential antineoplastic activity. Learn More
  30. Kevetrin HCl

    Catalog No. A13797
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    Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Learn More
  31. RG7112

    Catalog No. A11523
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    selective p53-MDM2 inhibitor
    RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. Learn More
  32. MI-773 (SAR405838)

    Catalog No. A14423
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    Mdm2 inhibitor
    MI-773 is a new small molecule inhibitor of the MDM2-p53 interaction, binds to MDM2 with high affinity (Ki=0.88 nM) and blocks the p53-MDM2 interaction. Learn More

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