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$0.00 Protein Kinase C (PKC)
| Catalog No. | Inhibitor Name | PKC | PKCα | PKCβ | PKCγ | PKCδ | PKCε | PKCζ | PKCη | PKCθ | PKCμ | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A10356 | Enzastaurin | ** | *** | * | * | |||||||
| A11554 | Sotrastaurin | **** | **** | **** | **** | **** | **** | |||||
| A10864 | Staurosporine | **** | **** | ** | * | * | **** | c-Fgr,phosphorylase kinase,S6 kinase | ||||
| A13790 | Go 6983 | *** | *** | *** | *** | ** | * | |||||
| A13197 | Bisindolylmaleimide I | ** | *** | ** | PDGFR | |||||||
| A13514 | Ro 31-8220 Mesylate | **** | *** | ** | ** | |||||||
| A12650 | Midostaurin | ** | ** | ** | * | * | * | * | PPK,KDR,c-Syk | |||
| A12419 | Go6976 | *** | **** | *** | FLT3,JAK2 | |||||||
| A10766 | Quercetin | Sirtuin,Src,PI3Kγ | ||||||||||
| A10616 | Myricitrin | |||||||||||
| A10196 | Chelerythrine chloride | * | ||||||||||
| A10261 | Bryostatin 1 | *** | ||||||||||
| A10286 | Daphnetin | * | EGFR, PKA | |||||||||
| A12399 | Ruboxistaurin (LY333531) | * | **** | * | * | ** | ||||||
| A14871 | PKC (19-36) | * |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Ro 31-8220 mesylate
Catalog No. A13514 PKC inhibitorRo 31-8220 mesylate is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%. Learn More -
Ro 31-8220
Catalog No. A21765 PKC inhibitorRo 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Learn More -
AS2521780
Catalog No. A21581 PKCθ selective inhibitorAS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM. Learn More -
DCPLA-ME
Catalog No. A21368 PKCε activatorDCPLA-ME, the methyl ester form of DCPLA, is a potent PKCε activator for use in the treatment of neurodegenerative diseases. Learn More -
Delcasertib
Catalog No. A12829 δ-protein kinase C (δPKC) inhibitorDelcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor. Learn More -
Roy-Bz
Catalog No. A13348 PKCδ activatorRoy-Bz is a selecive PKCδ activator. Roy-Bz potently inhibits the proliferation of colon cancer cells by inducing a PKCδ-dependent mitochondrial apoptotic pathway involving caspase-3 activation. Learn More -
PKC-theta inhibitor 1
Catalog No. A18966 PKCθ inhibitorPKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. Learn More -
LXS196
Catalog No. A19419 PKC inhibitorLXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma. Learn More -
BJE6-106
Catalog No. A18627 PKCδ inhibitorBJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). Learn More -
Ruboxistaurin (LY333531 HCl)
Catalog No. A16604 PKCβ1 and PKCβ2 inhibitorLY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively. Learn More -
NSC305787
Catalog No. A16213 PKC inhibitorNSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 uM, 9.4 uM, 55 uM for PKC phosphorylation of recombinant ezrin, of moesin, and of radixin. Learn More -
PKC-IN-1
Catalog No. A16212 PKC inhibitorPKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1. Learn More -
(-)-Indolactam V
Catalog No. A13043 PKC activator(-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm. Learn More -
PKC (19-36)
Catalog No. A14871 PKC inhibitorPKC (19-36), pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 uM). Learn More -
12-O-tetradecanoyl phorbol-13-acetate
Catalog No. A14616 PKC activator12-O-tetradecanoyl phorbol-13-acetate is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. Learn More -
GO6983
Catalog No. A13790 PKC inhibitorGO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Learn More -
PKC 412 (Midostaurin)
Catalog No. A12650 PKC inhibitorPKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Learn More -
Ruboxistaurin (LY333531)
Catalog No. A12399 PKC inhibitorRuboxistaurin (LY333531) is a potent, selective inhibitor of Protein Kinase C isozymes, PKC β I(IC50=4.7 nM) and PKC β II (IC50=5.9 nM). Learn More -
Daphnetin
Catalog No. A10286 EGFR, PKA,PKC inhibitorDaphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent. Learn More -
Quercetin (Sophoretin)
Catalog No. A10766 MAO-B inhibitorQuercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Learn More -
Chelerythrine Chloride
Catalog No. A10196 PKC inhibitorChelerythrine affects translocation of PKC from cytosol to plasma membrane. Shown to prevent neurite growth. Induces apoptosis in a concentration- and schedule-dependent manner.
Learn More -
Myricitrin (Myricitrine)
Catalog No. A10616 Myricitrin is the 3-O-rhamnoside of myricetin. Myricitrin is used by several beetle species in their communication system. Learn More -
Bryostatin 1
Catalog No. A10261 PKC inhibitorBryostatin 1 is a macrolactone isolated from the marine bryozoan, Bugula neritina, that modulates protein kinase C (PKC) activity. Bryostain 1 induces an initial rapid activation and autophosphorylation of PKC that results in the translocation of the PKC enzyme to the membrane. Learn More -
Sotrastaurin (AEB071)
Catalog No. A11554 PKC inhibitorSotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis. Learn More -
Staurosporine
Catalog No. A10864 PKC inhibitorStaurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase. Learn More -
Go 6976
Catalog No. A12419 PKC inhibitorGo6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3. Learn More -
Valrubicin
Catalog No. A14336 Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. Learn More -
alpha-Amyloid Precursor Protein Modulator
Catalog No. A13094 alpha-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblas. Learn More -
GF 109203X
Catalog No. A13197 PKC inhibitorGF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Learn More -
Ingenol Mebutate (PEP005)
Catalog No. A12963 Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. Learn More -
TAS 301
Catalog No. A15557 PKC inhibitorTAS 301 is an inhibitor of smooth muscle cell migration and proliferation. Learn More -
[Ser25] Protein Kinase C (19-31)
Catalog No. A14882 Protein Kinase C (19-31), this peptide derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase C substrate peptide for testing the protein kinase C activity. Learn More -
Verbascoside
Catalog No. A12014 PKC inhibitorVerbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity. Learn More -
NH125
Catalog No. A14307 -
LY317615 (Enzastaurin)
Catalog No. A10356 PKCβ inhibitorLY317615 (Enzastaurin) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC50= ~6 nM). Learn More -
Prostratin
Catalog No. A13679 PKC activatorProstratin is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans. Learn More
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