Protein Kinase C (PKC)

Catalog No.Inhibitor Name PKCPKCαPKCβPKCγPKCδPKCεPKCζPKCηPKCθPKCμOther
A10356Enzastaurin
**
***
*
*
A11554Sotrastaurin
****
****
****
****
****
****
A10864Staurosporine
****
****
**
*
*
****
c-Fgr,phosphorylase kinase,S6 kinase
A13790Go 6983
***
***
***
***
**
*
A13197Bisindolylmaleimide I
**
***
**
PDGFR
A13514Ro 31-8220 Mesylate
****
***
**
**
A12650Midostaurin
**
**
**
*
*
*
*
PPK,KDR,c-Syk
A12419Go6976
***
****
***
FLT3,JAK2
A10766Quercetin
Sirtuin,Src,PI3Kγ
A10616Myricitrin
A10196Chelerythrine chloride
*
A10261Bryostatin 1
***
A10286Daphnetin
*
EGFR, PKA
A12399Ruboxistaurin (LY333531)
*
****
*
*
**
A14871PKC (19-36)
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Ro 31-8220

    Catalog No. A21765
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    PKC inhibitor
    Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Learn More
  2. Ro 31-8220 mesylate

    Catalog No. A13514
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    PKC inhibitor
    Ro 31-8220 mesylate is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%. Learn More
  3. 12-O-tetradecanoyl phorbol-13-acetate

    Catalog No. A14616
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    PKC activator
    12-O-tetradecanoyl phorbol-13-acetate is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. Learn More
  4. PKC (19-36)

    Catalog No. A14871
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    PKC inhibitor
    PKC (19-36), pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 uM). Learn More
  5. (-)-Indolactam V

    Catalog No. A13043
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    PKC activator
    (-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm. Learn More
  6. PKC-IN-1

    Catalog No. A16212
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    PKC inhibitor
    PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1. Learn More
  7. NSC305787

    Catalog No. A16213
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    PKC inhibitor
    NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 uM, 9.4 uM, 55 uM for PKC phosphorylation of recombinant ezrin, of moesin, and of radixin. Learn More
  8. Ruboxistaurin (LY333531 HCl)

    Catalog No. A16604
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    PKCβ1 and PKCβ2 inhibitor
    LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively. Learn More
  9. BJE6-106

    Catalog No. A18627
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    PKCδ inhibitor
    BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). Learn More
  10. LXS196

    Catalog No. A19419
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    PKC inhibitor
    LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma. Learn More
  11. PKC-theta inhibitor 1

    Catalog No. A18966
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    PKCθ inhibitor
    PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. Learn More
  12. Roy-Bz

    Catalog No. A13348
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    PKCδ activator
    Roy-Bz is a selecive PKCδ activator. Roy-Bz potently inhibits the proliferation of colon cancer cells by inducing a PKCδ-dependent mitochondrial apoptotic pathway involving caspase-3 activation. Learn More
  13. Delcasertib

    Catalog No. A12829
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    δ-protein kinase C (δPKC) inhibitor
    Delcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor. Learn More
  14. DCPLA-ME

    Catalog No. A21368
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    PKCε activator
    DCPLA-ME, the methyl ester form of DCPLA, is a potent PKCε activator for use in the treatment of neurodegenerative diseases. Learn More
  15. AS2521780

    Catalog No. A21581
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    PKCθ selective inhibitor
    AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM. Learn More
  16. GO6983

    Catalog No. A13790
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    PKC inhibitor
    GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Learn More
  17. PKC 412 (Midostaurin)

    Catalog No. A12650
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    PKC inhibitor
    PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Learn More
  18. Go 6976

    Catalog No. A12419
    PKC inhibitor
    Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3. Learn More
  19. Staurosporine

    Catalog No. A10864
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    PKC inhibitor
    Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase. Learn More
  20. Sotrastaurin (AEB071)

    Catalog No. A11554
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    PKC inhibitor
    Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis. Learn More
  21. Bryostatin 1

    Catalog No. A10261
    PKC inhibitor
    Bryostatin 1 is a macrolactone isolated from the marine bryozoan, Bugula neritina, that modulates protein kinase C (PKC) activity. Bryostain 1 induces an initial rapid activation and autophosphorylation of PKC that results in the translocation of the PKC enzyme to the membrane. Learn More
  22. Myricitrin (Myricitrine)

    Catalog No. A10616
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    Myricitrin is the 3-O-rhamnoside of myricetin. Myricitrin is used by several beetle species in their communication system. Learn More
  23. Chelerythrine Chloride

    Catalog No. A10196
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    PKC inhibitor

    Chelerythrine affects translocation of PKC from cytosol to plasma membrane. Shown to prevent neurite growth. Induces apoptosis in a concentration- and schedule-dependent manner.

    Learn More
  24. Quercetin (Sophoretin)

    Catalog No. A10766
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    MAO-B inhibitor
    Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Learn More
  25. Daphnetin

    Catalog No. A10286
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    EGFR, PKA,PKC inhibitor
    Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent. Learn More
  26. Valrubicin

    Catalog No. A14336
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    Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. Learn More
  27. Ruboxistaurin (LY333531)

    Catalog No. A12399
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    PKC inhibitor
    Ruboxistaurin (LY333531) is a potent, selective inhibitor of Protein Kinase C isozymes, PKC β I(IC50=4.7 nM) and PKC β II (IC50=5.9 nM). Learn More
  28. Prostratin

    Catalog No. A13679
    PKC activator
    Prostratin is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans. Learn More
  29. NH125

    Catalog No. A14307
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    eEF-2 inhibitor
    NH125 is a selective eEF-2 kinase inhibitor. Learn More
  30. Verbascoside

    Catalog No. A12014
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    PKC inhibitor
    Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity. Learn More
  31. GF 109203X

    Catalog No. A13197
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    PKC inhibitor
    GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Learn More
  32. [Ser25] Protein Kinase C (19-31)

    Catalog No. A14882
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    Protein Kinase C (19-31), this peptide derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase C substrate peptide for testing the protein kinase C activity. Learn More
  33. TAS 301

    Catalog No. A15557
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    PKC inhibitor
    TAS 301 is an inhibitor of smooth muscle cell migration and proliferation. Learn More
  34. Ingenol Mebutate (PEP005)

    Catalog No. A12963
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    Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. Learn More
  35. alpha-Amyloid Precursor Protein Modulator

    Catalog No. A13094
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    alpha-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblas. Learn More
  36. LY317615 (Enzastaurin)

    Catalog No. A10356
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    PKCβ inhibitor
    LY317615 (Enzastaurin) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC50= ~6 nM). Learn More

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