CXCR

Catalog No.Inhibitor Name CXCR1CXCR2CXCR4Other
A10913Plerixafor 8HCl
**
CXCL12-mediated chemotaxis
A13074Plerixafor
**
CXCL12-mediated chemotaxis
A12588WZ811
****
A14209SB225002
***
A16351ATI-2341
*
A14997AMD-070 HCl
***
A15234SCH 563705
****
***
A14209SB225002
***
A11555SCH-527123 (Navarixin)
**
***
A12383Reparixin
****
**
CXCL8
A12596MSX-122
***
A11315AMD 070
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Plerixafor 8HCl (DB06809)

    Catalog No. A10913
    CXCR4 antagonist
    Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation. Learn More
  2. AZD-5069

    Catalog No. A15941
    CXCR2 antagonist
    AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD. Learn More
  3. AMD-070 HCl

    Catalog No. A14997
    CXCR4 antagonist
    AMD-070 hydrochloride is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, inhibit the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. Learn More
  4. SCH 563705

    Catalog No. A15234
    CXCR2/CXCR1 antagonist
    SCH 563705 is a potent dual CXCR2(IC50= 1.3 nM)/CXCR1(IC50= 7.3 nM) antagonist. Learn More
  5. SB265610

    Catalog No. A14195
    CXCR2 antagonist
    SB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site. It does not bind to the related CXCR1 receptor.1 It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury. Learn More
  6. SCH-527123 (Navarixin)

    Catalog No. A11555
    CXCR1/CXCR2 antagonist
    SCH527123 is a potent and selective antagonist of the human CXCR1 and CXCR2 receptors with IC50 of 42 nM and 3 nM, respectively. Learn More
  7. AMD3100 (Plerixafor)

    Catalog No. A13074
    CXCR4 antagonist
    Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation. Learn More
  8. Reparixin

    Catalog No. A12383
    CXCL8/CXCR1/2 Inhibitor
    Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM). Learn More
  9. SRT3190

    Catalog No. A11577
    SIRT1 activator
    SRT3190 is a potent CXCR2 ligand. Learn More
  10. AMD 070

    Catalog No. A11315
    CXCR4 antagonist
    AMD 070 is a CXCR4 chemokine receptor antagonist. Learn More
  11. AMD 3465 Hexahydrobromide

    Catalog No. A11953
    CXCR4 antagonist
    AMD 3465 is a potent, selective CXCR4 antagonist. Learn More
  12. SRT3109

    Catalog No. A11097
    CXCR2 ligand
    SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions. Learn More
  13. WZ811

    Catalog No. A12588
    CXCR4 antagonist
    WZ811 is a C-X-C chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM). Learn More
  14. MSX-122

    Catalog No. A12596
    CXCR4 Inhibitor
    MSX-122 is an orally bioavailable inhibitor of CXCR4 (IC50 = ~10 nM) with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration. Learn More
  15. Reparixin L-lysine salt

    Catalog No. A15219
    CXCL8 receptor inhibitor
    Reparixin L-lysine salt is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation,which has been shown to attenuate inflammatory responses in various injury models. Learn More
  16. SB225002

    Catalog No. A14209
    CXCR2 antagonist
    SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested. Learn More
  17. UNBS5162

    Catalog No. A15439
    CXCL chemokines antagonist
    UNBS5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers; the mean antiproliferative activity IC50 value is 17.9 uM for 9 cancer cell lines; hydrolysis product of UNBS3157. Learn More
  18. ATI-2341

    Catalog No. A16351
    CXCR4 agonist
    ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4) (EC50 = 194 nM, is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. Learn More

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