CXCR

Catalog No.Inhibitor Name CXCR1CXCR2CXCR4Other
A10913Plerixafor 8HCl
**
CXCL12-mediated chemotaxis
A13074Plerixafor
**
CXCL12-mediated chemotaxis
A12588WZ811
****
A14209SB225002
***
A16351ATI-2341
*
A14997AMD-070 HCl
***
A15234SCH 563705
****
***
A14209SB225002
***
A11555SCH-527123 (Navarixin)
**
***
A12383Reparixin
****
**
CXCL8
A12596MSX-122
***
A11315AMD 070
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. SCH 563705

    Catalog No. A15234
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    CXCR2/CXCR1 antagonist
    SCH 563705 is a potent dual CXCR2(IC50= 1.3 nM)/CXCR1(IC50= 7.3 nM) antagonist. Learn More
  2. NBI-74330

    Catalog No. A21158
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    CXCR3 antagonist
    NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively. Learn More
  3. AMG 487 S-enantiomer

    Catalog No. A21874
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    CXCR3 antagonist
    AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3. Learn More
  4. SCH 546738

    Catalog No. A21554
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    CXCR3 antagonist
    SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. Learn More
  5. AMG 487

    Catalog No. A21162
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    CXCR3 antagonist
    AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. Learn More
  6. Kynurenic acid sodium

    Catalog No. A20000
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    GPR35/CXCR8 agonist
    Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. Learn More
  7. GPR35 agonist 1

    Catalog No. A12462
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    GPR35/CXCR8 agonist
    GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good druggability. Learn More
  8. AZD-5069

    Catalog No. A15941
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    CXCR2 antagonist
    AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD. Learn More
  9. Reparixin L-lysine salt

    Catalog No. A15219
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    CXCL8 receptor inhibitor
    Reparixin L-lysine salt is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation,which has been shown to attenuate inflammatory responses in various injury models. Learn More
  10. AMD-070 HCl

    Catalog No. A14997
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    CXCR4 antagonist
    AMD-070 hydrochloride is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, inhibit the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. Learn More
  11. UNBS5162

    Catalog No. A15439
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    CXCL chemokines antagonist
    UNBS5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers; the mean antiproliferative activity IC50 value is 17.9 uM for 9 cancer cell lines; hydrolysis product of UNBS3157. Learn More
  12. ATI-2341

    Catalog No. A16351
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    CXCR4 agonist
    ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4) (EC50 = 194 nM, is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. Learn More
  13. NSC-23026

    Catalog No. A17151
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    CXCR4 receptor modulator
    NSC-23026 is a CXCR4 receptor modulator. Learn More
  14. MSX-130

    Catalog No. A17150
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    CXCR4 Antagonist
    MSX-130 is CXCR4 antagonist. Learn More
  15. USL311

    Catalog No. A18778
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    CXCR4 receptor antagonist
    USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. Learn More
  16. Kynurenic acid

    Catalog No. A16581
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    GPR35/CXCR8 agonist
    Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. Learn More
  17. PS372424

    Catalog No. A19421
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    Human CXCR3 agonist
    PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM. Learn More
  18. SB225002

    Catalog No. A14209
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    CXCR2 antagonist
    SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested. Learn More
  19. SB265610

    Catalog No. A14195
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    CXCR2 antagonist
    SB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site. It does not bind to the related CXCR1 receptor.1 It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury. Learn More
  20. SCH-527123 (Navarixin)

    Catalog No. A11555
    CXCR1/CXCR2 antagonist
    SCH527123 is a potent and selective antagonist of the human CXCR1 and CXCR2 receptors with IC50 of 42 nM and 3 nM, respectively. Learn More
  21. Plerixafor 8HCl (DB06809)

    Catalog No. A10913
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    CXCR4 antagonist
    Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation. Learn More
  22. AMD 070

    Catalog No. A11315
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    CXCR4 antagonist
    AMD 070 is a CXCR4 chemokine receptor antagonist. Learn More
  23. AMD 3465 Hexahydrobromide

    Catalog No. A11953
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    CXCR4 antagonist
    AMD 3465 is a potent, selective CXCR4 antagonist. Learn More
  24. SRT3109

    Catalog No. A11097
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    CXCR2 ligand
    SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions. Learn More
  25. WZ811

    Catalog No. A12588
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    CXCR4 antagonist
    WZ811 is a C-X-C chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM). Learn More
  26. MSX-122

    Catalog No. A12596
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    CXCR4 Inhibitor
    MSX-122 is an orally bioavailable inhibitor of CXCR4 (IC50 = ~10 nM) with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration. Learn More
  27. SRT3190

    Catalog No. A11577
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    SIRT1 activator
    SRT3190 is a potent CXCR2 ligand. Learn More
  28. Reparixin

    Catalog No. A12383
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    CXCL8/CXCR1/2 Inhibitor
    Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM). Learn More
  29. AMD3100 (Plerixafor)

    Catalog No. A13074
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    CXCR4 antagonist
    Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation. Learn More
  30. CXCR2-IN-1

    Catalog No. A12649
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    CXCR2 antagonists
    CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3. Learn More

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