TRP Channel

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  1. Pyr6

    Catalog No. A21927
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    TRPC3 inhibitor
    Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells). Learn More
  2. D-3263

    Catalog No. A20935
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    TRPM8 agonist
    D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity. Learn More
  3. SN 2

    Catalog No. A20839
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    TRPML3 ion channel activator
    SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8??0.13 μM. Learn More
  4. SAR7334

    Catalog No. A20836
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    TRPC6 inhibitor
    SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM. Learn More
  5. AMG-333

    Catalog No. A17182
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    TRPM8 Antagonist
    AMG-333 is a potent and selective TRPM8 Antagonist. Learn More
  6. AMG2850

    Catalog No. A19445
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    TRPM8 antagonist
    AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist. Learn More
  7. WS 12

    Catalog No. A17046
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    TRPM8 Agonist
    WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM). Learn More
    • New

    SAR-7334 HCl

    Catalog No. A17237
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    TRPC6 inhibitor
    SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected. Learn More
  8. TRPC6-IN-1

    Catalog No. A12309
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    TRPC6 inhibitor
    TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC50 of 4.66 μM. Learn More
  9. Pico145

    Catalog No. A13344
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    TRPC1/4/5 channels inhibitor
    Pico145 is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (?)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8. Learn More
  10. WS 3

    Catalog No. A17047
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    TRPM8 agonist
    WS 3 is TRPM8 receptors agonist (EC50 = 3.7 μM) and cooling agent. Learn More
  11. PF-4840154

    Catalog No. A13996
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    TrpA1 channel agonist
    PF-4840154 is a non-electrophilic reference agonist of the TrpA1 channel. The TRPA1 channel is considered an attractive pain target based on the fact that TRPA1 knockout mice showed near complete attenuation of pain behaviors in some pre-clinical development models. Learn More
  12. GsMTx4

    Catalog No. A16103
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    GsMTX4 is a 34 amino acid peptidyl toxin isolated from the Grammostola rosea (Chilean rose) tarantula venom and belongs to the huwentoxin-1 family. Learn More
  13. A 967079

    Catalog No. A12353
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    TRPA1 channel blocker
    A 967079 is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively). Learn More
  14. Optovin

    Catalog No. A12932
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    photoactive TRPA1 activator
    Optovin is a reversible photoactive TRPA1 activator. Learn More
  15. Icilin

    Catalog No. A13560
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    TRPM8 and TRPA1 activator
    Icilin is a cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) Learn More
  16. HC-030031

    Catalog No. A13278
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    TRPA1 inhibitor
    HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50 = 6.2 and 5.3 uM, respectively). Learn More
  17. TCS 5861528

    Catalog No. A14126
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    TRPA1 channel blocker
    TCS 5861528 is a TRPA1 channel blocker and an antagonizer of AITC- and 4-HNE-evoked calcium influx. Learn More
  18. ACA

    Catalog No. A13585
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    ACA is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 uM, respectively). Learn More
  19. Cannabichromene

    Catalog No. A15497
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    TRPA1 activatior/TRPM8 blocker
    Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1). Both endocannabinoids and TRPA1 may modulate gastrointestinal motility. Learn More
  20. ML204

    Catalog No. A15556
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    TRPC4/C5 inhibitor
    ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. Learn More
  21. RQ-00203078

    Catalog No. A15830
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    TRPM8 antagonist
    RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Learn More
  22. Evodiamine (Isoevodiamine)

    Catalog No. A10376
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    TRP agonist
    Evodiamine is a chemical extracted from the Tetradium family of plants. It acts primarily as a thermogenic and stimulant. Learn More

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