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| Catalog No. | Inhibitor Name | HIF | HIF1 | Other |
|---|---|---|---|---|
| A15530 | FG-2216 | **** | **** | |
| A15359 | KC7F2 | ** | ** | |
| A11237 | Roxadustat | |||
| A10012 | 2-Methoxyestradiol | Microtubule Associated | ||
| A14319 | PX-478 2HCl | |||
| A12978 | BAY 87-2243 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
37 Item(s)
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FG-4592 (Roxadustat)
Catalog No. A11237 HIF-PHs inhibitorFG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia. Learn More -
HIF-2α-IN-1
Catalog No. A20631 HIF-2α inhibitorHIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay. IC50 value: ?? 500 nM Target: HIF-2α. Learn More -
VH-298
Catalog No. A20326 VHL:HIF-α interaction inhibitorVH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM, used in PROTAC technology. Learn More -
PT2399
Catalog No. A19787 HIF-2α antagonistPT2399 is a potent and selective HIF-2α antagonist, which directly binds to HIF-2α PAS B domain with an IC50 of 6 nM. PT2399 displays potent antitumor activity in vivo. Learn More -
GN44028
Catalog No. A19693 HIF-1 inhibitorGN44028 is a hypoxia inducible factor (HIF)-1 inhibitor, with an IC50 of 14 nM. Learn More -
M1001
Catalog No. A19443 HIF-2α agonistM1001 is a weak agonist of HIF-2α, directly binds to the HIF-2α PAS-B domain, with a Kd of 667 nM. M1001 enhances the stabilities of HIF-2α-ARNT complex. Learn More -
Prolyl Hydroxylase inhibitor 1
Catalog No. A19227 HIF-PHD inhibitorProlyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC50 of 62.23 nM. Antianemia agent. Learn More -
AFP464
Catalog No. A20978 HIF-1α inhibitorAFP464, is an active HIF-1α inhibitor with an IC50 of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator. Learn More -
PT-2385
Catalog No. A21561 HIF-2α inhibitorPT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM. Learn More -
(Rac)-PT2399
Catalog No. A21376 HIF-2α inhibitor(Rac)-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM. Learn More -
EL-102
Catalog No. A20925 HIF1α inhibitorEL102 is a inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability. Learn More -
ZINC13466751
Catalog No. A12522 HIF-1α/von Hippel-Lindau interaction inhibitorZINC13466751 is a potent inhibitor of HIF-1α/von Hippel-Lindau interaction with an IC50 of 2.0 ?M. Learn More -
MK-8617
Catalog No. A12618 pan HIF PHD1-3 inhibitorMK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2. Learn More -
SYP-5
Catalog No. A13031 HIF-1 inhibitorSYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. Learn More -
IOX 2
Catalog No. A11924 HIF-PHD inhibitorIOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. Learn More -
DMOG
Catalog No. A13998 HIF-PH inhibitorDMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. Learn More -
Oroxylin A
Catalog No. A14367 Oroxylin A is an O-methylated flavone, It has demonstrated activity as a dopamine reuptake inhibitor and is also a negative allosteric modulator of the benzodiazepine site of the GABAA receptor. Learn More -
ML 228
Catalog No. A15360 HIF activatorML-228 is an activator of the HIF signaling pathway, as demonstrated by HIF response element (HRE) reporter assay, HIF-1α nuclear translocation assay, and increased VEGF expression. Learn More -
KC7F2
Catalog No. A15359 HIF inhibitorKC7F2 is an inhibitor of HIF-1α protein translation, but not transcription, that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K). Learn More -
Chetomin
Catalog No. A15358 HIF inhibitorChetomin is reported to be an antibiotic metabolite of Chaetomium spp. which contains bacteriostatic effects on Gram-positive bacteria. Learn More -
2-Methoxyestradiol
Catalog No. A10012 Apoptotic, antiproliferative and antiangiogenic agent2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Learn More -
FG-2216
Catalog No. A15530 HIF-prolyl hydroxylase inhibitorFG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo, Learn More -
FM19G11
Catalog No. A12883 HIFα inhibitorFM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), which are transcription factors that respond to changes in available oxygen in the cellular environment. Learn More -
HIF-C2
Catalog No. A12921 HIF-2 inhibitorHIF-C2 is a potent and selective allosteric inhibitor of hypoxia inducible factor-2 (HIF-2) Learn More -
BAY 87-2243
Catalog No. A12978 HIF inhibitorBAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Learn More -
PX-478 HCl
Catalog No. A14319 HIF-1alpha inhibitorPX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity. Learn More -
Molidustat
Catalog No. A14404 HIF-PH inhibitorMolidustat is a novel inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) which stimulates erythropoietin (EPO) production and the formation of red blood cells. Learn More -
Echinomycin
Catalog No. A14021 HIF-1α inhibitorHypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription Learn More -
PT2977
Catalog No. A18465 -
Desidustat
Catalog No. A16921 HIF hydroxylase inhibitorDesidustat is an antianaemic drug candidate. It is an inhibitor of HIF hydroxylase extracted from patent WO 2014102818 A1, compound example 2. Learn More -
IDF-11774
Catalog No. A16845 HIF-1 inhibitorBiological Activity Description IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells. Learn More -
Vadadustat
Catalog No. A16794 HIF prolyl-hydroxylase inhibitorVadadustat, also known as AKB-6548 and PG-1016548, is a potent Hypoxia-inducible factor-proline dioxygenase inhibitor. Learn More -
LW6 (CAY10585)
Catalog No. A12882 -
HIF-2a Translation Inhibitor
Catalog No. A16181 HIF-2a translation inhibitorHIF-2a translation inhibitor (IC50 value 5 uM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element). Learn More -
DASA-58
Catalog No. A15895 PKM2 ActivatorDASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator. Learn More -
GSK1278863 (Daprodustat)
Catalog No. A12671 HIF-prolyl hydroxylase InhibitorGSK1278863 is a novel HIF-prolyl hydroxylase inhibitor. Learn More -
JNJ-42041935
Catalog No. A15793 HIF-PHD Inhibitor IIJNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. Learn More
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