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| Catalog No. | Inhibitor Name | CXCR1 | CXCR2 | CXCR4 | Other |
|---|---|---|---|---|---|
| A10913 | Plerixafor 8HCl | ** | CXCL12-mediated chemotaxis | ||
| A13074 | Plerixafor | ** | CXCL12-mediated chemotaxis | ||
| A12588 | WZ811 | **** | |||
| A14209 | SB225002 | *** | |||
| A16351 | ATI-2341 | * | |||
| A14997 | AMD-070 HCl | *** | |||
| A15234 | SCH 563705 | **** | *** | ||
| A14209 | SB225002 | *** | |||
| A11555 | SCH-527123 (Navarixin) | ** | *** | ||
| A12383 | Reparixin | **** | ** | CXCL8 | |
| A12596 | MSX-122 | *** | |||
| A11315 | AMD 070 | *** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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UNBS5162
Catalog No. A15439 CXCL chemokines antagonistUNBS5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers; the mean antiproliferative activity IC50 value is 17.9 uM for 9 cancer cell lines; hydrolysis product of UNBS3157. Learn More -
NBI-74330
Catalog No. A21158 CXCR3 antagonistNBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively. Learn More -
AMG 487 S-enantiomer
Catalog No. A21874 CXCR3 antagonistAMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3. Learn More -
SCH 546738
Catalog No. A21554 CXCR3 antagonistSCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. Learn More -
AMG 487
Catalog No. A21162 CXCR3 antagonistAMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. Learn More -
Kynurenic acid sodium
Catalog No. A20000 GPR35/CXCR8 agonistKynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. Learn More -
GPR35 agonist 1
Catalog No. A12462 GPR35/CXCR8 agonistGPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good druggability. Learn More -
CXCR2-IN-1
Catalog No. A12649 CXCR2 antagonistsCXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3. Learn More -
PS372424
Catalog No. A19421 Human CXCR3 agonistPS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM. Learn More -
Kynurenic acid
Catalog No. A16581 GPR35/CXCR8 agonistKynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. Learn More -
USL311
Catalog No. A18778 CXCR4 receptor antagonistUSL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. Learn More -
NSC-23026
Catalog No. A17151 -
ATI-2341
Catalog No. A16351 CXCR4 agonistATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4) (EC50 = 194 nM, is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. Learn More -
AZD-5069
Catalog No. A15941 CXCR2 antagonistAZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD. Learn More -
Plerixafor 8HCl (DB06809)
Catalog No. A10913 CXCR4 antagonistPlerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation. Learn More -
AMD-070 HCl
Catalog No. A14997 CXCR4 antagonistAMD-070 hydrochloride is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, inhibit the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. Learn More -
SCH 563705
Catalog No. A15234 CXCR2/CXCR1 antagonistSCH 563705 is a potent dual CXCR2(IC50= 1.3 nM)/CXCR1(IC50= 7.3 nM) antagonist. Learn More -
Reparixin L-lysine salt
Catalog No. A15219 CXCL8 receptor inhibitorReparixin L-lysine salt is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation,which has been shown to attenuate inflammatory responses in various injury models. Learn More -
SB225002
Catalog No. A14209 CXCR2 antagonistSB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested. Learn More -
SB265610
Catalog No. A14195 CXCR2 antagonistSB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site. It does not bind to the related CXCR1 receptor.1 It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury. Learn More -
SCH-527123 (Navarixin)
Catalog No. A11555 CXCR1/CXCR2 antagonistSCH527123 is a potent and selective antagonist of the human CXCR1 and CXCR2 receptors with IC50 of 42 nM and 3 nM, respectively. Learn More -
AMD3100 (Plerixafor)
Catalog No. A13074 CXCR4 antagonistPlerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation. Learn More -
Reparixin
Catalog No. A12383 CXCL8/CXCR1/2 InhibitorReparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM). Learn More -
SRT3190
Catalog No. A11577 -
MSX-122
Catalog No. A12596 CXCR4 InhibitorMSX-122 is an orally bioavailable inhibitor of CXCR4 (IC50 = ~10 nM) with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration. Learn More -
WZ811
Catalog No. A12588 CXCR4 antagonistWZ811 is a C-X-C chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM). Learn More -
SRT3109
Catalog No. A11097 CXCR2 ligandSRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions. Learn More -
AMD 3465 Hexahydrobromide
Catalog No. A11953 CXCR4 antagonistAMD 3465 is a potent, selective CXCR4 antagonist. Learn More -
AMD 070
Catalog No. A11315 CXCR4 antagonistAMD 070 is a CXCR4 chemokine receptor antagonist. Learn More
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