IKK/IκB

Catalog No.Inhibitor Name IκBIKKOther
A11957BAY 11-7082
*
E2-conjugating enzymes
A12836IKK-16
***
A11579TPCA-1
****
A12559BMS-345541
**
A12746SC-514
**
CDK2/CyclinA,AUR2,PRAK
A12470Bay 11-7085
*
A12789PS-1145
***
A15488LY2409881
****
A11148BX-795
PDK-1,c-Kit,CDK2/CyclinE
A12837IMD 0354
A11323Bardoxolone Methyl
NF-κB,Nrf2
A15900AZD3264
A12953WS6
EBP1
A12952WS3
EBP1
A11318BMS-345541 HCl
**
A11339Bay 65-1942
*
A11485MRT67307
**
TBK1
A13108PHA 408
A15171MLN120B

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

29 Item(s)

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  1. Wedelolactone

    Catalog No. A14804
    IKK Inhibitor II
    Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1?? maturation and pathological apoptosis. Learn More
  2. Bay 65-1942 R form

    Catalog No. A15018
    IKK Inhibitor‎
    Bay 65-1942 (R form) is an ATP-competitive inhibitor that selectively targets IKKβ kinase. Learn More
  3. MLN120B

    Catalog No. A15171
    IκB Kinase β Inhibitor
    MLN120B is a potent and effective IKKbeta inhibitor. Learn More
  4. LY2409881

    Catalog No. A15488
    IKK2 inhibitor
    LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases. Learn More
  5. AZD3264

    Catalog No. A15900
    IKK2 inhibitor‎
    AZD3264 is a novel IKK2 inhibitor. Learn More
  6. MRT67307

    Catalog No. A11485
    SIK/TBK-1/IKKe inhibitor
    MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. Learn More
  7. IKK-2 inhibitor VIII

    Catalog No. A11452
    IKK Inhibitor
    IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM. Learn More
  8. IKK-3 Inhibitor

    Catalog No. A11463
    IKK Inhibitor
    IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-alpha and IKK-beta. Learn More
  9. Bardoxolone (CDDO)

    Catalog No. A11324
    IκB/IKK inhibitor
    Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). Learn More
  10. IKK epsilon-IN-1

    Catalog No. A16298
    IKK-ε inhibitor
    IKK epsilon-IN-1 is a potent IKKε inhibitor; inhibit the in-situ IKK ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. Learn More
  11. Bay 65-1942 HCl

    Catalog No. A11338
    IKKβ kinase inhibitor
    Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity. Learn More
  12. BMS-345541 HCl

    Catalog No. A11318
    IKK inhibitor
    BMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor that binds at allosteric site of the enzyme and blocks NF-kB-dependent transcription in mice. Learn More
  13. Bay 65-1942

    Catalog No. A11339
    IKKβ inhibitor
    Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity. Learn More
  14. IκB/IKK inhibitor
    Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation. Learn More
  15. Amlexanox

    Catalog No. A16297
    IKKε /TBK1 inhibitor
    Amlexanox is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions. Learn More
  16. PS-1145

    Catalog No. A12789
    IKK inhibitor
    PS-1145 is a highly specific IKB kinase (IKK) inhibitor that efficiently inhibits both basal and induced NF-kB activity in PC cells. Learn More
  17. BX-795

    Catalog No. A11148
    PDK-1 inhibitor
    BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis. Learn More
  18. BI605906

    Catalog No. A13537
    IKKβ inhibitor
    BI605906 is a novel inhibitors of the IKK beta. Learn More
  19. Bay 11-7821

    Catalog No. A11957
    E2 ubiquitin conjugating enzyme inhibitor
    Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation. Learn More
  20. SC-514

    Catalog No. A12746
    IκB/IKK Inhibitor
    SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Learn More
  21. IKK-16

    Catalog No. A12836
    IKK Inhibitor
    IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. Learn More
  22. IMD 0354

    Catalog No. A12837
    IKK Inhibitor
    IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Learn More
  23. PHA 408

    Catalog No. A13108
    IKK-2 inhibitor
    PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling. Learn More
  24. WS3

    Catalog No. A12952
    EBP1 Inhibitor
    WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Learn More
  25. WS6

    Catalog No. A12953
    EBP1 Inhibitor
    WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Learn More
  26. BAY 11-7085

    Catalog No. A12470
    κB/IKK inhibitor
    BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM Learn More
  27. BMS-345541

    Catalog No. A12559
    IKK2/IKK1 inhibitor
    BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM Learn More
  28. CDDO-EA

    Catalog No. A16299
    Nrf2 activator
    CDDO-EA is an activator of Nrf2/ARE; Neuroprotective effect. Learn More

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