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$0.00 IKK/IκB
| Catalog No. | Inhibitor Name | IκB | IKK | Other |
|---|---|---|---|---|
| A11957 | BAY 11-7082 | * | E2-conjugating enzymes | |
| A12836 | IKK-16 | *** | ||
| A11579 | TPCA-1 | **** | ||
| A12559 | BMS-345541 | ** | ||
| A12746 | SC-514 | ** | CDK2/CyclinA,AUR2,PRAK | |
| A12470 | Bay 11-7085 | * | ||
| A12789 | PS-1145 | *** | ||
| A15488 | LY2409881 | **** | ||
| A11148 | BX-795 | PDK-1,c-Kit,CDK2/CyclinE | ||
| A12837 | IMD 0354 | |||
| A11323 | Bardoxolone Methyl | NF-κB,Nrf2 | ||
| A15900 | AZD3264 | |||
| A12953 | WS6 | EBP1 | ||
| A12952 | WS3 | EBP1 | ||
| A11318 | BMS-345541 HCl | ** | ||
| A11339 | Bay 65-1942 | * | ||
| A11485 | MRT67307 | ** | TBK1 | |
| A13108 | PHA 408 | |||
| A15171 | MLN120B |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
34 Item(s)
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Wedelolactone
Catalog No. A14804 IKK Inhibitor IIWedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Learn More -
BMS-066
Catalog No. A21972 IKKβ/Tyk2 pseudokinase inhibitorBMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively. Learn More -
IKK epsilon-IN-1
Catalog No. A16298 IKK-ε inhibitorIKK epsilon-IN-1 is a potent IKKε inhibitor; inhibit the in-situ IKK ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. Learn More -
IKK-3 Inhibitor
Catalog No. A11463 IKK InhibitorIKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-alpha and IKK-beta. Learn More -
IKK-2 inhibitor VIII
Catalog No. A11452 IKK InhibitorIKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM. Learn More -
MRT67307
Catalog No. A11485 SIK/TBK-1/IKKe inhibitorMRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. Learn More -
AZD3264
Catalog No. A15900 -
LY2409881
Catalog No. A15488 IKK2 inhibitorLY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases. Learn More -
MLN120B
Catalog No. A15171 -
Bay 65-1942 R form
Catalog No. A15018 IKK InhibitorBay 65-1942 (R form) is an ATP-competitive inhibitor that selectively targets IKKβ kinase. Learn More -
Bardoxolone (CDDO)
Catalog No. A11324 IκB/IKK inhibitorBardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). Learn More -
Bardoxolone methyl (RTA 402)
Catalog No. A11323 IκB/IKK inhibitorBardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation. Learn More -
Bay 65-1942
Catalog No. A11339 IKKβ inhibitorBay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity. Learn More -
BMS-345541 HCl
Catalog No. A11318 IKK inhibitorBMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor that binds at allosteric site of the enzyme and blocks NF-kB-dependent transcription in mice. Learn More -
Bay 65-1942 HCl
Catalog No. A11338 IKKβ kinase inhibitorBay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity. Learn More -
BAY 11-7085
Catalog No. A12470 IκB/IKK inhibitorBAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM Learn More -
TPCA-1
Catalog No. A11579 IKK-2 inhibitorTPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. Learn More -
IKK 16 hydrochloride
Catalog No. A21588 IKK2/IKK complex/IKK1 inhibitorIKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. Learn More -
IKK-IN-1
Catalog No. A21221 IKK inhibitorIKK-IN-1 is an inhibitor of IKK extracted from patent WO2002024679A1, compound example 18-13. Learn More -
INH14
Catalog No. A19119 IKKα/IKKβ inhibitorINH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. Learn More -
TBK1/IKKε-IN-5
Catalog No. A18400 dual TBK1 and IKKε inhibitorTBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively. Learn More -
CDDO-EA
Catalog No. A16299 -
WS3
Catalog No. A12952 EBP1 InhibitorWS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Learn More -
Amlexanox
Catalog No. A16297 IKKε /TBK1 inhibitorAmlexanox is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions. Learn More -
WS6
Catalog No. A12953 EBP1 InhibitorWS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Learn More -
BMS-345541
Catalog No. A12559 IKK2/IKK1 inhibitorBMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM Learn More -
Bay 11-7821
Catalog No. A11957 E2 ubiquitin conjugating enzyme inhibitorBay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation. Learn More -
PHA 408
Catalog No. A13108 IKK-2 inhibitorPHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling. Learn More -
PS-1145
Catalog No. A12789 IKK inhibitorPS-1145 is a highly specific IKB kinase (IKK) inhibitor that efficiently inhibits both basal and induced NF-kB activity in PC cells. Learn More -
SC-514
Catalog No. A12746 IκB/IKK InhibitorSC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Learn More -
IKK-16
Catalog No. A12836 IKK InhibitorIKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. Learn More -
IMD 0354
Catalog No. A12837 IKK InhibitorIMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Learn More -
BX-795
Catalog No. A11148 PDK-1 inhibitorBX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis. Learn More -
BI605906
Catalog No. A13537
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