Metabotropic glutamate receptors (mGluR)

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  1. CPPHA

    Catalog No. A15053
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    mGluR1 modulator
    CPPHA is a selective positive allosteric modulator of mGluR5 receptor. Learn More
  2. MTEP hydrochloride

    Catalog No. A15174
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    mGlu5 antagonist
    MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively. Learn More
  3. DL-AP3

    Catalog No. A15378
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    mGluR1 antagonist
    DL-AP3, a racemic preparation of D-AP3 and L-AP3, is an inhibitor of phosphoserine phosphatase and an antagonist of the metabotropic glutamate receptor (mGluR), blocking phosphoinositide turnover mediated by the mGluR. Learn More
  4. CBiPES HCl

    Catalog No. A15811
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    mGlu2 receptor modulator
    CBiPES hydrochloride is a selective positive allosteric modulator of the mGluR-2 with IC50 value of 98.2 nM Learn More
  5. MPEP HCl

    Catalog No. A13236
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    mGlu5 receptor antagonist
    MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 uM. Learn More
  6. Perampanel

    Catalog No. A12498
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    GluR antagonist
    Perampanel is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials. Learn More
  7. JNJ 42153605

    Catalog No. A14330
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    mGluR-2 modulator
    JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor. Learn More
  8. LY341495

    Catalog No. A11484
    mGluR-2 antagonist
    LY 341495 has been shown to be a highly potent and selective group II metabotropic glutamate receptor (mGluR-2) antagonist with Ki / IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGluR-2, mGluR-3, mGluR-8 , mGluR-7a, mGluR-1a, mGluR-5a and mGluR-4a. Learn More
  9. A-841720

    Catalog No. A13854
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    mGluR-1 antagonist
    A 841720 is a potent, non-competitive mGluR-1 antagonist that displays 34-fold selectivity over mGluR-5 (IC50 values are 10 and 342 nM respectively). Learn More
  10. Ibotenic Acid

    Catalog No. A14006
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    NMDA& mGlu receptor agonist
    Ibotenic acid is a neuroexcitatory amino acid originally isolated from Amanita species that functions as a NMDA and metabotropic glutamate receptor agonist. Learn More
  11. Kainic acid monohydrate

    Catalog No. A13485
    Kainate receptor agonist
    Kainate class of ionotropic glutamate receptor agonist. Has been shown to induce seizures and neurodegeneration in vivo and has also been used to induce experimental epilepsy in rodents and to examine excitation-induced neuronal apoptosis mechanisms. Learn More
  12. Noopept

    Catalog No. A15189
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    Noopept is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic. Learn More
  13. VU0364289

    Catalog No. A15832
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    mGluR5 Modulator
    VU0364289 is a novel N-aryl piperazine mGlu5 positive allosteric modulator. Learn More
  14. (S)-3,5-DHPG

    Catalog No. A16108
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    mGluR agonist
    (S)-3,5-DHPG is an agonist of the group I metabotropic glutamate receptors (mGluRs), binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 uM, respectively) but not ionotropic glutamate receptors. Learn More
  15. VU 0364770

    Catalog No. A12139
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    mGlu4 receptors modulator
    VU 0364770 is a positive allosteric modulator at mGlu4 receptors with EC50 value of 290 nM in mGlu4-expressing HEK 293 cells. Learn More
  16. VU 0361737

    Catalog No. A12467
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    mGlu4 receptors modulator
    VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively). Learn More
  17. SIB 1757

    Catalog No. A13758
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    mGluR antagonist
    SIB 1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype. Learn More
  18. SIB 1893

    Catalog No. A13759
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    mGluR antagonist
    SIB 1893 is a highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype. Learn More
  19. (-)-Huperzine A

    Catalog No. A10006
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    GluR inhibitor
    (-)-Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata. Learn More
  20. ADX-47273

    Catalog No. A11181
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    mGluR5 modulator

    ADX-47273 is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.

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  21. BINA

    Catalog No. A11126
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    mGluR2 modulator
    BINA is a selective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). Learn More
  22. LY2140023 (LY404039)

    Catalog No. A10544
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    mGluR Agonist
    LY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results. Learn More
  23. VU 0357121

    Catalog No. A11754
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    mGluR5 PAM
    VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Learn More
  24. CTEP

    Catalog No. A11968
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    CTEP is a highly potent, selective and orally bioavailable allosteric antagonist of mGlu5 receptor with an IC50 of 2.2 nM. Learn More
  25. MPEP

    Catalog No. A12589
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    mGlu5 receptor antagonist
    MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Learn More
  26. VU 0364439

    Catalog No. A12664
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    GluR modulator
    VU 0364439 is a positive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4). Learn More
  27. PHCCC

    Catalog No. A12705
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    mGluR antagonist
    PHCCC is a group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM). Learn More
  28. LY 379268

    Catalog No. A13123
    mGlu2 receptor agonist
    LY 379268 is a highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Learn More
  29. JNJ-40411813

    Catalog No. A12909
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    mGluR2 PAM
    JNJ-40411813 is a novel mGluR2 PAM. Learn More
  30. LY2979165

    Catalog No. A11487
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    mGlu2 agonist
    LY2979165 is a mGlu2 agonist. Learn More

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