Metabotropic glutamate receptors (mGluR)

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  1. Eglumegad

    Catalog No. A21005
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    group II (mGlu2/3) receptor agonist
    Eglumegad (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. Learn More
  2. LY2812223

    Catalog No. A21100
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    mGlu2 receptor agonist
    LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively). Learn More
  3. ADX88178

    Catalog No. A20922
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    mGluR4 PAM
    ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4. Learn More
  4. Dipraglurant

    Catalog No. A11382
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    mGluR5 antagonists
    Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM. Learn More
  5. Lu AF21934

    Catalog No. A12140
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    mGlu4 receptor modulator
    Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an IC50 of 500 nM for human mGlu4. Learn More
  6. BMT-145027

    Catalog No. A12457
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    mGluR5 positive allosteric modulator
    BMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM. Learn More
  7. CBiPES HCl

    Catalog No. A15811
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    mGlu2 receptor modulator
    CBiPES hydrochloride is a selective positive allosteric modulator of the mGluR-2 with IC50 value of 98.2 nM Learn More
  8. LY2794193

    Catalog No. A19131
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    mGlu3 receptor agonist
    LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM??EC50=0.47 nM; hmGlu2 Ki=412 nM??EC50=47.5 nM). Learn More
  9. CPPHA

    Catalog No. A15053
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    mGluR1 modulator
    CPPHA is a selective positive allosteric modulator of mGluR5 receptor. Learn More
  10. MTEP hydrochloride

    Catalog No. A15174
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    mGlu5 antagonist
    MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively. Learn More
  11. DL-AP3

    Catalog No. A15378
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    mGluR1 antagonist
    DL-AP3, a racemic preparation of D-AP3 and L-AP3, is an inhibitor of phosphoserine phosphatase and an antagonist of the metabotropic glutamate receptor (mGluR), blocking phosphoinositide turnover mediated by the mGluR. Learn More
  12. O-Phospho-L-serine

    Catalog No. A21159
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    group III mGluR receptors agonist
    O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2. Learn More
  13. TCN238

    Catalog No. A21191
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    mGlu4 receptor modulator
    TCN238 is a positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM. Learn More
  14. Mavoglurant

    Catalog No. A21223
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    mGlu5 receptor antagonist
    Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist, has an IC50 of 30 nM in a functional assay with human mGluR5. Learn More
  15. Auglurant

    Catalog No. A20958
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    mGlu5 antagonist
    Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human). Auglurant (VU0424238) has an acceptable CNS penetration. Learn More
  16. CHPG sodium salt

    Catalog No. A21968
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    mGluR5 agonist
    CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Learn More
  17. (1R,2S)-VU0155041

    Catalog No. A21933
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    partial mGluR4 agonist
    (1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM. Learn More
  18. Methoxy-PEPy

    Catalog No. A21899
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    mGlu5 receptor antagonist
    Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM. Learn More
  19. (R)-ADX-47273

    Catalog No. A21887
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    mGluR5 positive allosteric modulator
    (R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation . Learn More
  20. L-APB

    Catalog No. A21872
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    mGluRs M3 agonist
    L-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively. Learn More
  21. Mavoglurant racemate

    Catalog No. A21799
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    mGlu5 receptor antagonist
    Mavoglurant (racemate) is the racemate of mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Learn More
  22. LY 541850

    Catalog No. A21651
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    mGlu2 agonist/mGlu3 antagonist
    LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively. Learn More
  23. Basimglurant

    Catalog No. A21225
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    mGlu5 negative allosteric modulator
    Basimglurant (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM. Learn More
  24. MPEP

    Catalog No. A12589
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    mGlu5 receptor antagonist
    MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Learn More
  25. VU0652835

    Catalog No. A18885
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    mGlu5 modulator
    VU0652835 is a metabotropic glutamate receptor subtype 5 (mGlu5) negative allosteric modulator with an IC50 of 81 nM. Learn More
  26. VU6005649

    Catalog No. A17023
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    CNS penetrant mGlu7/8 receptor agonist
    VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively. Learn More
  27. LY2979165

    Catalog No. A11487
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    mGlu2 agonist
    LY2979165 is a mGlu2 agonist. Learn More
  28. VU 0364770

    Catalog No. A12139
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    mGlu4 receptors modulator
    VU 0364770 is a positive allosteric modulator at mGlu4 receptors with EC50 value of 290 nM in mGlu4-expressing HEK 293 cells. Learn More
  29. (S)-3,5-DHPG

    Catalog No. A16108
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    mGluR agonist
    (S)-3,5-DHPG is an agonist of the group I metabotropic glutamate receptors (mGluRs), binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 uM, respectively) but not ionotropic glutamate receptors. Learn More
  30. JNJ-40411813

    Catalog No. A12909
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    mGluR2 PAM
    JNJ-40411813 is a novel mGluR2 PAM. Learn More
  31. LY 379268

    Catalog No. A13123
    mGlu2 receptor agonist
    LY 379268 is a highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Learn More
  32. PHCCC

    Catalog No. A12705
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    mGluR antagonist
    PHCCC is a group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM). Learn More
  33. VU 0364439

    Catalog No. A12664
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    GluR modulator
    VU 0364439 is a positive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4). Learn More
  34. CTEP

    Catalog No. A11968
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    CTEP is a highly potent, selective and orally bioavailable allosteric antagonist of mGlu5 receptor with an IC50 of 2.2 nM. Learn More
  35. VU 0357121

    Catalog No. A11754
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    mGluR5 PAM
    VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Learn More
  36. LY2140023 (LY404039)

    Catalog No. A10544
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    mGluR Agonist
    LY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results. Learn More
  37. BINA

    Catalog No. A11126
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    mGluR2 modulator
    BINA is a selective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). Learn More
  38. ADX-47273

    Catalog No. A11181
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    mGluR5 modulator

    ADX-47273 is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.

    Learn More
  39. SIB 1893

    Catalog No. A13759
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    mGluR antagonist
    SIB 1893 is a highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype. Learn More
  40. SIB 1757

    Catalog No. A13758
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    mGluR antagonist
    SIB 1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype. Learn More
  41. VU 0361737

    Catalog No. A12467
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    mGlu4 receptors modulator
    VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively). Learn More
  42. VU0364289

    Catalog No. A15832
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    mGluR5 Modulator
    VU0364289 is a novel N-aryl piperazine mGlu5 positive allosteric modulator. Learn More
  43. Ibotenic Acid

    Catalog No. A14006
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    NMDA& mGlu receptor agonist
    Ibotenic acid is a neuroexcitatory amino acid originally isolated from Amanita species that functions as a NMDA and metabotropic glutamate receptor agonist. Learn More
  44. Noopept

    Catalog No. A15189
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    Noopept is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic. Learn More
  45. Kainic acid monohydrate

    Catalog No. A13485
    Kainate receptor agonist
    Kainate class of ionotropic glutamate receptor agonist. Has been shown to induce seizures and neurodegeneration in vivo and has also been used to induce experimental epilepsy in rodents and to examine excitation-induced neuronal apoptosis mechanisms. Learn More
  46. A-841720

    Catalog No. A13854
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    mGluR-1 antagonist
    A 841720 is a potent, non-competitive mGluR-1 antagonist that displays 34-fold selectivity over mGluR-5 (IC50 values are 10 and 342 nM respectively). Learn More
  47. LY341495

    Catalog No. A11484
    mGluR-2 antagonist
    LY 341495 has been shown to be a highly potent and selective group II metabotropic glutamate receptor (mGluR-2) antagonist with Ki / IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGluR-2, mGluR-3, mGluR-8 , mGluR-7a, mGluR-1a, mGluR-5a and mGluR-4a. Learn More
  48. JNJ 42153605

    Catalog No. A14330
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    mGluR-2 modulator
    JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor. Learn More
  49. Perampanel

    Catalog No. A12498
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    GluR antagonist
    Perampanel is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials. Learn More
  50. MPEP HCl

    Catalog No. A13236
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    mGlu5 receptor antagonist
    MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 uM. Learn More

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