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$0.00 Metabotropic glutamate receptors (mGluR)
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Eglumegad
Catalog No. A21005 group II (mGlu2/3) receptor agonistEglumegad (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. Learn More -
CBiPES HCl
Catalog No. A15811 mGlu2 receptor modulatorCBiPES hydrochloride is a selective positive allosteric modulator of the mGluR-2 with IC50 value of 98.2 nM Learn More -
DL-AP3
Catalog No. A15378 mGluR1 antagonistDL-AP3, a racemic preparation of D-AP3 and L-AP3, is an inhibitor of phosphoserine phosphatase and an antagonist of the metabotropic glutamate receptor (mGluR), blocking phosphoinositide turnover mediated by the mGluR. Learn More -
MTEP hydrochloride
Catalog No. A15174 mGlu5 antagonistMTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively. Learn More -
CPPHA
Catalog No. A15053 mGluR1 modulatorCPPHA is a selective positive allosteric modulator of mGluR5 receptor. Learn More -
LY2794193
Catalog No. A19131 mGlu3 receptor agonistLY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM??EC50=0.47 nM; hmGlu2 Ki=412 nM??EC50=47.5 nM). Learn More -
BMT-145027
Catalog No. A12457 mGluR5 positive allosteric modulatorBMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM. Learn More -
Lu AF21934
Catalog No. A12140 mGlu4 receptor modulatorLu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an IC50 of 500 nM for human mGlu4. Learn More -
Dipraglurant
Catalog No. A11382 mGluR5 antagonistsDipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM. Learn More -
ADX88178
Catalog No. A20922 mGluR4 PAMADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4. Learn More -
LY2812223
Catalog No. A21100 mGlu2 receptor agonistLY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively). Learn More -
O-Phospho-L-serine
Catalog No. A21159 group III mGluR receptors agonistO-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2. Learn More -
TCN238
Catalog No. A21191 mGlu4 receptor modulatorTCN238 is a positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM. Learn More -
Mavoglurant
Catalog No. A21223 mGlu5 receptor antagonistMavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist, has an IC50 of 30 nM in a functional assay with human mGluR5. Learn More -
Basimglurant
Catalog No. A21225 mGlu5 negative allosteric modulatorBasimglurant (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM. Learn More -
LY 541850
Catalog No. A21651 mGlu2 agonist/mGlu3 antagonistLY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively. Learn More -
Mavoglurant racemate
Catalog No. A21799 mGlu5 receptor antagonistMavoglurant (racemate) is the racemate of mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Learn More -
L-APB
Catalog No. A21872 mGluRs M3 agonistL-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively. Learn More -
(R)-ADX-47273
Catalog No. A21887 mGluR5 positive allosteric modulator(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation . Learn More -
Methoxy-PEPy
Catalog No. A21899 mGlu5 receptor antagonistMethoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM. Learn More -
(1R,2S)-VU0155041
Catalog No. A21933 partial mGluR4 agonist(1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM. Learn More -
CHPG sodium salt
Catalog No. A21968 mGluR5 agonistCHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Learn More -
Auglurant
Catalog No. A20958 mGlu5 antagonistAuglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human). Auglurant (VU0424238) has an acceptable CNS penetration. Learn More -
VU0652835
Catalog No. A18885 mGlu5 modulatorVU0652835 is a metabotropic glutamate receptor subtype 5 (mGlu5) negative allosteric modulator with an IC50 of 81 nM. Learn More -
VU0364289
Catalog No. A15832 mGluR5 ModulatorVU0364289 is a novel N-aryl piperazine mGlu5 positive allosteric modulator. Learn More -
VU6005649
Catalog No. A17023 CNS penetrant mGlu7/8 receptor agonistVU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively. Learn More -
SIB 1757
Catalog No. A13758 mGluR antagonistSIB 1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype. Learn More -
ADX-47273
Catalog No. A11181 mGluR5 modulatorADX-47273 is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.
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BINA
Catalog No. A11126 mGluR2 modulatorBINA is a selective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). Learn More -
LY2140023 (LY404039)
Catalog No. A10544 mGluR AgonistLY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results. Learn More -
VU 0357121
Catalog No. A11754 mGluR5 PAMVU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Learn More -
CTEP
Catalog No. A11968 CTEP is a highly potent, selective and orally bioavailable allosteric antagonist of mGlu5 receptor with an IC50 of 2.2 nM. Learn More -
MPEP
Catalog No. A12589 mGlu5 receptor antagonistMPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Learn More -
VU 0364439
Catalog No. A12664 GluR modulatorVU 0364439 is a positive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4). Learn More -
PHCCC
Catalog No. A12705 mGluR antagonistPHCCC is a group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM). Learn More -
LY 379268
Catalog No. A13123 mGlu2 receptor agonistLY 379268 is a highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Learn More -
JNJ-40411813
Catalog No. A12909 -
SIB 1893
Catalog No. A13759 mGluR antagonistSIB 1893 is a highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype. Learn More -
VU 0364770
Catalog No. A12139 mGlu4 receptors modulatorVU 0364770 is a positive allosteric modulator at mGlu4 receptors with EC50 value of 290 nM in mGlu4-expressing HEK 293 cells. Learn More -
VU 0361737
Catalog No. A12467 mGlu4 receptors modulatorVU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively). Learn More -
MPEP HCl
Catalog No. A13236 mGlu5 receptor antagonistMPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 uM. Learn More -
JNJ 42153605
Catalog No. A14330 mGluR-2 modulatorJNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor. Learn More -
LY341495
Catalog No. A11484 mGluR-2 antagonistLY 341495 has been shown to be a highly potent and selective group II metabotropic glutamate receptor (mGluR-2) antagonist with Ki / IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGluR-2, mGluR-3, mGluR-8 , mGluR-7a, mGluR-1a, mGluR-5a and mGluR-4a. Learn More -
A-841720
Catalog No. A13854 mGluR-1 antagonistA 841720 is a potent, non-competitive mGluR-1 antagonist that displays 34-fold selectivity over mGluR-5 (IC50 values are 10 and 342 nM respectively). Learn More -
Ibotenic Acid
Catalog No. A14006 NMDA& mGlu receptor agonistIbotenic acid is a neuroexcitatory amino acid originally isolated from Amanita species that functions as a NMDA and metabotropic glutamate receptor agonist. Learn More -
Kainic acid monohydrate
Catalog No. A13485 Kainate receptor agonistKainate class of ionotropic glutamate receptor agonist. Has been shown to induce seizures and neurodegeneration in vivo and has also been used to induce experimental epilepsy in rodents and to examine excitation-induced neuronal apoptosis mechanisms. Learn More -
Noopept
Catalog No. A15189 Noopept is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic. Learn More -
(-)-Huperzine A
Catalog No. A10006 GluR inhibitor(-)-Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata. Learn More -
(S)-3,5-DHPG
Catalog No. A16108 mGluR agonist(S)-3,5-DHPG is an agonist of the group I metabotropic glutamate receptors (mGluRs), binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 uM, respectively) but not ionotropic glutamate receptors. Learn More
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