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MZ1
Catalog No. A17014 BRD4 protein degraderMZ1 is a potent inducer of reversible, long-lasting and selective removal of BRD4 over BRD2 and BRD3. Learn More -
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PROTAC BET degrader-2
Catalog No. A18785 PROTAC BET degraderPROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression. Learn More -
dBET57
Catalog No. A19133 BRD4BD1degraderdBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. Learn More -
MZP-55
Catalog No. A19415 BRD3/4 degraderMZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. Learn More -
MZP-54
Catalog No. A19426 BRD3/4 degraderMZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 4 nM for Brd4BD2. Learn More -
dBET1
Catalog No. A16858 BRD4 protein degraderdBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM. Learn More -
THAL-SNS-032
Catalog No. A19088 CDK9 degrader PROTACTHAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). Learn More -
PROTAC Sirt2 Degrader-1
Catalog No. A20005 Sirt2 degraderPROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. Learn More -
BETd-260
Catalog No. A12563 BET degraderBETd-260 is a potent BET degrader based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line. Learn More -
ARV-771
Catalog No. A13255 BET degraderARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively. Learn More -
PROTAC ER Degrader-3
Catalog No. A18519 PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). Learn More -
PROTAC FLT-3 degrader 1
Catalog No. A18682 FLT-3 ITD degraderPROTAC FLT-3 degrader 1 is an FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction. Learn More -
PROTAC CRBN Degrader-1
Catalog No. A18863 CRBN degraderPROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cereblon (CRBN) degrader. Learn More -
PROTAC ERRα Degrader-2
Catalog No. A18904 ERRa degraderPROTAC ERRalpha Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRalpha Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader. Learn More -
PROTAC ERRα Degrader-1
Catalog No. A18910 ERRα DegraderPROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. Learn More -
PROTAC ERRα ligand 2
Catalog No. A18939 ERRα inverse agonistPROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM). Learn More -
FKBP12 PROTAC dTAG-7
Catalog No. A19081 heterobifunctional degraderFKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. Learn More -
A1874
Catalog No. A18735 BRD4-degrading PROTACA1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation. Learn More -
Gefitinib-based PROTAC 3
Catalog No. A19093 Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively. Learn More -
dMCL1-2
Catalog No. A18378 MCL-1/PROTAC degraderdMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1. Learn More -
PROTAC Mcl1 degrader-1
Catalog No. A18373 Mcl-1 inhibitorPROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. Learn More -
PROTAC Bcl2 degrader-1
Catalog No. A18355 degraderPROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. Learn More -
ZXH-3-26
Catalog No. A18399 PROTAC BRD4 degraderZXH-3-26 is a selective PROTAC BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM. Learn More -
ERD-308
Catalog No. A18446 ER PROTAC degraderERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. Learn More -
MT-802
Catalog No. A18589 BTK degraderMT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL). Learn More -
SJFδ
Catalog No. A18599 10-atom linker PROTACSJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17?nM, but does not degrade p38α, p38β, or p38γ. Learn More -
SJFα
Catalog No. A18602 13-atom linker PROTACSJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16??nM, but is far less effective at degrading p38δ (DC50=299?nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5??M. Learn More -
VZ185
Catalog No. A18685 dual BRD7/9 PROTAC degraderVZ185 is a potent, fast, and selective dual BRD7/9 PROTAC degrader with DC50s of 4.5 and 1.8 nM, respectively. Learn More -
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MD-224
Catalog No. A18712 MDM2 degraderMD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent. Learn More -
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