COX

Catalog No.Inhibitor Name COXCOX-1COX-2Other
A10193Celecoxib
****
A10461Ibuprofen
*
*
A10474Indomethacin
**
*
A11918Rofecoxib
****
A10304Diclofenac Sodium
***
***
A11695Lornoxicam
****
****
A10623Naproxen Sodium
*
*
A13342Valdecoxib
****
A11693Tolfenamic Acid
***
A16399Amfenac Sodium Monohydrate
**
***
A11694Nimesulide
*
A12520Meclofenamate Sodium
****
***
A16428Carprofen
****
A10636Nepafenac
A10878Sulindac
A10565Meloxicam
A10820Aspirin
A11906Phenacetin
A10736Piroxicam
A10462Ibuprofen Lysine
A11641Pranoprofen
A10090Asaraldehyde
A11692Acemetacin
A13244Bromfenac Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

45 Item(s)

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  1. ATB 346

    Catalog No. A13983
    COX-2 inhibitor
    ATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity. Learn More
  2. (-)-Epicatechin

    Catalog No. A12043
    COX-1 inhibitor
    (-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1 Learn More
  3. Meclofenamate Sodium

    Catalog No. A12520
    COX inhibitor
    Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM. Learn More
  4. Paradol

    Catalog No. A15205
    COX-1 Inhibitor
    Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects Learn More
  5. Etoricoxib

    Catalog No. A13770
    COX-2 inhibitor
    Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. Learn More
  6. Xanthohumol

    Catalog No. A15919
    COX inhibitor
    Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Learn More
  7. Tepoxalin

    Catalog No. A12879
    COX/5-LOX inhibitor
    Tepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile Learn More
  8. SC 560

    Catalog No. A13023
    COX-1 inhibitor
    SC 560 is a COX-1 selective inhibitor, which can be used as a pharmacological tool to study the role of COX-1-derived PGs in inflammation and pain. Learn More
  9. Radicicol

    Catalog No. A11768
    Hsp90/SRC/COX-2 Inhibitor
    Radicicol is a potent inhibitor of Hsp90, SRC, and Cox-2 Learn More
  10. Fexofenadine HCl

    Catalog No. A11859
    COX inhibitor/histamine H1 receptor agonist
    Fexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist Learn More
  11. Pranoprofen

    Catalog No. A11641
    COX inhibitor
    Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology Learn More
  12. FK 3311

    Catalog No. A13332
    COX-2 Inhibitor
    FK3311 is a cell-permeable and orally available sulfonanilide that acts as a selective COX-2 inhibitor and NSAID. Learn More
  13. Naproxen sodium

    Catalog No. A10623
    COX inhibitor
    Naproxen sodium is a non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress. Learn More
  14. Valdecoxib

    Catalog No. A13342
    COX-2 inhibitor
  15. Acetaminophen

    Catalog No. A10030
    COX inhibitor
  16. Parecoxib

    Catalog No. A13572
    COX-2 inhibitor
    Parecoxib is a potent and selective COX-2 inhibitor. Learn More
  17. Timegadine

    Catalog No. A17108
    COX and lipo-oxygenase inhibitor
    Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets. Learn More
  18. Fenbufen

    Catalog No. A16002
    Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. Learn More
  19. Sulindac (Clinoril)

    Catalog No. A10878
    COX inhibitor
    Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions Learn More
  20. Diflunisal

    Catalog No. A16166
    COX inhibitor
    Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. Learn More
  21. Amfenac Sodium Monohydrate

    Catalog No. A16399
    COX inhibitor
    Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively. Learn More
  22. Ampiroxicam

    Catalog No. A16409
    COX inhibitor
    Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. Learn More
  23. Carprofen

    Catalog No. A16428
    COX-2 inhibitor
    Carprofen reduces inflammation by inhibition of COX-2 and other sources of inflammatory prostaglandins, does not interfere with COX-1 activity. Learn More
  24. Bromfenac sodium

    Catalog No. A13244
    COX-2 inhibitor
    Bromfenac sodium is a topically selective cyclooxygenase (COX)-2 inhibitor Learn More
  25. NS-398

    Catalog No. A13116
    COX-2 inhibitor‎
  26. (S)-(+)-Flurbiprofen

    Catalog No. A12434
    COX inhibitor
    (S)-(+)-Flurbiprofen is a non-selective Cox-1 and Cox-2 inhibitor. Learn More
  27. Nimesulide

    Catalog No. A11694
    COX-2 inhibitor
    Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Learn More
  28. Tolfenamic acid

    Catalog No. A11693
    COX-2 inhibitor
    Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM. It is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine. Learn More
  29. Acemetacin (Emflex)

    Catalog No. A11692
    COX inhibitor
    Acemetacin is a glycolic acid ester of indometacin. It is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. Learn More
  30. Flunixin meglumine

    Catalog No. A11686
    COX inhibitor
    Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity. Learn More
  31. Pravadoline (WIN 48098)

    Catalog No. A10749
    COX inhibitor
    Pravadoline (WIN 48,098) is antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX). Learn More
  32. Celecoxib

    Catalog No. A10193
    COX-2 inhibitor

    Celecoxib is a sulfa non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.

    Learn More
  33. COX-2 inhibitor
    Asaraldehyde is a selective COX-2 inhibitor. Learn More
  34. COX-1 inhibitor
    Ibuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug. Learn More
  35. Lornoxicam (Xefo)

    Catalog No. A11695
    COX inhibitor
    Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor. It is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. Learn More
  36. Licofelone

    Catalog No. A11697
    COX/LOX inhibitor
    Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. Learn More
  37. COX inhibitor
    Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Learn More
  38. Iguratimod (T 614)

    Catalog No. A11464
    COX-2 inhibitor
    Iguratimod(T 614) is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity. Iguratimod(T 614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor. Learn More
  39. Piroxicam (Feldene)

    Catalog No. A10736
    COX inhibitor
    Piroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor. Learn More
  40. COX inhibitor
    Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling. Learn More
  41. Phenacetin

    Catalog No. A11906
    Phenacetin is a non-opioid analgesic without anti-inflammatory properties. Learn More
  42. Rofecoxib (Vioxx)

    Catalog No. A11918
    COX-2 inhibitor
    Rofecoxib (Vioxx) is a?COX-2?inhibitor with?IC5N/A?of 18 nM. Learn More
  43. ATB-337

    Catalog No. A11986
    ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac Learn More
  44. Diclofenac sodium

    Catalog No. A10304
    COX inhibitor
    Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. Learn More
  45. Ibuprofen (Advil)

    Catalog No. A10461
    COX-1 inhibitor
    Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM. Learn More

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