COX

Catalog No.Inhibitor Name COXCOX-1COX-2Other
A10193Celecoxib
****
A10461Ibuprofen
*
*
A10474Indomethacin
**
*
A11918Rofecoxib
****
A10304Diclofenac Sodium
***
***
A11695Lornoxicam
****
****
A10623Naproxen Sodium
*
*
A13342Valdecoxib
****
A11693Tolfenamic Acid
***
A16399Amfenac Sodium Monohydrate
**
***
A11694Nimesulide
*
A12520Meclofenamate Sodium
****
***
A16428Carprofen
****
A10636Nepafenac
A10878Sulindac
A10565Meloxicam
A10820Aspirin
A11906Phenacetin
A10736Piroxicam
A10462Ibuprofen Lysine
A11641Pranoprofen
A10090Asaraldehyde
A11692Acemetacin
A13244Bromfenac Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Items 1 to 50 of 54 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction
  1. Xanthohumol

    Catalog No. A15919
    Quick View
    COX inhibitor
    Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Learn More
  2. SC 560

    Catalog No. A13023
    Quick View
    COX-1 inhibitor
    SC 560 is a COX-1 selective inhibitor, which can be used as a pharmacological tool to study the role of COX-1-derived PGs in inflammation and pain. Learn More
  3. Etoricoxib

    Catalog No. A13770
    Quick View
    COX-2 inhibitor
    Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. Learn More
  4. Paradol

    Catalog No. A15205
    Quick View
    COX-1 Inhibitor
    Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects Learn More
  5. Meclofenamate Sodium

    Catalog No. A12520
    Quick View
    COX inhibitor
    Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM. Learn More
  6. Radicicol

    Catalog No. A11768
    Hsp90/SRC/COX-2 Inhibitor
    Radicicol is a potent inhibitor of Hsp90, SRC, and Cox-2 Learn More
  7. Fexofenadine HCl

    Catalog No. A11859
    Quick View
    COX inhibitor/histamine H1 receptor agonist
    Fexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist Learn More
  8. (-)-Epicatechin

    Catalog No. A12043
    Quick View
    COX-1 inhibitor
    (-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1 Learn More
  9. ATB 346

    Catalog No. A13983
    Quick View
    COX-2 inhibitor
    ATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity. Learn More
  10. Tepoxalin

    Catalog No. A12879
    Quick View
    COX/5-LOX inhibitor
    Tepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile Learn More
  11. Pranoprofen

    Catalog No. A11641
    Quick View
    COX inhibitor
    Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology Learn More
  12. Iguratimod (T 614)

    Catalog No. A11464
    Quick View
    COX-2 inhibitor
    Iguratimod(T 614) is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity. Iguratimod(T 614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor. Learn More
  13. Parecoxib

    Catalog No. A13572
    Quick View
    COX-2 inhibitor
    Parecoxib is a potent and selective COX-2 inhibitor. Learn More
  14. Valdecoxib

    Catalog No. A13342
    Quick View
    COX-2 inhibitor
    Valdecoxib, also known as SC-65872, is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor. Learn More
  15. Metamizole sodium hydrate

    Catalog No. A18270
    Quick View
    COX inhibitor
    Dipyrone, also known as Anador and NSC-73205, is a nonsteroidal anti-inflammatory drug used to treat pain (postoperative, colic, cancer, and migraine). Learn More
  16. Fenbufen

    Catalog No. A16002
    Quick View
    Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. Learn More
  17. Bromfenac sodium hydrate

    Catalog No. A18194
    Quick View
    COX-2 inhibitor
    Bromfenac Sodium Sesquihydrate is a nonsteroidal anti-inflammatory drug (NSAID), which inhibits cyclooxygenase II (COX-2). Learn More
  18. Deracoxib

    Catalog No. A18077
    Quick View
    NSAID and COX-2 inhibitor
    Deracoxib is an NSAID and COX-2 inhibitor used to treat osteoarthritis. It induces cell cycle arrest and apoptosis in mammary tumor cells, decreases platelet aggregation, and lowers inflammatory responses. Learn More
  19. Imrecoxib

    Catalog No. A18027
    Quick View
    COX-2 inhibitor
    Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect. Learn More
  20. Naproxen

    Catalog No. A17550
    Quick View
    COX inhibitor
    Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Learn More
  21. Aceclofenac

    Catalog No. A17433
    Quick View
    COX-2 inhibitor
    Aceclofenac is a cyclooxygenase-2 inhibitor used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Learn More
    • New

    Firocoxib

    Catalog No. A17245
    Quick View
    COX-2 inhibitor
    Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses. Learn More
  22. Ketorolac

    Catalog No. A17248
    Quick View
    COX inhibitor
    Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Learn More
  23. Timegadine

    Catalog No. A17108
    Quick View
    COX and lipo-oxygenase inhibitor
    Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets. Learn More
  24. Carprofen

    Catalog No. A16428
    Quick View
    COX-2 inhibitor
    Carprofen reduces inflammation by inhibition of COX-2 and other sources of inflammatory prostaglandins, does not interfere with COX-1 activity. Learn More
  25. Ampiroxicam

    Catalog No. A16409
    Quick View
    COX inhibitor
    Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. Learn More
  26. Amfenac Sodium Monohydrate

    Catalog No. A16399
    Quick View
    COX inhibitor
    Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively. Learn More
  27. Diflunisal

    Catalog No. A16166
    Quick View
    COX inhibitor
    Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. Learn More
  28. FK 3311

    Catalog No. A13332
    Quick View
    COX-2 Inhibitor
    FK3311 is a cell-permeable and orally available sulfonanilide that acts as a selective COX-2 inhibitor and NSAID. Learn More
  29. Naproxen sodium

    Catalog No. A10623
    Quick View
    COX inhibitor
    Naproxen sodium is a non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress. Learn More
  30. Lornoxicam (Xefo)

    Catalog No. A11695
    Quick View
    COX inhibitor
    Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor. It is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. Learn More
  31. Nimesulide

    Catalog No. A11694
    Quick View
    COX-2 inhibitor
    Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Learn More
  32. Tolfenamic acid

    Catalog No. A11693
    Quick View
    COX-2 inhibitor
    Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM. It is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine. Learn More
  33. Acemetacin (Emflex)

    Catalog No. A11692
    Quick View
    COX inhibitor
    Acemetacin is a glycolic acid ester of indometacin. It is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. Learn More
  34. Flunixin meglumine

    Catalog No. A11686
    Quick View
    COX inhibitor
    Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity. Learn More
  35. Sulindac (Clinoril)

    Catalog No. A10878
    Quick View
    COX inhibitor
    Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions Learn More
  36. Pravadoline (WIN 48098)

    Catalog No. A10749
    Quick View
    COX inhibitor
    Pravadoline (WIN 48,098) is antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX). Learn More
  37. Celecoxib

    Catalog No. A10193
    Quick View
    COX-2 inhibitor

    Celecoxib is a sulfa non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.

    Learn More
  38. Asaraldehyde (Asaronaldehyde)

    Catalog No. A10090
    Quick View
    COX-2 inhibitor
    Asaraldehyde is a selective COX-2 inhibitor. Learn More
  39. Ibuprofen Lysine (NeoProfen)

    Catalog No. A10462
    Quick View
    COX-1 inhibitor
    Ibuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug. Learn More
  40. Licofelone

    Catalog No. A11697
    Quick View
    COX/LOX inhibitor
    Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. Learn More
  41. Diclofenac sodium

    Catalog No. A10304
    Quick View
    COX inhibitor
    Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. Learn More
  42. ATB-337

    Catalog No. A11986
    Quick View
    ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac Learn More
  43. Acetaminophen

    Catalog No. A10030
    Quick View
    COX inhibitor
    Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. Learn More
  44. Bromfenac sodium

    Catalog No. A13244
    Quick View
    COX-2 inhibitor
    Bromfenac sodium is a topically selective cyclooxygenase (COX)-2 inhibitor Learn More
  45. NS-398

    Catalog No. A13116
    Quick View
    COX-2 inhibitor‎
    NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM. Learn More
  46. (S)-(+)-Flurbiprofen

    Catalog No. A12434
    Quick View
    COX inhibitor
    (S)-(+)-Flurbiprofen is a non-selective Cox-1 and Cox-2 inhibitor. Learn More
  47. Jaceosidin

    Catalog No. A12080
    Quick View
    Jaceosidin is a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. Learn More
  48. Piroxicam (Feldene)

    Catalog No. A10736
    Quick View
    COX inhibitor
    Piroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor. Learn More
  49. Phenylbutazone (Butazolidin, Butatron)

    Catalog No. A10720
    Quick View
    COX inhibitor
    Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Learn More

Items 1 to 50 of 54 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction
Rewards