COX

Catalog No.Inhibitor Name COXCOX-1COX-2Other
A10193Celecoxib
****
A10461Ibuprofen
*
*
A10474Indomethacin
**
*
A11918Rofecoxib
****
A10304Diclofenac Sodium
***
***
A11695Lornoxicam
****
****
A10623Naproxen Sodium
*
*
A13342Valdecoxib
****
A11693Tolfenamic Acid
***
A16399Amfenac Sodium Monohydrate
**
***
A11694Nimesulide
*
A12520Meclofenamate Sodium
****
***
A16428Carprofen
****
A10636Nepafenac
A10878Sulindac
A10565Meloxicam
A10820Aspirin
A11906Phenacetin
A10736Piroxicam
A10462Ibuprofen Lysine
A11641Pranoprofen
A10090Asaraldehyde
A11692Acemetacin
A13244Bromfenac Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. ATB 346

    Catalog No. A13983
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    COX-2 inhibitor
    ATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity. Learn More
  2. Paradol

    Catalog No. A15205
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    COX-1 Inhibitor
    Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects Learn More
  3. Flufenamic acid

    Catalog No. A13333
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    COX inhibitor
    Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels. Learn More
  4. Etoricoxib

    Catalog No. A13770
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    COX-2 inhibitor
    Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. Learn More
  5. Xanthohumol

    Catalog No. A15919
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    COX inhibitor
    Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Learn More
  6. Etoricoxib D4

    Catalog No. A21877
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    COX-2 inhibitor
    Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. Learn More
  7. SC 560

    Catalog No. A13023
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    COX-1 inhibitor
    SC 560 is a COX-1 selective inhibitor, which can be used as a pharmacological tool to study the role of COX-1-derived PGs in inflammation and pain. Learn More
  8. Radicicol

    Catalog No. A11768
    Hsp90/SRC/COX-2 Inhibitor
    Radicicol is a potent inhibitor of Hsp90, SRC, and Cox-2 Learn More
  9. Fexofenadine HCl

    Catalog No. A11859
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    COX inhibitor/histamine H1 receptor agonist
    Fexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist Learn More
  10. Meclofenamate Sodium

    Catalog No. A12520
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    COX inhibitor
    Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM. Learn More
  11. Pranoprofen

    Catalog No. A11641
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    COX inhibitor
    Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology Learn More
  12. (-)-Epicatechin

    Catalog No. A12043
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    COX-1 inhibitor
    (-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1 Learn More
  13. Diclofenac

    Catalog No. A17814
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    COX inhibitor
    Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. Learn More
  14. Diclofenac diethylamine

    Catalog No. A16503
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    COX inhibitor
    Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor. Learn More
  15. Naproxen etemesil

    Catalog No. A13052
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    COX-1 and COX-2 inhibitor
    Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Learn More
  16. Aspirin

    Catalog No. A11797
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    COX-1/COX-2 inhibitor
    Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL. Learn More
  17. Eicosatetraynoic acid

    Catalog No. A19008
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    COX/LOX inhibitor
    Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 ?M?? Learn More
  18. GW-406381

    Catalog No. A19118
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    COX-2 inhibitor
    GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Learn More
  19. Tenidap

    Catalog No. A13340
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    COX-1 inhibitor
    Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 ?M and 1.2 ?M for COX-1 and COX-2, respectively. Learn More
  20. Etodolac (AY-24236)

    Catalog No. A10371
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    COX inhibitor
    Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM). Learn More
  21. Tepoxalin

    Catalog No. A12879
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    COX/5-LOX inhibitor
    Tepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile Learn More
  22. Fenbufen

    Catalog No. A16002
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    Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. Learn More
  23. Diflunisal

    Catalog No. A16166
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    COX inhibitor
    Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. Learn More
  24. Amfenac Sodium Monohydrate

    Catalog No. A16399
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    COX inhibitor
    Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively. Learn More
  25. Ampiroxicam

    Catalog No. A16409
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    COX inhibitor
    Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. Learn More
  26. Tolfenamic acid

    Catalog No. A11693
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    COX-2 inhibitor
    Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM. It is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine. Learn More
  27. Metamizole sodium hydrate

    Catalog No. A18270
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    COX inhibitor
    Dipyrone, also known as Anador and NSC-73205, is a nonsteroidal anti-inflammatory drug used to treat pain (postoperative, colic, cancer, and migraine). Learn More
  28. Bromfenac sodium hydrate

    Catalog No. A18194
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    COX-2 inhibitor
    Bromfenac Sodium Sesquihydrate is a nonsteroidal anti-inflammatory drug (NSAID), which inhibits cyclooxygenase II (COX-2). Learn More
  29. Deracoxib

    Catalog No. A18077
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    NSAID and COX-2 inhibitor
    Deracoxib is an NSAID and COX-2 inhibitor used to treat osteoarthritis. It induces cell cycle arrest and apoptosis in mammary tumor cells, decreases platelet aggregation, and lowers inflammatory responses. Learn More
  30. Imrecoxib

    Catalog No. A18027
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    COX-2 inhibitor
    Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect. Learn More
  31. Naproxen

    Catalog No. A17550
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    COX inhibitor
    Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Learn More
  32. Aceclofenac

    Catalog No. A17433
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    COX-2 inhibitor
    Aceclofenac is a cyclooxygenase-2 inhibitor used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Learn More
    • New

    Firocoxib

    Catalog No. A17245
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    COX-2 inhibitor
    Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses. Learn More
  33. Timegadine

    Catalog No. A17108
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    COX and lipo-oxygenase inhibitor
    Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets. Learn More
  34. Carprofen

    Catalog No. A16428
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    COX-2 inhibitor
    Carprofen reduces inflammation by inhibition of COX-2 and other sources of inflammatory prostaglandins, does not interfere with COX-1 activity. Learn More
  35. Ketorolac

    Catalog No. A17248
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    COX inhibitor
    Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Learn More
  36. Parecoxib

    Catalog No. A13572
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    COX-2 inhibitor
    Parecoxib is a potent and selective COX-2 inhibitor. Learn More
  37. ATB-337

    Catalog No. A11986
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    ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac Learn More
  38. Diclofenac sodium

    Catalog No. A10304
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    COX inhibitor
    Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. Learn More
  39. Licofelone

    Catalog No. A11697
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    COX/LOX inhibitor
    Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. Learn More
  40. Lornoxicam (Xefo)

    Catalog No. A11695
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    COX inhibitor
    Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor. It is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. Learn More
  41. Nimesulide

    Catalog No. A11694
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    COX-2 inhibitor
    Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Learn More
  42. Acemetacin (Emflex)

    Catalog No. A11692
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    COX inhibitor
    Acemetacin is a glycolic acid ester of indometacin. It is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. Learn More
  43. Flunixin meglumine

    Catalog No. A11686
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    COX inhibitor
    Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity. Learn More
  44. Sulindac (Clinoril)

    Catalog No. A10878
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    COX inhibitor
    Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions Learn More
  45. Pravadoline (WIN 48098)

    Catalog No. A10749
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    COX inhibitor
    Pravadoline (WIN 48,098) is antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX). Learn More
  46. Celecoxib

    Catalog No. A10193
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    COX-2 inhibitor

    Celecoxib is a sulfa non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.

    Learn More
  47. Asaraldehyde (Asaronaldehyde)

    Catalog No. A10090
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    COX-2 inhibitor
    Asaraldehyde is a selective COX-2 inhibitor. Learn More
  48. Ibuprofen Lysine (NeoProfen)

    Catalog No. A10462
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    COX-1 inhibitor
    Ibuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug. Learn More
  49. Rofecoxib (Vioxx)

    Catalog No. A11918
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    COX-2 inhibitor
    Rofecoxib (Vioxx) is a COX-2 inhibitor with IC50 of 18 nM. Learn More

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