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| Catalog No. | Inhibitor Name | COX | COX-1 | COX-2 | Other |
|---|---|---|---|---|---|
| A10193 | Celecoxib | **** | |||
| A10461 | Ibuprofen | * | * | ||
| A10474 | Indomethacin | ** | * | ||
| A11918 | Rofecoxib | **** | |||
| A10304 | Diclofenac Sodium | *** | *** | ||
| A11695 | Lornoxicam | **** | **** | ||
| A10623 | Naproxen Sodium | * | * | ||
| A13342 | Valdecoxib | **** | |||
| A11693 | Tolfenamic Acid | *** | |||
| A16399 | Amfenac Sodium Monohydrate | ** | *** | ||
| A11694 | Nimesulide | * | |||
| A12520 | Meclofenamate Sodium | **** | *** | ||
| A16428 | Carprofen | **** | |||
| A10636 | Nepafenac | ||||
| A10878 | Sulindac | ||||
| A10565 | Meloxicam | ||||
| A10820 | Aspirin | ||||
| A11906 | Phenacetin | ||||
| A10736 | Piroxicam | ||||
| A10462 | Ibuprofen Lysine | ||||
| A11641 | Pranoprofen | ||||
| A10090 | Asaraldehyde | ||||
| A11692 | Acemetacin | ||||
| A13244 | Bromfenac Sodium |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Etoricoxib D4
Catalog No. A21877 COX-2 inhibitorEtoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. Learn More -
ATB 346
Catalog No. A13983 COX-2 inhibitorATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity. Learn More -
(-)-Epicatechin
Catalog No. A12043 COX-1 inhibitor(-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1 Learn More -
Pranoprofen
Catalog No. A11641 COX inhibitorPranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology Learn More -
Meclofenamate Sodium
Catalog No. A12520 COX inhibitorMeclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM. Learn More -
Paradol
Catalog No. A15205 COX-1 InhibitorParadol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects Learn More -
Flufenamic acid
Catalog No. A13333 COX inhibitorFlufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels. Learn More -
Etoricoxib
Catalog No. A13770 COX-2 inhibitorEtoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. Learn More -
Xanthohumol
Catalog No. A15919 COX inhibitorXanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Learn More -
SC 560
Catalog No. A13023 COX-1 inhibitorSC 560 is a COX-1 selective inhibitor, which can be used as a pharmacological tool to study the role of COX-1-derived PGs in inflammation and pain. Learn More -
Tepoxalin
Catalog No. A12879 COX/5-LOX inhibitorTepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile Learn More -
Fexofenadine HCl
Catalog No. A11859 COX inhibitor/histamine H1 receptor agonistFexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist Learn More -
Radicicol
Catalog No. A11768 Hsp90/SRC/COX-2 InhibitorRadicicol is a potent inhibitor of Hsp90, SRC, and Cox-2 Learn More -
Diclofenac
Catalog No. A17814 COX inhibitorDiclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. Learn More -
Diclofenac diethylamine
Catalog No. A16503 COX inhibitorDiclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor. Learn More -
Naproxen etemesil
Catalog No. A13052 COX-1 and COX-2 inhibitorNaproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Learn More -
Aspirin
Catalog No. A11797 COX-1/COX-2 inhibitorAspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL. Learn More -
Eicosatetraynoic acid
Catalog No. A19008 COX/LOX inhibitorEicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 ?M?? Learn More -
GW-406381
Catalog No. A19118 COX-2 inhibitorGW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Learn More -
Tenidap
Catalog No. A13340 COX-1 inhibitorTenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 ?M and 1.2 ?M for COX-1 and COX-2, respectively. Learn More -
Etodolac (AY-24236)
Catalog No. A10371 COX inhibitorEtodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM). Learn More -
Amfenac Sodium Monohydrate
Catalog No. A16399 COX inhibitorAmfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively. Learn More -
Parecoxib
Catalog No. A13572 -
Fenbufen
Catalog No. A16002 Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. Learn More -
Diflunisal
Catalog No. A16166 COX inhibitorDiflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. Learn More -
Imrecoxib
Catalog No. A18027 COX-2 inhibitorImrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect. Learn More -
Metamizole sodium hydrate
Catalog No. A18270 COX inhibitorDipyrone, also known as Anador and NSC-73205, is a nonsteroidal anti-inflammatory drug used to treat pain (postoperative, colic, cancer, and migraine). Learn More -
Ampiroxicam
Catalog No. A16409 COX inhibitorAmpiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. Learn More -
Carprofen
Catalog No. A16428 COX-2 inhibitorCarprofen reduces inflammation by inhibition of COX-2 and other sources of inflammatory prostaglandins, does not interfere with COX-1 activity. Learn More -
Bromfenac sodium hydrate
Catalog No. A18194 COX-2 inhibitorBromfenac Sodium Sesquihydrate is a nonsteroidal anti-inflammatory drug (NSAID), which inhibits cyclooxygenase II (COX-2). Learn More -
Deracoxib
Catalog No. A18077 NSAID and COX-2 inhibitorDeracoxib is an NSAID and COX-2 inhibitor used to treat osteoarthritis. It induces cell cycle arrest and apoptosis in mammary tumor cells, decreases platelet aggregation, and lowers inflammatory responses. Learn More -
Timegadine
Catalog No. A17108 COX and lipo-oxygenase inhibitorTimegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets. Learn More -
Ketorolac
Catalog No. A17248 COX inhibitorKetorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Learn More -
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New
Firocoxib
Catalog No. A17245 COX-2 inhibitorFirocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses. Learn More -
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Aceclofenac
Catalog No. A17433 COX-2 inhibitorAceclofenac is a cyclooxygenase-2 inhibitor used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Learn More -
Naproxen
Catalog No. A17550 COX inhibitorNaproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Learn More -
Rofecoxib (Vioxx)
Catalog No. A11918 COX-2 inhibitorRofecoxib (Vioxx) is a COX-2 inhibitor with IC50 of 18 nM. Learn More -
Ibuprofen Lysine (NeoProfen)
Catalog No. A10462 COX-1 inhibitorIbuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug. Learn More -
Asaraldehyde (Asaronaldehyde)
Catalog No. A10090 -
Celecoxib
Catalog No. A10193 COX-2 inhibitorCelecoxib is a sulfa non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.
Learn More -
Pravadoline (WIN 48098)
Catalog No. A10749 COX inhibitorPravadoline (WIN 48,098) is antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX). Learn More -
Sulindac (Clinoril)
Catalog No. A10878 COX inhibitorSulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions Learn More -
Flunixin meglumine
Catalog No. A11686 COX inhibitorFlunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity. Learn More -
Acemetacin (Emflex)
Catalog No. A11692 COX inhibitorAcemetacin is a glycolic acid ester of indometacin. It is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. Learn More -
Tolfenamic acid
Catalog No. A11693 COX-2 inhibitorTolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM. It is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine. Learn More -
Nimesulide
Catalog No. A11694 COX-2 inhibitorNimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Learn More -
Lornoxicam (Xefo)
Catalog No. A11695 COX inhibitorLornoxicam is a non-steroidal COX-1/COX-2 inhibitor. It is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. Learn More -
Licofelone
Catalog No. A11697 COX/LOX inhibitorLicofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. Learn More -
Diclofenac sodium
Catalog No. A10304 COX inhibitorDiclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. Learn More -
ATB-337
Catalog No. A11986 ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac Learn More
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