COX

Catalog No.Inhibitor Name COXCOX-1COX-2Other
A10193Celecoxib
****
A10461Ibuprofen
*
*
A10474Indomethacin
**
*
A11918Rofecoxib
****
A10304Diclofenac Sodium
***
***
A11695Lornoxicam
****
****
A10623Naproxen Sodium
*
*
A13342Valdecoxib
****
A11693Tolfenamic Acid
***
A16399Amfenac Sodium Monohydrate
**
***
A11694Nimesulide
*
A12520Meclofenamate Sodium
****
***
A16428Carprofen
****
A10636Nepafenac
A10878Sulindac
A10565Meloxicam
A10820Aspirin
A11906Phenacetin
A10736Piroxicam
A10462Ibuprofen Lysine
A11641Pranoprofen
A10090Asaraldehyde
A11692Acemetacin
A13244Bromfenac Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Diclofenac

    Catalog No. A17814
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    COX inhibitor
    Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. Learn More
  2. ATB 346

    Catalog No. A13983
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    COX-2 inhibitor
    ATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity. Learn More
  3. (-)-Epicatechin

    Catalog No. A12043
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    COX-1 inhibitor
    (-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1 Learn More
  4. Pranoprofen

    Catalog No. A11641
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    COX inhibitor
    Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology Learn More
  5. Parecoxib

    Catalog No. A13572
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    COX-2 inhibitor
    Parecoxib is a potent and selective COX-2 inhibitor. Learn More
  6. Valdecoxib

    Catalog No. A13342
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    COX-2 inhibitor
    Valdecoxib, also known as SC-65872, is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor. Learn More
  7. Flufenamic acid

    Catalog No. A13333
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    COX inhibitor
    Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels. Learn More
  8. FK 3311

    Catalog No. A13332
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    COX-2 Inhibitor
    FK3311 is a cell-permeable and orally available sulfonanilide that acts as a selective COX-2 inhibitor and NSAID. Learn More
  9. Naproxen sodium

    Catalog No. A10623
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    COX inhibitor
    Naproxen sodium is a non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress. Learn More
  10. Acetaminophen

    Catalog No. A10030
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    COX inhibitor
    Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. Learn More
  11. Bromfenac sodium

    Catalog No. A13244
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    COX-2 inhibitor
    Bromfenac sodium is a topically selective cyclooxygenase (COX)-2 inhibitor Learn More
  12. Meclofenamate Sodium

    Catalog No. A12520
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    COX inhibitor
    Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM. Learn More
  13. Paradol

    Catalog No. A15205
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    COX-1 Inhibitor
    Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects Learn More
  14. Etoricoxib

    Catalog No. A13770
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    COX-2 inhibitor
    Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. Learn More
  15. Diclofenac diethylamine

    Catalog No. A16503
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    COX inhibitor
    Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor. Learn More
  16. Naproxen etemesil

    Catalog No. A13052
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    COX-1 and COX-2 inhibitor
    Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Learn More
  17. Aspirin

    Catalog No. A11797
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    COX-1/COX-2 inhibitor
    Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL. Learn More
  18. Eicosatetraynoic acid

    Catalog No. A19008
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    COX/LOX inhibitor
    Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 ?M?? Learn More
  19. GW-406381

    Catalog No. A19118
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    COX-2 inhibitor
    GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Learn More
  20. Tenidap

    Catalog No. A13340
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    COX-1 inhibitor
    Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 ?M and 1.2 ?M for COX-1 and COX-2, respectively. Learn More
  21. Etodolac (AY-24236)

    Catalog No. A10371
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    COX inhibitor
    Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM). Learn More
  22. Etoricoxib D4

    Catalog No. A21877
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    COX-2 inhibitor
    Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. Learn More
  23. SC 560

    Catalog No. A13023
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    COX-1 inhibitor
    SC 560 is a COX-1 selective inhibitor, which can be used as a pharmacological tool to study the role of COX-1-derived PGs in inflammation and pain. Learn More
  24. Xanthohumol

    Catalog No. A15919
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    COX inhibitor
    Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Learn More
  25. NS-398

    Catalog No. A13116
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    COX-2 inhibitor‎
    NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM. Learn More
  26. (S)-(+)-Flurbiprofen

    Catalog No. A12434
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    COX inhibitor
    (S)-(+)-Flurbiprofen is a non-selective Cox-1 and Cox-2 inhibitor. Learn More
  27. Lornoxicam (Xefo)

    Catalog No. A11695
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    COX inhibitor
    Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor. It is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. Learn More
  28. Ibuprofen Lysine (NeoProfen)

    Catalog No. A10462
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    COX-1 inhibitor
    Ibuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug. Learn More
  29. Nimesulide

    Catalog No. A11694
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    COX-2 inhibitor
    Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Learn More
  30. Asaraldehyde (Asaronaldehyde)

    Catalog No. A10090
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    COX-2 inhibitor
    Asaraldehyde is a selective COX-2 inhibitor. Learn More
  31. Celecoxib

    Catalog No. A10193
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    COX-2 inhibitor

    Celecoxib is a sulfa non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.

    Learn More
  32. Pravadoline (WIN 48098)

    Catalog No. A10749
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    COX inhibitor
    Pravadoline (WIN 48,098) is antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX). Learn More
  33. Sulindac (Clinoril)

    Catalog No. A10878
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    COX inhibitor
    Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions Learn More
  34. Flunixin meglumine

    Catalog No. A11686
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    COX inhibitor
    Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity. Learn More
  35. Tolfenamic acid

    Catalog No. A11693
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    COX-2 inhibitor
    Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM. It is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine. Learn More
  36. Acemetacin (Emflex)

    Catalog No. A11692
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    COX inhibitor
    Acemetacin is a glycolic acid ester of indometacin. It is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. Learn More
  37. Licofelone

    Catalog No. A11697
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    COX/LOX inhibitor
    Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. Learn More
  38. Diclofenac sodium

    Catalog No. A10304
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    COX inhibitor
    Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. Learn More
  39. ATB-337

    Catalog No. A11986
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    ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac Learn More
  40. Tepoxalin

    Catalog No. A12879
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    COX/5-LOX inhibitor
    Tepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile Learn More
  41. Ibuprofen (Advil)

    Catalog No. A10461
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    COX-1 inhibitor
    Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM. Learn More
  42. Iguratimod (T 614)

    Catalog No. A11464
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    COX-2 inhibitor
    Iguratimod(T 614) is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity. Iguratimod(T 614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor. Learn More
  43. Fexofenadine HCl

    Catalog No. A11859
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    COX inhibitor/histamine H1 receptor agonist
    Fexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist Learn More
  44. Radicicol

    Catalog No. A11768
    Hsp90/SRC/COX-2 Inhibitor
    Radicicol is a potent inhibitor of Hsp90, SRC, and Cox-2 Learn More
  45. Piroxicam (Feldene)

    Catalog No. A10736
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    COX inhibitor
    Piroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor. Learn More
  46. Phenylbutazone (Butazolidin, Butatron)

    Catalog No. A10720
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    COX inhibitor
    Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Learn More
  47. Indomethacin (Indocid, Indocin)

    Catalog No. A10474
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    COX inhibitor
    Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling. Learn More
  48. Phenacetin

    Catalog No. A11906
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    Phenacetin is a non-opioid analgesic without anti-inflammatory properties. Learn More
  49. Rofecoxib (Vioxx)

    Catalog No. A11918
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    COX-2 inhibitor
    Rofecoxib (Vioxx) is a COX-2 inhibitor with IC50 of 18 nM. Learn More
  50. Metamizole sodium hydrate

    Catalog No. A18270
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    COX inhibitor
    Dipyrone, also known as Anador and NSC-73205, is a nonsteroidal anti-inflammatory drug used to treat pain (postoperative, colic, cancer, and migraine). Learn More

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