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| Catalog No. | Inhibitor Name | COX | COX-1 | COX-2 | Other |
|---|---|---|---|---|---|
| A10193 | Celecoxib | **** | |||
| A10461 | Ibuprofen | * | * | ||
| A10474 | Indomethacin | ** | * | ||
| A11918 | Rofecoxib | **** | |||
| A10304 | Diclofenac Sodium | *** | *** | ||
| A11695 | Lornoxicam | **** | **** | ||
| A10623 | Naproxen Sodium | * | * | ||
| A13342 | Valdecoxib | **** | |||
| A11693 | Tolfenamic Acid | *** | |||
| A16399 | Amfenac Sodium Monohydrate | ** | *** | ||
| A11694 | Nimesulide | * | |||
| A12520 | Meclofenamate Sodium | **** | *** | ||
| A16428 | Carprofen | **** | |||
| A10636 | Nepafenac | ||||
| A10878 | Sulindac | ||||
| A10565 | Meloxicam | ||||
| A10820 | Aspirin | ||||
| A11906 | Phenacetin | ||||
| A10736 | Piroxicam | ||||
| A10462 | Ibuprofen Lysine | ||||
| A11641 | Pranoprofen | ||||
| A10090 | Asaraldehyde | ||||
| A11692 | Acemetacin | ||||
| A13244 | Bromfenac Sodium |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Etoricoxib
Catalog No. A13770 COX-2 inhibitorEtoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. Learn More -
Bromfenac sodium
Catalog No. A13244 COX-2 inhibitorBromfenac sodium is a topically selective cyclooxygenase (COX)-2 inhibitor Learn More -
Acetaminophen
Catalog No. A10030 COX inhibitorAcetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. Learn More -
Naproxen sodium
Catalog No. A10623 COX inhibitorNaproxen sodium is a non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress. Learn More -
FK 3311
Catalog No. A13332 COX-2 InhibitorFK3311 is a cell-permeable and orally available sulfonanilide that acts as a selective COX-2 inhibitor and NSAID. Learn More -
Flufenamic acid
Catalog No. A13333 COX inhibitorFlufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels. Learn More -
Valdecoxib
Catalog No. A13342 COX-2 inhibitorValdecoxib, also known as SC-65872, is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor. Learn More -
Ibuprofen (Advil)
Catalog No. A10461 COX-1 inhibitorIbuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM. Learn More -
Pranoprofen
Catalog No. A11641 COX inhibitorPranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology Learn More -
(-)-Epicatechin
Catalog No. A12043 COX-1 inhibitor(-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1 Learn More -
ATB 346
Catalog No. A13983 COX-2 inhibitorATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity. Learn More -
Meclofenamate Sodium
Catalog No. A12520 COX inhibitorMeclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM. Learn More -
Paradol
Catalog No. A15205 COX-1 InhibitorParadol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects Learn More -
Parecoxib
Catalog No. A13572 -
Xanthohumol
Catalog No. A15919 COX inhibitorXanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Learn More -
SC 560
Catalog No. A13023 COX-1 inhibitorSC 560 is a COX-1 selective inhibitor, which can be used as a pharmacological tool to study the role of COX-1-derived PGs in inflammation and pain. Learn More -
Etodolac (AY-24236)
Catalog No. A10371 COX inhibitorEtodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM). Learn More -
Tenidap
Catalog No. A13340 COX-1 inhibitorTenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 ?M and 1.2 ?M for COX-1 and COX-2, respectively. Learn More -
GW-406381
Catalog No. A19118 COX-2 inhibitorGW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Learn More -
Eicosatetraynoic acid
Catalog No. A19008 COX/LOX inhibitorEicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 ?M?? Learn More -
Aspirin
Catalog No. A11797 COX-1/COX-2 inhibitorAspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL. Learn More -
Naproxen etemesil
Catalog No. A13052 COX-1 and COX-2 inhibitorNaproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Learn More -
Diclofenac diethylamine
Catalog No. A16503 COX inhibitorDiclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor. Learn More -
Diclofenac
Catalog No. A17814 COX inhibitorDiclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. Learn More -
Etoricoxib D4
Catalog No. A21877 COX-2 inhibitorEtoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. Learn More -
(S)-(+)-Flurbiprofen
Catalog No. A12434 COX inhibitor(S)-(+)-Flurbiprofen is a non-selective Cox-1 and Cox-2 inhibitor. Learn More -
Ibuprofen Lysine (NeoProfen)
Catalog No. A10462 COX-1 inhibitorIbuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug. Learn More -
Asaraldehyde (Asaronaldehyde)
Catalog No. A10090 -
Celecoxib
Catalog No. A10193 COX-2 inhibitorCelecoxib is a sulfa non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.
Learn More -
Pravadoline (WIN 48098)
Catalog No. A10749 COX inhibitorPravadoline (WIN 48,098) is antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX). Learn More -
Sulindac (Clinoril)
Catalog No. A10878 COX inhibitorSulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions Learn More -
Flunixin meglumine
Catalog No. A11686 COX inhibitorFlunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity. Learn More -
Acemetacin (Emflex)
Catalog No. A11692 COX inhibitorAcemetacin is a glycolic acid ester of indometacin. It is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. Learn More -
Tolfenamic acid
Catalog No. A11693 COX-2 inhibitorTolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM. It is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine. Learn More -
Nimesulide
Catalog No. A11694 COX-2 inhibitorNimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Learn More -
Lornoxicam (Xefo)
Catalog No. A11695 COX inhibitorLornoxicam is a non-steroidal COX-1/COX-2 inhibitor. It is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. Learn More -
Licofelone
Catalog No. A11697 COX/LOX inhibitorLicofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. Learn More -
Diclofenac sodium
Catalog No. A10304 COX inhibitorDiclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. Learn More -
Rofecoxib (Vioxx)
Catalog No. A11918 COX-2 inhibitorRofecoxib (Vioxx) is a COX-2 inhibitor with IC50 of 18 nM. Learn More -
NS-398
Catalog No. A13116 COX-2 inhibitorNS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM. Learn More -
Tepoxalin
Catalog No. A12879 COX/5-LOX inhibitorTepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile Learn More -
Iguratimod (T 614)
Catalog No. A11464 COX-2 inhibitorIguratimod(T 614) is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity. Iguratimod(T 614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor. Learn More -
Fexofenadine HCl
Catalog No. A11859 COX inhibitor/histamine H1 receptor agonistFexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist Learn More -
Radicicol
Catalog No. A11768 Hsp90/SRC/COX-2 InhibitorRadicicol is a potent inhibitor of Hsp90, SRC, and Cox-2 Learn More -
Piroxicam (Feldene)
Catalog No. A10736 COX inhibitorPiroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor. Learn More -
Phenylbutazone (Butazolidin, Butatron)
Catalog No. A10720 COX inhibitorPhenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Learn More -
Indomethacin (Indocid, Indocin)
Catalog No. A10474 COX inhibitorIndomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling. Learn More -
ATB-337
Catalog No. A11986 ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac Learn More -
Phenacetin
Catalog No. A11906 Phenacetin is a non-opioid analgesic without anti-inflammatory properties. Learn More -
Timegadine
Catalog No. A17108 COX and lipo-oxygenase inhibitorTimegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets. Learn More
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