ALK



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Catalog No. Product Name Application Product Information
A14436

A 77-01

ALK5 inhibitor
A 77-01 is a potent inhibitor of TGF-?? type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
A11948 SALE

AP26113

ALK inhibitor
AP26113 has exhibited activity as a potent dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR).
A11773

ASP3026

ALK inhibitor
ASP3026 is a novel and selective inhibitor for the ALK kinase. ASP3026 potently inhibited ALK kinase activity and was more selective than crizotinib in a Tyr-kinase panel.
A13065

AZD3463

ALK/IGF1R inhibitor
AZD-3463 is a ALK/IGF1R inhibitor.
A13450

Brigatinib

ALK Inhibitor
Brigatinib is a highly potent and selective investigational ALK inhibitor with mean IC50 value ?? 100 nM in Ba/F3 cells.
A13744

CEP-28122

ALK inhibitor
CEP-28122 is a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers.
A15543

CEP-37440

FAK/ALK inhibitor
CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).
A11134 SALE

CH5424802

ALK Inhibitor
CH5424802 is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK.
A16245

Crizotinib hydrochloride

c-Met/NPM-ALK inhibitor
Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK.
A15801

Entrectinib

TRK, ROS1, ALK inhibitor
Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.
A14213 SALE

EW-7197

ALK4/ALK5 inhibitor
EW-7197 is a highly potent, selective, and orally bioavailable TGF-?? I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively
A11175 SALE

GSK1838705A

IGF-1R Inhibitor

GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.

A11083 SALE

GW788388

TGF-beta/Smad inhibitor
GW788388 is a potent, orally active and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5).
A16267

HG-14-10-04

ALK inhibitor
HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM.
A15511

KRCA-0008

ACK1/ALK inhibitor
KRCA-0008 is a potent and selective ALK/Ack1 inhibitor with IC50 of 12 nM/4 nM for ALK and Ack1 respectively; displays drug-like properties without hERG liability.
A13238 SALE

LDK-378

ALK Inhibitor
LDK378 is a highly selective, orally bioavailable and ATP-competitive small molecule inhibitor of ALK (Anaplastic Lymphoma Kinase), a receptor tyrosine kinase considered to be an important lung cancer drug target.
A15142

LDK378 dihydrochloride

ALK inhibitor
LDK378 dihydrochloride is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
A16096

LDN-214117

ALK2 inhibitor
LDN-214117 is a selective and potent ALK2 inhibitor. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM.
A11205 SALE

LDN193189

ALK inhibitor
LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.
A14207

PF-06463922

ALK inhibitor
PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
A10712 SALE

PF-2341066 (Crizotinib)

ALK/ c-Met inhibitor
PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
A16207

R-268712

ALK5 inhibitor
R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.
A10826 SALE

SB 431542

TGF-beta/Smad inhibitor
SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 .
A10827 SALE

SB 525334

ALK Inhibitor
SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells
A11157 SALE

SB-505124

ALK5 inhibitor
SB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively).

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