ALK

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  1. Inhibitor (21)


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Catalog No. Product Name Product Information
A14436

A 77-01

A 77-01 is a potent inhibitor of TGF-?? type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
A11948

AP26113

AP26113 has exhibited activity as a potent dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR).
A11773

ASP3026

ASP3026 is a novel and selective inhibitor for the ALK kinase. ASP3026 potently inhibited ALK kinase activity and was more selective than crizotinib in a Tyr-kinase panel.
A13065

AZD3463

AZD-3463 is a ALK/IGF1R inhibitor.
A13450

Brigatinib

Brigatinib is a highly potent and selective investigational ALK inhibitor with mean IC50 value ?? 100 nM in Ba/F3 cells.
A13744

CEP-28122

CEP-28122 is a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers.
A15543

CEP-37440

CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).
A11134

CH5424802

CH5424802 is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK.
A16245

Crizotinib hydrochloride

Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK.
A15801

Entrectinib

Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.
A14213

EW-7197

EW-7197 is a highly potent, selective, and orally bioavailable TGF-?? I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively
A11175

GSK1838705A

GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.

A11083

GW788388

GW788388 is a potent, orally active and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5).
A16267

HG-14-10-04

HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM.
A15511

KRCA-0008

KRCA-0008 is a potent and selective ALK/Ack1 inhibitor with IC50 of 12 nM/4 nM for ALK and Ack1 respectively; displays drug-like properties without hERG liability.
A13238

LDK-378

LDK378 is a highly selective, orally bioavailable and ATP-competitive small molecule inhibitor of ALK (Anaplastic Lymphoma Kinase), a receptor tyrosine kinase considered to be an important lung cancer drug target.
A15142

LDK378 dihydrochloride

LDK378 dihydrochloride is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
A16096

LDN-214117

LDN-214117 is a selective and potent ALK2 inhibitor. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM.
A11205

LDN193189

LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.
A14207

PF-06463922

PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
A10712

PF-2341066 (Crizotinib)

PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
A16207

R-268712

R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.
A10826

SB 431542

SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 .
A10827

SB 525334

SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells
A11157

SB-505124

SB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively).

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