NF-kB/IkB

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  1. Givinostat

    Catalog No. A21126
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    HDAC inhibitor
    Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Learn More
  2. HDAC-IN-7

    Catalog No. A21252
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    HDAC1/2/3/10 inhibitor
    HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor. Learn More
  3. Givinostat hydrochloride

    Catalog No. A21487
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    HDAC inhibitor
    Givinostat hydrochloride (ITF-2357 hydrochloride) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Learn More
  4. Nanatinostat

    Catalog No. A21625
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    HDAC inhibitor
    Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM. Learn More
  5. Belinostat

    Catalog No. A21772
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    HDAC inhibitor
    Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts. Learn More
  6. HDAC-IN-5

    Catalog No. A20972
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    HDAC inhibitor
    HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor. Learn More
  7. Domatinostat tosylate

    Catalog No. A20986
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    HDAC1 inhibitor
    Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Learn More
  8. Nexturastat A

    Catalog No. A14032
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    HDAC6 inhibitor
    Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM). Learn More
  9. HPOB

    Catalog No. A14197
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    HDAC6 inhibitor
    HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM). Learn More
  10. Splitomicin

    Catalog No. A14221
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    NAD(+)-dependent histone deacetylase Sir2p inhibitor
    Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 uM, showing a higher activity in a cell-based assay. Learn More
  11. Tasquinimod

    Catalog No. A12616
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    HDAC4 inhibitor
    Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Learn More
  12. Santacruzamate A

    Catalog No. A14236
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    HDAC inhibitor
    Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs. Learn More
  13. LMK-235

    Catalog No. A14341
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    HDAC4/5 inhibitor
    LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor. Learn More
  14. ST7612AA1

    Catalog No. A14418
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    HDAC inhibitor
    ST7612AA1 is a new and potent HDAC inhibitor with potential anticancer activity. Learn More
  15. Domatinostat (4SC-202)

    Catalog No. A14354
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    HDAC inhibitor
    4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. Learn More
  16. TMP 195

    Catalog No. A14326
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    HDAC inhibitor
    TMP195 is the most potent and selective class IIa HDAC inhibitor. Learn More
  17. UF010

    Catalog No. A15781
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    HADC inhibitor
    UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 uM, 0.1 uM, 0.5 uM and 1.5 uM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs. Learn More
  18. HDAC inhibitor

    Catalog No. A13405
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    HDAC inhibitor
  19. SR-4370

    Catalog No. A16899
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    HDAC inhibitor
    SR-4370 is an HDAC inhibitor. SR-4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. Learn More
  20. HDAC8-IN-1

    Catalog No. A17091
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    HDAC8 inhibitor
    HDAC8-IN-1, is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. Learn More
  21. Tinostamustine (EDO-S101)

    Catalog No. A18342
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    HDAC inhibitor
    EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. Learn More
  22. SKLB-23bb

    Catalog No. A18339
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    HDAC6 inhibitor
    SKLB-23bb is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively. Learn More
  23. Valproic acid

    Catalog No. A17323
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    HDAC inhibitor
    Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Learn More
  24. Tucidinostat (Chidamide)

    Catalog No. A17861
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    HDAC inhibitor
    Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9. Learn More
  25. CM-675

    Catalog No. A18741
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    PDE5/HDAC-1 inhibitor
    CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. Learn More
  26. SIS-17

    Catalog No. A18463
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    HDAC 11 inhibitor
    SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. Learn More
  27. Ac-Lys-AMC

    Catalog No. A18461
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    fluorescent substrate for HDAC
    Ac-Lys-AMC (Hexanamide), also termed MAL, is a fluorescent substrate for histone deacetylase HDACs. Learn More
  28. AES-135

    Catalog No. A19087
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    HDAC inhibitor
    AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 with IC50s of 654, 190, and 636 nM, respectively. Anti-tumor activity. Learn More
  29. MPT0E028

    Catalog No. A18982
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    HDAC inhibitor
    MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. Learn More
  30. SS-208

    Catalog No. A18952
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    HDAC6 inhibitor
    SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma. Learn More
  31. SW-100

    Catalog No. A18947
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    HDAC6 inhibitor
    SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. Learn More
  32. CHDI-390576

    Catalog No. A18899
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    HDAC inhibitor
    CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. Learn More
  33. ACY-775

    Catalog No. A12456
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    HDAC6 inhibitor
    ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5?nM. Learn More
  34. Remetinostat

    Catalog No. A12149
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    HDAC inhibitor
    Remetinostat (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma. Learn More
  35. CXD101

    Catalog No. A12253
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    HDAC inhibitor
    CXD101 is a class I-selective HDAC inhibitor (HDAC1 (IC50, 63 nM), HDAC2 (IC50, 570 nM), HDAC3 (IC50, 550 nM). CXD101 has no activity against HDAC class II. Learn More
  36. BRD-6929

    Catalog No. A12511
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    HDAC1/HDAC2 inhibitor
    BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50=?1 and 8 nM), extracted from patent US2018360927. Learn More
  37. HDACs/mTOR Inhibitor 1

    Catalog No. A13462
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    HDACs/mTOR Inhibitor 1
    HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies. Learn More
  38. Sulforaphane

    Catalog No. A21984
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    HDAC inhibitor
    Sulforaphane activates Nrf2 and inhibits high glucose-induced progression of pancreatic cancer via AMPK dependent signaling. Sulforaphane has shown anti-cancer and anti-inflammatory activities. Learn More

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