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JW74
Catalog No. A16219 Wnt inhibitorJW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM. Learn More -
Hexachlorophene
Catalog No. A16217 Wnt/beta-catenin inhibitorHexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 uM; also is an inhibitor of Wnt/beta-catenin signaling. Learn More -
CCT251545
Catalog No. A16216 Wnt inhibitorCCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM. Learn More -
IWP-3
Catalog No. A13192 Wnt inhibitorIWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM). Learn More -
WAY-262611
Catalog No. A16094 Wnt pathway activatorWAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay. Learn More -
IQ-1
Catalog No. A16064 Wnt/beta-catenin inhibitorIQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/beta-catenin signaling. Learn More -
ETC-159
Catalog No. A15840 Wnt inhibitorETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits beta-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM. Learn More -
BML-284 (Wnt agonist 1)
Catalog No. A15851 Wnt agonist 1Wnt agonist 1 is a cell-permeable Wnt signaling activator. It nduces beta-catenin and TCF-dependent transcriptional activity with EC50 value of 0.7 uM. Learn More -
iCRT3
Catalog No. A16847 Wnt/β-catenin antagonistiCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays. Learn More -
KYA1797K
Catalog No. A16353 Wnt/beta-catenin inhibitorKYA1797K is a highly potent and selective Wnt/beta-catenin inhibitor with IC50 of 0.75 μM (TOPflash assay). Learn More -
Longdaysin
Catalog No. A21022 Wnt/β-catenin signaling inhibitorLongdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Learn More -
LF3
Catalog No. A16851 Wnt inhibitorLF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. Learn More -
IWP-4
Catalog No. A17004 Wnt/β-catenin signaling inhibitorIWP-4 is a novel potent inhibitor of Wnt/β-catenin signaling. Learn More -
pyrvinium
Catalog No. A17784 Wnt inhibitorPyrvinium pamoate is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling. Learn More -
Wnt/β-catenin agonist 1
Catalog No. A18689 Wnt/β-catenin agonistWnt/β-catenin agonist 1 is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM. Learn More -
HLY78
Catalog No. A18402 Wnt/β-catenin activatorHLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction. Learn More -
SKL2001
Catalog No. A16707 Wnt/β-catenin agonistSKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction. Learn More -
ICG-001
Catalog No. A11039 Wnt/beta-catenin inhibitorICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) . Learn More -
Cardiogenol C HCl
Catalog No. A16198 Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 uM. Cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Learn More -
Salinomycin sodium salt
Catalog No. A15229 Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Learn More -
IWP-L6
Catalog No. A13978 PORCN inhibitorIWP-L6 is a potent inhibitor of Porcupine (Porcn), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Learn More -
Wnt-C59
Catalog No. A12951 PORCN/Wnt inhibitorWnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. Learn More -
IWP-2
Catalog No. A12707 Wnt inhibitorIWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent. Learn More -
IWR-1-endo
Catalog No. A12737 Wnt inhibitorIWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. Learn More -
LGK-974
Catalog No. A12816 PORCN inhibitorLGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay. Learn More -
KY02111
Catalog No. A12362 Wnt inhibitorKY02111 is a potent and selective Wnt signaling pathway inhibitor discovered by a cell-based screening, which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation. Learn More -
XAV 939
Catalog No. A10994 PARP inhibitorXAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively). Learn More
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