Wnt

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  1. ETC-159

    Catalog No. A15840
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    Wnt inhibitor
    ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits beta-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM. Learn More
  2. IQ-1

    Catalog No. A16064
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    Wnt/beta-catenin inhibitor
    IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/beta-catenin signaling. Learn More
  3. BML-284 (Wnt agonist 1)

    Catalog No. A15851
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    Wnt agonist 1
    Wnt agonist 1 is a cell-permeable Wnt signaling activator. It nduces beta-catenin and TCF-dependent transcriptional activity with EC50 value of 0.7 uM. Learn More
  4. WAY-262611

    Catalog No. A16094
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    Wnt pathway activator
    WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay. Learn More
  5. CCT251545

    Catalog No. A16216
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    Wnt inhibitor
    CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM. Learn More
  6. Hexachlorophene

    Catalog No. A16217
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    Wnt/beta-catenin inhibitor
    Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 uM; also is an inhibitor of Wnt/beta-catenin signaling. Learn More
  7. IWP-3

    Catalog No. A13192
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    Wnt inhibitor
    IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM). Learn More
  8. JW74

    Catalog No. A16219
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    Wnt inhibitor
    JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM. Learn More
  9. Cardiogenol C HCl

    Catalog No. A16198
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    Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 uM. Cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Learn More
  10. KYA1797K

    Catalog No. A16353
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    Wnt/beta-catenin inhibitor
    KYA1797K is a highly potent and selective Wnt/beta-catenin inhibitor with IC50 of 0.75 μM (TOPflash assay). Learn More
  11. iCRT3

    Catalog No. A16847
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    Wnt/β-catenin antagonist
    iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays. Learn More
  12. LF3

    Catalog No. A16851
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    Wnt inhibitor
    LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. Learn More
  13. ICG-001

    Catalog No. A11039
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    Wnt/beta-catenin inhibitor
    ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) . Learn More
  14. PRI-724

    Catalog No. A15856
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    CBP/beta-catenin antagonist

    PRI-724, an isomer or enantiomer of ICG-001 (A11039), is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity.

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  15. XAV 939

    Catalog No. A10994
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    PARP inhibitor
    XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively). Learn More
  16. KY02111

    Catalog No. A12362
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    Wnt inhibitor
    KY02111 is a potent and selective Wnt signaling pathway inhibitor discovered by a cell-based screening, which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation. Learn More
  17. LGK-974

    Catalog No. A12816
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    PORCN inhibitor
    LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay. Learn More
  18. IWR-1-endo

    Catalog No. A12737
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    Wnt inhibitor
    IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. Learn More
  19. IWP-2

    Catalog No. A12707
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    Wnt inhibitor
    IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent. Learn More
  20. Wnt-C59

    Catalog No. A12951
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    PORCN/Wnt inhibitor
    Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. Learn More
  21. IWP-L6

    Catalog No. A13978
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    PORCN inhibitor
    IWP-L6 is a potent inhibitor of Porcupine (Porcn), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Learn More
  22. Salinomycin sodium salt

    Catalog No. A15229
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    Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Learn More
  23. IWP-4

    Catalog No. A17004
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    Wnt/β-catenin signaling inhibitor
    IWP-4 is a novel potent inhibitor of Wnt/β-catenin signaling. Learn More

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