Microtubules

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  1. Inhibitor (11)


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Catalog No. Product Name Application Product Information
A10024

ABT-751 (E-7010)

Microtubule Associated inhibitor
ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis.
A12591

Cevipabulin (TTI-237)

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Cevipabulin (TTI-237), an antimicrotubule agent, is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules.
A13827

CK-636

Arp2/3 inhibitor
CK-636 is a Arp2/3 complex inhibitor. CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation.
A10238

Colchicine

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Colchicine is an inhibitor of microtubules by specific binding to tubulin.
A13735

CW069

Microtubule Associated inhibitor
CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 uM, significant selectivity over KSP.
A10264

CYT997 (Lexibulin)

Microtubule Inhibitor
CYT997 is a novel anti-cancer vascular disrupting agent (VDA). In vitro, CYT997 is shown to potently inhibit the proliferation of vascular endothelial growth factor-stimulated human umbilical vein endothelial cells (IC(50) 3.7 ± 1.8 nM) and cause significant morphological changes at 100 nM, including membrane blebbing.
A10326

Docetaxel (Taxotere)

Microtubule Associated inhibitor
Docetaxel (Taxotere) is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions.
A10359

Epothilone A

Microtubule Associated inhibitor
Epothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.
A10360

Epothilone B (EPO906)

Microtubule Associated inhibitor
Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.
A11412

Epothilone D

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Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
A12804

Eribulin Mesylate

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Eribulin mesylate is the mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity.
A13081

Fosbretabulin disodium (CA4P)

microtubule-targeting agent
Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities.
A11449

Ixabepilone

microtubule inhibitor
Ixabepilone is an epothilone B analog
A13219

Nocodazole

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Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.
A10689

Paclitaxel (Taxol)

Microtubule Associated inhibitor
Paclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division.
A10740

Podophyllotoxin

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Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin.
A11617

Vincristine

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Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 ??M.
A10973

Vincristine sulfate

Tubulin inhibitor
Vincristine is a mitotic inhibitor, and is used in cancer chemotherapy.
A10975

Vinflunine Tartrate

Microtubule Associated inhibitor
Vinflunine Tartrate is a tartrate salt of vinflunine that destabilizes microtubules with an IC50 of 18.8 nM and interferes with the dynamics of microtubules during cell division.

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