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NF-κB/IκB

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Catalog No.
Product Name
Application
Product Information
Product Citation
  1. A10492
    JNJ-26481585 (Quisinostat)

    HDAC inhibitor

    JNJ-26481585 (Quisinostat) is a pan-HDAC inhibitor with marked potency toward HDAC1 (IC(50), 0.16 nmol/L).
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  2. A10516
    LAQ824 (NVP-LAQ824, Dacinostat)

    HDAC Inhibitor

    LAQ824 (NVP-LAQ824) is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.
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  3. A10947
    Trichostatin-A (TSA)

    HDAC Inhibitor

    Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.
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  4. A11148
    BX-795

    PDK-1 inhibitor

    BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.
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  5. A11324
    Bardoxolone (CDDO)

    IκB/IKK inhibitor

    Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs).
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  6. A11338
    Bay 65-1942 HCl

    IKKβ kinase inhibitor

    Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.
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  7. A11452
    IKK-2 inhibitor VIII

    IKK Inhibitor

    IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
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  8. A11463
    IKK-3 Inhibitor

    IKK Inhibitor

    IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-alpha and IKK-beta.
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  9. A11485
    MRT67307

    SIK/TBK-1/IKKe inhibitor

    MRT67307 is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.
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  10. A11920
    Romidepsin (FK228 ,Depsipeptide)

    HDAC inhibitor

    Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.
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  11. A12149
    Remetinostat

    HDAC inhibitor

    Remetinostat (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma.
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  12. A12511
    BRD-6929

    HDAC1/HDAC2 inhibitor

    BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50=?1 and 8 nM), extracted from patent US2018360927.
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  13. A12556
    Resminostat

    HDAC inhibitor

    Resminostat, also known as RAS2410, is a potent inhibitor of histone deacetylase (HDAC) classes I and II. It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones.
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  14. A12616
    Tasquinimod

    HDAC4 inhibitor

    Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling.
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  15. A12745
    Apicidin

    HDAC inhibitor

    Apicidin is a a potent histone deacetylases (HDAC) inhibitor with potential anticancer activity.
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  16. A12758
    Citarinostat (ACY-241)

    HDAC6 inhibitor

    ACY-241 is a new, selective and orally available inhibitor of HDAC6.
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  17. A12911
    BRD9757

    HDAC6 inhibitor

    BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6.
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  18. A13108
    PHA 408

    IKK-2 inhibitor

    PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.
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  19. A13362
    JAK/HDAC-IN-1

    JAK2/HDAC dual inhibitor

    JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines.
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  20. A13405
    HDAC inhibitor

    HDAC inhibitor

    N/A
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  21. A13537
    BI605906

    IKKβ inhibitor

    BI605906 is a novel inhibitors of the IKK beta.
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  22. A14278
    SC75741

    NF-κB inhibitor

    SC75741 is a potent NF-kB inhibitor with EC50 of 200 nM.
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  23. A14326
    TMP 195

    HDAC inhibitor

    TMP195 is the most potent and selective class IIa HDAC inhibitor.
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  24. A14354
    Domatinostat (4SC-202)

    HDAC inhibitor

    4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity.
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  25. A14804
    Wedelolactone

    IKK Inhibitor II

    Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis.
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  26. A15220
    Resminostat hydrochloride

    HDAC inhibitor

    Resminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM.
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  27. A15354
    KD 5170

    HDAC inhibitor

    KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.
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  28. A15355
    PTACH (NCH 51)

    HDAC Inhibitor

    NCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM.
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  29. A15437
    R306465

    HDAC inhibitor

    R306465 is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models.
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  30. A15781
    UF010

    HDAC inhibitor

    UF010 is a potent and selective HDAC inhibitor with IC50 ~0.06 uM, 0.1 uM, 0.5 uM and 1.5 uM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.

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  31. A15900
    AZD3264

    IKK2 inhibitor?€?

    AZD3264 is a novel IKK2 inhibitor.
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  32. A15934
    ACY-738

    HDAC6 inhibitor

    ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs.
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  33. A16301
    (+)-DHMEQ

    NF-kB inhibitor

    The (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-kB.
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  34. A16302
    (-)-DHMEQ

    NF-kB inhibitor

    (-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ.

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  35. A16836
    CBL-0137

    p53 activator / NF-κB inhibitor

    CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).
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  36. A16899
    SR-4370

    HDAC inhibitor

    SR-4370 is an HDAC inhibitor. SR-4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp.
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  37. A17091
    HDAC8-IN-1

    HDAC8 inhibitor

    HDAC8-IN-1, is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines.
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  38. A17143
    CBL0137

    FACT inhibitor

    CBL0137 is a FACT inhibitor that functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death.
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  39. A17205
    Ac2-26

    NF-κB Inhibitor

    Ac2-26 is an active N-terminal peptide of annexin A1 (AnxA1).
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  40. A18339
    SKLB-23bb

    HDAC6 inhibitor

    SKLB-23bb is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively.
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  41. A18342
    Tinostamustine (EDO-S101)

    HDAC inhibitor

    EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively.
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  42. A19174
    J22352

    HDAC6 inhibitor

    J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM.
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  43. A19224
    IMD-0560

    IκB kinase β inhibitor

    IMD-0560 is a novel IκB kinase β inhibitor.
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  44. A20369
    TAK-243

    UAE (UBA1) inhibitor

    TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination.
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  45. A20785
    HDAC-IN-3

    HDAC inhibitor

    HDAC-IN-3 is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2008040934 A1.
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  46. A20927
    DMAPT

    NF-κB inhibitor

    DMAPT (Dimethylamino Parthenolide), a water soluble analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD50 of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect.
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  47. A20986
    Domatinostat tosylate

    HDAC1 inhibitor

    Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).
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  48. A21126
    Givinostat

    HDAC inhibitor

    Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
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  49. A21221
    IKK-IN-1

    IKK inhibitor

    IKK-IN-1 is an inhibitor of IKK extracted from patent WO2002024679A1, compound example 18-13.
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  • NF-κB 8 items
  • IκK/IκB 12 items
  • HDAC 29 items
Target
  1. HDAC 1 item
  2. HDAC1 3 items
  3. HDAC2 3 items
  4. HDAC3 2 items
  5. HDAC4 2 items
  6. HDAC5 1 item
  7. HDAC6 1 item
  8. HDAC8 2 items
  9. HDAC9 1 item
  10. HDAC10 1 item
  11. HDAC11 1 item