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EHT 1864
Catalog No. A13886 Rac family GTPase inhibitorEHT 1864 is an antiproliferative chemical shown to inhibit Rac family GTPases. Learn More -
APS-2-79 HCl
Catalog No. A16175 KSR/Ras inhibitorAPS-2-79 HCl, small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Learn More -
XRP44X
Catalog No. A16049 Ras-Net inhibitorXRP44X is a Ras-Net (Elk-3) pathway inhibitor (IC50 = 10-20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Learn More -
APS-2-79
Catalog No. A16231 KSR/Ras inhibitorAPS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site. Learn More -
BQU57
Catalog No. A14956 GTPase Ral inhibitorBQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. Learn More -
ARS-1620
Catalog No. A16809 KRAS-G12C inhibitorARS-1620 is a potent, orally bioavailable covalent inhibitor of KRAS-G12C) and could achieve rapid and sustained in vivo target occupancy to induce tumor regression. Learn More -
BDP5290
Catalog No. A16966 ROCK and MRCK inhibitorBDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively. Learn More -
BDP9066
Catalog No. A16874 MRCK inhibitorBDP9066 is a potent and selective MRCK inhibitor, reducing substrate phosphorylation. Learn More -
ARS-1323
Catalog No. A17060 mutant K-ras G12C inhibitorARS-1323 is a novel inhibitor of mutant K-ras G12C. Learn More -
Antineoplaston A10
Catalog No. A17183 Ras inhibitorAntineoplaston A 10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. Learn More -
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MRTX1257
Catalog No. A17223 KRAS-G12C inhibitorMRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM. Learn More -
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Ras-IN-3144
Catalog No. A17222 pan-RAS inhibitorRas-IN-3144 is a pan-RAS inhibitor which inhibits RAS signaling pathways in cancer cells and prevents the growth of RAS mutant mouse cancer xenografts. Learn More -
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AMG-510 racemate
Catalog No. A18752 KRAS G12C covalent inhibitorAMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity. Learn More -
ZT-12-037-01
Catalog No. A18395 ATP-competitive STK19 inhibitorZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor. ZT-12-037-01 effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo. Learn More -
KRAS G12C inhibitor 13
Catalog No. A19041 KRAS G12C inhibitorKRAS G12C inhibitor 13 is a KRAS G12C inhibitor extracted from patent WO2018143315A1, compound 30. Learn More -
KRAS G12C inhibitor 5
Catalog No. A18840 KRas G12C inhibitorKRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147. Learn More -
KRAS G12C inhibitor 15
Catalog No. A18447 KRAS G12C inhibitorKRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM. Learn More -
KRAS G12C inhibitor 16
Catalog No. A18444 KRAS G12C inhibitorKRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC50 of 97 nM. Learn More -
KRAS G12C inhibitor 17
Catalog No. A18441 KRAS G12C inhibitorKRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM. Learn More -
K-Ras(G12C) inhibitor 6
Catalog No. A14103 K-Ras(G12C) inhibitorK-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP. Learn More -
Azathioprine
Catalog No. A10107 Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases. Learn More -
NSC 23766
Catalog No. A12546 Rac1 activation inhibitorNSC 23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation. Learn More -
GGTI-2418
Catalog No. A13112 GGTase inhibitorGGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. Learn More -
Balamapimod (MKI-833)
Catalog No. A13119 Ras/Raf/MEK inhibitorBalamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor. Learn More -
ZCL-278
Catalog No. A13403 Cdc42 GTPase inhibitorZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects. Learn More -
Kobe0065
Catalog No. A13135 Ras-Raf interaction inhibitorKobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. Learn More -
Kobe2602
Catalog No. A12578 Ras–Raf inhibitorKobe2602 is an analog of Kobe0065. Exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM. Learn More -
EHop-016
Catalog No. A12740 Rac GTPase InhibitorEHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity that inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration. Learn More -
6H05
Catalog No. A16097 K-Ras inhibitor6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). Learn More -
K-Ras(G12C) inhibitor 12
Catalog No. A14227 K-Ras(G12C) inhibitorK-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). Learn More -
6H05 (trifluoroacetate salt)
Catalog No. A14235 K-Ras inhibitor6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C). Learn More -
K-Ras(G12C) inhibitor 9
Catalog No. A14250 K-Ras(G12C) inhibitorK-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). Learn More -
NSC-23766 HCl
Catalog No. A13975 Rac GTPase inhibitorNSC 23766 is a cell-permeable, reversible inhibitor of Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC50 = 50 uM). Learn More -
CCG-1423
Catalog No. A14430 Rho inhibitorCCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. Learn More -
ML-098
Catalog No. A15925 Rab7 activatorML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM). Learn More -
Salirasib
Catalog No. A11572 PPMTase inhibitorSalirasib is an inhibitor of prenylated protein methyltransferase (PPMTase) with Ki value of 2.6 uM. Learn More -
Zoledronic Acid
Catalog No. A11010 osteoclastic bone resorption inhibitorZoledronic acid is a bisphosphonate which used to multiple myeloma and prostate cancer treament. Learn More
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