Ras

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  1. Zoledronic Acid

    Catalog No. A11010
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    osteoclastic bone resorption inhibitor
    Zoledronic acid is a bisphosphonate which used to multiple myeloma and prostate cancer treament. Learn More
  2. K-Ras(G12C) inhibitor 9

    Catalog No. A14250
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    K-Ras(G12C) inhibitor
    K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). Learn More
  3. NSC-23766 HCl

    Catalog No. A13975
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    Rac GTPase inhibitor
    NSC 23766 is a cell-permeable, reversible inhibitor of Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC50 = 50 uM). Learn More
  4. CCG-1423

    Catalog No. A14430
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    Rho inhibitor
    CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. Learn More
  5. ML-098

    Catalog No. A15925
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    Rab7 activator
    ML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM). Learn More
  6. Salirasib

    Catalog No. A11572
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    PPMTase inhibitor
    Salirasib is an inhibitor of prenylated protein methyltransferase (PPMTase) with Ki value of 2.6 uM. Learn More
  7. XRP44X

    Catalog No. A16049
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    Ras-Net inhibitor
    XRP44X is a Ras-Net (Elk-3) pathway inhibitor (IC50 = 10-20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Learn More
  8. 6H05

    Catalog No. A16097
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    K-Ras inhibitor
    6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). Learn More
  9. APS-2-79 HCl

    Catalog No. A16175
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    KSR/Ras inhibitor
    APS-2-79 HCl, small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Learn More
  10. AMI5

    Catalog No. A16376
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    protein methyltransferase inhibitor
    AMI5 is a non-selective protein methyltransferase inhibitor. Learn More
  11. 6H05 (trifluoroacetate salt)

    Catalog No. A14235
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    K-Ras inhibitor
    6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C). Learn More
  12. K-Ras(G12C) inhibitor 12

    Catalog No. A14227
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    K-Ras(G12C) inhibitor
    K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). Learn More
  13. Azathioprine

    Catalog No. A10107
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    Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases. Learn More
  14. NSC 23766

    Catalog No. A12546
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    Rac1 activation inhibitor
    NSC 23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation. Learn More
  15. GGTI-2418

    Catalog No. A13112
    GGTase inhibitor
    GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. Learn More
  16. Balamapimod (MKI-833)

    Catalog No. A13119
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    Ras/Raf/MEK inhibitor
    Balamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor. Learn More
  17. ZCL-278

    Catalog No. A13403
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    Cdc42 GTPase inhibitor
    ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects. Learn More
  18. Kobe0065

    Catalog No. A13135
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    Ras-Raf interaction inhibitor
    Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. Learn More
  19. Kobe2602

    Catalog No. A12578
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    Ras–Raf inhibitor
    Kobe2602 is an analog of Kobe0065. Exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM. Learn More
  20. EHT 1864

    Catalog No. A13886
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    Rac family GTPase inhibitor
    EHT 1864 is an antiproliferative chemical shown to inhibit Rac family GTPases. Learn More
  21. K-Ras(G12C) inhibitor 6

    Catalog No. A14103
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    K-Ras(G12C) inhibitor
    K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP. Learn More
  22. BQU57

    Catalog No. A14956
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    GTPase Ral inhibitor
    BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. Learn More

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