Ras

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  1. Zoledronic Acid

    Catalog No. A11010
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    osteoclastic bone resorption inhibitor
    Zoledronic acid is a bisphosphonate which used to multiple myeloma and prostate cancer treament. Learn More
  2. APS-2-79

    Catalog No. A16231
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    KSR/Ras inhibitor
    APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site. Learn More
  3. BQU57

    Catalog No. A14956
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    GTPase Ral inhibitor
    BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. Learn More
  4. ARS-1620

    Catalog No. A16809
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    KRAS-G12C inhibitor
    ARS-1620 is a potent, orally bioavailable covalent inhibitor of KRAS-G12C) and could achieve rapid and sustained in vivo target occupancy to induce tumor regression. Learn More
  5. BDP5290

    Catalog No. A16966
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    ROCK and MRCK inhibitor
    BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively. Learn More
  6. BDP9066

    Catalog No. A16874
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    MRCK inhibitor
    BDP9066 is a potent and selective MRCK inhibitor, reducing substrate phosphorylation. Learn More
  7. ARS-1630

    Catalog No. A17061
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    mutant K-ras G12C inhibitor
    ARS-1630 is a novel inhibitor of mutant K-ras G12C. Learn More
  8. ARS-1323

    Catalog No. A17060
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    mutant K-ras G12C inhibitor
    ARS-1323 is a novel inhibitor of mutant K-ras G12C. Learn More
  9. Antineoplaston A10

    Catalog No. A17183
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    Ras inhibitor
    Antineoplaston A 10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. Learn More
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    MRTX1257

    Catalog No. A17223
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    KRAS-G12C inhibitor
    MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM. Learn More
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    Ras-IN-3144

    Catalog No. A17222
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    pan-RAS inhibitor
    Ras-IN-3144 is a pan-RAS inhibitor which inhibits RAS signaling pathways in cancer cells and prevents the growth of RAS mutant mouse cancer xenografts. Learn More
  10. AMG-510

    Catalog No. A18752
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    KRAS G12C covalent inhibitor
    AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity. Learn More
  11. ZT-12-037-01

    Catalog No. A18395
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    ATP-competitive STK19 inhibitor
    ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor. ZT-12-037-01 effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo. Learn More
  12. KRAS G12C inhibitor 13

    Catalog No. A19041
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    KRAS G12C inhibitor
    KRAS G12C inhibitor 13 is a KRAS G12C inhibitor extracted from patent WO2018143315A1, compound 30. Learn More
  13. KRAS G12C inhibitor 5

    Catalog No. A18840
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    KRas G12C inhibitor
    KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147. Learn More
  14. KRAS G12C inhibitor 15

    Catalog No. A18447
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    KRAS G12C inhibitor
    KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM. Learn More
  15. KRAS G12C inhibitor 16

    Catalog No. A18444
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    KRAS G12C inhibitor
    KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC50 of 97 nM. Learn More
  16. APS-2-79 HCl

    Catalog No. A16175
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    KSR/Ras inhibitor
    APS-2-79 HCl, small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Learn More
  17. 6H05

    Catalog No. A16097
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    K-Ras inhibitor
    6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). Learn More
  18. XRP44X

    Catalog No. A16049
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    Ras-Net inhibitor
    XRP44X is a Ras-Net (Elk-3) pathway inhibitor (IC50 = 10-20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Learn More
  19. Azathioprine

    Catalog No. A10107
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    Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases. Learn More
  20. NSC 23766

    Catalog No. A12546
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    Rac1 activation inhibitor
    NSC 23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation. Learn More
  21. GGTI-2418

    Catalog No. A13112
    GGTase inhibitor
    GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. Learn More
  22. Balamapimod (MKI-833)

    Catalog No. A13119
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    Ras/Raf/MEK inhibitor
    Balamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor. Learn More
  23. ZCL-278

    Catalog No. A13403
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    Cdc42 GTPase inhibitor
    ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects. Learn More
  24. Kobe0065

    Catalog No. A13135
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    Ras-Raf interaction inhibitor
    Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. Learn More
  25. Kobe2602

    Catalog No. A12578
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    Ras–Raf inhibitor
    Kobe2602 is an analog of Kobe0065. Exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM. Learn More
  26. EHT 1864

    Catalog No. A13886
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    Rac family GTPase inhibitor
    EHT 1864 is an antiproliferative chemical shown to inhibit Rac family GTPases. Learn More
  27. K-Ras(G12C) inhibitor 6

    Catalog No. A14103
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    K-Ras(G12C) inhibitor
    K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP. Learn More
  28. K-Ras(G12C) inhibitor 12

    Catalog No. A14227
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    K-Ras(G12C) inhibitor
    K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). Learn More
  29. 6H05 (trifluoroacetate salt)

    Catalog No. A14235
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    K-Ras inhibitor
    6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C). Learn More
  30. K-Ras(G12C) inhibitor 9

    Catalog No. A14250
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    K-Ras(G12C) inhibitor
    K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). Learn More
  31. NSC-23766 HCl

    Catalog No. A13975
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    Rac GTPase inhibitor
    NSC 23766 is a cell-permeable, reversible inhibitor of Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC50 = 50 uM). Learn More
  32. CCG-1423

    Catalog No. A14430
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    Rho inhibitor
    CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. Learn More
  33. ML-098

    Catalog No. A15925
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    Rab7 activator
    ML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM). Learn More
  34. Salirasib

    Catalog No. A11572
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    PPMTase inhibitor
    Salirasib is an inhibitor of prenylated protein methyltransferase (PPMTase) with Ki value of 2.6 uM. Learn More
  35. KRAS G12C inhibitor 17

    Catalog No. A18441
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    KRAS G12C inhibitor
    KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM. Learn More

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