Aurora Kinase
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A11066 AMG 900
AMG 900 is a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. -
A10095 AT9283
AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation. -
A10100 Aurora A Inhibitor I
Aurora A Inhibitor I is a potent and selective inhibitor of Aurora A kinase (AurA), with IC50 values to be 3.4 nM (Aurora A) and unusually high selectivity 1000 fold against Aurora B; a useful tool compound for investigating the cellular role of Aurora A kinases.
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A10109 AZD1152-HQPA (Barasertib)
AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, with Ki values to be 0.36 (Aurora B) and 1369 nM (Aurora A) respectively and has a high specificity versus a panel of 50 other kinases. -
A10184 CCT129202
CCT129202 is a representative of a structurally novel series of imidazopyridine small-molecule inhibitors of Aurora kinase activity. It shows high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines.
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A11081 CCT137690
CCT137690 is a potent inhibitor of Aurora kinases that inhibits Aurora A and B kinases with low nanomolar IC50 values in both biochemical and cellular assays.
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A10248 CYC116
Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. -
A10715 Danusertib (PHA-739358)
Danusertib (PHA-739358) is a novel combined pan-Aurora kinases and third generation Bcr-Abl tyrosine kinase inhibitor -
A11168 GSK1070916
GSK1070916 is a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models.
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A10448 Hesperadin
Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate.
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