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Aurora Kinase

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  1. Antagonist (1)
  2. Inhibitor (26)


Items 1 to 25 of 27 total

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Catalog No. Product Name Product Information
A11066

AMG 900

AMG 900 is a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Learn More
A10095

AT9283

AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation. Learn More
A10100

Aurora A Inhibitor I

Aurora A Inhibitor I is a potent and selective inhibitor of Aurora A kinase (AurA), with IC50 values to be 3.4 nM (Aurora A) and unusually high selectivity 1000 fold against Aurora B; a useful tool compound for investigating the cellular role of Aurora A kinases.

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A15011

AZD1152

AZD1152 is a pro-drug that rapidly undergoes phosphatase-mediated cleavage in serum to release barasertib-hQPA, a selective Aurora B kinase inhibitor that has shown preliminary activity in clinical studies of patients with acute myeloid leukemia (AML). Learn More
A10109

AZD1152-HQPA (Barasertib)

AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, with Ki values to be 0.36 (Aurora B) and 1369 nM (Aurora A) respectively and has a high specificity versus a panel of 50 other kinases. Learn More
A15762

BI-847325

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. Learn More
A10184

CCT129202

CCT129202 is a representative of a structurally novel series of imidazopyridine small-molecule inhibitors of Aurora kinase activity. It shows high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines.

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A11081

CCT137690

CCT137690 is a potent inhibitor of Aurora kinases that inhibits Aurora A and B kinases with low nanomolar IC50 values in both biochemical and cellular assays. Learn More
A10248

CYC116

Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Learn More
A10715

Danusertib (PHA-739358)

Danusertib (PHA-739358) is a novel combined pan-Aurora kinases and third generation Bcr-Abl tyrosine kinase inhibitor Learn More
A10352

ENMD-2076

ENMD-2076 is a novel, orally-active antimitotic and antiangiogenic molecule inhibits Aurora A as well as tyrosine kinases that drive tumor vascularization, including VEGFR2 (KDR), PDGFR and the FGF receptors. Learn More
A11168

GSK1070916

GSK1070916 is a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models.

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A10448

Hesperadin

Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. Learn More
A10494

JNJ-7706621

JNJ-7706621 is a novel cell cycle inhibitor that showed potent inhibition of several cyclin-dependent kinases (CDK) and Aurora kinases. Learn More
A10508

KW-2449

KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. Learn More
A11410

MK-5108 (VX-689)

MK-5108, also known as VX-689, is a competitive inhibitor of the ATP-binding site of aurora A kinase. Learn More
A13396

MK-8745

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Learn More
A10601

MLN8054

MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo. Learn More
A10004

MLN8237 (Alisertib)

MLN8237 (Alisertib) is a selective Aurora kinase A inhibitor with a median IC50 of 61 nM. Learn More
A11171

PF-03814735

PF-03814735 is a novel, potent, orally bioavailable, reversible inhibitor of both Aurora1 and Aurora2 kinases. PF-03814735 produces a block in cytokinesis, resulting in inhibition of cell proliferation and the formation of polyploid multinucleated cells.

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A10714

PHA-680632

PHA-680632 is the first representative of a new class of Aurora inhibitors with a high potential for further development as an anticancer therapeutic. Learn More
A13250

Reversine

Reversine, which induces the dedifferentiation and regeneration of human cells, inhibits MPS1 and Aurora B with IC50 of 6 nM and 98.5 nM, respectively. Learn More
A14382

SAR156497

SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A), 1 nM (Aurora B / incenp), 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP 3A4 and PDE3 inhibition. Learn More
A10851

SNS-314

SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Learn More
A11067

TAK-901

TAK-901 is a small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Learn More

Items 1 to 25 of 27 total

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Aurora Kinase

Minimal Price: $32.00