Chk

Catalog No.Inhibitor Name Chk1Chk2Other
A10113AZD7762
***
A11036LY2603618
***
A11167MK-8776
***
*
CDK2
A11046CHIR-124
****
*
FLT3,PDGFR,GSK-3
A11520PF-477736
****
**
VEGFR2,Fms,YES
A11108CCT241533
****
A13575BML-277
***
A15480SB 218078
***
cdc2, PKC
A15550CCT244747
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. SB 218078

    Catalog No. A15480
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    Chk1 Inhibitor
    SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively) Learn More
  2. CCT244747

    Catalog No. A15550
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    CHK1 inhibitor
    CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity, Learn More
  3. CCT241533 hydrochloride

    Catalog No. A15038
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    Chk2 inhibitor
    CCT241533 Hcl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM; shows minimal cross-reactivity against a panel of kinases at 1 uM. Learn More
  4. AZD7762

    Catalog No. A10113
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    Chk1 & Chk2 inhibitor
    AZD7762 is a potent ATP-competitive checkpoint kinase inhibitor that drives checkpoint abrogation and potentiates DNA-targeted therapies. Learn More
  5. GDC-0575 (ARRY-575, RG7741)

    Catalog No. A16811
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    Chk1 inhibitor
    GDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2?nM. Learn More
  6. PD0166285

    Catalog No. A15863
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    Wee1 inhibitor
    PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator. Learn More
  7. LY2606368

    Catalog No. A13684
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    Chk1 inhibitor
    LY2606368 is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. Learn More
  8. GNE-900

    Catalog No. A14178
    Chk1 inhibitor
    GNE-900 is an ATP-competitive, selective, and orally bioavailable ChK1 inhibitor. Learn More
  9. BML-277

    Catalog No. A13575
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    Chk2 Inhibitor
    BML-277 (Chk2 Inhibitor II) is a Chk2 (checkpoint kinase 2) inhibitor. Learn More
  10. SCH900776 (S-isomer)

    Catalog No. A12703
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    CHK1 Inhibitor
    SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Learn More
  11. PF 477736

    Catalog No. A11520
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    Chk Inhibitor
    PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Learn More
  12. SCH 900776 (MK-8776)

    Catalog No. A11167
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    Chk1 inhibitor

    SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

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  13. CCT241533

    Catalog No. A11108
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    Chk2 inhibitor
    CCT241533 is a potent and selective Inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Learn More
  14. CHIR-124

    Catalog No. A11046
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    CHK Inhibitor
    CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively). Learn More
  15. LY2603618 (IC-83)

    Catalog No. A11036
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    Chk inhibitor
    LY2603618 is a chk2 inhibitor that binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents. Learn More
    • New

    CCT245737

    Catalog No. A17239
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    CHK1 inhibitor
    CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%. Learn More

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