DNA, RNA Synthesis

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  1. Tubercidin

    Catalog No. A13285
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    Tubercidin is an adenosine analog, is an antibiotic obtained from Streptomyces tubercidicus. Learn More
  2. YK 4-279

    Catalog No. A11612
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    RHA inhibitor
    YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. Learn More
  3. 4EGI-1

    Catalog No. A14199
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    eIF4E/eIF4G inhibitor
    4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 uM. Learn More
  4. CRT0044876

    Catalog No. A14304
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    APE1 inhibitor
    CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM. Learn More
  5. 4E1RCat

    Catalog No. A14301
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    eIF4F subunit interaction inhibitor
    4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Learn More
  6. Puromycin 2HCl

    Catalog No. A14268
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    protein synthesis inhibitor
    Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor. Learn More
  7. Chloroambucil

    Catalog No. A14252
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    DNA/RNA Synthesis inhibitor
    Chlorambucil is a nitrogen mustard alkylating agent. Learn More
  8. Mupirocin

    Catalog No. A14230
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    isoleucyl t-RNA synthetase inhibitor
    Mupirocin is an isoleucyl t-RNA synthetase inhibitor. Learn More
  9. Blasticidin S HCl

    Catalog No. A14212
    Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor. Learn More
  10. Ifosfamide

    Catalog No. A10466
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    Ifosfamide is a cytostatic agent that is structurally related to cyclophosphamide. Learn More
  11. Epirubicin

    Catalog No. A12409
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    Topoisomerase inhibitor
    Epirubicin is a cell-permeable antitumor antibiotic. A stereoisomer of Doxorubicin that exhibits reduced cardiotoxicity. Epirubicin’s antitumor actions are mediated by targeting and inhibiting Topo II (topoisomerase II). Learn More
  12. Apaziquone

    Catalog No. A12406
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    Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Learn More
  13. Bleomycin

    Catalog No. A14378
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    Bleomycin is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. It acts by induction of DNA strand breaks. Learn More
  14. SCR7

    Catalog No. A15447
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    DNA ligase IV inhibitor
    SCR7 is a specific DNA Ligase IV inhibitor. SCR7 inhibits end joining of double strand breaks in diverse cell types resulting in tumour regression by activation of p53 mediated apoptosis. Learn More
  15. Chebulinic acid

    Catalog No. A16208
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    Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. Learn More
  16. AN2718

    Catalog No. A16203
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    RNA synthetase inhibitor
    AN2718 is a novel boron-containing small molecule that inhibits an essential protein synthesis enzyme, leucyl-transfer RNA synthetase, or LeuRS. Learn More
  17. RK-33

    Catalog No. A16194
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    DDX3 inhibitor
    RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Learn More
  18. Saccharin 1-methylimidazole

    Catalog No. A16114
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    DNA and RNA synthesis activator
    Saccharin 1-methylimidazole is considered a general-purpose activator for DNA and RNA synthesis. Learn More
  19. L67

    Catalog No. A15978
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    DNA ligases inhibitor
    L67 is a DNA Ligase Inhibitor. L67 inhibited DNA ligases I and III. L67 is a simple competitive inhibitor with respect to nicked DNA. Learn More
  20. Trifluridine

    Catalog No. A10948
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    Trifluridine is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name, Viroptic, by Glaxo Wellcome, now merged into GlaxoSmithKline. Learn More
  21. 6-Mercaptopurine Monohydrate

    Catalog No. A15898
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    de novo purine synthesis inhibitor
    6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. Learn More
  22. E3330

    Catalog No. A14440
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    APE1 Redox Inhibitor
    E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. Learn More
  23. L189

    Catalog No. A15790
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    DNA Ligase Inhibitor
    L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM. Learn More
  24. Mitomycin C

    Catalog No. A11491
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    DNA synthesis inhibitor
    Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells. Learn More
  25. TAS-102

    Catalog No. A15533
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    Trifluridine-tipiracil hydrochloride mixture
    TAS-102 is an orally bioavailable combination agent composed of the cytotoxic pyrimidine analog Trifluridine (5-trifluoro-2??-deoxythymidine or TFT) and a thymidine phosphorylase inhibitor (TPI) tipiracil hydrochloride, in a molar ratio of 1.0:0.5 (TFT:TPI), with potential antineoplastic activity, Learn More
  26. Thiostrepton

    Catalog No. A12890
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    natural cyclic oligopeptide antibiotic
    Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression. Learn More
  27. Bleomycin hydrochloride

    Catalog No. A12773
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  28. Adenine sulfate

    Catalog No. A11804
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    Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. Learn More
  29. Clafen (Cyclophosphamide)

    Catalog No. A10224
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    Clafen (Cyclophosphamide) is a nitrogen mustard alkylating agent. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring. Learn More
  30. Cisplatin

    Catalog No. A10221
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    Cisplatin was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death). Learn More
  31. Nelarabine (Arranon)

    Catalog No. A10632
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    Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Learn More
  32. NSC-207895 (XI-006)

    Catalog No. A11179
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    MDMX Inhibitor

    NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

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  33. Carboplatin

    Catalog No. A10182
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    Carboplatin is a chemotherapy drug used against some forms of cancer (mainly ovarian carcinoma, lung, head and neck cancers). Cisplatin and carboplatin, as well as oxaliplatin, interact with DNA, akin to the mechanism of alkylating agents.

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  34. CCT239065

    Catalog No. A11147
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    DNA, RNA Synthesis Inhibitor
    CCT239065 is a mutant protein kinase inhibitor that inhibits signaling downstream of V600EBRAF in cancer cells, blocking DNA synthesis, and inhibiting proliferation. Learn More
  35. CX-5461

    Catalog No. A11065
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    DNA/RNA Synthesis inhibitor
    CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. Learn More
  36. Cidofovir (Vistide)

    Catalog No. A10214
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    DNA/RNA Synthesis inhibitor
    Cidofovir (Vistide) is an antiviral used for the treatment of cytomegalovirus (CMV) infection (ie: retinitis). Learn More
  37. Gemcitabine HCl (Gemzar)

    Catalog No. A10423
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    DNA/RNA Synthesis inhibitor
    Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth. Learn More
  38. Fluorouracil (Adrucil)

    Catalog No. A10042
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  39. Bleomycin sulfate

    Catalog No. A10152
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    DNA/RNA Synthesis inhibitor
    Bleomycin sulfate is a mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Learn More
  40. Clofarabine

    Catalog No. A10228
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    DNA/RNA Synthesis inhibitor
    Clofarabine is a second generation purine nucleoside analog with antineoplastic activity Learn More
  41. Oxaliplatin (Eloxatin)

    Catalog No. A10346
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    DNA/RNA Synthesis inhibitor
    Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. In vivo studies showed that Oxaliplatin has anti-tumor activity against colon carcinoma through its (non-targeted) cytotoxic effects. Learn More
  42. Azithromycin (Zithromax)

    Catalog No. A11803
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  43. Mizoribine

    Catalog No. A10597
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    Mizoribine is an imidazole nucleoside immunosuppressant agent that was first isolated from the mold Eupenicillium brefeldimium with antibiotic and cytotoxic effects. Learn More
  44. Mercaptopurine

    Catalog No. A10568
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    Mercaptopurine has been shown to interfere with DNA and RNA synthesis and cause inhibition of de novo purine syntehsis. Learn More
  45. Lomustine (CeeNU)

    Catalog No. A10535
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    Lomustine is an alkylating nitrosourea compound that possesses antitumor activity similar to Carmustine causing DNA interstrand cross-linking. Learn More
  46. Lincomycin hydrochloride (U-10149A)

    Catalog No. A10532
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    Lincomycin is a lincosamide antibiotic isolated from Streptomyces lincolnensis which is reported to inhibit bacterial protein synthesis and is concentration dependent. Learn More
  47. INNO-206 (Aldoxorubicin)

    Catalog No. A12326
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    Aldoxorubicin, also known as INNO-206, is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. Learn More
  48. Tegafur

    Catalog No. A10407
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    DNA/RNA Synthesis inhibitor
    Tegafur is a chemotherapeutic 5-FU prodrug used in the treatment of cancers. It is a component of tegafur-uracil. Learn More
  49. Dacarbazine

    Catalog No. A10281
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    Dacarbazine is an antineoplastic chemotherapy drug used in the treatment of various cancers.Dacarbazine is a member of the class of alkylating agents, which destroy cancer cells by adding an alkyl group (CnH2n+1) to its DNA. Learn More
  50. Floxuridine

    Catalog No. A10392
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    DNA/RNA Synthesis inhibitor
    Floxuridine is an oncology drug that belongs to the class known as antimetabolites. Learn More

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