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Oxaliplatin (Eloxatin)
Catalog No. A10346 DNA/RNA Synthesis inhibitorOxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. In vivo studies showed that Oxaliplatin has anti-tumor activity against colon carcinoma through its (non-targeted) cytotoxic effects. Learn More -
Bleomycin hydrochloride
Catalog No. A12773 Bleomycin hydrochloride is an antitumor antibiotic which induces apoptosis. Learn More -
Azithromycin (Zithromax)
Catalog No. A11803 Azithromycin is an azalide antibiotic, which inhibits the growth of gram negative bacteria, such as Haemophilus influenza. Learn More -
Epirubicin
Catalog No. A12409 Topoisomerase inhibitorEpirubicin is a cell-permeable antitumor antibiotic. A stereoisomer of Doxorubicin that exhibits reduced cardiotoxicity. Epirubicin’s antitumor actions are mediated by targeting and inhibiting Topo II (topoisomerase II). Learn More -
INNO-206 (Aldoxorubicin)
Catalog No. A12326 Aldoxorubicin, also known as INNO-206, is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. Learn More -
Tegafur
Catalog No. A10407 DNA/RNA Synthesis inhibitorTegafur is a chemotherapeutic 5-FU prodrug used in the treatment of cancers. It is a component of tegafur-uracil. Learn More -
Bleomycin
Catalog No. A14378 Bleomycin is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. It acts by induction of DNA strand breaks. Learn More -
RK-33
Catalog No. A16194 DDX3 inhibitorRK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Learn More -
Cycloheximide (Actidione)
Catalog No. A10036 Protein Synthesis InhibitorCycloheximide (also known as actidione) is used as an selective antibiotic. It inhibits the protein synthesis (DNA-dependent RNA) of saprobic fungi eukaryotes. by binding with the 80S ribosome, while inactive against dermatophytes and systemic fungi. Learn More -
YK 4-279
Catalog No. A11612 RHA inhibitorYK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. Learn More -
Clofarabine
Catalog No. A10228 DNA/RNA Synthesis inhibitorClofarabine is a second generation purine nucleoside analog with antineoplastic activity Learn More -
Clafen (Cyclophosphamide)
Catalog No. A10224 Clafen (Cyclophosphamide) is a nitrogen mustard alkylating agent. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring. Learn More -
Cisplatin
Catalog No. A10221 Cisplatin was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death). Learn More -
Carboplatin
Catalog No. A10182 Carboplatin is a chemotherapy drug used against some forms of cancer (mainly ovarian carcinoma, lung, head and neck cancers). Cisplatin and carboplatin, as well as oxaliplatin, interact with DNA, akin to the mechanism of alkylating agents.
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Daptomycin
Catalog No. A10289 DNA/RNA Synthesis inhibitorDaptomycin is a lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. Learn More -
CX-5461
Catalog No. A11065 DNA/RNA Synthesis inhibitorCX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. Learn More -
Cidofovir (Vistide)
Catalog No. A10214 DNA/RNA Synthesis inhibitorCidofovir (Vistide) is an antiviral used for the treatment of cytomegalovirus (CMV) infection (ie: retinitis). Learn More -
Gemcitabine HCl (Gemzar)
Catalog No. A10423 DNA/RNA Synthesis inhibitorGemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth. Learn More -
Fluorouracil (Adrucil)
Catalog No. A10042 DNA and RNA synthesis inhibitorFluorouracil (Adrucil) is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. Learn More -
Bleomycin sulfate
Catalog No. A10152 DNA/RNA Synthesis inhibitorBleomycin sulfate is a mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Learn More -
CRT0044876
Catalog No. A14304 APE1 inhibitorCRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM. Learn More -
4EGI-1
Catalog No. A14199 eIF4E/eIF4G inhibitor4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 uM. Learn More -
MB-7133
Catalog No. A22007 -
SCR7
Catalog No. A15447 DNA ligase IV inhibitorSCR7 is a specific DNA Ligase IV inhibitor. SCR7 inhibits end joining of double strand breaks in diverse cell types resulting in tumour regression by activation of p53 mediated apoptosis. Learn More -
TAS-102
Catalog No. A15533 Trifluridine-tipiracil hydrochloride mixtureTAS-102 is an orally bioavailable combination agent composed of the cytotoxic pyrimidine analog Trifluridine (5-trifluoro-2??-deoxythymidine or TFT) and a thymidine phosphorylase inhibitor (TPI) tipiracil hydrochloride, in a molar ratio of 1.0:0.5 (TFT:TPI), with potential antineoplastic activity, Learn More -
Mitomycin C
Catalog No. A11491 DNA synthesis inhibitorMitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells. Learn More -
L189
Catalog No. A15790 DNA Ligase InhibitorL189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM. Learn More -
E3330
Catalog No. A14440 APE1 Redox InhibitorE3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. Learn More -
6-Mercaptopurine Monohydrate
Catalog No. A15898 de novo purine synthesis inhibitor6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. Learn More -
Trifluridine
Catalog No. A10948 Trifluridine is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name, Viroptic, by Glaxo Wellcome, now merged into GlaxoSmithKline. Learn More -
L67
Catalog No. A15978 DNA ligases inhibitorL67 is a DNA Ligase Inhibitor. L67 inhibited DNA ligases I and III. L67 is a simple competitive inhibitor with respect to nicked DNA. Learn More -
Saccharin 1-methylimidazole
Catalog No. A16114 DNA and RNA synthesis activatorSaccharin 1-methylimidazole is considered a general-purpose activator for DNA and RNA synthesis. Learn More -
AN2718
Catalog No. A16203 RNA synthetase inhibitorAN2718 is a novel boron-containing small molecule that inhibits an essential protein synthesis enzyme, leucyl-transfer RNA synthetase, or LeuRS. Learn More -
Chebulinic acid
Catalog No. A16208 Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. Learn More -
Tubercidin
Catalog No. A13285 Tubercidin is an adenosine analog, is an antibiotic obtained from Streptomyces tubercidicus. Learn More -
Mizoribine
Catalog No. A10597 Mizoribine is an imidazole nucleoside immunosuppressant agent that was first isolated from the mold Eupenicillium brefeldimium with antibiotic and cytotoxic effects. Learn More -
CCT239065
Catalog No. A11147 DNA, RNA Synthesis InhibitorCCT239065 is a mutant protein kinase inhibitor that inhibits signaling downstream of V600EBRAF in cancer cells, blocking DNA synthesis, and inhibiting proliferation. Learn More -
NSC-207895 (XI-006)
Catalog No. A11179 MDMX InhibitorNSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.
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Nelarabine (Arranon)
Catalog No. A10632 Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Learn More -
Fludarabine Phosphate (Fludara)
Catalog No. A10395 Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas) .Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells. Learn More -
Floxuridine
Catalog No. A10392 DNA/RNA Synthesis inhibitorFloxuridine is an oncology drug that belongs to the class known as antimetabolites. Learn More -
Dacarbazine
Catalog No. A10281 Dacarbazine is an antineoplastic chemotherapy drug used in the treatment of various cancers.Dacarbazine is a member of the class of alkylating agents, which destroy cancer cells by adding an alkyl group (CnH2n+1) to its DNA. Learn More -
Lincomycin hydrochloride (U-10149A)
Catalog No. A10532 Lincomycin is a lincosamide antibiotic isolated from Streptomyces lincolnensis which is reported to inhibit bacterial protein synthesis and is concentration dependent. Learn More -
Lomustine (CeeNU)
Catalog No. A10535 Lomustine is an alkylating nitrosourea compound that possesses antitumor activity similar to Carmustine causing DNA interstrand cross-linking. Learn More -
Mercaptopurine
Catalog No. A10568 Mercaptopurine has been shown to interfere with DNA and RNA synthesis and cause inhibition of de novo purine syntehsis. Learn More -
4E1RCat
Catalog No. A14301 eIF4F subunit interaction inhibitor4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Learn More -
Adenine sulfate
Catalog No. A11804 Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. Learn More -
Thiostrepton
Catalog No. A12890 natural cyclic oligopeptide antibioticAntibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression. Learn More -
Apaziquone
Catalog No. A12406 Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Learn More -
Ifosfamide
Catalog No. A10466 Ifosfamide is a cytostatic agent that is structurally related to cyclophosphamide. Learn More
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