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Proteases

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Items 51-100 of 223

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Catalog No.
Product Name
Application
Product Information
Product Citation
  1. A11570
    Saquinavir Mesylate

    HIV Protease Inhibitor

    Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy.
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  2. A11580
    Simeprevir

    HCV NS3/4A protease inhibitor

    Simeprevir is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).
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  3. A11601
    MG-115

    Reversible Proteasome Inhibitor

    MG-115 is a potent, reversible peptide aldehyde inhibitor of proteasome chymotrypsin-like and caspase-like activities. It induces p53 dependent apoptosis.
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  4. A11674
    Epalrestat

    aldose reductase inhibitor

    Epalrestat is an aldose reductase inhibitor.
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  5. A11764
    Camostat mesylate

    Camostat mesylate is an orally active protease inhibitor. Known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin.
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  6. A11774
    Argatroban

    Thrombin inhibitor

    Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor.
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  7. A11790
    Fidarestat (SNK-860)

    Aldose reductase inhibitor

    Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.
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  8. A11791
    Calyculin A

    PP2A inhibitor

    Calyculin A is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM.
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  9. A11853
    Darunavir Ethanolate (Prezista)

    HIV protease inhibitor

    Darunavir Ethanolate (Prezista) is an HIV protease inhibitor.
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  10. A11871
    Indinavir sulfate

    Indinavir sulfate is a novel hydroxyaminopentane amide class of HIV-1 protease inhibitors.
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  11. A11901
    PMSF

    Serine/cysteine protease inhibitor

    PMSF is an irreversible serine/cysteine protease inhibitor.
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  12. A11944
    Apoptosis Activator 2

    Apoptosis Activator

    Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells
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  13. A11985
    Amprenavir

    Amprenavir is an human immunodeficiency virus (HIV) protease inhibitor with IC50 of 14.6 ?? 12.5 ng/ml for wild-type HIV isolates
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  14. A12002
    Arctigenin

    Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. It inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM)
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  15. A12020
    Balicatib

    Cathepsin K inhibitor

    Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys.
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  16. A12304
    D-erythro-Sphingosine

    p32-kinase activator

    D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator.
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  17. A12373
    Z-VAD-FMK

    Pan Caspase Inhibitor

    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
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  18. A12433
    Flurizan

    gamma-secretase modulator

    Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.
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  19. A12509
    Ximelagatran

    Thrombin inhibitor

    Ximelagatran is an anticoagulant that has been investigated extensively as a replacement for warfarin that would overcome the problematic dietary, drug interaction, and monitoring issues associated with warfarin therapy.
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  20. A12528
    Vildagliptin

    DPP-IV Inhibitor

    Vildagliptin is a dipeptidyl peptidase-4 (CD26) inhibitor.
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  21. A12611
    Z-VEID-FMK

    Caspase-6 inhibitor

    Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2. Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability.
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  22. A12637
    Z-VDVAD-FMK

    Caspase-2 inhibitor

    Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes.
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  23. A12653
    ONX-0914

    Immunoproteasome inhibitor

    ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.
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  24. A12697
    Z-DQMD-FMK

    Caspase-3 inhibitor

    Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3.
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  25. A12778
    Lomitapide

    MTP inhibitor

    Lomitapide is a potent microsomal triglyceride transfer protein (MTP) inhibitor.
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  26. A12779
    Alvelestat

    neutrophil elastase inhibitor

    Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE).
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  27. A12791
    Sephin1

    PPP1R15A inhibitor

    Sephin1 is a selective inhibitor of stress-induced PPP1R15A and targets disease associated with accumulation of misfolded protein.
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  28. A12817
    3AC (3α-Aminocholestane)

    SHIP1 Inhibitor

    3AC is a cell-permeable, selective inhibitor of SHIP1 polyphosphatase activity toward PIP3 (IC50 = 10 μM), but has no effect on SHIP2 or PTEN activity on PIP3.
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  29. A12826
    Marimastat

    MMP inhibitor

    Marimastat acted as a broad-spectrum matrix metalloproteinase inhibitor.
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  30. A12980
    RN-18

    HIV-1 Vif inhibitor

    RN-18 is a HIV-1 viral infectivity factor (HIV-1 Vif) inhibitor with an IC50 of 6 μM in nonpermissive H9 cells.
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  31. A12985
    Batimastat (BB-94)

    MMP inhibitor

    Batimastat (BB-94) is a potent and synthetic inhibitor of a broad spectrum of matrix metalloproteinases (MMPs), including interstitial collagenase (IC50 = 3 nM), stromelysin (IC50 = 20 nM), Mr 72,000 type IV collagenase (IC50 = 4 nM), Mr 92,000 type IV collagenase (IC50 = 4 nM), and matrilysin (IC50 = 6 nM). It is a low-molecular-weight (MW = 478) and peptide-like collagen substrate analogue consisting of a peptide backbone and a hydroxamic acid group which bind to MMPs and the catalytically active zinc atom respectively.
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  32. A13026
    Prodipine hydrochloride

    Prodipine, a diphenyl-phosphonate derivative. The IC50s of Prodipine for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit are 4.5 μM and 30 μM, respectively.
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  33. A13070
    LY573636 (Tasisulam)

    Apoptosis inducer

    LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.
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  34. A13072
    NSC 405020

    MT1-MMP inhibitor

    NSC-405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L).
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  35. A13155
    Ledipasvir (GS 5885)

    NS5A inhibitor

    Ledipasvir is an inhibitor of the hepatitis C virus HCV NS5A protein
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  36. A13183
    Trifloxystrobin

    Trifloxystrobin (CGA 279202) is a fungicide, with EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h.
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  37. A13199
    Trovirdine

    HIV-1 RT inhibitor

    Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.
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  38. A13256
    CA-074

    Cathepsin B inhibitor

    CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
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  39. A13257
    E-64

    Cysteine Protease inhibitor

    E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain.
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  40. A13258
    Loxistatin Acid (E64-C)

    Cysteine Protease inhibitor

    Loxistatin Acid, a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
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  41. A13259
    E 64d (Aloxistatin)

    Cysteine Protease inhibitor

    E-64d is an inhibitor of cathepsins B and L and it is lysosome and cell permeable.
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  42. A13310
    MK-3102

    DPP-4 inhibitor

    Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).
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  43. A13311
    Alogliptin Benzoate

    DPP-4 inhibitor

    Alogliptin Benzoate is a dipeptidyl-peptidase-4 (DPP 4) inhibitor
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  44. A13312
    Trelagliptin Succinate (SYR-472)

    DPP-4 inhibitor

    Trelagliptin is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D).
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  45. A13330
    Apratastat

    dual TACE/MMPs inhibitor

    Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) .
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  46. A13404
    FABP4 Inhibitor

    FABP4 Inhibitor is a cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively).
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  47. A13490
    4-Butylresorcinol

    4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM.
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  48. A13503
    Z-DEVD-FMK

    Caspase-3 Inhibitor

    Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.
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  49. A13546
    HTS01037

    FABP inhibitor

    HTS01037 is an inhibitor of fatty acid binding; and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 with a Ki of 0.67 μM.
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  50. A13571
    Alogliptin

    DPP-4 inhibitor

    Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
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