Aurora Kinase

Catalog No.Inhibitor Name Aurora AAurora BAurora COther
A10004Alisertib
****
*
A10981Tozasertib
****
**
***
Bcr-Abl,FLT3
A10109Barasertib
*
****
A11009ZM 447439
**
*
LCK,Src,MEK1
A10601MLN8054
****
*
LCK,PKA,CK2
A10715Danusertib
***
**
**
Abl,TrkA,RET
A10095AT9283
****
****
JAK3,JAK2,Abl1 (T315I)
A10494JNJ-7706621
***
***
CDK2/CyclinE,CDK2/CyclinA,CDK1/CyclinB
A10448Hesperadin
*
TbAUK1
A10100Aurora A Inhibitor I
****
*
*
A10508KW-2449
**
FLT3 (D835Y),Abl (T315I),FLT3
A10851SNS-314 Mesylate
***
**
****
A10352ENMD-2076
***
*
FLT3,RET,VEGFR3/FLT4
A10714PHA-680632
**
*
*
FGFR1,PLK1,FLT3
A11410MK-5108
****
A10248CYC116
***
***
VEGFR2,FLT3,CDK2/CyclinE
A11066AMG-900
***
****
****
p38α,TYK2,JNK2
A11171PF-03814735
****
***
FLT1,FAK,TrkA
A10184CCT129202
**
*
*
A11168GSK1070916
*
****
***
FLT1,Tie-2,SIK
A11067TAK-901
**
***
JAK3,c-Src,YES1
A11081CCT137690
***
**
**
A13396MK-8745
****
*
A10352ENMD-2076 L-(*)-Tartaric acid
***
*
FLT3,RET,VEGFR3/FLT4
A15762BI-847325
**
****
***
A13250Reversine
***
***
**
human A3 adenosine receptor

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

32 Item(s)

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  1. MLN8237 (Alisertib)

    Catalog No. A10004
    Aurora A Kinase inhibitor
    MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3.. Learn More
  2. GSK1070916

    Catalog No. A11168
    Aurora Kinase B/C inhibitor

    GSK1070916 is a potent Aurora B/C kinase inhibitor (with IC50 of 3.5 nM/6.5 nM) with broad antitumor activity in tissue culture cells and human tumor xenograft models.

    Learn More
  3. PF-03814735

    Catalog No. A11171
    Aurora A/B Kinase inhibitor
    PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1. Learn More
  4. PHA-680632

    Catalog No. A10714
    Aurora inhibitor
    PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3. Learn More
  5. MK-5108 (VX-689)

    Catalog No. A11410
    Aurora A Kinase inhibitor
    MK-5108, also known as VX-689, is a competitive inhibitor of the ATP-binding site of aurora A kinase. Learn More
  6. SNS-314

    Catalog No. A10851
    Aurora inhibitor
    SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1. Learn More
  7. ZM-447439

    Catalog No. A11009
    Aurora Kinase inhibitor
    ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc. Learn More
  8. CYC116 (CYC-116)

    Catalog No. A10248
    Aurora Kinase inhibitor
    Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Learn More
  9. Reversine

    Catalog No. A13250
    human A3 adenosine receptor antagonist /Aurora inhibitor
    Reversine is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 12 nM/13 nM/20 nM, respectively. Also used for stem cell dedifferentiation. Learn More
  10. MK-8745

    Catalog No. A13396
    Aurora Kinase A Inhibitor
    MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Learn More
  11. SAR156497

    Catalog No. A14382
    Aurora Kinase inhibitor
    SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A), 1 nM (Aurora B / incenp), 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP3A4 and PDE3 inhibition. Learn More
  12. AZD1152

    Catalog No. A15011
    Aurora B inhibitor
    AZD1152 is a pro-drug that rapidly undergoes phosphatase-mediated cleavage in serum to release barasertib-hQPA, a selective Aurora B kinase inhibitor that has shown preliminary activity in clinical studies of patients with acute myeloid leukemia (AML). Learn More
  13. BI-847325

    Catalog No. A15762
    MEK/Aurora Inhibitor
    BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. Learn More
  14. CCT129202

    Catalog No. A10184
    Aurora Inhibitor

    CCT129202 is a representative of a structurally novel series of imidazopyridine small-molecule inhibitors of Aurora kinase activity. It shows high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines.

    Learn More
  15. Aurora A Inhibitor

    Aurora A Inhibitor I is a potent and selective inhibitor of Aurora A kinase (AurA), with IC50 values to be 3.4 nM (Aurora A) and unusually high selectivity 1000 fold against Aurora B; a useful tool compound for investigating the cellular role of Aurora A kinases.

    Learn More
  16. Hesperadin

    Catalog No. A10448
    Aurora B Kinase inhibitor
    Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo. Learn More
  17. AT9283

    Catalog No. A10095
    Aurora/JAK inhibitor
    AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation. Learn More
  18. AZD1152-HQPA (Barasertib)

    Catalog No. A10109
    Aurora Kinase B inhibitor
    AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, with Ki values to be 0.36 (Aurora B) and 1369 nM (Aurora A) respectively and has a high specificity versus a panel of 50 other kinases. Learn More
  19. Aurora Kinase inhibitor
    VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases. Learn More
  20. Danusertib (PHA-739358)

    Catalog No. A10715
    Aurora inhibitor
    Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2 Learn More
  21. MLN8054

    Catalog No. A10601
    Aurora A Inhibitor
    MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo. Learn More
  22. JNJ-7706621

    Catalog No. A10494
    CDK/Aurora A/B Inhibitor
    JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1. Learn More
  23. ENMD-2076

    Catalog No. A10352
    Aurora A / FLT3 Inhibitor
    ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2. Learn More
  24. KW-2449

    Catalog No. A10508
    FLT3/FGFR/Bcr-Abl/Aurora Inhibitor
    KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. Learn More
  25. AMG 900

    Catalog No. A11066
    Aurora Kinase inhibitor
    AMG 900 is a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Learn More
  26. TAK-901

    Catalog No. A11067
    Aurora Kinase A/B inhibitor
    TAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1. Learn More
  27. CCT137690

    Catalog No. A11081
    Aurora Kinase inhibitor
    CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM. It has little effect on hERG ion-channel. Learn More
  28. HOI-07

    Catalog No. A15970
    Aurora B inhibitor
    HOI-07 is a potently Aurora B kinase inhibitor. Learn More
  29. SCH-1473759

    Catalog No. A14059
    Aurora A/B inhibitor
    SCH-1473759 is a novel sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively. Learn More
  30. TC-A-2317 HCl

    Catalog No. A13567
    Aurora kinase A inhibitor
    TC-A-2317 hydrochloride is a potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity. Learn More
  31. XL-228

    Catalog No. A13069
    IGF-1R, Aurora, FGFR, ABL, SRC inhibitor
    XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases. Learn More
  32. LY3295668

    Catalog No. A16869
    Aurora A Inhibitor
    LY3295668, also known as AK-01, is potent Aurora-A kinase inhibitor. Learn More

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