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Mc-MMAD
Catalog No. A15156 Tubulin inhibitorMonomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate; Mc-MMAD is a protective group (maleimidocaproyl) -conjugated MMAD. Learn More -
Cabazitaxel
Catalog No. A11831 Microtubule Associated inhibitorCabazitaxel is a semi-synthetic derivative of a natural taxoid. Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment Learn More -
CW069
Catalog No. A13735 Microtubule Associated inhibitorCW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 uM, significant selectivity over KSP. Learn More -
INH1
Catalog No. A13872 Hec1 imhibitorINH1 is a Hec1 inhibitor. It binds Hec1, inhibiting its association with Nek2 and kinetochores. Learn More -
INH6
Catalog No. A14200 Hec1 InhibitorINH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. Learn More -
Vinorelbine Tartrate
Catalog No. A14295 Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Learn More -
VcMMAE
Catalog No. A14362 VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Learn More -
Sagopilone
Catalog No. A14328 microtubule stabilizerSagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Learn More -
Cucurbitacin B
Catalog No. A14665 Microtubule polymerization inhibitorCucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. Also it is an potent Microtubule polymerization inhibitor Learn More -
7-Epi 10-Desacetyl Paclitaxel
Catalog No. A14980 7-Epi 10-Desacetyl Paclitaxel is a derivative of Paclitaxel, which is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. Learn More -
7-xylosyltaxol
Catalog No. A14981 7-xylosyltaxol is a taxol derivative, Paclitaxel binds to tubulin and inhibits the disassembly of microtubules. Learn More -
Docetaxel Trihydrate
Catalog No. A15070 Docetaxel trihydrate, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. Learn More -
CK-636
Catalog No. A13827 Arp2/3 inhibitorCK-636 is a Arp2/3 complex inhibitor. CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. Learn More -
MMAD
Catalog No. A15172 Tubulin inhibitorMMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. Learn More -
Vc-MMAD
Catalog No. A15273 Tubulin inhibitorVc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate. Learn More -
D-64131
Catalog No. A14442 Tubulin inhibitorD-64131 is a novel inhibitor of tubulin polymerization that inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Learn More -
ELR510444
Catalog No. A15455 Microtubule DisruptorELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in ??III-tubulin-overexpressing cell lines. Learn More -
Vinblastine sulfate
Catalog No. A13661 microtubule dynamics inhibitorVinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Learn More -
DM1-Sme
Catalog No. A15960 maytansinoid microtubular inhibitorDM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. Learn More -
TRx0237 (LMTX) mesylate
Catalog No. A16124 tau protein aggregation inhibitorTRx 0237 (LMT) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Learn More -
Tasidotin hydrochloride
Catalog No. A21944 microtubule assembly and microtubule dynamics inhibitorTasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics. Learn More -
CK-869
Catalog No. A20970 Arp2/3 complex inhibitorCK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM. Learn More -
CK-666
Catalog No. A20973 Arp2/3 complex inhibitorCK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation. Learn More -
Entasobulin
Catalog No. A21027 β-tubulin polymerization inhibitorEntasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity. Learn More -
Podophyllotoxin
Catalog No. A10740 Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin. Learn More -
Paclitaxel (Taxol)
Catalog No. A10689 Microtubule Associated inhibitorPaclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Learn More -
Vincristine sulfate
Catalog No. A10973 Tubulin inhibitorVincristine is a mitotic inhibitor, and is used in cancer chemotherapy. Learn More -
Epothilone A
Catalog No. A10359 Microtubule Associated inhibitorEpothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Learn More -
Epothilone B (EPO906)
Catalog No. A10360 Microtubule Associated inhibitorEpothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. Learn More -
Vinflunine Tartrate
Catalog No. A10975 Microtubule Associated inhibitorVinflunine Tartrate is a tartrate salt of vinflunine that destabilizes microtubules with an IC50 of 18.8 nM and interferes with the dynamics of microtubules during cell division. Learn More -
CYT997 (Lexibulin)
Catalog No. A10264 Microtubule InhibitorCYT997 is a novel anti-cancer vascular disrupting agent (VDA). In vitro, CYT997 is shown to potently inhibit the proliferation of vascular endothelial growth factor-stimulated human umbilical vein endothelial cells (IC(50) 3.7 ± 1.8 nM) and cause significant morphological changes at 100 nM, including membrane blebbing. Learn More -
ABT-751 (E-7010)
Catalog No. A10024 Microtubule Associated inhibitorABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. Learn More -
Vinorelbine (Navelbine)
Catalog No. A10976 Vinorelbine is the first 5´NOR semi-synthetic vinca alkaloid. It is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus. Learn More -
Chloroxine
Catalog No. A10204 Chloroxine is an antibacterial drug useful for dandruff and seborrheic dermatitis. Learn More -
Albendazole
Catalog No. A10049 Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. Learn More -
Epothilone D
Catalog No. A11412 Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. Learn More -
Docetaxel (Taxotere)
Catalog No. A10326 Microtubule Associated inhibitorDocetaxel (Taxotere) is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions. Learn More -
Ixabepilone
Catalog No. A11449 microtubule inhibitorIxabepilone is an epothilone B analog Learn More -
Cevipabulin (TTI-237)
Catalog No. A12591 Cevipabulin (TTI-237), an antimicrotubule agent, is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. Learn More -
Combretastatin A4
Catalog No. A12601 Combretastatin A4 is an antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. Learn More -
Vincristine
Catalog No. A11617 Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM. Learn More -
Eribulin Mesylate
Catalog No. A12804 Eribulin mesylate is the mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Learn More -
Fosbretabulin disodium (CA4P)
Catalog No. A13081 microtubule-targeting agentFosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Learn More -
Nocodazole
Catalog No. A13219 microtubule inhibitorNocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion. Learn More -
Ansamitocin P-3
Catalog No. A13268 microtubule depolymerizing agentAnsamitocin P-3 is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. Learn More -
4-Demethylepipodophyllotoxin
Catalog No. A10014 microtubule assembly inhibitor4-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly. Learn More -
Colchicine
Catalog No. A10238 Colchicine is an inhibitor of microtubules by specific binding to tubulin. Learn More -
Monomethyl auristatin E
Catalog No. A12954 Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity. Learn More
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