Topoisomerase

Inhibitory Selectivity
Catalog No.Inhibitor Name TopoisomeraseTopo ITopo IITopo IVOther
A10174Camptothecin
**
A10939Topotecan HCl
****
A10465Idarubicin HCl
***
Multicellular spheroids
A10194Daunorubicin HCl
***
A11999Betulinic acid
**
HIV-1,Aminopeptidase N
A11861Flumequine
*
A14403Doxorubicin
A10373Etoposide
A10478Irinotecan
A10345Epirubicin HCl
A10596Mitoxantrone HCl
A10609Moxifloxacin HCl
A10479Irinotecan HCl Trihydrate
A12011SN-38
A10071Amonafide
A10907Teniposide
A10419Gatifloxacin
A10426Genistein
EGFR
A10595Mitoxantrone
A10735Pirarubicin
A10041Adriamycin
A10557Marbofloxacin
A10666Ofloxacin
A10740Podophyllotoxin
A12663Amrubicin
A13059Beta-Lapachone
IDO1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A11997 SALE

(S)-10-Hydroxycamptothecin

-
(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis.
A15064 SALE

ABT 492 meglumine (Delafloxacin meglumine)

-
ABT 492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms. in vitro:
A10023 SALE

ABT-492 (Delafloxacin)

Fluoroquinolone antibiotic
ABT-492 is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.
A10041 SALE

Adriamycin

topoisomerase II inhibitor

Adriamycin is an anthracycline antibiotic, it works by intercalating DNA, while most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas.

A10071 SALE

Amonafide (AS1413)

Topoisomerase inhibitor

Amonafide is a DNA intercalator and topoisomerase II inhibitor for the treatment of neoplastic diseases, one of Antitumor agent.

A12663

Amrubicin

topoisomerase II inhibitor
Amrubicin is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II. Antineoplastic.
A13059 SALE

Beta-Lapachone

-
Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.
A11999 SALE

Betulinic acid

-
Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties.
A10174 SALE

Camptothecin

Topoisomerase I inhibitor
Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I).
A10194 SALE

Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

-

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

A14403

Doxorubicin

-
Doxorubicin is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
A10345 SALE

Epirubicin HCl

-
Epirubicin is a cell-permeable anthracycline antitumor antibiotic. It is a stereoisomer(4′-epi-isomer) of doxorubicin that exhibits reduced cardiotoxicity. It is used to inhibit topoisomerase II and DNA helicase activity.
A10373 SALE

Etoposide (VP-16)

topoisomerase II inhibitor
Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.
A11231

Exatecan mesylate

topoisomerase I-inhibitor
Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death.
A11861

Flumequine

-
Flumequine is a synthetic chemotherapeutic antibiotic which affecting mammalian chromosome and DNA unwinding at the level of gyrase/topoisomerases.
A10419 SALE

Gatifloxacin

-
Gatifloxacin is a fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 ng/ml) and topoisomerase IV (IC50 = 13.8 ng/ml).
A10426 SALE

Genistin (Genistoside)

-
Genistin is an isoflavone found in a number of dietary plants like soy and kudzu. It was shown to stimulate estrogen-dependent breast cancer cell growth in vivo.
A10465

Idarubicin HCl

Topoisomerase inhibitor
Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin.
A10478 SALE

Irinotecan

-
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
A10479 SALE

Irinotecan HCl Trihydrate (Campto)

Topoisomerase inhibitor
Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of topoisomerase 1 involved in cellular DNA replication and transcription.
A10557 SALE

Marbofloxacin

Topoisomerase inhibitor
Marbofloxacin is a potent antibiotic of the 3rd generation fluoroquinolone group and acts by inhibiting bacterial DNA replication.
A10595 SALE

Mitoxantrone

-
Mitoxantrone is a synthetic antineoplastic anthracenedione (IC50 = 0.42 mM).
A10596

Mitoxantrone Hydrochloride

-
Mitoxantrone Dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative.
A10609 SALE

Moxifloxacin HCl

Topoisomerase inhibitor
Moxifloxacin is a quinolone/fluoroquinolone antibiotic.
A10652 SALE

Norfloxacin (Norxacin)

Topoisomerase inhibitor
Norfloxacin(Norxacin) is a broad-spectrum antibiotic.

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