Topoisomerase

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  1. Antagonist (1)
  2. Inhibitor (16)


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Catalog No. Product Name Product Information
A11997

(S)-10-Hydroxycamptothecin

(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis.
A10041

Adriamycin

Adriamycin is an anthracycline antibiotic, it works by intercalating DNA, while most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas.

A10071

Amonafide (AS1413)

Amonafide is a DNA intercalator and topoisomerase II inhibitor for the treatment of neoplastic diseases, one of Antitumor agent.

A12663

Amrubicin

Amrubicin is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II. Antineoplastic.
A13059

Beta-Lapachone

Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.
A10174

Camptothecin

Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I).
A10194

Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

A10345

Epirubicin HCl

Epirubicin is a cell-permeable anthracycline antitumor antibiotic. It is a stereoisomer(4′-epi-isomer) of doxorubicin that exhibits reduced cardiotoxicity. It is used to inhibit topoisomerase II and DNA helicase activity.
A10373

Etoposide (VP-16)

Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.
A11231

Exatecan mesylate

Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death.
A11861

Flumequine

Flumequine is a synthetic chemotherapeutic antibiotic which affecting mammalian chromosome and DNA unwinding at the level of gyrase/topoisomerases.
A10465

Idarubicin HCl

Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin.
A10477

Irbesartan (Avapro)

Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
A10478

Irinotecan

Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
A10479

Irinotecan HCl Trihydrate (Campto)

Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of topoisomerase 1 involved in cellular DNA replication and transcription.
A10557

Marbofloxacin

Marbofloxacin is a potent antibiotic of the 3rd generation fluoroquinolone group and acts by inhibiting bacterial DNA replication.
A10596

Mitoxantrone Hydrochloride

Mitoxantrone Dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative.
A10609

Moxifloxacin HCl

Moxifloxacin is a quinolone/fluoroquinolone antibiotic.
A10652

Norfloxacin (Norxacin)

Norfloxacin(Norxacin) is a broad-spectrum antibiotic.
A10666

Ofloxacin (DL8280)

Ofloxacin is a synthetic broad-spectrum antimicrobial agent.
A11902

Pefloxacin mesylate

Pefloxacin mesylate is a synthetic chemotherapeutic agent and an antibacterial agent with IC5N/A of 6.7 nM.
A10735

Pirarubicin

Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin. Intercalates into DNA and interacts with Topo II (topoisomerase II) and supressing DNA replication
A10740

Podophyllotoxin

Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin.
A12011

SN 38

SN 38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor).
A10939

Topotecan HCl (Hycamtin)

Topotecan HCl (Hycamtin) is a chemotherapeutic agent that is a topoisomerase inhibitor.

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