Topoisomerase

Inhibitory Selectivity
Catalog No.Inhibitor Name TopoisomeraseTopo ITopo IITopo IVOther
A10174Camptothecin
**
A10939Topotecan HCl
****
A10465Idarubicin HCl
***
Multicellular spheroids
A10194Daunorubicin HCl
***
A11999Betulinic acid
**
HIV-1,Aminopeptidase N
A11861Flumequine
*
A14403Doxorubicin
A10373Etoposide
A10478Irinotecan
A10345Epirubicin HCl
A10596Mitoxantrone HCl
A10609Moxifloxacin HCl
A10479Irinotecan HCl Trihydrate
A12011SN-38
A10071Amonafide
A10907Teniposide
A10419Gatifloxacin
A10426Genistein
EGFR
A10595Mitoxantrone
A10735Pirarubicin
A10041Adriamycin
A10557Marbofloxacin
A10666Ofloxacin
A10740Podophyllotoxin
A12663Amrubicin
A13059Beta-Lapachone
IDO1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A16458

Clinafloxacin

DNA gyrase and topoisomerase IV inhibitor
Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.
A14141

TAS 103 2HCl

topoisomerase I/II inhibitor
TAS 103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models
A14158

Voreloxin

Topoisomerase II inhibitor
Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication
A12569

Ametantrone

topoisomerase II inhibitor
Ametantrone (AM) is a synthetic 9,10-anthracenedione bearing two (hydroxyethylamino)ethylamino residues at positions 1 and 4 along with other anthraquinones and anthracyclines.
A12011 SALE

SN 38

DNA topoisomerase Inhibitor
SN 38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor).
A13059 SALE

Beta-Lapachone

DNA topoisomerase II inhibitor
Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.
A10666 SALE

Ofloxacin (DL8280)

Topoisomerase inhibitor
Ofloxacin is a synthetic broad-spectrum antimicrobial agent.
A10419 SALE

Gatifloxacin

DNA gyrase/topoisomerase IV inhibitor
Gatifloxacin is a fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 ng/ml) and topoisomerase IV (IC50 = 13.8 ng/ml).
A12856

Gimatecan

topoisomerase I inhibitor
Gimatecan is an orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic and antiangiogenic activities.
A12663

Amrubicin

Topoisomerase II inhibitor
Amrubicin is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II. Antineoplastic.
A11861

Flumequine

Topoisomerase II inhibitor
Flumequine is a synthetic chemotherapeutic antibiotic which affecting mammalian chromosome and DNA unwinding at the level of gyrase/topoisomerases.
A14403

Doxorubicin

Topoisomerase II inhibitor
Doxorubicin is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
A14363

Nemorubicin

Topoisomerase II inhibitor
Nemorubicin is an anticancer drug with IC50 value of 0.08 uM. It is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition.
A16167

Levofloxacin hydrate

topoisomerase II IV inhibitor
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.
A10907

Teniposide

-
Teniposide is a semisynthetic derivative of podophyllotoxin with antineoplastic activity.
A15837

SW044248

TOP1 inhibitor‎
SW044248 is a novel noncanonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.
A15467

Clorobiocin

DNA Gyrase Inhibitor
Clorobiocin is an aminocoumarin.
A15280

Voreloxin Hydrochloride

Topoisomerase inhibitor
Voreloxin Hcl is a small molecule and a naphthyridine analogue with antineoplastic activity; inhibitor of Topo II.
A15064 SALE

ABT 492 meglumine (Delafloxacin meglumine)

-
ABT 492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms. in vitro:
A13443

BNS-22

Topo II inhibitor
BNS-22 is a potent small molecule inhibitor of Topo II (IC50 2.8 M and 0.42 M for Topo II alpha and Topo II beta, respectively).
A13993

NK314

Topoisomerase II inhibitor
NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes.
A13656

CKD602

Topoisomerase I inhibitor
CKD-602 is a topoisomerase I inhibitor.
A13780 SALE

Ellipticine

DNA topoisomerase II inhibitor
Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor.
A10735 SALE

Pirarubicin

Topoisomerase II inhibitor
Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin. Intercalates into DNA and interacts with Topo II (topoisomerase II) and supressing DNA replication
A10596

Mitoxantrone Hydrochloride

-
Mitoxantrone Dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative.
A10740 SALE

Podophyllotoxin

-
Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin.
A11231

Exatecan mesylate

Topoisomerase I inhibitor
Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death.
A10194 SALE

Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

Topoisomerase inhibitor

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

A10071 SALE

Amonafide (AS1413)

Topoisomerase inhibitor

Amonafide is a DNA intercalator and topoisomerase II inhibitor for the treatment of neoplastic diseases, one of Antitumor agent.

A10041 SALE

Adriamycin

topoisomerase II inhibitor

Adriamycin is an anthracycline antibiotic, it works by intercalating DNA, while most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas.

A10023 SALE

ABT-492 (Delafloxacin)

Fluoroquinolone antibiotic
ABT-492 is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.
A10479 SALE

Irinotecan HCl Trihydrate (Campto)

Topoisomerase inhibitor
Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of topoisomerase 1 involved in cellular DNA replication and transcription.
A10939 SALE

Topotecan HCl (Hycamtin)

DNA topoisomerase I inhibitor
Topotecan HCl (Hycamtin) is a chemotherapeutic agent that is a topoisomerase inhibitor.
A10557 SALE

Marbofloxacin

Topoisomerase inhibitor
Marbofloxacin is a potent antibiotic of the 3rd generation fluoroquinolone group and acts by inhibiting bacterial DNA replication.
A10609 SALE

Moxifloxacin HCl

Topoisomerase inhibitor
Moxifloxacin is a quinolone/fluoroquinolone antibiotic.
A10652 SALE

Norfloxacin (Norxacin)

Topoisomerase inhibitor
Norfloxacin(Norxacin) is a broad-spectrum antibiotic.
A10174 SALE

Camptothecin

Topoisomerase I inhibitor
Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I).
A10345 SALE

Epirubicin HCl

Topoisomerase II inhibitor
Epirubicin is a cell-permeable anthracycline antitumor antibiotic. It is a stereoisomer(4′-epi-isomer) of doxorubicin that exhibits reduced cardiotoxicity. It is used to inhibit topoisomerase II and DNA helicase activity.
A11999 SALE

Betulinic acid

-
Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties.
A11997 SALE

(S)-10-Hydroxycamptothecin

Topoisomerase
(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis.
A11902 SALE

Pefloxacin mesylate

-
Pefloxacin mesylate is a synthetic chemotherapeutic agent and an antibacterial agent with IC5N/A of 6.7 nM.
A11659 SALE

Sarafloxacin HCl

Topoisomerase inhibitor
Sarafloxacin hydrochloride is a fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase).
A11658

Balofloxacin

Topoisomerase inhibitor
Balofloxacin is a quinolone antibiotic. The bactericidal action of Balofloxacin results from interference with the enqyme DNA gyrase which is needed for the synthesis of bacterial DNA. Balofloxacin is efficacious against Gram-negative bacteria. It also has enhanced activity against Gram positive bacteria, including MRSA and Streptococcus pneumoniae.
A10595 SALE

Mitoxantrone

-
Mitoxantrone is a synthetic antineoplastic anthracenedione (IC50 = 0.42 mM).
A10478 SALE

Irinotecan

Topoisomerase I inhibitor
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
A10465

Idarubicin HCl

Topoisomerase inhibitor
Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin.
A10426 SALE

Genistin (Genistoside)

-
Genistin is an isoflavone found in a number of dietary plants like soy and kudzu. It was shown to stimulate estrogen-dependent breast cancer cell growth in vivo.
A10373 SALE

Etoposide (VP-16)

Topoisomerase II inhibitor
Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.
A10005 SALE

(-)-Epigallocatechin gallate

Antioxidant, antiangiogenic, antitumor agent
(-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea.

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