Epigenetic Reader Domain

Catalog No.Inhibitor Name Epigenetic Reader Domain
A12729(*)-JQ1
***
A11783I-BET151
*
A12545PFI-1
**
A11440I-BET-762
***
A13956RVX-208
*
A13227SGC-CBP30
****
A13163Bromosporine
****
A13890OTX015
****
A12948UNC1215
**
A13717UNC669
*
A14133GSK1324726A
***
A13749MS436
**
A13068CPI-203
***
A13957PFI-3

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. GSK 1210151A (I-BET151)

    Catalog No. A11783
    Quick View
    BET Bromodomain Inhibitor
    GSK1210151A is a novel selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3, and BRD4. Learn More
  2. BI-9564

    Catalog No. A16196
    Quick View
    BRD7/9 inhibitor
    BI-9564 is a potent and selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 uM, respectively). Learn More
  3. BI-7273

    Catalog No. A16068
    Quick View
    BRD9 BD Inhibitor
    BI-7273 is a selective, and cell-permeable BRD9 BD inhibitor. Learn More
  4. I-BRD9

    Catalog No. A15872
    Quick View
    Selective BRD9 inhibitor
    I-BRD9 is a potent and selective BRD9 inhibitor with pIC50 of 7.3, while it displayed a pIC50 of 5.3 against BRD4. Learn More
  5. MS436

    Catalog No. A13749
    Quick View
    BRD4 inhibitor
    MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM. Learn More
  6. I-CBP112

    Catalog No. A13165
    Quick View
    CBP/p300 bromodomain inhibitor
    I-CBP112 is a highly potent and selective p300/CBP bromodomain inhibitor (IC50 ~0.14-0.17 uM for CBP and ~0.625 uM for p300). Learn More
  7. UNC1215

    Catalog No. A12948
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    L3MBTL3 inhibitor
    UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. Learn More
  8. OTX015

    Catalog No. A13890
    Quick View
    BET inhibitor
    OTX015 is an orally bioavailable, small molecule inhibitor of BRD2, BRD3, and BRD4 (EC50s = 10-19 nM). Learn More
  9. SGC-CBP30

    Catalog No. A13227
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    CBP/p300 bromodomain inhibitor
    SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. Learn More
  10. PFI-1

    Catalog No. A12545
    Quick View
    BET inhibitor
    PFI-1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. Learn More
  11. GSK 525762A (I-BET-762)

    Catalog No. A11440
    Quick View
    BET inhibitor
    GSK-525762A is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family Learn More
  12. CPI-203

    Catalog No. A13068
    Quick View
    BET bromodomain Inhibitor
    CPI203 is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~37 nM (BRD4 α-screen assay). Learn More
  13. Bromosporine

    Catalog No. A13163
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    bromodomain inhibitor
    Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively. Learn More
  14. UNC 669

    Catalog No. A13717
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    L3MBTL inhibitor
    UNC669 is a small-molecule antagonist of methyl-lysine (KMe) reader protein with selectivity for L3MBTL1 and L3MBTL3 (IC50 of 4.2μM and 3.1μM respectively) Learn More
  15. (+)-JQ1

    Catalog No. A12729
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    BET Inhibitor
    (+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor. Learn More
  16. ABBV-744

    Catalog No. A16831
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    BET bromodomain inhibitor
    ABBV-744 is a BDII-selective BET bromodomain inhibitor that is being investigated to treat AML and metastic castration-resistant prostate cancer. Learn More
  17. A-485

    Catalog No. A16830
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    p300/CBP inhibitor
    A-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs. Learn More
  18. ZL0420

    Catalog No. A16829
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    BRD4 inhibitor
    ZL0420 is a potent and selective BRD4 inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2 respectively and good selectivity over that of the related BRD2 homolog. Learn More
  19. CPI-637

    Catalog No. A16470
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    CBP/EP300 bromodomain inhibitor
    CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor. Learn More
  20. BET-BAY 002

    Catalog No. A16368
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    BET inhibitor
    BET-BAY 002 is a potent BET inhibitor; shows efficacy in a multiple myeloma model. Learn More
  21. GW841819X

    Catalog No. A16367
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    BET Inhibitor
    GW841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomains. GW841819X was a single enantiomer but of undefined chirality at the 4-position of the benzodiazepine ring 3. Learn More
  22. OXF BD 02

    Catalog No. A16366
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    BRD4 inhibitor
    OXF BD 02, selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC50 = 382 nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains. Learn More
  23. BAY1238097

    Catalog No. A16881
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    BET inhibitor
    BAY1238097 is a potent and selective BET inhibitor. BAY1238097 binds to the acetylated lysine recognition motifs on the BRD of BET proteins, thereby preventing the interaction between BET proteins and histones. Learn More
  24. HJB-97

    Catalog No. A16872
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    BET bromodomian inhibitor
    HJB-97 is a potent BET bromodomian inhibitor. It acts by targeting BRD2/3/4 BD1 and BD2. Learn More
  25. ARV-825

    Catalog No. A16859
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    BRD4 Inhibitor
    ARV-825 is a hetero-bifunctional molecule that is composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety using proteolysis targeting chimera (PROTAC) technology. Learn More
  26. dBET1

    Catalog No. A16858
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    BRD4 protein degrader
    dBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM. Learn More
  27. E-7386

    Catalog No. A17089
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    CBP/beta-catenin modulator
    E-7386 is an orally active CBP/beta-catenin modulator. Learn More
  28. TP-472

    Catalog No. A17180
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    BRD9/7 inhibitor
    TP-472 is a potent BRD9/7 inhibitor with Kd of 33 and 340 nM, respectively. Learn More
  29. CF53

    Catalog No. A17175
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    BET inhibitor
    CF53 is a bromodomain and extra-terminal (BET) bromodomain Inhibitor with IC50 value of 11.7 nM. Learn More
    • New

    MZ1

    Catalog No. A17014
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    BRD4 protein degrader
    MZ1 is a potent inducer of reversible, long-lasting and selective removal of BRD4 over BRD2 and BRD3. Learn More
  30. PLX51107

    Catalog No. A18345
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    selective BET inhibitor
    PLX51107 is a potent and selective BET inhibitor, with Kds of 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1, and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively; PLX51107 also interacts with the bromodomains of CBP and EP300 (Kd, in the 100 nM range). Learn More
    • New

    Mivebresib (ABBV-075)

    Catalog No. A17226
    Quick View
    BET inhibitor
    Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity. Learn More
  31. CeMMEC13

    Catalog No. A16355
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    TAF1 inhibitor
    CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM). Learn More
  32. GSK6853

    Catalog No. A16330
    Quick View
    BRPF1 bromodomain inhibitor
    GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain. shows excellent BRPF1 potency (pKd 9.5) and greater than 1600-fold selectivity over all other bromodomains tested. Learn More
  33. C646

    Catalog No. A12815
    Quick View
    p300/CBP inhibitor
    C646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM). Learn More
  34. GSK2801

    Catalog No. A14015
    Quick View
    BAZ2A and BAZ2B inhibitor
    GSK2801 is a very potent inhibitor of the BAZ2 family of bromodomain containing proteins Learn More
  35. (-)-JQ1

    Catalog No. A14160
    Quick View
    BET bromodomain inhibitor
    The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. Learn More
  36. GSK1324726A (I-BET726)

    Catalog No. A14133
    Quick View
    BET inhibitor
    GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), and BRD4 (IC50= 22 nM). Learn More
  37. GSK 525768A

    Catalog No. A14134
    Quick View
    GSK 525768A is the enantiomer compound of GSK 525762A, which is a potent small molecule inhibitor that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4); GSK 525768A has NO activity towards BET. Learn More
  38. Anacardic Acid

    Catalog No. A14226
    KAT5 (Tip60), p300/PCAF inhibitor
    Anacardic Acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. Learn More
  39. PFI-3

    Catalog No. A13957
    Quick View
    SMARCA bromodomains probe
    PFI-3 is a selective chemical probe for SMARCA bromodomains. Learn More
  40. RVX-208

    Catalog No. A13956
    Quick View
    BET bromodomain inhibitor
    RVX-208 is a potent BET bromodomain inhibitor with IC50 of 0.510 uM for BD2, about 170-fold selectivity over BD1. Learn More
  41. UNC 926 hydrochloride

    Catalog No. A15367
    Quick View
    MBT Domain (L3MBTL1) Inhibitor
    UNC 926 is a methyl lysine reader domain inhibitor. Learn More
  42. PF-4

    Catalog No. A13451
    Quick View
    BRPF1 bromodomain inhibitor
    PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. Learn More
  43. PF-CBP1

    Catalog No. A15876
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    CREBBP inhibitor
    PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. Learn More
  44. BAZ2-ICR

    Catalog No. A15947
    Quick View
    BAZ2 bromodomain inhibitor
    BAZ2-ICR is an excellent chemical probe for functional studies of the BAZ2 bromodomains in vitro and in vivo. Learn More
  45. OF-1

    Catalog No. A16000
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    BRPF1B/BRPF2 bromodomain inhibitor
    OF-1 is a chemical probe for BRPF bromodomains. OF-1 has been shown to bind to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 uM (ITC). Learn More
  46. CPI 0610

    Catalog No. A16076
    Quick View
    BET bromodomain inhibitor
    CPI 0610 is a small molecule inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Learn More
  47. GSK 5959

    Catalog No. A16092
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    BRPF1 bromodomain inhibitor
    GSK 5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM. Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Learn More
  48. EML 425

    Catalog No. A16180
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    CBP/p300 inhibitor
    EML 425 is a reversible and non-competitive CBP/p300 inhibitor that is cell permeable (IC50 values are 1.1 and 2.9 uM, respectively). Learn More

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