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G007-LK
Catalog No. A15528 TNKS inhibitorG007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice, Learn More -
BMN-673 8R,9S
Catalog No. A15024 PARP InhibitorBMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM. Learn More -
PJ34
Catalog No. A15215 PARP inhibitorPJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM. Learn More -
4-HQN
Catalog No. A15370 PARP inhibitor4-HQN has been shown to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. Learn More -
BYK 204165
Catalog No. A15371 PARP-1 inhibitorBYK204165 is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1). Learn More -
BYK 49187
Catalog No. A15372 PARP-1/PARP-2 inhibitorBYK 49187, PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively). Learn More -
DR 2313
Catalog No. A15373 PARP inhibitorPARP Inhibitor XIDR 2313, PARP Inhibitor XI, is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor. Learn More -
ABT-888 (Veliparib)
Catalog No. A10026 PARP inhibitorABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor. Learn More -
NU 1025
Catalog No. A15375 PARP inhibitorNU 1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. Learn More -
EB 47
Catalog No. A15374 -
NVP-TNKS656
Catalog No. A15786 TNKS2 inhibitorNVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2. Learn More -
MN-64
Catalog No. A15927 TNKS inhibitorMN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). Learn More -
AZ6102
Catalog No. A15873 TNKS1/2 inhibitorAZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells. Learn More -
BGP-15
Catalog No. A16344 PARP inhibitorBGP-15 is a PARP inhibitor, that can protect against heart failure and atrial fibrillation in mice. Learn More -
GeA-69
Catalog No. A19705 PARP14 inhibitorGeA-69 is a selective, highly cell permeable allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2, with a Kd of 2.1 ?M. Learn More -
Talazoparib tosylate
Catalog No. A20238 PARP1/2 inhibitorTalazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC50 of 0.57 nM for PARP1. Learn More -
PARP-2-IN-1
Catalog No. A20240 PARP-2 inhibitorPARP-2-IN-1 is a potent and selective PARP-2 inhibitor with an IC50 of 11.5 nM. Learn More -
INO-1001
Catalog No. A20680 PARP inhibitorINO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. Learn More -
Benzamide
Catalog No. A14371 PARP-1 inhibitorBenzamide is the amide derivative of benzoic acid and an inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Learn More -
Olaparib (AZD2281)
Catalog No. A10111 PARP inhibitorOlaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. Learn More -
BSI-201 (Iniparib)
Catalog No. A10164 PARP inhibitorBSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier. Learn More -
AG-014699 (Rucaparib)
Catalog No. A10045 PARP inhibitorAG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair. Learn More -
AG14361
Catalog No. A10046 PARP inhibitorAG14361 is a potent PARP inhibitor, enhanced TMZ cytotoxicity in MMR(mismatch repair)-proficient / deficient cells. Learn More -
3-Aminobenzamide
Catalog No. A10475 PARP Inhibitor3-Aminobenzamide is a novel PARP inhibitor, known to sensitize cells to radiation in vitro by inhibiting the repair of DNA damage. Learn More -
A-966492
Catalog No. A10019 PARP1 inhibitorA-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. Learn More -
MK-4827 (Niraparib)
Catalog No. A11026 PARP inhibitorMK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor. Learn More -
BMN673
Catalog No. A11243 PARP inhibitorBMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Learn More -
UPF 1069
Catalog No. A12750 PARP2 inhibitorUPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively). Learn More -
AZD-2461
Catalog No. A12393 PARP InhibitorAZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein. Learn More -
PJ 34 hydrochloride
Catalog No. A12665 PARP inhibitorPJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM). Learn More -
JW 55
Catalog No. A13731 TNKS1/2 inhibitorJW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Learn More -
ME0328
Catalog No. A14309 PARP3 inhibitorME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. Learn More -
Rucaparib
Catalog No. A14182 PARP-1 inhibitorRucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells. Learn More -
AIM-100
Catalog No. A14986 Ack1 (TNK2) inhibitorAIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM. Learn More -
WIKI4
Catalog No. A14283 Tankyrase inhibitorWIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2. Learn More -
NMS-P118
Catalog No. A20994 PARP-1 InhibitorNMS-P118 is a potent, orally available, and highly selective PARP-1 Inhibitor for cancer therapy. Learn More -
Veliparib dihydrochloride
Catalog No. A21356 PARP inhibitorVeliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. Learn More -
Niraparib R-enantiomer
Catalog No. A21880 PARP1 inhibitorNiraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM. Learn More -
E7449
Catalog No. A21553 PARP1/PARP2 inhibitorE7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ?50 and ?50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. Learn More -
Niraparib hydrochloride
Catalog No. A18018 PARP1 and PARP2 inhibitorNiraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Learn More -
Niraparib tosylate
Catalog No. A16618 PARP1/PARP2 inhibitorNiraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. Learn More -
PARP14 inhibitor H10
Catalog No. A18616 PARP14 inhibitorPARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (??24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis. Learn More -
NMS-P515
Catalog No. A18449 PARP-1 inhibitorNMS-P515 is a potent inhibitor of PARP-1 both in biochemical (Kd: 0.016 μM) and cellular (IC50: 0.027 μM) assays. Learn More -
Rucaparib (Camsylate)
Catalog No. A18013 PARP inhibitorRucaparib Camsylate is an inhibitor of PARP with a Ki of 1.4 nM for PARP1, and also shows binding affinity to eight other PARP domains. Learn More -
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New
XMD16-5
Catalog No. A17130 -
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XMD8-87
Catalog No. A17134 TNK2 InhibitorXMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC50 value of 1.9 μM Learn More -
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Lanifibranor
Catalog No. A17041 PARP agonistLanifibranor, also known as IVA-337, is a peroxisome proliferator-activated receptors (PPAR) agonist. Learn More -
Pamiparib
Catalog No. A17073 PARP inhibitorPamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. CAS: 1446261-44-1 (free base) 2086689-94-1 (maleate) 2086689-93-0 (hydrate) Learn More -
TC-E 5001
Catalog No. A11454 TNKS inhibitorTC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels. Learn More
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