HSP

Inhibitory Selectivity
Catalog No.Inhibitor Name HSP70HSP90HSP90αHSP90βHSP105Other
A10010Tanespimycin
***
A10659Luminespib
***
***
***
A10011Alvespimycin HCl
*
A11402Ganetespib
***
A10143BIIB021
****
A11062Onalespib
***
A11025Geldanamycin
*
p185
A10660NVP-BEP800
*
*
A11189SNX-2112
**
**
**
A11074PF-04929113
**
HER2
A11195KW-2478
****
A11251XL888
**
A13351VER155008
*
A13817VER-50589
***
***
A14282CH5138303
****
****
A13812VER-49009
**
**
A14292NMS-E973
***
A11130PU-H71
*
A12850HSP990
****
****
****
A14389KNK437
A11131MPC-3100
*
A11269IPI-504 (Retaspimycin HCl)
A11272IPI-493
**
A12388MKT 077
A12648CUDC-305 (DEBIO-0932 )
A16050Macbecin I
A16053TRC 051384
A16056EC 144
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A10010 SALE

17-AAG (KOS953)

HSP90 inhibitor
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90.
A10011 SALE

17-DMAG HCl (Alvespimycin)

Hsp90 inhibitor
17-DMAG is a water-soluble analog of 17-AAG and geldanamycin that binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG.
A14990

Alvespimycin

Hsp90 inhibitor
Alvespimycin is a selective Hsp90 inhibitor with a GI50 of 53 nM.
A11062 SALE

AT13387

HSP90 Inhibitor
AT13387 is a targeted inhibitor of Hsp90,inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.
A10659 SALE

AUY922 (NVP-AUY922)

HSP90 Inhibitor
AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
A10143 SALE

BIIB021

HSP90 inhibitor
BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival.
A14282

CH5138303

HSP90 inhibitor
CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
A12648

CUDC-305 (DEBIO-0932 )

HSP90 inhibitor
Debio 0932 is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents.
A16056

EC 144

HSP90 inhibitor
EC 144 is a potent inhibitor of the heat shock protein 90 and was found to be effective in tumor growth suppression.
A10343

Elesclomol (STA-4783)

-
Elesclomol induces oxidative stress by provoking a buildup of reactive oxygen species within cancer cells.
A11402 SALE

Ganetespib (STA-9090)

Hsp90 inhibitor
Ganetespib is a potent, synthetic, small molecule inhibitor of Hsp90, a chaperone protein that is essential to the function of certain other proteins that drive the growth, proliferation, and survival of many different types of cancer.
A16034

Gedunin

HSP90 inhibitor
Gedunin, a naturally occurring Hsp90 inhibitor, is tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica).
A11025 SALE

Geldanamycin

Hsp90 inhibitor
Geldanamycin binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity.
A13667

Geranylgeranylacetone

-
Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1.
A12850 SALE

HSP-990

HSP90 Inhibitor
HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.
A11272

IPI-493

HSP90 inhibitor
IPI-493 is a potent and orally bioavailable HSP90 inhibitor with Ki of 21 nM.
A11269

IPI-504 (Retaspimycin HCl)

Hsp90 inhibitor
IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90).
A14389

KNK437

pan-HSP inhibitor
KNK437, dose-dependently inhibited the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells.
A16347

KRIBB11

HSF inhibitor
KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor, with IC50 of 1.2 uM.
A11195

KW-2478

HSP90 inhibitor

KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.

A16050

Macbecin I

HSP90 inhibitor
Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 activity with IC50 value of μM by binding to the ATP-binding site.
A12388 SALE

MKT 077

HSP70 Inhibitor
Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.
A11131

MPC-3100

Hsp90 inhibitor
MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
A14292

NMS-E973

HSP90 inhibitor
NMS-E973 is a potent and selective Hsp90 inhibitor.
A10660

NVP-BEP800

HSP90 Inhibitor
NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH2-terminal ATP-binding pocket of Hsp90.

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