HSP

Inhibitory Selectivity
Catalog No.Inhibitor Name HSP70HSP90HSP90αHSP90βHSP105Other
A10010Tanespimycin
***
A10659Luminespib
***
***
***
A10011Alvespimycin HCl
*
A11402Ganetespib
***
A10143BIIB021
****
A11062Onalespib
***
A11025Geldanamycin
*
p185
A10660NVP-BEP800
*
*
A11189SNX-2112
**
**
**
A11074PF-04929113
**
HER2
A11195KW-2478
****
A11251XL888
**
A13351VER155008
*
A13817VER-50589
***
***
A14282CH5138303
****
****
A13812VER-49009
**
**
A14292NMS-E973
***
A11130PU-H71
*
A12850HSP990
****
****
****
A14389KNK437
A11131MPC-3100
*
A11269IPI-504 (Retaspimycin HCl)
A11272IPI-493
**
A12388MKT 077
A12648CUDC-305 (DEBIO-0932 )
A16050Macbecin I
A16053TRC 051384
A16056EC 144
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



36 Item(s)

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Catalog No. Product Name Application Product Information
A10010 SALE

17-AAG (KOS953)

HSP90 inhibitor
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90.
A12850 SALE

HSP-990

HSP90 Inhibitor
HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.
A12388 SALE

MKT 077

HSP70 Inhibitor
Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.
A13817

VER-50589

Hsp90 inhibitor
VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM.
A13351 SALE

VER 155008

HSP 70 inhibitor
VER 155008 is a small molecule, ATP-derivative inhibitor of HSP70 (IC50 = 500 nM).
A13667

Geranylgeranylacetone

-
Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1.
A13812

VER-49009

Hsp90 inhibitor
VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM.
A14282

CH5138303

HSP90 inhibitor
CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
A14292

NMS-E973

HSP90 inhibitor
NMS-E973 is a potent and selective Hsp90 inhibitor.
A14990

Alvespimycin

Hsp90 inhibitor
Alvespimycin is a selective Hsp90 inhibitor with a GI50 of 53 nM.
A14129

PU-WS13

Grp94 Inhibitor
PU-WS13 is a potent, Grp94-specific Hsp90 inhibitor of the purine scaffold class. PU-WS13 is a cell-permeable inhibitor of Grp94 with EC50 of 220 nM.
A16050

Macbecin I

HSP90 inhibitor
Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 activity with IC50 value of μM by binding to the ATP-binding site.
A12765

Rocaglamide

Heat shock reporter
Rocaglamide is the first cyclopenta[b]benzofuran derivative (flavagline), isolated from Aglaia elliptifolia in 1982 by King and colleagues based on its antileukemic activity.
A14389

KNK437

pan-HSP inhibitor
KNK437, dose-dependently inhibited the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells.
A16034

Gedunin

HSP90 inhibitor
Gedunin, a naturally occurring Hsp90 inhibitor, is tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica).
A16053

TRC 051384

HSP70 inducer
TRC 051384, belonging to substituted 2-propen-1-one class, is a potent inducer of heat shock protein 70 (HSP70) [1]. Induction of HSP70 is a natural response of stressed cells that protects neuronal cells from a variety of insults including acute ischemia.
A16056

EC 144

HSP90 inhibitor
EC 144 is a potent inhibitor of the heat shock protein 90 and was found to be effective in tumor growth suppression.
A11272

IPI-493

HSP90 inhibitor
IPI-493 is a potent and orally bioavailable HSP90 inhibitor with Ki of 21 nM.
A12648

CUDC-305 (DEBIO-0932 )

HSP90 inhibitor
Debio 0932 is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents.
A10659 SALE

AUY922 (NVP-AUY922)

HSP90 Inhibitor
AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
A10660

NVP-BEP800

HSP90 Inhibitor
NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH2-terminal ATP-binding pocket of Hsp90.
A10143 SALE

BIIB021

HSP90 inhibitor
BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival.
A11062 SALE

AT13387

HSP90 Inhibitor
AT13387 is a targeted inhibitor of Hsp90,inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.
A11025 SALE

Geldanamycin

Hsp90 inhibitor
Geldanamycin binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity.
A11074

PF-04929113 (SNX-5422)

Hsp90 inhibitor
PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor.
A11402 SALE

Ganetespib (STA-9090)

Hsp90 inhibitor
Ganetespib is a potent, synthetic, small molecule inhibitor of Hsp90, a chaperone protein that is essential to the function of certain other proteins that drive the growth, proliferation, and survival of many different types of cancer.
A10011 SALE

17-DMAG HCl (Alvespimycin)

Hsp90 inhibitor
17-DMAG is a water-soluble analog of 17-AAG and geldanamycin that binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG.
A11189 SALE

SNX-2112

Hsp90 inhibitor

SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent

A11195

KW-2478

HSP90 inhibitor

KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.

A11131

MPC-3100

Hsp90 inhibitor
MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
A11130

PU-H71

Hsp90 Inhibitor
PU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM).
A10343

Elesclomol (STA-4783)

-
Elesclomol induces oxidative stress by provoking a buildup of reactive oxygen species within cancer cells.
A11269

IPI-504 (Retaspimycin HCl)

Hsp90 inhibitor
IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90).
A11768

Radicicol

Hsp90/SRC/COX-2 Inhibitor
Radicicol is a potent inhibitor of Hsp90, SRC, and Cox-2
A11251 SALE

XL-888

HSP90 Inhibitor
XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
A16347

KRIBB11

HSF inhibitor
KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor, with IC50 of 1.2 μM.

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