Akt

Catalog No.Inhibitor Name Akt Akt1 Akt2 Akt3 Other Targets
A10003MK-2206 2HCl
***
***
**
A10709Perifosine
*
A11030GSK690693
****
***
***
PKCθ,PKCη,PrkX
A11246Ipatasertib
****
**
***
A11759AZD5363
****
***
***
ROCK2
A11024PF-04691502
****
PI3Kδ,PI3Kα,PI3Kγ
A10094AT7867
**
***
**
PKA,p70 S6K
A13210Triciribine
*
HIV-1
A11031CCT128930
****
p70 S6K,PKA
A11034A-674563
***
PKA,CDK2,GSK-3β
A11032PHT-427
*
PDK-1
A11286Akti-1/2
**
*
*
A15809Uprosertib
*
*
**
A16392Afuresertib
****
****
****
A12464AT13148
**
*
**
PKA,ROCK2,ROCK1
A14138Miltefosine
PI3K,PKC
A10453Honokiol
MEK
A12720TIC10 Analogue
ERK
A13460Deguelin
PI3K
A15903TIC10
ERK
A11287A-443654
****
A1359010-DEBC HCl
*
A16286ARQ-092 (Miransertib)
****
****
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

33 Item(s)

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  1. Akt Inhibitor
    GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays Learn More
  2. 10-DEBC HCl

    Catalog No. A13590
    AKT/PKB inhibitor‎
    10-DEBC HCl is a selective inhibitor of Akt/PKB. It inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Learn More
  3. SR-13668

    Catalog No. A13554
    AKT inhibitor‎
    SR-13668 is an Akt inhibitor, is also an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities. Learn More
  4. Afuresertib HCl

    Catalog No. A13030
    AKT inhibitor‎
    Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Learn More
  5. TIC10 isomer

    Catalog No. A12720
    AKT inhibitor‎
    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Learn More
  6. SC79

    Catalog No. A15541
    Akt phosphorylation activator
    SC79 is an AKT activator. SC79 binds to the plecktrin homology (PH) domain of Akt that mimics the binding of PtdIns(3,4,5)P3 to induce a conformational change in Akt that enhances phosphorylation and activation. Learn More
  7. Akt inhibitor
    Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Learn More
  8. SC 66

    Catalog No. A12081
    Akt inhibitor
    SC 66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. It exhibits anticancer activity in vitro and in vivo. Learn More
  9. TIC10

    Catalog No. A15903
    Akt Inhibitor‎
    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2. Learn More
  10. Akt1 and Akt2-IN-1

    Catalog No. A16285
    AKT 1/2 inhibitor
    Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity. Learn More
  11. ARQ-092 (Miransertib)

    Catalog No. A16286
    AKT inhibitor
    ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). Learn More
  12. AT13148

    Catalog No. A12464
    multi-AGC kinase inhibitor
    AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. Learn More
  13. MK-2206 2HCl

    Catalog No. A10003
    AKT Inhibitor
    MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Learn More
  14. Miltefosine

    Catalog No. A14138
    PI3K/Akt inhibitor
    Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa Learn More
  15. AT7867 2HCl

    Catalog No. A15006
    Akt inhibitor
    AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. Learn More
  16. Tomatidine

    Catalog No. A16233
    ERK/Akt/NF-kB inhibitor
    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties. Learn More
  17. Akt-l-1

    Catalog No. A12435
    AKT1 inhibitor
    Akt-I-1 is a specific inhibitor of Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3 Learn More
  18. Triciribine

    Catalog No. A13210
    AKT Inhibitor
    Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt. Learn More
  19. Perifosine (NSC-639966)

    Catalog No. A10709
    Akt inhibitor
    Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor. Learn More
  20. PF-04691502

    Catalog No. A11024
    PI3K/mTOR Inhibitor
    PF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway. Learn More
  21. GSK690693

    Catalog No. A11030
    AKT inhibitor
    GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Learn More
  22. AT7867

    Catalog No. A10094
    AKT inhibitor
    AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. Learn More
  23. CCT128930

    Catalog No. A11031
    AKT Inhibitor
    CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. Learn More
  24. PHT-427

    Catalog No. A11032
    AKT Inhibitor
    PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Learn More
  25. AKT Inhibitor
    Triciribine phosphate inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Learn More
  26. A-674563

    Catalog No. A11034
    Akt inhibitor
    A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More
  27. Honokiol

    Catalog No. A10453
    Antiangiogenic and Antitumor Agent
    Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Learn More
  28. AKT inhibitor
    AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). Learn More
  29. A-443654

    Catalog No. A11287
    Akt inhibitor
    A-443654, a specific Akt inhibitor with Ki value of 160 pM, interferes with mitotic progression and bipolar spindle formation. Learn More
  30. AZD5363

    Catalog No. A11759
    AKT inhibitor
    AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent. Learn More
  31. KP372-1

    Catalog No. A12877
    Akt Inhibitor
    KP372-1 is a synthetic small molecule AKT inhibitor. Learn More
  32. Deguelin

    Catalog No. A13460
    Deguelin is a natural product that displays profound antiproliferative activity. Learn More
  33. Afuresertib

    Catalog No. A16392
    Akt inhibitor
    Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2. Learn More

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