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| Catalog No. | Inhibitor Name | Akt | Akt1 | Akt2 | Akt3 | Other Targets |
|---|---|---|---|---|---|---|
| A10003 | MK-2206 2HCl | *** | *** | ** | ||
| A10709 | Perifosine | * | ||||
| A11030 | GSK690693 | **** | *** | *** | PKCθ,PKCη,PrkX | |
| A11246 | Ipatasertib | **** | ** | *** | ||
| A11759 | AZD5363 | **** | *** | *** | ROCK2 | |
| A11024 | PF-04691502 | **** | PI3Kδ,PI3Kα,PI3Kγ | |||
| A10094 | AT7867 | ** | *** | ** | PKA,p70 S6K | |
| A13210 | Triciribine | * | HIV-1 | |||
| A11031 | CCT128930 | **** | p70 S6K,PKA | |||
| A11034 | A-674563 | *** | PKA,CDK2,GSK-3β | |||
| A11032 | PHT-427 | * | PDK-1 | |||
| A11286 | Akti-1/2 | ** | * | * | ||
| A15809 | Uprosertib | * | * | ** | ||
| A16392 | Afuresertib | **** | **** | **** | ||
| A12464 | AT13148 | ** | * | ** | PKA,ROCK2,ROCK1 | |
| A14138 | Miltefosine | PI3K,PKC | ||||
| A10453 | Honokiol | MEK | ||||
| A12720 | TIC10 Analogue | ERK | ||||
| A13460 | Deguelin | PI3K | ||||
| A15903 | TIC10 | ERK | ||||
| A11287 | A-443654 | **** | ||||
| A13590 | 10-DEBC HCl | * | ||||
| A16286 | ARQ-092 (Miransertib) | **** | **** | *** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
47 Item(s)
per page
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SR-13668
Catalog No. A13554 AKT inhibitorSR-13668 is an Akt inhibitor, is also an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities. Learn More -
API-1
Catalog No. A22093 Akt inhibitorAPI-1 (NSC 177223) is a potent inhibitor of Akt that induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis. Learn More -
Miransertib hydrochloride
Catalog No. A22376 Akt inhibitorMiransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. Learn More -
BAY1125976
Catalog No. A20421 allosteric Akt1/Akt2 inhibitorBAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively. Learn More -
AKT-IN-2
Catalog No. A20147 AKT inhibitorAKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1. Learn More -
ARQ-092 (Miransertib)
Catalog No. A16286 AKT inhibitorARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). Learn More -
Akt1 and Akt2-IN-1
Catalog No. A16285 AKT 1/2 inhibitorAkt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity. Learn More -
TIC10
Catalog No. A15903 Akt InhibitorTIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2. Learn More -
SC 66
Catalog No. A12081 Akt inhibitorSC 66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. It exhibits anticancer activity in vitro and in vivo. Learn More -
GSK2141795 (Uprosertib, GSK795)
Catalog No. A15809 Akt inhibitorAkt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Learn More -
SC79
Catalog No. A15541 Akt phosphorylation activatorSC79 is an AKT activator. SC79 binds to the plecktrin homology (PH) domain of Akt that mimics the binding of PtdIns(3,4,5)P3 to induce a conformational change in Akt that enhances phosphorylation and activation. Learn More -
Afuresertib HCl
Catalog No. A13030 AKT inhibitorAfuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Learn More -
MK-2206 2HCl
Catalog No. A10003 AKT InhibitorMK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Learn More -
10-DEBC HCl
Catalog No. A13590 AKT/PKB inhibitor10-DEBC HCl is a selective inhibitor of Akt/PKB. It inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Learn More -
TIC10 isomer
Catalog No. A12720 AKT inhibitorTIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Learn More -
Perifosine (NSC-639966)
Catalog No. A10709 Akt inhibitorPerifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor. Learn More -
A-674563
Catalog No. A11034 Akt inhibitorA-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More -
AKT inhibitor VIII (AKTI-1/2)
Catalog No. A11286 AKT inhibitorAKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). Learn More -
AZD5363
Catalog No. A11759 AKT inhibitorAZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent. Learn More -
GDC-0068 (Ipatasertib, RG-7440)
Catalog No. A11246 Akt InhibitorGDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays Learn More -
GSK690693
Catalog No. A11030 AKT inhibitorGSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Learn More -
Palomid 529 (P529)
Catalog No. A10693 AKT InhibitorPalomid 529 is a dual TORC1/2 inhibitor of the PI3K/Akt/mTOR pathway having broad activity in angiogenesis and cellular proliferation. Learn More -
AKT-IN-1
Catalog No. A21009 AKT inhibitorAKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. Learn More -
PF-AKT400
Catalog No. A21991 Akt inhibitorPF-AKT400 is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM). Learn More -
PF-04691502
Catalog No. A11024 PI3K/mTOR InhibitorPF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway. Learn More -
Ipatasertib dihydrochloride
Catalog No. A21734 pan-Akt inhibitorIpatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. Learn More -
YS-49
Catalog No. A21198 PI3K/Akt activatorYS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. Learn More -
CCT128930
Catalog No. A11031 AKT InhibitorCCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. Learn More -
Solenopsin
Catalog No. A21087 ATP-competitive AKT inhibitorSolenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM . Learn More -
3CAI
Catalog No. A20924 -
Isobavachalcone
Catalog No. A11453 Akt inhibitorIsobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Learn More -
AKT Kinase Inhibitor
Catalog No. A11285 Akt kinase inhibitorAKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity. Learn More -
Borussertib
Catalog No. A13364 Akt inhibitorBorussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. Learn More -
Afuresertib
Catalog No. A16392 Akt inhibitorAfuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2. Learn More -
AT7867
Catalog No. A10094 AKT inhibitorAT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. Learn More -
KP372-1
Catalog No. A12877 -
Tomatidine
Catalog No. A16233 ERK/Akt/NF-kB inhibitorTomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties. Learn More -
PHT-427
Catalog No. A11032 AKT InhibitorPHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Learn More -
Triciribine phosphate (NSC-280594)
Catalog No. A11033 AKT InhibitorTriciribine phosphate inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Learn More -
Honokiol
Catalog No. A10453 Antiangiogenic and Antitumor AgentHonokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Learn More -
AT7867 2HCl
Catalog No. A15006 Akt inhibitorAT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. Learn More -
A-443654
Catalog No. A11287 Akt inhibitorA-443654, a specific Akt inhibitor with Ki value of 160 pM, interferes with mitotic progression and bipolar spindle formation. Learn More -
Miltefosine
Catalog No. A14138 PI3K/Akt inhibitorMiltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa Learn More -
AT13148
Catalog No. A12464 multi-AGC kinase inhibitorAT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. Learn More -
Akt-l-1
Catalog No. A12435 AKT1 inhibitorAkt-I-1 is a specific inhibitor of Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3 Learn More -
Triciribine
Catalog No. A13210 AKT InhibitorTriciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt. Learn More -
Deguelin
Catalog No. A13460 Deguelin is a natural product that displays profound antiproliferative activity. Learn More
47 Item(s)
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