Autophagy

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  1. 3-Methyladenine

    Catalog No. A11151
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    Autophagy/PI3K Inhibitor
    3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase). Learn More
  2. Monensin sodium

    Catalog No. A10603
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    autophagy inhibitor
    Monensin sodium is an ionophore and inhibitor of autophagy commercially used in livestock feed. It inhibits autophagy, interfering with the fusion of the autophagosome and the lysosome. Learn More
  3. ROC-325

    Catalog No. A17031
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    Autophagy inhibitor
    ROC-325 is an autophagy inhibitor. ROC-325 exhibited superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in 12 different cancer cell lines with diverse genetic backgrounds. Learn More
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    Autophinib

    Catalog No. A17241
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    Autophagy inhibitor
    Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34. Learn More
  4. ALLO-1

    Catalog No. A18670
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    autophagy receptor
    ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. Learn More
  5. IITZ-01

    Catalog No. A20192
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    Lysosomotropic autophagy inhibitor
    IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. Learn More
  6. EACC

    Catalog No. A19062
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    Autophagy inhibitor
    EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. Learn More
  7. Aumitin

    Catalog No. A18838
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    Autophagy inhibitor
    Aumitin is an autophagy inhibitor, targeting mitochondrial complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively. Learn More
  8. EN6

    Catalog No. A18524
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    Autophagy activator
    EN6 is a novel covalent autophagy activator, targeting cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase, which activates mTORC1 via the Rag guanosine triphosphatases. Learn More
  9. QX77

    Catalog No. A13379
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    autophagy (CMA) activator
    QX77 is a chaperone-mediated autophagy (CMA) activator. Learn More
  10. Lys01 trihydrochloride

    Catalog No. A21702
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    lysosomal autophagy inhibitor
    Lys01 trihydrochloride (Lys05) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. Learn More
  11. PIK-III

    Catalog No. A15868
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    Autophagy Inhibitor
    PIK-III is a selective inhibitor of ?VPS34 enzymatic activity. Learn More
  12. SMER28

    Catalog No. A15867
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    Autophagy Activator
    SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells. Learn More
  13. Scutellarein

    Catalog No. A12234
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    Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz, has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases. Learn More
  14. Resveratrol

    Catalog No. A10785
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    Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Learn More
  15. STF-62247

    Catalog No. A10866
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    Autophagy Inducer
    STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). Learn More
  16. Flubendazole (Flutelmium)

    Catalog No. A11656
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    autophagy inducer
    Flubendazole is an anthelmintic used for protection against internal parasites and worms in dogs and cats. Learn More
  17. Hydroxychloroquine Sulfate

    Catalog No. A14208
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    Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9. Learn More
  18. Spautin-1

    Catalog No. A12942
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    Autophagy Inhibitor
    Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03μM. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM. Learn More
  19. SBC-115076

    Catalog No. A15769
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    PCSK9 antagonist
    SBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases. Learn More
  20. SBI-0206965

    Catalog No. A15795
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    ULK1 inhibitor
    SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 . Learn More
  21. MRT68921

    Catalog No. A15880
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    Autophagy ULK1/2 inhibitor
    MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. Learn More
  22. Chloroquine Phosphate

    Catalog No. A16445
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    Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Learn More
  23. Azithromycin Dihydrate

    Catalog No. A16421
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    Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. Learn More
  24. Lys05

    Catalog No. A16358
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    Autophagy inhibitor
    Lys05 is a potent lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Learn More

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