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Lys01 trihydrochloride
Catalog No. A21702 lysosomal autophagy inhibitorLys01 trihydrochloride (Lys05) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. Learn More -
QX77
Catalog No. A13379 autophagy (CMA) activatorQX77 is a chaperone-mediated autophagy (CMA) activator. Learn More -
EN6
Catalog No. A18524 Autophagy activatorEN6 is a novel covalent autophagy activator, targeting cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase, which activates mTORC1 via the Rag guanosine triphosphatases. Learn More -
Aumitin
Catalog No. A18838 Autophagy inhibitorAumitin is an autophagy inhibitor, targeting mitochondrial complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively. Learn More -
EACC
Catalog No. A19062 Autophagy inhibitorEACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. Learn More -
IITZ-01
Catalog No. A20192 Lysosomotropic autophagy inhibitorIITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. Learn More -
ALLO-1
Catalog No. A18670 autophagy receptorALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. Learn More -
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Autophinib
Catalog No. A17241 Autophagy inhibitorAutophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34. Learn More -
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SMER28
Catalog No. A15867 Autophagy ActivatorSMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells. Learn More -
PIK-III
Catalog No. A15868 Autophagy InhibitorPIK-III is a selective inhibitor of ?VPS34 enzymatic activity. Learn More -
ROC-325
Catalog No. A17031 Autophagy inhibitorROC-325 is an autophagy inhibitor. ROC-325 exhibited superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in 12 different cancer cell lines with diverse genetic backgrounds. Learn More -
3-Methyladenine
Catalog No. A11151 Autophagy/PI3K Inhibitor3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase). Learn More -
Monensin sodium
Catalog No. A10603 autophagy inhibitorMonensin sodium is an ionophore and inhibitor of autophagy commercially used in livestock feed. It inhibits autophagy, interfering with the fusion of the autophagosome and the lysosome. Learn More -
Lys05
Catalog No. A16358 Autophagy inhibitorLys05 is a potent lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Learn More -
Chloroquine Phosphate
Catalog No. A16445 Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Learn More -
Azithromycin Dihydrate
Catalog No. A16421 Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. Learn More -
Scutellarein
Catalog No. A12234 Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz, has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases. Learn More -
MRT68921
Catalog No. A15880 Autophagy ULK1/2 inhibitorMRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. Learn More -
SBI-0206965
Catalog No. A15795 ULK1 inhibitorSBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 . Learn More -
SBC-115076
Catalog No. A15769 PCSK9 antagonistSBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases. Learn More -
Spautin-1
Catalog No. A12942 Autophagy InhibitorSpautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03μM. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM. Learn More -
Hydroxychloroquine Sulfate
Catalog No. A14208 Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9. Learn More -
Flubendazole (Flutelmium)
Catalog No. A11656 autophagy inducerFlubendazole is an anthelmintic used for protection against internal parasites and worms in dogs and cats. Learn More -
STF-62247
Catalog No. A10866 Autophagy InducerSTF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). Learn More -
Resveratrol
Catalog No. A10785 Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Learn More
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